ZA992445B - Benzoxazinones/benzothiazinones as serine protease inhibitors. - Google Patents
Benzoxazinones/benzothiazinones as serine protease inhibitors.Info
- Publication number
- ZA992445B ZA992445B ZA9902445A ZA992445A ZA992445B ZA 992445 B ZA992445 B ZA 992445B ZA 9902445 A ZA9902445 A ZA 9902445A ZA 992445 A ZA992445 A ZA 992445A ZA 992445 B ZA992445 B ZA 992445B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzothiazinones
- benzoxazinones
- protease inhibitors
- serine protease
- serine
- Prior art date
Links
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8014298P | 1998-03-31 | 1998-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA992445B true ZA992445B (en) | 1999-10-01 |
Family
ID=22155527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9902445A ZA992445B (en) | 1998-03-31 | 1999-03-30 | Benzoxazinones/benzothiazinones as serine protease inhibitors. |
Country Status (15)
Country | Link |
---|---|
US (2) | US6509335B1 (is) |
EP (1) | EP1068191A1 (is) |
JP (1) | JP2002509925A (is) |
KR (1) | KR20010042296A (is) |
AU (1) | AU765223C (is) |
BR (1) | BR9815784A (is) |
CA (1) | CA2319551A1 (is) |
HU (1) | HUP0101699A3 (is) |
IL (1) | IL137656A0 (is) |
IS (1) | IS5590A (is) |
NO (1) | NO20004698D0 (is) |
NZ (1) | NZ506985A (is) |
PL (1) | PL343317A1 (is) |
WO (1) | WO1999050257A1 (is) |
ZA (1) | ZA992445B (is) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
MXPA01008084A (es) * | 1999-02-09 | 2004-09-10 | Dimensional Pharm Inc | Heteroarilamidinas, metilamidinas y guanidinas como inhibidores de proteasa. |
FR2801885B1 (fr) * | 1999-12-06 | 2002-01-11 | Adir | Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1255741A2 (en) | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
AU2001236606A1 (en) * | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa |
US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
AU2002303264A1 (en) | 2001-04-09 | 2002-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
US6794385B2 (en) | 2001-08-08 | 2004-09-21 | Pharmacia & Upjohn, S.P.A. | Benzoxazine derivatives useful as integrin receptor antagonists |
US6750215B2 (en) | 2001-08-08 | 2004-06-15 | Pharmacia & Upjohn, S.P.A. | Substituted benzoxazines as integrin antagonists |
US6916398B2 (en) | 2001-10-26 | 2005-07-12 | Applied Materials, Inc. | Gas delivery apparatus and method for atomic layer deposition |
ATE304533T1 (de) * | 2001-12-28 | 2005-09-15 | Acadia Pharm Inc | Tetrahydrochinolinderivate als muscarinische agonisten |
US6759298B2 (en) * | 2002-06-24 | 2004-07-06 | Micron Technology, Inc. | Methods of forming an array of flash field effect transistors and circuitry peripheral to such array |
SI1569912T1 (sl) | 2002-12-03 | 2015-09-30 | Pharmacyclics Llc | Derivati 2-(2-hidroksibifenil-3-il)-1h-benzoimidazol-5-karboksamidina kot inhibitorji faktorja viia |
TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
CN1859904A (zh) * | 2003-10-03 | 2006-11-08 | 默克公司 | 用于治疗阿尔茨海默氏病的苄醚和苄氨基β-分泌酶抑制剂 |
SI21658A (sl) * | 2003-11-28 | 2005-06-30 | Univerza V Ljubljani | Antitrombotične učinkovine z dualnim mehanizmom delovanja na osnovi 3,4-dihidro-2H-1,4-benzoksazinskega skeleta |
WO2006040625A1 (en) * | 2004-10-12 | 2006-04-20 | Glenmark Pharmaceuticals S.A. | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
WO2006050054A2 (en) * | 2004-11-01 | 2006-05-11 | Nuada, Llc | Compounds and methods of use thereof |
GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
US20070197512A1 (en) * | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
WO2011024987A1 (ja) * | 2009-08-31 | 2011-03-03 | 塩野義製薬株式会社 | 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物 |
MX2013012588A (es) * | 2011-04-29 | 2014-05-20 | Icahn School Med Mount Sinai | Inhibidores de cinasa. |
JP6497808B2 (ja) * | 2015-06-12 | 2019-04-10 | アグロカネショウ株式会社 | 1,4−ベンゾチアジン−1,3−ジオン又は−1,1,3−トリオン誘導体およびこれを有効成分とする殺菌剤 |
MX2022003929A (es) | 2019-10-01 | 2022-06-14 | Molecular Skin Therapeutics Inc | Compuestos de benzoxazinona como inhibidores dobles de klk5/7. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3006916A (en) * | 1961-10-31 | W-dialkylaminoalkyl | ||
US3124577A (en) * | 1964-03-10 | Hydroxyalkyl cyclic amlno | ||
US3089872A (en) * | 1961-03-31 | 1963-05-14 | Olin Mathieson | Benzothiazine and benzothiazepine compounds |
US3401166A (en) | 1966-08-01 | 1968-09-10 | Squibb & Sons Inc | Therapeutically active benzothiazines |
GB1174626A (en) * | 1967-05-23 | 1969-12-17 | Bellon Labor Sa Roger | New Benzoxazine Derivatives |
DE2044530A1 (de) | 1970-02-04 | 1971-08-19 | VEB Deutsches Hydrierwerk Rodleben, χ 4530 Roßlau | Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one |
US3725403A (en) | 1970-10-20 | 1973-04-03 | Squibb & Sons Inc | Benzothiazine derivatives |
FR2332756A1 (fr) | 1975-11-26 | 1977-06-24 | Squibb & Sons Inc | Nouvelles 1, 4-benzoxazin-3(4h)-ones |
US4584300A (en) | 1983-02-07 | 1986-04-22 | Santen Pharmaceutical Co., Ltd. | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor |
JPS60166674A (ja) | 1984-02-09 | 1985-08-29 | Santen Pharmaceut Co Ltd | ベンゾチアジン誘導体 |
KR890004196B1 (ko) * | 1985-07-29 | 1989-10-27 | 산텐세이야꾸가부시끼가이샤 | 신규 벤조티아진 유도체의 제조방법 |
JPH01272524A (ja) | 1988-04-21 | 1989-10-31 | Japan Found Cancer Res | 癌化学療法剤 |
JP2886570B2 (ja) | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
JPH09227561A (ja) | 1996-02-21 | 1997-09-02 | Tanabe Seiyaku Co Ltd | キサンチン誘導体 |
CA2271116A1 (en) | 1996-11-13 | 1998-05-22 | Gregory J. Wells | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors |
AU8330898A (en) | 1997-05-02 | 1998-11-27 | Schering Aktiengesellschaft | Substituted heterocycles and their use in medicaments |
-
1998
- 1998-12-15 PL PL98343317A patent/PL343317A1/xx not_active Application Discontinuation
- 1998-12-15 KR KR1020007010839A patent/KR20010042296A/ko not_active Application Discontinuation
- 1998-12-15 IL IL13765698A patent/IL137656A0/xx unknown
- 1998-12-15 US US09/622,265 patent/US6509335B1/en not_active Expired - Fee Related
- 1998-12-15 JP JP2000541161A patent/JP2002509925A/ja active Pending
- 1998-12-15 HU HU0101699A patent/HUP0101699A3/hu unknown
- 1998-12-15 AU AU19183/99A patent/AU765223C/en not_active Expired - Fee Related
- 1998-12-15 NZ NZ506985A patent/NZ506985A/en unknown
- 1998-12-15 WO PCT/US1998/026708 patent/WO1999050257A1/en not_active Application Discontinuation
- 1998-12-15 EP EP98963965A patent/EP1068191A1/en not_active Withdrawn
- 1998-12-15 BR BR9815784-1A patent/BR9815784A/pt not_active Application Discontinuation
- 1998-12-15 CA CA002319551A patent/CA2319551A1/en not_active Abandoned
-
1999
- 1999-03-30 ZA ZA9902445A patent/ZA992445B/xx unknown
-
2000
- 2000-08-18 IS IS5590A patent/IS5590A/is unknown
- 2000-09-20 NO NO20004698A patent/NO20004698D0/no unknown
-
2002
- 2002-11-12 US US10/292,771 patent/US20030187256A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1068191A1 (en) | 2001-01-17 |
AU765223C (en) | 2004-03-18 |
IL137656A0 (en) | 2001-10-31 |
WO1999050257A1 (en) | 1999-10-07 |
AU765223B2 (en) | 2003-09-11 |
BR9815784A (pt) | 2000-11-21 |
IS5590A (is) | 2000-08-18 |
JP2002509925A (ja) | 2002-04-02 |
NO20004698L (no) | 2000-09-20 |
US6509335B1 (en) | 2003-01-21 |
KR20010042296A (ko) | 2001-05-25 |
HUP0101699A3 (en) | 2002-05-28 |
AU1918399A (en) | 1999-10-18 |
HUP0101699A2 (hu) | 2002-04-29 |
US20030187256A1 (en) | 2003-10-02 |
PL343317A1 (en) | 2001-08-13 |
CA2319551A1 (en) | 1999-10-07 |
NZ506985A (en) | 2003-10-31 |
NO20004698D0 (no) | 2000-09-20 |
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