GB2021587A - Benzoquinolizines - Google Patents

Benzoquinolizines

Info

Publication number
GB2021587A
GB2021587A GB7918221A GB7918221A GB2021587A GB 2021587 A GB2021587 A GB 2021587A GB 7918221 A GB7918221 A GB 7918221A GB 7918221 A GB7918221 A GB 7918221A GB 2021587 A GB2021587 A GB 2021587A
Authority
GB
United Kingdom
Prior art keywords
benzoquinolizines
lower alkyl
lower alkoxy
hydrogen
cxnhr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7918221A
Other versions
GB2021587B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB7918221A priority Critical patent/GB2021587B/en
Publication of GB2021587A publication Critical patent/GB2021587A/en
Application granted granted Critical
Publication of GB2021587B publication Critical patent/GB2021587B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Benzoquinolizines of the general formula (I> <IMAGE> and the pharmaceutically acceptable acid addition salts thereof, wherein R<1> and R<2> which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen and R represents -CXNHR<3> (where X is O, S or =NH and R<3> is hydrogen or lower alkyl) or -(CH2)nR<4> (where n is 0 or 1 and R<4> is aryl) lower blood pressure. Some are also anti-ulcer agents. The compounds in which R<1>, R<2> and R are as defined above, with the proviso that when R is phenyl, R<1> and R<2> are not both lower alkoxy, are novel.
GB7918221A 1978-05-26 1979-05-24 Benzoquinolizines Expired GB2021587B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7918221A GB2021587B (en) 1978-05-26 1979-05-24 Benzoquinolizines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2332778 1978-05-26
GB7918221A GB2021587B (en) 1978-05-26 1979-05-24 Benzoquinolizines

Publications (2)

Publication Number Publication Date
GB2021587A true GB2021587A (en) 1979-12-05
GB2021587B GB2021587B (en) 1982-11-03

Family

ID=26256453

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7918221A Expired GB2021587B (en) 1978-05-26 1979-05-24 Benzoquinolizines

Country Status (1)

Country Link
GB (1) GB2021587B (en)

Also Published As

Publication number Publication date
GB2021587B (en) 1982-11-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee