NO20001052L - 1C, 15N, 2H merkede proteiner for NMR-strukturbestemmelser og deres fremstilling - Google Patents

1C, 15N, 2H merkede proteiner for NMR-strukturbestemmelser og deres fremstilling

Info

Publication number
NO20001052L
NO20001052L NO20001052A NO20001052A NO20001052L NO 20001052 L NO20001052 L NO 20001052L NO 20001052 A NO20001052 A NO 20001052A NO 20001052 A NO20001052 A NO 20001052A NO 20001052 L NO20001052 L NO 20001052L
Authority
NO
Norway
Prior art keywords
labeled proteins
preparation
labeled
proteins
methods
Prior art date
Application number
NO20001052A
Other languages
English (en)
Other versions
NO20001052D0 (no
Inventor
Iii Frank Elbert Anderson
Jonathan Miles Brown
Philip Edward Coughlin
Steven William Homans
Charles Tobias Weller
Carrie Ann Zimmerman-Wilson
Jr Eddie James Oliver
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Publication of NO20001052D0 publication Critical patent/NO20001052D0/no
Publication of NO20001052L publication Critical patent/NO20001052L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
NO20001052A 1997-09-02 2000-03-01 1C, 15N, 2H merkede proteiner for NMR-strukturbestemmelser og deres fremstilling NO20001052L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/921,554 US6111066A (en) 1997-09-02 1997-09-02 Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
PCT/US1998/018197 WO1999011589A1 (en) 1997-09-02 1998-09-02 13c, 15n, 2h labeled proteins for nmr structure determinations and their preparation

Publications (2)

Publication Number Publication Date
NO20001052D0 NO20001052D0 (no) 2000-03-01
NO20001052L true NO20001052L (no) 2000-04-28

Family

ID=25445613

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001052A NO20001052L (no) 1997-09-02 2000-03-01 1C, 15N, 2H merkede proteiner for NMR-strukturbestemmelser og deres fremstilling

Country Status (12)

Country Link
US (4) US6111066A (no)
EP (2) EP1009725B1 (no)
JP (1) JP2001514239A (no)
AT (1) ATE420061T1 (no)
AU (1) AU754232B2 (no)
CA (1) CA2301046C (no)
DE (1) DE69840448D1 (no)
HU (1) HUP0003383A3 (no)
NO (1) NO20001052L (no)
TW (1) TW581772B (no)
WO (1) WO1999011589A1 (no)
ZA (1) ZA987975B (no)

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US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
EP1328815A1 (en) * 2000-10-20 2003-07-23 Martek Biosciences Corporation Rapid determination of protein global folds
US6882939B2 (en) * 2000-10-20 2005-04-19 Prospect Pharma Rapid determination of protein global folds
WO2003002724A2 (en) * 2001-03-12 2003-01-09 Affinium Pharmaceuticals, Inc. Proteins, druggable regions of proteins and target analysis for chemistry of therapeutics
WO2003006488A1 (en) * 2001-07-13 2003-01-23 The Regents Of The University Of California In-cell nmr spectroscopy
JP2003096098A (ja) * 2001-09-25 2003-04-03 Nippon Sanso Corp 安定同位体標識抗体及びその製造方法ならびにこれを用いた検出方法
US20030077572A1 (en) * 2001-10-11 2003-04-24 Abramson Fred P. Quantitative differential display using isotope ratio monitoring
US20040030239A1 (en) * 2001-12-13 2004-02-12 The Johns Hopkins University School Of Medicine Method for MR/NMR imaging
WO2003053910A1 (fr) * 2001-12-19 2003-07-03 Japan Science And Technology Agency Amino acide marque par isotope stable, technique d'integration de cet amino acide dans une proteine cible, technique d'analyse structurelle par irm de proteine et technique de production d'acide fumarique et d'acide tartrique marques par isotope stable a selection de site
EP1551291A4 (en) * 2002-06-10 2007-11-28 Prospect Pharma METHOD FOR OBTAINING DYNAMIC AND STRUCTURAL DATA RELATING TO PROTEINS AND PROTEIN / LIGANDEN COMPLEXES
EP2801616A1 (en) 2002-06-17 2014-11-12 Thrasos Innovation, Inc. Single domain TDF-related compounds and analogs thereof
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7553455B1 (en) * 2003-04-02 2009-06-30 Sandia Corporation Micromanifold assembly
US7672791B2 (en) * 2003-06-13 2010-03-02 International Business Machines Corporation Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules
EP1644474B1 (en) 2003-07-11 2012-06-27 Tatiana A. Egorova-Zachernyuk Compositions and methods for stable isotope labelling of biological compounds
WO2005037853A2 (en) * 2003-10-07 2005-04-28 Prospect Pharma Side chain deuterated amino acids and methods of use
DK1679302T3 (da) 2003-10-31 2014-06-10 Japan Science & Tech Agency Aromatisk aminosyre mærket med en stabil isotop fremgangsmåde til inkorporering deraf i target-protein og fremgangsmåde til analyse af proteinstruktur under anvendelse af nmr
JP4475237B2 (ja) * 2004-02-02 2010-06-09 三菱化学株式会社 Ｎｍｒシグナル帰属方法
EP2789342A1 (en) 2004-06-17 2014-10-15 Thrasos Innovation, Inc. TDF-related compounds and analogs thereof
US7480356B2 (en) * 2004-12-08 2009-01-20 Telefonaktiebolaget L M Ericsson (Publ) Method of and system for path selection in rich multipath conditions
US7372895B2 (en) * 2004-12-08 2008-05-13 Telefonaktiebolaget Lm Ericsson (Publ) Method of and system for delay estimation with minimized finger allocation
EP3238543B1 (en) 2005-06-07 2019-03-20 DSM Nutritional Products AG Eukaryotic microorganisms for producing lipids and antioxidants
CA2623415A1 (en) 2005-09-20 2007-03-29 Thrasos, Inc. Tdf-related compounds and analogs thereof
US20070196280A1 (en) * 2006-02-21 2007-08-23 The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services In vivo magnetic resonance spectroscopy of aspartate transaminase activity
GB0604647D0 (en) * 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Ｎｍｒシグナルの帰属方法
CA2659603C (en) * 2006-08-01 2017-03-07 Ocean Nutrition Canada Limited Oil producing microbes and methods of modification thereof
EP2268604B1 (en) * 2008-03-14 2017-02-15 Retrotope, Inc. Therapies for cancer using isotopically substituted lysine
US8637486B2 (en) * 2008-03-14 2014-01-28 Retrotope, Inc. Therapeutic substances that modulate genome methylation
US10052299B2 (en) 2009-10-30 2018-08-21 Retrotope, Inc. Alleviating oxidative stress disorders with PUFA derivatives
CN101914030B (zh) * 2010-07-23 2013-04-24 上海化工研究院 一种13c，15n双标记甘氨酸的合成方法
EP2701698B1 (en) 2011-04-26 2020-12-23 Retrotope, Inc. Disorders implicating pufa oxidation
AU2012249918B2 (en) 2011-04-26 2017-06-15 Biojiva Llc Impaired energy processing disorders and mitochondrial deficiency
US10154983B2 (en) 2011-04-26 2018-12-18 Retrotope, Inc. Neurodegenerative disorders and muscle diseases implicating PUFAs
JP6106158B2 (ja) 2011-04-26 2017-03-29 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． 酸化的網膜疾患
WO2014141098A1 (en) 2013-03-13 2014-09-18 Dsm Nutritional Products Ag Engineering microorganisms
KR102643910B1 (ko) 2015-11-23 2024-03-06 레트로토프 인코포레이티드 1,4-다이엔 시스템에 대한 부위 특이적인 동위원소 표지법
FR3055337A1 (fr) * 2016-08-24 2018-03-02 Commissariat A L'energie Atomique Et Aux Energies Alternatives Methode de preparation de milieux de culture riches pour le marquage d'acides amines incorpores dans des proteines
JP2023514711A (ja) 2020-02-21 2023-04-07 レトロトップ、 インコーポレイテッド 多価不飽和脂肪酸及びその誘導体の同位体修飾方法

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JPH0768446B2 (ja) * 1988-11-09 1995-07-26 三菱化学株式会社 芳香族ポリカーボネート樹脂組成物を用いた医療用部品
JP2518917B2 (ja) 1989-02-07 1996-07-31 日本電子株式会社 蛋白質の構造解析方法
JPH04506154A (ja) 1989-06-14 1992-10-29 マーテック・コーポレイション 細胞培養培地及びその作成法
JP2517688B2 (ja) * 1989-12-25 1996-07-24 日本電子株式会社 ３次元核磁気共鳴スペクトルの対称化処理方法
JPH0446143A (ja) * 1990-06-11 1992-02-17 Hitachi Ltd 同位体多重標識アミノ酸の合成法
US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US5891643A (en) 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
US6043024A (en) 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains

Also Published As

Publication number Publication date
EP1009725A1 (en) 2000-06-21
AU754232B2 (en) 2002-11-07
WO1999011589A1 (en) 1999-03-11
CA2301046C (en) 2009-03-10
DE69840448D1 (de) 2009-02-26
EP1889823A1 (en) 2008-02-20
US6335196B1 (en) 2002-01-01
US6340578B1 (en) 2002-01-22
HUP0003383A2 (hu) 2001-02-28
ATE420061T1 (de) 2009-01-15
CA2301046A1 (en) 1999-03-11
US6376253B1 (en) 2002-04-23
ZA987975B (en) 2000-01-21
TW581772B (en) 2004-04-01
HUP0003383A3 (en) 2003-07-28
JP2001514239A (ja) 2001-09-11
NO20001052D0 (no) 2000-03-01
EP1009725B1 (en) 2009-01-07
US6111066A (en) 2000-08-29
AU9298898A (en) 1999-03-22

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