ES2084660T3 - Compuestos de indenoindol. - Google Patents

Compuestos de indenoindol.

Info

Publication number
ES2084660T3
ES2084660T3 ES90306718T ES90306718T ES2084660T3 ES 2084660 T3 ES2084660 T3 ES 2084660T3 ES 90306718 T ES90306718 T ES 90306718T ES 90306718 T ES90306718 T ES 90306718T ES 2084660 T3 ES2084660 T3 ES 2084660T3
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
group
cor
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90306718T
Other languages
English (en)
Inventor
Malcolm Sainsbury
Howard G Shertzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bath
University of Cincinnati
Original Assignee
University of Bath
University of Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Bath, University of Cincinnati filed Critical University of Bath
Application granted granted Critical
Publication of ES2084660T3 publication Critical patent/ES2084660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

COMPUESTODE LA FORMULA FIG EN DEONDE R ES H O UN GRUPO BAJO ALQUIL O COR15; R1, R2, R11 Y R12, SON H O UN GRUPO BAJO ALQUIL; R3,R4,R5 Y R6 SON H, HIDROXI, HALOGENO, UN GRUPO BAJO ALQUIL, UN GRUPO BAJO ALCOXI O UN GRUPO AMINO MONO NR13COR14; R7,R8,R9 Y R10 SON H, HIDROXI, UN GRUPO BAJO ALQUIL, UN GRUPO BAJO ALQUILAMINO MONO13, R14 Y R15 SON H O UN GRUPO BAJO ALQUIL, ENANCIOMEROS Y SALES DERIVADAS, CON TAL QUE CUANDO R ES COR15 ENTONCES AL MENOS UNO DE R3 A R10 SEA HIDROXI O UN GRUPO ALQUILAMINO BAJO MONOO DI-. ESTOS COMPUESTOS SON UTILES COMO ANTIOXIDANTES, DENTRO DEL CAMPO MEDICO Y NO MEDICO. MUCHOS DE LOS COMPUESTOS DE LA FORMULA IA E IB SON NUEVOS Y SE DESCRIBEN VARIOS METODOS PARA PREPARARLOS.
ES90306718T 1989-06-22 1990-06-20 Compuestos de indenoindol. Expired - Lifetime ES2084660T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8902274A SE8902274D0 (sv) 1989-06-22 1989-06-22 Indenoidole compounds ii

Publications (1)

Publication Number Publication Date
ES2084660T3 true ES2084660T3 (es) 1996-05-16

Family

ID=20376370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90306718T Expired - Lifetime ES2084660T3 (es) 1989-06-22 1990-06-20 Compuestos de indenoindol.

Country Status (34)

Country Link
EP (1) EP0409410B1 (es)
JP (1) JP3064411B2 (es)
KR (1) KR920702679A (es)
CN (1) CN1033029C (es)
AT (1) ATE135688T1 (es)
BG (1) BG60317B2 (es)
CA (1) CA2060897A1 (es)
DD (1) DD297960A5 (es)
DE (1) DE69025998T2 (es)
DK (1) DK0409410T3 (es)
DZ (1) DZ1428A1 (es)
ES (1) ES2084660T3 (es)
FI (1) FI100800B (es)
GR (1) GR3019779T3 (es)
HR (1) HRP920903B1 (es)
HU (1) HUT59097A (es)
IE (1) IE74682B1 (es)
IL (1) IL94830A (es)
IS (1) IS3590A7 (es)
LT (1) LT3675B (es)
LV (1) LV10253B (es)
MX (1) MX21244A (es)
MY (1) MY107311A (es)
NO (1) NO177932C (es)
NZ (1) NZ234175A (es)
PL (1) PL167761B1 (es)
PT (1) PT94468B (es)
RO (1) RO111573B1 (es)
RU (1) RU2104270C1 (es)
SE (1) SE8902274D0 (es)
SI (1) SI9011223B (es)
WO (1) WO1990015799A1 (es)
YU (1) YU122390A (es)
ZA (1) ZA904827B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67274A (en) * 1990-10-16 1995-03-28 Univ Bath Process for producing of tetrahydroindenoindoles and farmaceutical composition comprising them
JPH0656669A (ja) * 1992-06-11 1994-03-01 Asahi Breweries Ltd 活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) * 1993-07-16 1993-07-16 Ab Astra Use of indenoindole compounds
AU675141B2 (en) * 1993-07-20 1997-01-23 Adir Et Compagnie (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them
US6288099B1 (en) 1998-12-04 2001-09-11 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
EP1135393A2 (en) * 1998-12-04 2001-09-26 American Home Products Corporation Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2007009120A2 (en) 2005-07-14 2007-01-18 Irm Llc Heterotetracyclic compounds as tpo mimetics
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
MX363405B (es) * 2011-06-16 2019-03-22 Katholieke Univ Leuven K U Leuven R&D Derivados de indanona, sales farmaceuticamente aceptables o isomeros opticos de los mismos, metodo de preparacion de los mismos, y composiciones farmaceuticas que contienen los mismos como ingrediente activo para prevención o tratamiento de enfermedades virales.
EP3882244A1 (en) 2012-12-14 2021-09-22 Korea Research Institute of Chemical Technology Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
CA3176727A1 (en) 2020-04-20 2021-10-28 Novartis Ag Antiviral 1,3-di-oxo-indene compounds

Also Published As

Publication number Publication date
KR920702679A (ko) 1992-10-06
SE8902274D0 (sv) 1989-06-22
WO1990015799A1 (en) 1990-12-27
DD297960A5 (de) 1992-01-30
IL94830A0 (en) 1991-04-15
PL285752A1 (en) 1991-03-11
LT3675B (en) 1996-01-25
AU644084B2 (en) 1993-12-02
LV10253B (en) 1995-04-20
RO111573B1 (ro) 1996-11-29
SI9011223A (en) 1997-10-31
NO177932C (no) 1995-12-20
NZ234175A (en) 1992-12-23
HU904825D0 (en) 1992-03-30
CA2060897A1 (en) 1990-12-23
DE69025998D1 (de) 1996-04-25
IE74682B1 (en) 1997-07-30
IS3590A7 (is) 1990-12-23
IE902247A1 (en) 1991-01-16
PT94468B (pt) 1997-12-31
JPH04505923A (ja) 1992-10-15
ATE135688T1 (de) 1996-04-15
EP0409410A1 (en) 1991-01-23
IE902247L (en) 1990-12-22
DE69025998T2 (de) 1996-08-08
MX21244A (es) 1994-03-31
FI100800B (fi) 1998-02-27
AU5836990A (en) 1991-01-08
ZA904827B (en) 1991-04-24
PT94468A (pt) 1991-02-08
IL94830A (en) 1996-07-23
CN1033029C (zh) 1996-10-16
NO177932B (no) 1995-09-11
LV10253A (lv) 1994-10-20
EP0409410B1 (en) 1996-03-20
FI915999A0 (fi) 1991-12-19
LTIP912A (en) 1995-03-27
RU2104270C1 (ru) 1998-02-10
DZ1428A1 (fr) 2004-09-13
PL167761B1 (pl) 1995-10-31
SI9011223B (sl) 1998-08-31
DK0409410T3 (da) 1996-04-29
NO915049D0 (no) 1991-12-20
HRP920903B1 (en) 1998-06-30
YU122390A (sh) 1992-09-07
CN1051554A (zh) 1991-05-22
GR3019779T3 (en) 1996-07-31
HUT59097A (en) 1992-04-28
NO915049L (no) 1992-02-21
JP3064411B2 (ja) 2000-07-12
HRP920903A2 (hr) 1994-04-30
MY107311A (en) 1995-11-30
BG60317B2 (bg) 1994-07-25

Similar Documents

Publication Publication Date Title
DE3473763D1 (en) Novel 4'-demethyl-4-epipodophyllotoxin derivatives, a process for their preparation and their use as medicaments
ES2006142A6 (es) Un metodo para preparar derivados de acidos quinolincarboxilicos
GR3004139T3 (es)
ES2084660T3 (es) Compuestos de indenoindol.
SE8902273D0 (sv) Indenoindole compounds i
ZA895623B (en) Tetracyclic antidepressants
JO1676B1 (en) Extra compounds indinol II
AU566243B2 (en) Optically active imidazolylpropanols
ATE96144T1 (de) 2-aminoacetamid derivate.
GB2021587A (en) Benzoquinolizines

Legal Events

Date Code Title Description
FC2A Grant refused

Effective date: 19920930

FG2A Definitive protection

Ref document number: 409410

Country of ref document: ES