NO174965C - Syntetisk polypeptidanalog av humaninsulinlignende vekstfaktor med redusert binding til bærerproteiner i serum, samt syntetiske gener som koder for slike analoger og preparater som omfatter en slik analog - Google Patents
Syntetisk polypeptidanalog av humaninsulinlignende vekstfaktor med redusert binding til bærerproteiner i serum, samt syntetiske gener som koder for slike analoger og preparater som omfatter en slik analogInfo
- Publication number
- NO174965C NO174965C NO884183A NO884183A NO174965C NO 174965 C NO174965 C NO 174965C NO 884183 A NO884183 A NO 884183A NO 884183 A NO884183 A NO 884183A NO 174965 C NO174965 C NO 174965C
- Authority
- NO
- Norway
- Prior art keywords
- analog
- growth factor
- human insulin
- carrier proteins
- promoting
- Prior art date
Links
- 108010078791 Carrier Proteins Proteins 0.000 title abstract 3
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 3
- 210000002966 serum Anatomy 0.000 title abstract 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 2
- 102000013275 Somatomedins Human genes 0.000 title abstract 2
- 108700005078 Synthetic Genes Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 230000001737 promoting effect Effects 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000282412 Homo Species 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000010437 erythropoiesis Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000006651 lactation Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/099,367 US4876242A (en) | 1987-09-21 | 1987-09-21 | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO884183D0 NO884183D0 (no) | 1988-09-20 |
| NO884183L NO884183L (no) | 1989-03-22 |
| NO174965B NO174965B (no) | 1994-05-02 |
| NO174965C true NO174965C (no) | 1994-08-10 |
Family
ID=22274659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO884183A NO174965C (no) | 1987-09-21 | 1988-09-20 | Syntetisk polypeptidanalog av humaninsulinlignende vekstfaktor med redusert binding til bærerproteiner i serum, samt syntetiske gener som koder for slike analoger og preparater som omfatter en slik analog |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4876242A (fr) |
| EP (1) | EP0309050B1 (fr) |
| JP (1) | JPH01156998A (fr) |
| KR (1) | KR890005150A (fr) |
| AT (1) | ATE100139T1 (fr) |
| AU (1) | AU608364B2 (fr) |
| DE (1) | DE3887052T2 (fr) |
| DK (1) | DK521888A (fr) |
| FI (1) | FI884276A (fr) |
| HU (1) | HU205170B (fr) |
| IL (1) | IL87754A (fr) |
| NO (1) | NO174965C (fr) |
| NZ (1) | NZ226132A (fr) |
| PT (1) | PT88546B (fr) |
| YU (2) | YU46987B (fr) |
| ZA (1) | ZA886966B (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE81779T1 (de) * | 1985-08-22 | 1992-11-15 | Gropep Pty Ltd | Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren. |
| DE3852636T2 (de) * | 1987-12-24 | 1995-05-04 | Gropep Pty Ltd | Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2). |
| US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
| NZ236618A (en) * | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
| US5679771A (en) * | 1990-02-13 | 1997-10-21 | Gropep Pty. Ltd. | Method for treating intestinal diseases |
| EP0607278B1 (fr) * | 1991-10-07 | 2002-04-17 | The Brigham And Women's Hospital, Inc. | Procede permettant d'ameliorer l'absorption intestinale |
| JPH07508025A (ja) * | 1992-05-08 | 1995-09-07 | トーマス・ジェファーソン・ユニバーシティ | インスリン様増殖因子（ｉｇｆ−１）類似体 |
| AU678764B2 (en) * | 1992-06-03 | 1997-06-12 | Case Western Reserve University | Bandage for continuous application of biologicals |
| WO1993025226A1 (fr) * | 1992-06-08 | 1993-12-23 | Kabi Pharmacia Ab | Utilisation du facteur de croissance igf-i et/ou igf-ii |
| US5444045A (en) * | 1992-09-17 | 1995-08-22 | Gropep, Pty. Ltd. | Method of administering IGF-1, IGF-2, and analogs thereof to birds |
| US5401830A (en) * | 1992-10-05 | 1995-03-28 | The State University Of New Jersey | Insulin receptor-like protein |
| ATE297214T1 (de) * | 1993-09-20 | 2005-06-15 | Celtrix Pharma | Behandlung von immunologischen und hematologischen störungen mit igfbp allein oder als komplex mit igf |
| EP0779927A1 (fr) * | 1994-09-08 | 1997-06-25 | Chiron Corporation | Procede de production amelioree des facteurs de croissance proches de l'insuline |
| US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US7700353B2 (en) | 1998-07-22 | 2010-04-20 | E-P Therapeutics, Inc. | Compositions and methods for inducing apoptosis in tumor cells |
| US6358916B1 (en) | 1998-07-22 | 2002-03-19 | Thomas T. Chen | Biological activity of IGF-I E domain peptide |
| US7118752B2 (en) | 1998-07-22 | 2006-10-10 | University Of Connecticut | Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I |
| US7173005B2 (en) | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
| AU762351B2 (en) * | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
| ATE251466T1 (de) * | 1999-04-08 | 2003-10-15 | Genentech Inc | Zusammensetzung auf basis gegensätzlich geladener polypeptide |
| US6703040B2 (en) * | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
| AU2000239309A1 (en) * | 2000-03-29 | 2001-10-08 | Dgi Biotechnologies Llc | Insulin and igf-1 receptor agonists and antagonists |
| ES2301547T3 (es) * | 2000-05-16 | 2008-07-01 | Genentech, Inc. | Tratamiento de trastornos del cartilago. |
| CN1469752A (zh) | 2000-08-29 | 2004-01-21 | 通过给予igf结构类似物治疗中枢神经系统疾病的方法 | |
| GB2369572A (en) | 2000-11-29 | 2002-06-05 | Raft Trustees Ltd | Wound treatment composition comprising insulin |
| EP1772464B1 (fr) * | 2001-02-09 | 2009-08-12 | Genentech, Inc. | Procédés d'identification d'agonistes indirects de IGF-1 |
| JP2005534650A (ja) * | 2002-06-11 | 2005-11-17 | ザ バーナム インスティテュート | エリスロポイエチンおよびインスリン様増殖因子の神経保護的相乗作用 |
| EP1667521B1 (fr) | 2003-09-12 | 2011-12-07 | Tercica, Inc. | Methodes de traitement de la deficience du facteur de croissance de type insuline 1 (igf-1) |
| WO2005041865A2 (fr) * | 2003-10-21 | 2005-05-12 | Igf Oncology, Llc | Composes et methode de traitement du cancer |
| US9011880B2 (en) * | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
| WO2005072292A2 (fr) * | 2004-01-24 | 2005-08-11 | Hugh Mctavish | Procedes d'amelioration de radiotherapie |
| JP2008517917A (ja) * | 2004-10-21 | 2008-05-29 | アイジーエフ オンコロジー エルエルシー | 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| EP2376520B1 (fr) | 2008-12-19 | 2014-02-12 | Indiana University Research&Technology Corporation | Analogues d'insuline |
| EP2376521B1 (fr) | 2008-12-19 | 2016-04-13 | Indiana University Research and Technology Corporation | Promédicaments insuliniques à base d'amide |
| EP2376099A4 (fr) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | Facteurs de croissance semblables à l'insuline à base d'yl exprimant une haute activité au récepteur de l'insuline |
| KR20110126644A (ko) * | 2009-01-31 | 2011-11-23 | 아이쥐에프 온콜로지, 엘엘씨 | 항암 단백질-백금 결합체 |
| WO2010109053A1 (fr) | 2009-03-27 | 2010-09-30 | Proyeto De Biomedicina Cima, S.L. | Méthodes et compositions pour le traitement de la cirrhose et de la fibrose hépatique |
| DK2498796T3 (en) | 2009-11-09 | 2018-03-05 | Aal Scient Inc | HEART DISEASE TREATMENT |
| WO2011159895A2 (fr) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Agonistes de l'insuline à une seule chaîne très actifs au niveau du récepteur à l'insuline |
| CA2803164C (fr) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Promedicaments insuliniques a base d'amide |
| CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| WO2014004512A1 (fr) | 2012-06-25 | 2014-01-03 | Surmodics, Inc. | Poly(étherestéramides) biodégradables et utilisations dans des articles médicaux |
| JP6387008B2 (ja) | 2012-09-26 | 2018-09-05 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリンアナローグダイマー |
| RU2678134C2 (ru) | 2013-03-14 | 2019-01-23 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты инсулин-инкретин |
| CA2936675C (fr) | 2014-01-12 | 2023-06-27 | Igf Oncology, Llc | Proteines de fusion contenant un facteur-1 de croissance de type insuline et un facteur de croissance epidermique et leurs variantes, et leurs utilisations |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| WO2016049174A1 (fr) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Promédicaments insuliniques à base d'amide lipidique |
| AU2018273370A1 (en) | 2017-05-21 | 2019-10-31 | Igf Oncology, Llc | An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985000831A1 (fr) * | 1983-08-10 | 1985-02-28 | Amgen | Expression microbienne d'un facteur de croissance semblable a l'insuline |
| GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
| ATE81779T1 (de) * | 1985-08-22 | 1992-11-15 | Gropep Pty Ltd | Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren. |
| US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
| AU613876B2 (en) * | 1986-10-01 | 1991-08-15 | Merck & Co., Inc. | Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins |
| ES2007309T3 (es) * | 1987-04-23 | 1994-11-01 | Monsanto Co | Secrecion del factor de crecimiento insulinoide 1 en e.coli. |
-
1987
- 1987-09-21 US US07/099,367 patent/US4876242A/en not_active Expired - Lifetime
-
1988
- 1988-09-12 NZ NZ226132A patent/NZ226132A/en unknown
- 1988-09-15 IL IL87754A patent/IL87754A/xx unknown
- 1988-09-16 DE DE3887052T patent/DE3887052T2/de not_active Expired - Fee Related
- 1988-09-16 FI FI884276A patent/FI884276A/fi not_active IP Right Cessation
- 1988-09-16 AT AT88202032T patent/ATE100139T1/de not_active IP Right Cessation
- 1988-09-16 EP EP88202032A patent/EP0309050B1/fr not_active Expired - Lifetime
- 1988-09-19 ZA ZA886966A patent/ZA886966B/xx unknown
- 1988-09-19 PT PT88546A patent/PT88546B/pt not_active IP Right Cessation
- 1988-09-19 KR KR1019880012070A patent/KR890005150A/ko not_active Application Discontinuation
- 1988-09-20 YU YU177388A patent/YU46987B/sh unknown
- 1988-09-20 HU HU884922A patent/HU205170B/hu not_active IP Right Cessation
- 1988-09-20 DK DK521888A patent/DK521888A/da not_active Application Discontinuation
- 1988-09-20 NO NO884183A patent/NO174965C/no unknown
- 1988-09-21 JP JP63237488A patent/JPH01156998A/ja active Pending
- 1988-09-21 AU AU22455/88A patent/AU608364B2/en not_active Ceased
-
1989
- 1989-11-14 YU YU02167/89A patent/YU216789A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL87754A0 (en) | 1989-02-28 |
| AU608364B2 (en) | 1991-03-28 |
| EP0309050A1 (fr) | 1989-03-29 |
| YU46987B (sh) | 1994-09-09 |
| FI884276A0 (fi) | 1988-09-16 |
| YU177388A (en) | 1990-04-30 |
| DK521888D0 (da) | 1988-09-20 |
| FI884276A (fi) | 1989-03-22 |
| IL87754A (en) | 1993-08-18 |
| DK521888A (da) | 1989-05-03 |
| HUT49375A (en) | 1989-09-28 |
| PT88546B (pt) | 1992-11-30 |
| NO884183L (no) | 1989-03-22 |
| US4876242A (en) | 1989-10-24 |
| NO174965B (no) | 1994-05-02 |
| DE3887052D1 (de) | 1994-02-24 |
| NO884183D0 (no) | 1988-09-20 |
| YU216789A (en) | 1991-04-30 |
| PT88546A (pt) | 1988-10-01 |
| EP0309050B1 (fr) | 1994-01-12 |
| ZA886966B (en) | 1989-05-30 |
| HU205170B (en) | 1992-03-30 |
| NZ226132A (en) | 1992-02-25 |
| DE3887052T2 (de) | 1994-07-21 |
| KR890005150A (ko) | 1989-05-13 |
| ATE100139T1 (de) | 1994-01-15 |
| AU2245588A (en) | 1989-06-01 |
| JPH01156998A (ja) | 1989-06-20 |
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