HUP0003383A3 - 13c, 15n, 2h labeled proteins for nmr structure determinations and their preparation - Google Patents
13c, 15n, 2h labeled proteins for nmr structure determinations and their preparationInfo
- Publication number
- HUP0003383A3 HUP0003383A3 HU0003383A HUP0003383A HUP0003383A3 HU P0003383 A3 HUP0003383 A3 HU P0003383A3 HU 0003383 A HU0003383 A HU 0003383A HU P0003383 A HUP0003383 A HU P0003383A HU P0003383 A3 HUP0003383 A3 HU P0003383A3
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- labeled proteins
- nmr structure
- structure determinations
- determinations
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/921,554 US6111066A (en) | 1997-09-02 | 1997-09-02 | Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0003383A2 HUP0003383A2 (hu) | 2001-02-28 |
HUP0003383A3 true HUP0003383A3 (en) | 2003-07-28 |
Family
ID=25445613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0003383A HUP0003383A3 (en) | 1997-09-02 | 1998-09-02 | 13c, 15n, 2h labeled proteins for nmr structure determinations and their preparation |
Country Status (12)
Country | Link |
---|---|
US (4) | US6111066A (hu) |
EP (2) | EP1889823A1 (hu) |
JP (1) | JP2001514239A (hu) |
AT (1) | ATE420061T1 (hu) |
AU (1) | AU754232B2 (hu) |
CA (1) | CA2301046C (hu) |
DE (1) | DE69840448D1 (hu) |
HU (1) | HUP0003383A3 (hu) |
NO (1) | NO20001052L (hu) |
TW (1) | TW581772B (hu) |
WO (1) | WO1999011589A1 (hu) |
ZA (1) | ZA987975B (hu) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6111066A (en) | 1997-09-02 | 2000-08-29 | Martek Biosciences Corporation | Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains |
US6882939B2 (en) * | 2000-10-20 | 2005-04-19 | Prospect Pharma | Rapid determination of protein global folds |
US20020098517A1 (en) * | 2000-10-20 | 2002-07-25 | Homans Steven W. | Rapid determination of protein global folds |
US20030068651A1 (en) * | 2001-03-12 | 2003-04-10 | Cheryl Arrowsmith | Multi-target analysis of gene families for chemistry of high affinity and selective small molecules and other therapeutics |
WO2003006488A1 (en) * | 2001-07-13 | 2003-01-23 | The Regents Of The University Of California | In-cell nmr spectroscopy |
JP2003096098A (ja) * | 2001-09-25 | 2003-04-03 | Nippon Sanso Corp | 安定同位体標識抗体及びその製造方法ならびにこれを用いた検出方法 |
US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
WO2003049604A2 (en) * | 2001-12-13 | 2003-06-19 | The Johns Hopkins University School Of Medicine | Method for mr/nmr imaging |
EP1457482B9 (en) * | 2001-12-19 | 2012-10-24 | Japan Science and Technology Agency | Stable isotope-labeled amino acid, method of integrating the same into target protein, method of NMR structural analysis of protein |
US20060154323A1 (en) * | 2002-06-10 | 2006-07-13 | Prospect Pharma | Method for obtaining dynamic and structural data pertaining to proteins and protein/ligand complexes |
AU2003247551C1 (en) | 2002-06-17 | 2010-12-09 | Thrasos Innovation, Inc. | Single domain TDF-related compounds and analogs thereof |
US7473535B2 (en) * | 2002-08-20 | 2009-01-06 | The Institute For Systems Biology | Chemical reagents and methods for detection and quantification of proteins in complex mixtures |
US7553455B1 (en) * | 2003-04-02 | 2009-06-30 | Sandia Corporation | Micromanifold assembly |
US7672791B2 (en) * | 2003-06-13 | 2010-03-02 | International Business Machines Corporation | Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules |
RU2409657C2 (ru) | 2003-07-11 | 2011-01-20 | Татьяна А. ЕГОРОВА-ЗАЧЕРНЮК | Композиции и способы для мечения стабильным изотопом биологических соединений |
EP1678198A4 (en) * | 2003-10-07 | 2007-12-05 | Prospect Pharma | SIDE CHAIN DEUTERATED AMINO ACIDS AND METHOD OF USE |
CA2544305C (en) | 2003-10-31 | 2011-07-12 | Japan Science And Technology Agency | Stable isotope-labeled aromatic amino acids, method for incorporating the same in target protein and method for nmr-structural analysis of proteins |
JP4475237B2 (ja) * | 2004-02-02 | 2010-06-09 | 三菱化学株式会社 | Nmrシグナル帰属方法 |
EP2789342A1 (en) | 2004-06-17 | 2014-10-15 | Thrasos Innovation, Inc. | TDF-related compounds and analogs thereof |
US7480356B2 (en) * | 2004-12-08 | 2009-01-20 | Telefonaktiebolaget L M Ericsson (Publ) | Method of and system for path selection in rich multipath conditions |
US7372895B2 (en) * | 2004-12-08 | 2008-05-13 | Telefonaktiebolaget Lm Ericsson (Publ) | Method of and system for delay estimation with minimized finger allocation |
JP5886511B2 (ja) | 2005-06-07 | 2016-03-16 | ディーエスエム ニュートリショナル プロダクツ アーゲーDSM Nutritional Products AG | 脂質および抗酸化剤の製造のための真核微生物 |
ES2537527T3 (es) | 2005-09-20 | 2015-06-09 | Thrasos Innovation, Inc. | Compuestos relacionados con el TDF y análogos de los mismos |
US20070196280A1 (en) * | 2006-02-21 | 2007-08-23 | The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services | In vivo magnetic resonance spectroscopy of aspartate transaminase activity |
GB0604647D0 (en) | 2006-03-08 | 2006-04-19 | Shchepinov Mikhail | Stabilized food supplements and their derivatives |
JP2007255910A (ja) * | 2006-03-20 | 2007-10-04 | Hokkaido Univ | Nmrシグナルの帰属方法 |
WO2008129358A2 (en) * | 2006-08-01 | 2008-10-30 | Ocean Nutrition Canada Ltd. | Oil producing microbes and methods of modification thereof |
EP2268604B1 (en) * | 2008-03-14 | 2017-02-15 | Retrotope, Inc. | Therapies for cancer using isotopically substituted lysine |
WO2009114814A2 (en) | 2008-03-14 | 2009-09-17 | Retrotope, Inc. | Therapeutic substances that modulate genome methylation |
WO2011053870A1 (en) | 2009-10-30 | 2011-05-05 | Retrotope, Inc. | Alleviating oxidative stress disorders with pufa derivatives |
CN101914030B (zh) * | 2010-07-23 | 2013-04-24 | 上海化工研究院 | 一种13c,15n双标记甘氨酸的合成方法 |
KR102020579B1 (ko) | 2011-04-26 | 2019-09-10 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
US10154978B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Disorders implicating PUFA oxidation |
KR102111997B1 (ko) | 2011-04-26 | 2020-05-18 | 레트로토프 인코포레이티드 | Pufa와 관련된 신경퇴행성 질환 및 근육 질환 |
WO2012148930A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Oxidative retinal diseases |
CN105189740B (zh) | 2013-03-13 | 2019-01-15 | 帝斯曼营养品股份公司 | 工程化微生物 |
JP7048976B2 (ja) | 2015-11-23 | 2022-04-06 | レトロトップ、 インコーポレイテッド | 1,4-ジエン系の部位特異的同位体標識 |
FR3055337A1 (fr) * | 2016-08-24 | 2018-03-02 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Methode de preparation de milieux de culture riches pour le marquage d'acides amines incorpores dans des proteines |
EP4107163A4 (en) | 2020-02-21 | 2024-06-19 | Retrotope, Inc. | PROCESS FOR ISOTOPIC MODIFICATION OF POLYUNSATURATED FATTY ACIDS AND THEIR DERIVATIVES |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0768446B2 (ja) * | 1988-11-09 | 1995-07-26 | 三菱化学株式会社 | 芳香族ポリカーボネート樹脂組成物を用いた医療用部品 |
JP2518917B2 (ja) | 1989-02-07 | 1996-07-31 | 日本電子株式会社 | 蛋白質の構造解析方法 |
ES2102984T3 (es) | 1989-06-14 | 1997-08-16 | Martek Corp | Medios para el crecimiento de celulas y procedimiento para preparar los mismos. |
JP2517688B2 (ja) * | 1989-12-25 | 1996-07-24 | 日本電子株式会社 | 3次元核磁気共鳴スペクトルの対称化処理方法 |
JPH0446143A (ja) * | 1990-06-11 | 1992-02-17 | Hitachi Ltd | 同位体多重標識アミノ酸の合成法 |
US5393669A (en) * | 1993-02-05 | 1995-02-28 | Martek Biosciences Corp. | Compositions and methods for protein structural determinations |
US5891643A (en) | 1995-11-14 | 1999-04-06 | Abbott Laboratories | Use of nuclear magnetic resonance to design ligands to target biomolecules |
US5698401A (en) * | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
US6043024A (en) | 1997-04-18 | 2000-03-28 | Abbott Laboratories | Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules |
US6111066A (en) | 1997-09-02 | 2000-08-29 | Martek Biosciences Corporation | Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains |
-
1997
- 1997-09-02 US US08/921,554 patent/US6111066A/en not_active Expired - Lifetime
-
1998
- 1998-09-01 ZA ZA9807975A patent/ZA987975B/xx unknown
- 1998-09-02 TW TW087114552A patent/TW581772B/zh not_active IP Right Cessation
- 1998-09-02 JP JP2000508633A patent/JP2001514239A/ja active Pending
- 1998-09-02 EP EP07120079A patent/EP1889823A1/en not_active Withdrawn
- 1998-09-02 HU HU0003383A patent/HUP0003383A3/hu unknown
- 1998-09-02 EP EP98945835A patent/EP1009725B1/en not_active Expired - Lifetime
- 1998-09-02 AU AU92988/98A patent/AU754232B2/en not_active Ceased
- 1998-09-02 CA CA002301046A patent/CA2301046C/en not_active Expired - Fee Related
- 1998-09-02 US US09/486,837 patent/US6335196B1/en not_active Expired - Lifetime
- 1998-09-02 AT AT98945835T patent/ATE420061T1/de not_active IP Right Cessation
- 1998-09-02 WO PCT/US1998/018197 patent/WO1999011589A1/en active IP Right Grant
- 1998-09-02 DE DE69840448T patent/DE69840448D1/de not_active Expired - Lifetime
-
2000
- 2000-03-01 NO NO20001052A patent/NO20001052L/no not_active Application Discontinuation
- 2000-07-10 US US09/613,571 patent/US6340578B1/en not_active Expired - Lifetime
- 2000-07-10 US US09/613,570 patent/US6376253B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HUP0003383A2 (hu) | 2001-02-28 |
ZA987975B (en) | 2000-01-21 |
AU754232B2 (en) | 2002-11-07 |
CA2301046A1 (en) | 1999-03-11 |
EP1009725A1 (en) | 2000-06-21 |
DE69840448D1 (de) | 2009-02-26 |
NO20001052L (no) | 2000-04-28 |
US6340578B1 (en) | 2002-01-22 |
US6111066A (en) | 2000-08-29 |
EP1889823A1 (en) | 2008-02-20 |
US6376253B1 (en) | 2002-04-23 |
CA2301046C (en) | 2009-03-10 |
WO1999011589A1 (en) | 1999-03-11 |
ATE420061T1 (de) | 2009-01-15 |
AU9298898A (en) | 1999-03-22 |
EP1009725B1 (en) | 2009-01-07 |
NO20001052D0 (no) | 2000-03-01 |
TW581772B (en) | 2004-04-01 |
JP2001514239A (ja) | 2001-09-11 |
US6335196B1 (en) | 2002-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0003383A3 (en) | 13c, 15n, 2h labeled proteins for nmr structure determinations and their preparation | |
GB2312751B (en) | NMR diffusion measurement | |
GB9903309D0 (en) | Probe card | |
PL335700A1 (en) | Novel preparation | |
PL337970A1 (en) | Novel preparation | |
EP1088831A4 (en) | HEMOPOIETIN RECEPTOR PROTEINS | |
AU738809C (en) | Novel liposomal active-principle vectors | |
EP0981757A4 (en) | CIRCUITS WITH TEST MODE ON STRAP BAND | |
EP1159962A4 (en) | liposome | |
AU7830498A (en) | Instant yogurt preparation | |
GB9701710D0 (en) | Mammalian protein | |
EP1198474A4 (en) | DECOUPLED PROTEINS | |
ZA984322B (en) | Sucrose-binding proteins | |
EP1105734A4 (en) | WITH 'HOMER' INTERACTIVE PROTEINS | |
GB9816337D0 (en) | Proteins | |
IL135639A0 (en) | Novel methylenebisphosphonic acid derivatives | |
AU4214800A (en) | Vesicle associated proteins | |
ZA989147B (en) | Human toll homologues. | |
EP1127066A4 (en) | MODIFIED PROTEINS | |
MD836F1 (en) | Face cream | |
GB9816336D0 (en) | Proteins | |
GB9816335D0 (en) | Proteins | |
GB0320970D0 (en) | Proteins | |
ZA985940B (en) | Amino acid derivatives | |
TW334758U (en) | Improved measuring can structure for powered milk |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |