DE69819349D1 - 1-amino-7-isochinolin-derivate als serin protease inhibitoren - Google Patents

1-amino-7-isochinolin-derivate als serin protease inhibitoren

Info

Publication number
DE69819349D1
DE69819349D1 DE69819349T DE69819349T DE69819349D1 DE 69819349 D1 DE69819349 D1 DE 69819349D1 DE 69819349 T DE69819349 T DE 69819349T DE 69819349 T DE69819349 T DE 69819349T DE 69819349 D1 DE69819349 D1 DE 69819349D1
Authority
DE
Germany
Prior art keywords
amino
protease inhibitors
serine protease
isochinoline derivatives
isochinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69819349T
Other languages
English (en)
Other versions
DE69819349T2 (de
Inventor
John Walter Liebeschuetz
William Alexander Wylie
Bohdan Waszkowycz
Christopher William Murray
Andrew David Rimmer
Pauline Mary Welsh
Stuart Donald Jones
Jonathan Michael Ernest Roscoe
Stephen Clinton Young
Phillip John Morgan
Nicholas Paul Camp
Andrew Philip Austin Crew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Ltd
Original Assignee
Tularik Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9718392.5A external-priority patent/GB9718392D0/en
Priority claimed from GBGB9803173.5A external-priority patent/GB9803173D0/en
Application filed by Tularik Ltd filed Critical Tularik Ltd
Application granted granted Critical
Publication of DE69819349D1 publication Critical patent/DE69819349D1/de
Publication of DE69819349T2 publication Critical patent/DE69819349T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69819349T 1997-08-29 1998-08-28 1-amino-7-isochinolin-derivate als serin protease inhibitoren Expired - Lifetime DE69819349T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9718392.5A GB9718392D0 (en) 1997-08-29 1997-08-29 Compounds
GB9718392 1997-08-29
GBGB9803173.5A GB9803173D0 (en) 1998-02-13 1998-02-13 Compounds
GB9803173 1998-02-13
PCT/GB1998/002600 WO1999011657A1 (en) 1997-08-29 1998-08-28 1-amino-7-isoquinoline derivatives as serine protease inhibitors

Publications (2)

Publication Number Publication Date
DE69819349D1 true DE69819349D1 (de) 2003-12-04
DE69819349T2 DE69819349T2 (de) 2004-07-22

Family

ID=26312149

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69819349T Expired - Lifetime DE69819349T2 (de) 1997-08-29 1998-08-28 1-amino-7-isochinolin-derivate als serin protease inhibitoren
DE69830410T Expired - Lifetime DE69830410T2 (de) 1997-08-29 1998-08-28 Meta-benzamidinderivate als serinprotease-inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69830410T Expired - Lifetime DE69830410T2 (de) 1997-08-29 1998-08-28 Meta-benzamidinderivate als serinprotease-inhibitoren

Country Status (5)

Country Link
US (2) US6262069B1 (de)
EP (2) EP1009758B1 (de)
AU (2) AU8875798A (de)
DE (2) DE69819349T2 (de)
WO (2) WO1999011657A1 (de)

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DE69819349T2 (de) * 1997-08-29 2004-07-22 Tularik Ltd. 1-amino-7-isochinolin-derivate als serin protease inhibitoren
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
EP1065200A4 (de) * 1998-03-19 2003-01-02 Ajinomoto Kk Aminoisochinolin-derivate
EP1181270A2 (de) * 1999-05-24 2002-02-27 Cor Therapeutics, Inc. Faktor xa-inhibitoren
DE60022508T2 (de) * 1999-06-14 2006-06-08 Eli Lilly And Co., Indianapolis Inhibitoren von serin proteasen
AU5413600A (en) * 1999-06-14 2001-01-02 Eli Lilly And Company Compounds
GB9929552D0 (en) * 1999-12-14 2000-02-09 Proteus Molecular Design Compounds
JP2003514897A (ja) * 1999-11-24 2003-04-22 シーオーアール セラピューティクス インコーポレイテッド ベータ−アミノ酸系、アスパラギン酸系およびジアミノプロピオン酸系Ｘａ因子阻害剤
GB0030305D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
AU6407701A (en) * 2000-06-13 2001-12-24 Tularik Ltd Serine protease inhibitors
GB0030304D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030303D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds
US7074934B2 (en) * 2000-06-13 2006-07-11 Tularik Limited Serine protease inhibitors
GB0030306D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
DE10046272A1 (de) * 2000-09-19 2002-03-28 Merck Patent Gmbh Aminoheterocyclen (Faktor Xa Inhibitoren 14)
GB0114185D0 (en) * 2001-06-12 2001-08-01 Protherics Molecular Design Lt Compounds
US20030114448A1 (en) * 2001-05-31 2003-06-19 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7115607B2 (en) * 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
US7265121B2 (en) 2001-07-26 2007-09-04 Eli Lilly And Company Chemical compounds
HU228783B1 (en) * 2001-07-26 2013-05-28 Greenearth Cleaning Dry cleaning apparatus and method capable of utilizing a siloxane solvent
MY130373A (en) * 2001-10-29 2007-06-29 Malesci Sas Linear basic compounds having nk-2 antagonist activity and formulations thereof
ES2242086T3 (es) 2001-12-12 2005-11-01 Eli Lilly And Company Ciertos derivados de glicina como inhibidores del factor xa para el tratamiento de trastornos tromboticos.
AU2002359458A1 (en) * 2001-12-12 2003-06-23 Eli Lilly And Company Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases
WO2003049737A1 (en) 2001-12-12 2003-06-19 Eli Lilly And Company Chemical compounds
DE10209692A1 (de) 2002-03-06 2003-09-18 Merck Patent Gmbh Isochinolinderivate
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
DK1492767T3 (da) 2002-04-01 2005-11-28 Lilly Co Eli Visse 1-(D-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazinforbindelser som inhibitorer af serinproteasefaktoren XA
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
US20040018984A1 (en) * 2002-07-17 2004-01-29 Mizuo Miyazaki Methods for preventing adhesion formation using protease inhibitors
ES2543588T3 (es) 2002-12-03 2015-08-20 Pharmacyclics Llc Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa
US7427632B2 (en) 2002-12-30 2008-09-23 Eli Lilly And Company Factor Xa inhibitors
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
WO2005082865A1 (ja) * 2004-02-27 2005-09-09 Astellas Pharma Inc. 縮合二環性ピリミジン誘導体
DK1637141T3 (da) 2004-09-21 2012-02-27 Trobio Ab Stabiliseret proteasesammensætning omfattende en serinprotease, morpholinderivater og reversible inhibitorer af serinproteasen
JP5080476B2 (ja) * 2005-09-22 2012-11-21 トルービオ・アーベー 安定化プロテアーゼ組成物
US7615556B2 (en) * 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
MX2011003991A (es) 2008-10-17 2011-06-24 Exelixis Inc Antagonistas del receptor esfingosina-1-fosfato.
CA2905451A1 (en) 2013-03-14 2014-10-02 Convergene Llc Methods and compositions for inhibition of bromodomain-containing proteins
CN103804270B (zh) * 2014-01-23 2016-06-22 中国药科大学 5-(4-甲脒基苄氧基)色氨酸衍生物、其制法及应用
CA3006300C (en) * 2015-11-25 2024-02-27 Convergene Llc Bicyclic bet bromodomain inhibitors and uses thereof
GB201601301D0 (en) * 2016-01-25 2016-03-09 Takeda Pharmaceutical Novel compounds
CN111848430B (zh) * 2020-07-22 2022-12-09 马鞍山诺恩特医药科技有限公司 2-([1,1’-联苯]-4-基)-2-甘氨酸类化合物的合成方法

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US5346907A (en) 1988-04-05 1994-09-13 Abbott Laboratories Amino acid analog CCK antagonists
IE902295A1 (en) 1989-07-07 1991-01-16 Abbott Lab Amino acid analog cck antagonists
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1992008709A1 (de) * 1990-11-15 1992-05-29 Pentapharm Ag Meta-substituierte phenylalanin-derivate
DE4127404A1 (de) 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
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DE4332168A1 (de) 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
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JP4223560B2 (ja) 1996-12-13 2009-02-12 アヴェンティス ファーマシューティカルズ インコーポレイテッド スルホン酸又はスルホニルアミノｎ−（ヘテロアラルキル）アザヘテロシクリルアミド化合物
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DE69819349T2 (de) * 1997-08-29 2004-07-22 Tularik Ltd. 1-amino-7-isochinolin-derivate als serin protease inhibitoren
EP1185509A2 (de) 1999-05-24 2002-03-13 Cor Therapeutics, Inc. Inhibitoren von faktor xa

Also Published As

Publication number Publication date
EP1009758B1 (de) 2005-06-01
EP1012166B1 (de) 2003-10-29
AU8875798A (en) 1999-03-22
DE69819349T2 (de) 2004-07-22
AU8875398A (en) 1999-03-22
US6262069B1 (en) 2001-07-17
EP1012166A1 (de) 2000-06-28
WO1999011657A1 (en) 1999-03-11
US20020040144A1 (en) 2002-04-04
EP1009758A1 (de) 2000-06-21
DE69830410T2 (de) 2006-01-26
WO1999011658A1 (en) 1999-03-11
US6420438B1 (en) 2002-07-16
DE69830410D1 (de) 2005-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN