YU216789A - Process for obtaining polypeptidic analog higf-1 - Google Patents
Process for obtaining polypeptidic analog higf-1Info
- Publication number
- YU216789A YU216789A YU02167/89A YU216789A YU216789A YU 216789 A YU216789 A YU 216789A YU 02167/89 A YU02167/89 A YU 02167/89A YU 216789 A YU216789 A YU 216789A YU 216789 A YU216789 A YU 216789A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- higf
- analog
- promoting
- animals
- protein
- Prior art date
Links
- 230000001737 promoting effect Effects 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 3
- 108010078791 Carrier Proteins Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000282412 Homo Species 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 102000013275 Somatomedins Human genes 0.000 abstract 1
- 108700005078 Synthetic Genes Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 230000010437 erythropoiesis Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000006651 lactation Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/099,367 US4876242A (en) | 1987-09-21 | 1987-09-21 | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU216789A true YU216789A (en) | 1991-04-30 |
Family
ID=22274659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU177388A YU46987B (sh) | 1987-09-21 | 1988-09-20 | Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu |
| YU02167/89A YU216789A (en) | 1987-09-21 | 1989-11-14 | Process for obtaining polypeptidic analog higf-1 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU177388A YU46987B (sh) | 1987-09-21 | 1988-09-20 | Analog faktora rasta sličan humanom insulinu sa smanjenim vezivanjem za nosač serumskih proteina i njegova proizvodnja u kvascu |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4876242A (xx) |
| EP (1) | EP0309050B1 (xx) |
| JP (1) | JPH01156998A (xx) |
| KR (1) | KR890005150A (xx) |
| AT (1) | ATE100139T1 (xx) |
| AU (1) | AU608364B2 (xx) |
| DE (1) | DE3887052T2 (xx) |
| DK (1) | DK521888A (xx) |
| FI (1) | FI884276A (xx) |
| HU (1) | HU205170B (xx) |
| IL (1) | IL87754A (xx) |
| NO (1) | NO174965C (xx) |
| NZ (1) | NZ226132A (xx) |
| PT (1) | PT88546B (xx) |
| YU (2) | YU46987B (xx) |
| ZA (1) | ZA886966B (xx) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0720993B2 (ja) * | 1985-08-22 | 1995-03-08 | グロペップ プロプライエタリー リミテッド | 生長因子 |
| EP0346429B1 (en) * | 1987-12-24 | 1994-12-28 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
| US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
| NZ236618A (en) * | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
| US5679771A (en) * | 1990-02-13 | 1997-10-21 | Gropep Pty. Ltd. | Method for treating intestinal diseases |
| DK0607278T3 (da) * | 1991-10-07 | 2002-06-17 | Brigham & Womens Hospital | Fremgangsmåde til forstærkning af tarmabsorption |
| JPH07508025A (ja) * | 1992-05-08 | 1995-09-07 | トーマス・ジェファーソン・ユニバーシティ | インスリン様増殖因子（ｉｇｆ−１）類似体 |
| EP0648264A4 (en) * | 1992-06-03 | 1997-10-01 | Univ Case Western Reserve | BANDAGE ALLOWING THE CONTINUOUS APPLICATION OF ORGANIC PRODUCTS. |
| JPH06510065A (ja) * | 1992-06-08 | 1994-11-10 | カイロン コーポレーション | 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法 |
| US5444045A (en) * | 1992-09-17 | 1995-08-22 | Gropep, Pty. Ltd. | Method of administering IGF-1, IGF-2, and analogs thereof to birds |
| US5401830A (en) * | 1992-10-05 | 1995-03-28 | The State University Of New Jersey | Insulin receptor-like protein |
| JPH09507832A (ja) * | 1993-09-20 | 1997-08-12 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | Ｉｇｆｂｐ単独またはｉｇｆｂｐとｉｇｆとの複合体による免疫疾患および血液疾患の処置 |
| AU3545795A (en) * | 1994-09-08 | 1996-03-27 | Chiron Corporation | A method of improved production of insulin-like growth factor |
| US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| US6403764B1 (en) * | 1999-01-06 | 2002-06-11 | Genentech, Inc. | Insulin-like growth factor-1 protein variants |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6358916B1 (en) * | 1998-07-22 | 2002-03-19 | Thomas T. Chen | Biological activity of IGF-I E domain peptide |
| US7118752B2 (en) | 1998-07-22 | 2006-10-10 | University Of Connecticut | Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I |
| US7700353B2 (en) | 1998-07-22 | 2010-04-20 | E-P Therapeutics, Inc. | Compositions and methods for inducing apoptosis in tumor cells |
| US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
| US7173005B2 (en) | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| CA2369451C (en) | 1999-04-08 | 2009-09-22 | Genentech, Inc. | Composition based on oppositely-charged polypeptides |
| US6703040B2 (en) | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
| AU2000239309A1 (en) * | 2000-03-29 | 2001-10-08 | Dgi Biotechnologies Llc | Insulin and igf-1 receptor agonists and antagonists |
| WO2001087323A2 (en) | 2000-05-16 | 2001-11-22 | Genentech, Inc. | Method for treating cartilage disorders |
| CA2419561A1 (en) | 2000-08-29 | 2002-03-07 | Colorado State University Research Foundation | Method for treating the central nervous system by administration of igf structural analogs |
| GB2369572A (en) * | 2000-11-29 | 2002-06-05 | Raft Trustees Ltd | Wound treatment composition comprising insulin |
| JP4489352B2 (ja) * | 2001-02-09 | 2010-06-23 | ジェネンテック， インコーポレイテッド | Ｉｇｆ−１の結晶化 |
| JP2005534650A (ja) * | 2002-06-11 | 2005-11-17 | ザ バーナム インスティテュート | エリスロポイエチンおよびインスリン様増殖因子の神経保護的相乗作用 |
| DK2274978T3 (en) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
| WO2005041865A2 (en) * | 2003-10-21 | 2005-05-12 | Igf Oncology, Llc | Compounds and method for treating cancer |
| US9011880B2 (en) * | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
| WO2005072292A2 (en) * | 2004-01-24 | 2005-08-11 | Hugh Mctavish | Methods for enhancing radiation therapy |
| JP2008517917A (ja) * | 2004-10-21 | 2008-05-29 | アイジーエフ オンコロジー エルエルシー | 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| WO2009099763A1 (en) | 2008-01-30 | 2009-08-13 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | YL-BASED INSULIN-LIKE GROWTH FACTORS EXPRESSING HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| CN102256992B (zh) | 2008-12-19 | 2015-04-22 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物 |
| EP2376521B1 (en) | 2008-12-19 | 2016-04-13 | Indiana University Research and Technology Corporation | Amide-based insulin prodrugs |
| KR20110126644A (ko) * | 2009-01-31 | 2011-11-23 | 아이쥐에프 온콜로지, 엘엘씨 | 항암 단백질-백금 결합체 |
| WO2010109053A1 (es) | 2009-03-27 | 2010-09-30 | Proyeto De Biomedicina Cima, S.L. | Métodos y composiciones para el tratamiento de cirrosis y fibrosis hepática |
| EP2498796B1 (en) | 2009-11-09 | 2017-12-27 | AAL Scientifics, Inc. | Treatment of heart disease |
| WO2011159895A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| JP5912112B2 (ja) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | アミド系インスリンプロドラッグ |
| EP2793932B1 (en) | 2011-12-20 | 2018-10-03 | Indiana University Research and Technology Corporation | Ctp-based insulin analogs for treatment of diabetes |
| WO2014004512A1 (en) | 2012-06-25 | 2014-01-03 | Surmodics, Inc. | Bioerodable poly(etheresteramides) and medical article uses |
| EP3395358B1 (en) | 2012-09-26 | 2019-11-06 | Indiana University Research and Technology Corporation | Insulin analog dimers |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン‐インクレチン複合物 |
| CA2936675C (en) | 2014-01-12 | 2023-06-27 | Igf Oncology, Llc | Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof |
| WO2016049174A1 (en) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Lipidated amide-based insulin prodrugs |
| US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| CA3059593A1 (en) | 2017-05-21 | 2018-11-29 | Igf Oncology, Llc | An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
| GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
| JPH0720993B2 (ja) * | 1985-08-22 | 1995-03-08 | グロペップ プロプライエタリー リミテッド | 生長因子 |
| US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
| AU613876B2 (en) * | 1986-10-01 | 1991-08-15 | Merck & Co., Inc. | Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins |
| AU607209B2 (en) * | 1987-04-23 | 1991-02-28 | Monsanto Technology Llc | Secretion of insulin-like growth factor-i in e. coli |
-
1987
- 1987-09-21 US US07/099,367 patent/US4876242A/en not_active Expired - Lifetime
-
1988
- 1988-09-12 NZ NZ226132A patent/NZ226132A/en unknown
- 1988-09-15 IL IL87754A patent/IL87754A/xx unknown
- 1988-09-16 AT AT88202032T patent/ATE100139T1/de not_active IP Right Cessation
- 1988-09-16 FI FI884276A patent/FI884276A/fi not_active IP Right Cessation
- 1988-09-16 DE DE3887052T patent/DE3887052T2/de not_active Expired - Fee Related
- 1988-09-16 EP EP88202032A patent/EP0309050B1/en not_active Expired - Lifetime
- 1988-09-19 PT PT88546A patent/PT88546B/pt not_active IP Right Cessation
- 1988-09-19 ZA ZA886966A patent/ZA886966B/xx unknown
- 1988-09-19 KR KR1019880012070A patent/KR890005150A/ko not_active Application Discontinuation
- 1988-09-20 NO NO884183A patent/NO174965C/no unknown
- 1988-09-20 HU HU884922A patent/HU205170B/hu not_active IP Right Cessation
- 1988-09-20 YU YU177388A patent/YU46987B/sh unknown
- 1988-09-20 DK DK521888A patent/DK521888A/da not_active Application Discontinuation
- 1988-09-21 JP JP63237488A patent/JPH01156998A/ja active Pending
- 1988-09-21 AU AU22455/88A patent/AU608364B2/en not_active Ceased
-
1989
- 1989-11-14 YU YU02167/89A patent/YU216789A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK521888D0 (da) | 1988-09-20 |
| AU2245588A (en) | 1989-06-01 |
| EP0309050A1 (en) | 1989-03-29 |
| PT88546B (pt) | 1992-11-30 |
| JPH01156998A (ja) | 1989-06-20 |
| NZ226132A (en) | 1992-02-25 |
| HU205170B (en) | 1992-03-30 |
| DE3887052D1 (de) | 1994-02-24 |
| IL87754A (en) | 1993-08-18 |
| YU177388A (en) | 1990-04-30 |
| AU608364B2 (en) | 1991-03-28 |
| NO174965C (no) | 1994-08-10 |
| FI884276A0 (fi) | 1988-09-16 |
| NO174965B (no) | 1994-05-02 |
| ATE100139T1 (de) | 1994-01-15 |
| KR890005150A (ko) | 1989-05-13 |
| NO884183D0 (no) | 1988-09-20 |
| YU46987B (sh) | 1994-09-09 |
| HUT49375A (en) | 1989-09-28 |
| IL87754A0 (en) | 1989-02-28 |
| PT88546A (pt) | 1988-10-01 |
| NO884183L (no) | 1989-03-22 |
| EP0309050B1 (en) | 1994-01-12 |
| ZA886966B (en) | 1989-05-30 |
| FI884276A (fi) | 1989-03-22 |
| US4876242A (en) | 1989-10-24 |
| DE3887052T2 (de) | 1994-07-21 |
| DK521888A (da) | 1989-05-03 |
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