NO180375C - Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Info

Publication number
NO180375C
NO180375C NO912100A NO912100A NO180375C NO 180375 C NO180375 C NO 180375C NO 912100 A NO912100 A NO 912100A NO 912100 A NO912100 A NO 912100A NO 180375 C NO180375 C NO 180375C
Authority
NO
Norway
Prior art keywords
hydrogen
halo
amino
alkyl
propylpiperazin
Prior art date
Application number
NO912100A
Other languages
English (en)
Norwegian (no)
Other versions
NO912100L (no
NO180375B (no
NO912100D0 (no
Inventor
Michael John Leach
Malcolm Stuart Nobbs
Ramachandran Iyer
Clive Leonard Yeates
Philip Alan Skone
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO912100D0 publication Critical patent/NO912100D0/no
Publication of NO912100L publication Critical patent/NO912100L/no
Priority to NO954109A priority Critical patent/NO954109D0/no
Publication of NO180375B publication Critical patent/NO180375B/no
Publication of NO180375C publication Critical patent/NO180375C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO912100A 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin NO180375C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO954109A NO954109D0 (no) 1990-06-01 1995-10-16 Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (4)

Publication Number Publication Date
NO912100D0 NO912100D0 (no) 1991-05-31
NO912100L NO912100L (no) 1991-12-02
NO180375B NO180375B (no) 1996-12-30
NO180375C true NO180375C (no) 1997-04-09

Family

ID=10676964

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912100A NO180375C (no) 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Country Status (25)

Country Link
EP (2) EP0679645A1 (mo)
JP (1) JPH06340634A (mo)
KR (1) KR920000733A (mo)
AT (1) ATE141263T1 (mo)
AU (2) AU652753B2 (mo)
CA (1) CA2043640A1 (mo)
CZ (1) CZ281070B6 (mo)
DE (1) DE69121317T2 (mo)
DK (1) DK0459819T3 (mo)
ES (1) ES2093078T3 (mo)
FI (1) FI912623A7 (mo)
GB (1) GB9012316D0 (mo)
GR (1) GR3021237T3 (mo)
HU (2) HUT58707A (mo)
IE (1) IE911861A1 (mo)
IL (2) IL113599A (mo)
MY (2) MY136248A (mo)
NO (1) NO180375C (mo)
NZ (3) NZ238360A (mo)
PL (2) PL166656B1 (mo)
PT (1) PT97827B (mo)
RU (1) RU2091374C1 (mo)
SK (1) SK278444B6 (mo)
TW (1) TW224460B (mo)
ZA (1) ZA914165B (mo)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
ES2089498T3 (es) * 1991-01-30 1996-10-01 Wellcome Found Comprimidos dispersables en agua.
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
AU5704594A (en) * 1992-12-18 1994-07-19 Wellcome Foundation Limited, The Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
TR200200701T2 (tr) 1999-09-16 2002-06-21 Tanabe Seiyaku Co., Ltd. Altı-elementli aromatik nitrojenli halka bileşimleri.
HRP20020673A2 (en) * 2000-02-25 2004-12-31 Hoffmann La Roche Adenosine receptor modulators
WO2001083460A1 (en) 2000-04-28 2001-11-08 Tanabe Seiyaku Co., Ltd. Cyclic compounds
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
DE60142236D1 (de) * 2000-07-24 2010-07-08 Krenitsky Pharmaceuticals Inc Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung
MXPA03007623A (es) 2001-02-26 2003-12-04 Tanabe Seiyaku Co Derivado de piridopirimidina o naftiridina.
EP1474401A2 (en) * 2002-02-05 2004-11-10 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
JP5121707B2 (ja) 2005-07-04 2013-01-16 ハイ ポイント ファーマシューティカルズ，エルエルシー 新規医薬
JP2009537596A (ja) 2006-05-23 2009-10-29 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用
SI2079732T1 (sl) 2006-05-29 2012-03-30 High Point Pharmaceuticals Llc benzodioksol il ciklopropilpiperazin il piridazin njegove soli in solvati in njegova uporaba kot antagonist histaminskega receptorja H
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
ES2923760T3 (es) 2011-06-10 2022-09-30 Merck Patent Gmbh Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de BTK
JP6523303B2 (ja) 2014-01-17 2019-05-29 ノバルティス アーゲー Ｓｈｐ２の活性を阻害するための１−ピリダジン／トリアジン−３−イル−ピペラジン／ピペリジン／ピロリジン誘導体およびその組成物
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
RU2021106500A (ru) 2016-06-14 2021-04-16 Новартис Аг Соединения и композиции для подавления активности shp2
AU2018207464B2 (en) 2017-01-10 2020-05-14 Novartis Ag Pharmaceutical combination comprising an ALK inhibitor and a SHP2 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (mo) *
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
AU680252B2 (en) 1997-07-24
DK0459819T3 (da) 1996-09-02
PT97827B (pt) 1998-10-30
IL98330A (en) 1996-10-31
GR3021237T3 (en) 1997-01-31
PL170373B1 (pl) 1996-12-31
PL166656B1 (pl) 1995-06-30
RU2091374C1 (ru) 1997-09-27
ES2093078T3 (es) 1996-12-16
PT97827A (pt) 1992-03-31
FI912623A0 (fi) 1991-05-31
EP0459819A2 (en) 1991-12-04
AU6745594A (en) 1994-09-15
AU7809791A (en) 1991-12-05
CA2043640A1 (en) 1991-12-02
ATE141263T1 (de) 1996-08-15
EP0459819A3 (en) 1992-03-11
KR920000733A (ko) 1992-01-29
IL98330A0 (en) 1992-06-21
JPH06340634A (ja) 1994-12-13
TW224460B (mo) 1994-06-01
HU211649A9 (en) 1995-12-28
MY109958A (en) 1997-10-31
IE911861A1 (en) 1991-12-04
NZ238360A (en) 1997-03-24
NZ272001A (en) 1997-03-24
EP0459819B1 (en) 1996-08-14
HU911826D0 (en) 1991-12-30
EP0679645A1 (en) 1995-11-02
DE69121317D1 (de) 1996-09-19
NO912100L (no) 1991-12-02
CS164391A3 (en) 1992-02-19
IL113599A (en) 1997-09-30
AU652753B2 (en) 1994-09-08
NZ248501A (en) 1997-03-24
ZA914165B (en) 1993-03-01
SK278444B6 (en) 1997-05-07
FI912623A7 (fi) 1991-12-02
NO180375B (no) 1996-12-30
CZ281070B6 (cs) 1996-06-12
DE69121317T2 (de) 1997-01-02
GB9012316D0 (en) 1990-07-18
IL113599A0 (en) 1995-08-31
NO912100D0 (no) 1991-05-31
HUT58707A (en) 1992-03-30
MY136248A (en) 2008-08-29

Similar Documents

Publication Publication Date Title
NO180375C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin
MD960225A (ro) Compuşi noi cu activitate erbicidă, acaricidă şi insecticidă
BR8500720A (pt) Amina contendo carbamato de hidroalquila,composicao de revestimento termo-fixavel;polimero auto-reticulavel,catodicamente eletropepositavel,composicao para revestimento catodico;polimero hidrofilico;polimero acricilo auto-reticulavel;e sistema de ligacao para ligar superficies de objetos
YU53700A (sh) Biciklo(2.2.1.) heptani i srodna jedinjenja
FI93832B (fi) Menetelmä terapeuttisesti aktiivisten piperatsiniijohdannaisten valmistamiseksi
GR3020583T3 (en) Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production
ES8708136A1 (es) Procedimiento para la obtencion de derivados de acido barbiturico
ATE113601T1 (de) Verbindungen.
GB2023137A (en) Derivatives of cyclohexene-1,2- dicarboxylic acid diamide and the herbicidal compositions containing them
FI94630B (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten N,N'-bis(alkoksi- ja hydroksialkyyli)pyridiini-2,4-dikarboksyylihappodiamidien valmistamiseksi
ATE84028T1 (de) Biologisch aktive verbindungen.
ES2001781A6 (es) Procedimiento para la obtencion de heterociclialquilesteres de acidos 2-imidazolinon-nicotinicos
ES8703861A1 (es) Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
ES2034642T3 (es) Un procedimiento para preparar derivados de 1,5-benzotiazepina y su utilizacion en el tratamiento de las alteraciones cardiovasculares.
HK74287A (en) Imidazolylphenyl amidines
DK0451626T3 (da) Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
BR8603928A (pt) Compostos de hidrazino-eteres difenilicos,processo para sua preparacao,composicao herbicida e processo para combater o crescimento de plantas indesejaveis
NO954109L (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner
GR3015529T3 (en) Heterocyclic amide derivatives and their use as pesticides.