NO177932C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser

Info

Publication number
NO177932C
NO177932C NO915049A NO915049A NO177932C NO 177932 C NO177932 C NO 177932C NO 915049 A NO915049 A NO 915049A NO 915049 A NO915049 A NO 915049A NO 177932 C NO177932 C NO 177932C
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
group
cor
preparation
Prior art date
Application number
NO915049A
Other languages
English (en)
Norwegian (no)
Other versions
NO177932B (no
NO915049D0 (no
NO915049L (no
Inventor
Malcolm Sainsbury
Howard G Shertzer
Original Assignee
Univ Bath
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath
Publication of NO915049D0 publication Critical patent/NO915049D0/no
Publication of NO915049L publication Critical patent/NO915049L/no
Priority to NO952303A priority Critical patent/NO300063B1/no
Publication of NO177932B publication Critical patent/NO177932B/no
Publication of NO177932C publication Critical patent/NO177932C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO915049A 1989-06-22 1991-12-20 Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser NO177932C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO952303A NO300063B1 (no) 1989-06-22 1995-06-12 Nye indenoindolforbindelser og anvendelse av indenoindolforbindelsene som antioksydanter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8902274A SE8902274D0 (sv) 1989-06-22 1989-06-22 Indenoidole compounds ii
PCT/GB1990/000949 WO1990015799A1 (en) 1989-06-22 1990-06-20 Indenoindole compounds ii

Publications (4)

Publication Number Publication Date
NO915049D0 NO915049D0 (no) 1991-12-20
NO915049L NO915049L (no) 1992-02-21
NO177932B NO177932B (no) 1995-09-11
NO177932C true NO177932C (no) 1995-12-20

Family

ID=20376370

Family Applications (1)

Application Number Title Priority Date Filing Date
NO915049A NO177932C (no) 1989-06-22 1991-12-20 Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser

Country Status (34)

Country Link
EP (1) EP0409410B1 (he)
JP (1) JP3064411B2 (he)
KR (1) KR920702679A (he)
CN (1) CN1033029C (he)
AT (1) ATE135688T1 (he)
BG (1) BG60317B2 (he)
CA (1) CA2060897A1 (he)
DD (1) DD297960A5 (he)
DE (1) DE69025998T2 (he)
DK (1) DK0409410T3 (he)
DZ (1) DZ1428A1 (he)
ES (1) ES2084660T3 (he)
FI (1) FI100800B (he)
GR (1) GR3019779T3 (he)
HR (1) HRP920903B1 (he)
HU (1) HUT59097A (he)
IE (1) IE74682B1 (he)
IL (1) IL94830A (he)
IS (1) IS3590A7 (he)
LT (1) LT3675B (he)
LV (1) LV10253B (he)
MX (1) MX21244A (he)
MY (1) MY107311A (he)
NO (1) NO177932C (he)
NZ (1) NZ234175A (he)
PL (1) PL167761B1 (he)
PT (1) PT94468B (he)
RO (1) RO111573B1 (he)
RU (1) RU2104270C1 (he)
SE (1) SE8902274D0 (he)
SI (1) SI9011223B (he)
WO (1) WO1990015799A1 (he)
YU (1) YU122390A (he)
ZA (1) ZA904827B (he)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67274A (en) * 1990-10-16 1995-03-28 Univ Bath Process for producing of tetrahydroindenoindoles and farmaceutical composition comprising them
JPH0656669A (ja) * 1992-06-11 1994-03-01 Asahi Breweries Ltd 活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) * 1993-07-16 1993-07-16 Ab Astra Use of indenoindole compounds
AU675141B2 (en) * 1993-07-20 1997-01-23 Adir Et Compagnie (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them
US6288099B1 (en) 1998-12-04 2001-09-11 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
EP1135393A2 (en) * 1998-12-04 2001-09-26 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2007009120A2 (en) 2005-07-14 2007-01-18 Irm Llc Heterotetracyclic compounds as tpo mimetics
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
MX363405B (es) * 2011-06-16 2019-03-22 Katholieke Univ Leuven K U Leuven R&D Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales.
EP3882244A1 (en) 2012-12-14 2021-09-22 Korea Research Institute of Chemical Technology Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
CA3176727A1 (en) 2020-04-20 2021-10-28 Novartis Ag Antiviral 1,3-di-oxo-indene compounds

Also Published As

Publication number Publication date
KR920702679A (ko) 1992-10-06
SE8902274D0 (sv) 1989-06-22
WO1990015799A1 (en) 1990-12-27
DD297960A5 (de) 1992-01-30
IL94830A0 (en) 1991-04-15
PL285752A1 (en) 1991-03-11
LT3675B (en) 1996-01-25
AU644084B2 (en) 1993-12-02
LV10253B (en) 1995-04-20
RO111573B1 (ro) 1996-11-29
SI9011223A (en) 1997-10-31
NZ234175A (en) 1992-12-23
HU904825D0 (en) 1992-03-30
CA2060897A1 (en) 1990-12-23
ES2084660T3 (es) 1996-05-16
DE69025998D1 (de) 1996-04-25
IE74682B1 (en) 1997-07-30
IS3590A7 (is) 1990-12-23
IE902247A1 (en) 1991-01-16
PT94468B (pt) 1997-12-31
JPH04505923A (ja) 1992-10-15
ATE135688T1 (de) 1996-04-15
EP0409410A1 (en) 1991-01-23
IE902247L (en) 1990-12-22
DE69025998T2 (de) 1996-08-08
MX21244A (es) 1994-03-31
FI100800B (fi) 1998-02-27
AU5836990A (en) 1991-01-08
ZA904827B (en) 1991-04-24
PT94468A (pt) 1991-02-08
IL94830A (he) 1996-07-23
CN1033029C (zh) 1996-10-16
NO177932B (no) 1995-09-11
LV10253A (lv) 1994-10-20
EP0409410B1 (en) 1996-03-20
FI915999A0 (fi) 1991-12-19
LTIP912A (en) 1995-03-27
RU2104270C1 (ru) 1998-02-10
DZ1428A1 (fr) 2004-09-13
PL167761B1 (pl) 1995-10-31
SI9011223B (sl) 1998-08-31
DK0409410T3 (da) 1996-04-29
NO915049D0 (no) 1991-12-20
HRP920903B1 (en) 1998-06-30
YU122390A (sh) 1992-09-07
CN1051554A (zh) 1991-05-22
GR3019779T3 (en) 1996-07-31
HUT59097A (en) 1992-04-28
NO915049L (no) 1992-02-21
JP3064411B2 (ja) 2000-07-12
HRP920903A2 (hr) 1994-04-30
MY107311A (en) 1995-11-30
BG60317B2 (bg) 1994-07-25

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