NO174467C - Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater

Info

Publication number
NO174467C
NO174467C NO891866A NO891866A NO174467C NO 174467 C NO174467 C NO 174467C NO 891866 A NO891866 A NO 891866A NO 891866 A NO891866 A NO 891866A NO 174467 C NO174467 C NO 174467C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
analogous process
chromane derivatives
chromane
Prior art date
Application number
NO891866A
Other languages
English (en)
Norwegian (no)
Other versions
NO891866D0 (no
NO174467B (no
NO891866L (no
Inventor
Rolf Gericke
Manfred Baumgarth
Ingeborg Lues
Rolf Bergmann
Jacques De Peyer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3815504A external-priority patent/DE3815504A1/de
Priority claimed from DE3835011A external-priority patent/DE3835011A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO891866D0 publication Critical patent/NO891866D0/no
Publication of NO891866L publication Critical patent/NO891866L/no
Publication of NO174467B publication Critical patent/NO174467B/no
Publication of NO174467C publication Critical patent/NO174467C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO891866A 1988-05-06 1989-05-05 Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater NO174467C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3815504A DE3815504A1 (de) 1988-05-06 1988-05-06 4-n-heterocyclyl-chromanderivate, verfahren sowie zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3835011A DE3835011A1 (de) 1988-10-14 1988-10-14 Chromanderivate

Publications (4)

Publication Number Publication Date
NO891866D0 NO891866D0 (no) 1989-05-05
NO891866L NO891866L (no) 1989-11-07
NO174467B NO174467B (no) 1994-01-31
NO174467C true NO174467C (no) 1994-05-11

Family

ID=25867854

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891866A NO174467C (no) 1988-05-06 1989-05-05 Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater

Country Status (17)

Country Link
US (1) US5013853A (pt)
EP (1) EP0340718B1 (pt)
JP (1) JPH01319481A (pt)
KR (1) KR0150781B1 (pt)
AR (1) AR246966A1 (pt)
AT (1) ATE108786T1 (pt)
AU (1) AU628331B2 (pt)
DE (1) DE58908062D1 (pt)
DK (1) DK223289A (pt)
ES (1) ES2057010T3 (pt)
FI (1) FI93358C (pt)
HU (1) HU207311B (pt)
IE (1) IE63794B1 (pt)
IL (1) IL90198A (pt)
NO (1) NO174467C (pt)
NZ (1) NZ228991A (pt)
PT (1) PT90471B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
EP0373204A1 (en) * 1988-05-09 1990-06-20 Beecham Group Plc Novel compounds and treatment
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3923839A1 (de) * 1989-07-19 1991-01-31 Beiersdorf Ag Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5223629A (en) * 1989-07-21 1993-06-29 Alkaloida Vegyeszeti Gyar Process for the preparation of anti-hypertensive benzopyran
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten
DE4038752A1 (de) * 1990-12-05 1992-06-11 Merck Patent Gmbh Chromanderivate
NZ240933A (en) * 1990-12-21 1993-05-26 Ortho Pharma Corp Preparing enantiomerically pure thienopyran derivatives
US5332168A (en) * 1991-04-01 1994-07-26 Fuji Photo Film Co., Ltd. Photographic film cassette with improved separator claw
JP3442815B2 (ja) * 1992-05-13 2003-09-02 第一製薬株式会社 ジアザビシクロアルケン誘導体
EP0665733B1 (en) * 1992-10-21 2003-05-07 Gynetech Laboratories, Inc. Vaginal sponge delivery system
GB9316111D0 (en) * 1993-08-04 1993-09-22 Pfizer Ltd Benzopyrans
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
CA2153498A1 (en) * 1993-11-10 1995-05-18 Hidetsura Cho Chroman derivative and medicinal use thereof
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
AU7453900A (en) * 1999-10-05 2001-05-10 Nissan Chemical Industries Ltd. 4-oxybenzopyran derivative
FR2820974B1 (fr) * 2001-02-21 2004-02-13 Pharmascience Lab Composition topique comprenant une solution vraie contenant un derive de chromane ou de chromene, son procede de preparation et son utilisation cosmetique et therapeutique
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
US10981951B2 (en) 2014-01-31 2021-04-20 Mayo Foundation For Medical Education And Research Therapeutics for the treatment of glaucoma

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1077066A (en) * 1963-09-10 1967-07-26 Benger Lab Ltd Improvements in or relating to the synthesis of chromanones
US3467676A (en) * 1967-04-05 1969-09-16 American Home Prod 5-hydroxy-2,2,7-trialkylchroman-4-ones and derivatives
CH619701A5 (pt) * 1975-08-07 1980-10-15 Bayer Ag
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
DE2814983A1 (de) * 1978-04-07 1979-10-18 Bayer Ag Neue chromanon-derivate
JPS6047269B2 (ja) * 1978-04-14 1985-10-21 日産化学工業株式会社 クロマノ−ル類化合物およびその製造方法
US4241069A (en) * 1979-09-04 1980-12-23 Miles Laboratories, Inc. 3-Methylene flavanones and 3-methylene chromanones
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
EP0107423B1 (en) * 1982-10-19 1986-07-23 Beecham Group Plc Novel chromans and chromenes
JPS6016983A (ja) * 1983-07-08 1985-01-28 Daicel Chem Ind Ltd 3−メチレン−4−クロマノン誘導体
HU194855B (en) * 1983-02-16 1988-03-28 Alkaloida Vegyeszeti Gyar Process for producing chromene derivatives, insecticide and nematocide compositions containing chromene derivatives as active components
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
US4777168A (en) * 1984-10-23 1988-10-11 Rorer Pharmaceutical Corporation Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate

Also Published As

Publication number Publication date
KR890017246A (ko) 1989-12-15
IE891474L (en) 1989-11-06
EP0340718A1 (de) 1989-11-08
IL90198A (en) 1994-01-25
FI93358C (fi) 1995-03-27
FI892182A (fi) 1989-11-07
DK223289A (da) 1989-11-07
FI93358B (fi) 1994-12-15
HU207311B (en) 1993-03-29
FI892182A0 (fi) 1989-05-05
NZ228991A (en) 1990-12-21
AU3390189A (en) 1989-11-09
AU628331B2 (en) 1992-09-17
ATE108786T1 (de) 1994-08-15
ES2057010T3 (es) 1994-10-16
DK223289D0 (da) 1989-05-05
EP0340718B1 (de) 1994-07-20
AR246966A1 (es) 1994-10-31
PT90471A (pt) 1989-11-30
KR0150781B1 (ko) 1998-10-15
NO891866D0 (no) 1989-05-05
IE63794B1 (en) 1995-06-14
PT90471B (pt) 1994-09-30
IL90198A0 (en) 1989-12-15
NO174467B (no) 1994-01-31
HUT56094A (en) 1991-07-29
NO891866L (no) 1989-11-07
US5013853A (en) 1991-05-07
DE58908062D1 (de) 1994-08-25
JPH01319481A (ja) 1989-12-25

Similar Documents

Publication Publication Date Title
NO174467C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
FI96861C (fi) Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
NO176759C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
NO179584C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
FI92934B (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
NO176319C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive furanderivater
NO176275C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazinonderivater
NO178543C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive benzopyranderivater
NO178068C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidindionderivater
NO903941D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive diazepinon-derivater.
NO173334C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
NO174391C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
NO174959C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive N-aminobutyl-N-fenyl-arylamidderivater
FI884910A (fi) Menetelmä terapeuttisesti käyttökelpoisten bentsopyraanijohdannaisten valmistamiseksi
NO173784C (no) Anaslogifremgangsmaate for fremstilling av terapeutisk aktive tieno-tri-azolo-diazepinderivater
NO176477C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-alkoksymetylsubstituerte kromanderivater
NO174422C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
FI902727A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
NO176100C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive oksodihydropyridyl- og oksodihydropyridazinylkromanderivater
FI884660A (fi) Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
NO178698C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive glycerolderivater
NO173607C (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive tienotriazolo-diazepin-derivater
FI903077A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivisia R(-)-3-kinuklidinolijohdannaisia
NO174203C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive
NO176099C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 4-(2-okso-3-pyridyl)-kromanderivater