DE3887052D1 - Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. - Google Patents

Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Info

Publication number
DE3887052D1
DE3887052D1 DE88202032T DE3887052T DE3887052D1 DE 3887052 D1 DE3887052 D1 DE 3887052D1 DE 88202032 T DE88202032 T DE 88202032T DE 3887052 T DE3887052 T DE 3887052T DE 3887052 D1 DE3887052 D1 DE 3887052D1
Authority
DE
Germany
Prior art keywords
promoting
higf
animals
carrier proteins
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88202032T
Other languages
English (en)
Other versions
DE3887052T2 (de
Inventor
Joy D Applebaum
Marvin L Bayne
Margaret A Cascieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE3887052D1 publication Critical patent/DE3887052D1/de
Application granted granted Critical
Publication of DE3887052T2 publication Critical patent/DE3887052T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE3887052T 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe. Expired - Fee Related DE3887052T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/099,367 US4876242A (en) 1987-09-21 1987-09-21 Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast

Publications (2)

Publication Number Publication Date
DE3887052D1 true DE3887052D1 (de) 1994-02-24
DE3887052T2 DE3887052T2 (de) 1994-07-21

Family

ID=22274659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887052T Expired - Fee Related DE3887052T2 (de) 1987-09-21 1988-09-16 Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.

Country Status (16)

Country Link
US (1) US4876242A (de)
EP (1) EP0309050B1 (de)
JP (1) JPH01156998A (de)
KR (1) KR890005150A (de)
AT (1) ATE100139T1 (de)
AU (1) AU608364B2 (de)
DE (1) DE3887052T2 (de)
DK (1) DK521888A (de)
FI (1) FI884276A (de)
HU (1) HU205170B (de)
IL (1) IL87754A (de)
NO (1) NO174965C (de)
NZ (1) NZ226132A (de)
PT (1) PT88546B (de)
YU (2) YU46987B (de)
ZA (1) ZA886966B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
JP2507106B2 (ja) * 1987-12-24 1996-06-12 グロペップ プロプライエタリー リミテッド インスリン様成長因子１（ｉｇｆ―１）または因子２（ｉｇｆ―２）の類縁ペプチド
US5470828A (en) * 1987-12-24 1995-11-28 Gropep Pty. Ltd. Peptide analogs of insulin-like growth factor II
NZ236618A (en) * 1990-01-03 1997-06-24 Ciba Geigy Ag Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound
US5679771A (en) * 1990-02-13 1997-10-21 Gropep Pty. Ltd. Method for treating intestinal diseases
DK0607278T3 (da) * 1991-10-07 2002-06-17 Brigham & Womens Hospital Fremgangsmåde til forstærkning af tarmabsorption
CA2135306A1 (en) * 1992-05-08 1993-11-25 Bradford A. Jameson Igf-1 analogs
EP0648264A4 (de) * 1992-06-03 1997-10-01 Univ Case Western Reserve Permanenter verband zur verabreichung von biologischen produkten.
JPH06510065A (ja) * 1992-06-08 1994-11-10 カイロン　コーポレーション 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法
US5444045A (en) * 1992-09-17 1995-08-22 Gropep, Pty. Ltd. Method of administering IGF-1, IGF-2, and analogs thereof to birds
US5401830A (en) * 1992-10-05 1995-03-28 The State University Of New Jersey Insulin receptor-like protein
ATE297214T1 (de) * 1993-09-20 2005-06-15 Celtrix Pharma Behandlung von immunologischen und hematologischen störungen mit igfbp allein oder als komplex mit igf
JPH10504971A (ja) * 1994-09-08 1998-05-19 カイロン コーポレイション インスリン様増殖因子の改善された生産方法
US5565428A (en) * 1995-05-22 1996-10-15 Genentech, Inc. Method of administration of IGF-I
US5741776A (en) * 1995-05-22 1998-04-21 Genentech, Inc. Method of administration of IGF-I
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US7118752B2 (en) 1998-07-22 2006-10-10 University Of Connecticut Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
US6358916B1 (en) 1998-07-22 2002-03-19 Thomas T. Chen Biological activity of IGF-I E domain peptide
US7700353B2 (en) 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
US6875741B2 (en) 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
US7173005B2 (en) 1998-09-02 2007-02-06 Antyra Inc. Insulin and IGF-1 receptor agonists and antagonists
IL143866A0 (en) * 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
CA2369451C (en) * 1999-04-08 2009-09-22 Genentech, Inc. Composition based on oppositely-charged polypeptides
US6703040B2 (en) * 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
AU2000239309A1 (en) * 2000-03-29 2001-10-08 Dgi Biotechnologies Llc Insulin and igf-1 receptor agonists and antagonists
DK1282437T3 (da) 2000-05-16 2008-06-30 Genentech Inc Behandling af brusklidelser
ES2346185T3 (es) * 2000-08-29 2010-10-13 Aurogen Incorporated Metodo para tratar el sistema nervioso central mediante la administracion de analogos estructurales de igf.
GB2369572A (en) 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
BR0207422A (pt) * 2001-02-09 2005-04-19 Genentech Inc Cristal formado por igf-1, composição, método de tratamento de mamìferos que sofrem de disfunção de um agonista, método de cristalização de igf-1, igf-1 cristalino, métodos de identificação de agonistas indiretos de igf-1, complexo co-cristalino, método de determinação de estrutura tridimensional de igf-1, meio de armazenagem de dados legìvel por máquina, cristal de igf-1, método de uso de estrutura tridimensional de igf-1, método de identificação de agonistas ou antagonistas de igf-1, método de projeto de composto, método de identificação de peptidomimético, método de determinação de pelo menos uma parte de estrutura tridimensional de um complexo molecular, método de avaliação da capacidade de uma entidade quìmica de associar-se com igf-1, entidade quìmica, derivado de átomo pesado, método de avaliação experimental ou computacional de uma entidade quìmica e uso de uma composição
CA2488497A1 (en) * 2002-06-11 2003-12-18 The Burnham Institute Neuroprotective synergy of erythropoietin and insulin-like growth factor
ES2541673T3 (es) 2003-09-12 2015-07-23 Ipsen Biopharmaceuticals, Inc. Métodos para el tratamiento de la deficiencia de factor 1 de crecimiento similar a la insulina (IGF-1)
CA2542834C (en) * 2003-10-21 2012-04-24 Igf Oncology, Llc Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents
US9011880B2 (en) * 2003-10-21 2015-04-21 Igf Oncology, Llc Compounds and methods for treating cancer
WO2005072292A2 (en) * 2004-01-24 2005-08-11 Hugh Mctavish Methods for enhancing radiation therapy
JP2008517917A (ja) 2004-10-21 2008-05-29 アイジーエフ オンコロジー エルエルシー 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US20110065633A1 (en) 2008-01-30 2011-03-17 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
CN102245624B (zh) 2008-12-19 2016-08-10 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
EP2376099A4 (de) * 2008-12-19 2012-04-25 Univ Indiana Res & Tech Corp Insulinähnliche wachstumsfaktoren auf yl-basis mit hoher aktivität am insulinrezeptor
CA2747490C (en) 2008-12-19 2017-02-14 Indiana University Research And Technology Corporation Insulin analogs
KR20110126644A (ko) * 2009-01-31 2011-11-23 아이쥐에프 온콜로지, 엘엘씨 항암 단백질-백금 결합체
US20120093775A1 (en) 2009-03-27 2012-04-19 Proyecto De Biomedicina Cima, S.L. Methods and compositions for the treatment of cirrhosis and liver fibrosis
EP2498796B1 (de) 2009-11-09 2017-12-27 AAL Scientifics, Inc. Behandlung von herzkrankheiten
US8940860B2 (en) 2010-06-16 2015-01-27 Indiana University Research And Technology Corporation Single-chain insulin agonists exhibiting high activity at the insulin receptor
EP2585102B1 (de) 2010-06-24 2015-05-06 Indiana University Research and Technology Corporation Auf amid basierende insulin-prodrugs
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
US9375519B2 (en) 2012-06-25 2016-06-28 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
EP3395358B1 (de) 2012-09-26 2019-11-06 Indiana University Research and Technology Corporation Insulinanalogdimere
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
JP6835590B2 (ja) 2014-01-12 2021-02-24 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
WO2016049174A1 (en) 2014-09-24 2016-03-31 Indiana University Research And Technology Corporation Lipidated amide-based insulin prodrugs
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
CN110636867B (zh) 2017-05-21 2023-09-05 Igf肿瘤公司 胰岛素样生长因子——用于治疗骨髓增生异常综合症的化学治疗缀合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
US4963665A (en) * 1986-01-07 1990-10-16 Washington University Human preproinsulin-like growth factor I
AU613876B2 (en) * 1986-10-01 1991-08-15 Merck & Co., Inc. Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
AU607209B2 (en) * 1987-04-23 1991-02-28 Monsanto Technology Llc Secretion of insulin-like growth factor-i in e. coli

Also Published As

Publication number Publication date
ZA886966B (en) 1989-05-30
HUT49375A (en) 1989-09-28
YU46987B (sh) 1994-09-09
KR890005150A (ko) 1989-05-13
AU608364B2 (en) 1991-03-28
NO884183D0 (no) 1988-09-20
HU205170B (en) 1992-03-30
EP0309050B1 (de) 1994-01-12
IL87754A (en) 1993-08-18
NO884183L (no) 1989-03-22
AU2245588A (en) 1989-06-01
FI884276A0 (fi) 1988-09-16
JPH01156998A (ja) 1989-06-20
IL87754A0 (en) 1989-02-28
DK521888A (da) 1989-05-03
FI884276A (fi) 1989-03-22
NO174965C (no) 1994-08-10
DK521888D0 (da) 1988-09-20
EP0309050A1 (de) 1989-03-29
YU177388A (en) 1990-04-30
US4876242A (en) 1989-10-24
PT88546B (pt) 1992-11-30
YU216789A (en) 1991-04-30
NZ226132A (en) 1992-02-25
ATE100139T1 (de) 1994-01-15
PT88546A (pt) 1988-10-01
NO174965B (no) 1994-05-02
DE3887052T2 (de) 1994-07-21

Similar Documents

Publication Publication Date Title
DE3887052D1 (de) Menschliche, Insulin ähnliche Wachstumfaktoren mit reduzierter Bindung zu Serumträgerproteinen und ihre Herstellung in Hefe.
Madsen et al. Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage
Maciag et al. High and low molecular weight forms of endothelial cell growth factor.
EP0177957A3 (en) Expression of biologically active platelet derived growth factor analogs in eucaryotic cells
EP0134385A3 (en) A protein having cell growth stimulating action, composition thereof and method for producing the same
Kurtz et al. Insulin stimulates erythroid colony formation independently of erythropoietin
DE3751632D1 (de) Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
CA2007886A1 (en) Human insulin-like growth factor analogs with reduced binding to 28 k igf binding proteins and their production in yeast
DE3666840D1 (en) Process for the simultaneous production of alcohol and protein-rich fodder
DE69306273T2 (de) Mitogen für die glatte Muskulatur und dessen kodierende DNS
Hill et al. Control of cellular multiplication and differentiation
Sherman QUANTITATIVE RESEARCH CHEMISTRY OF NUTRITION
CN1114133A (zh) 一种促进动物快速生长的新方法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee