NO173279C - Fremgangsm}te for fremstilling av et stabilt zink-protamin-alfa-interferonkompleks - Google Patents

Fremgangsm}te for fremstilling av et stabilt zink-protamin-alfa-interferonkompleks

Info

Publication number
NO173279C
NO173279C NO884596A NO884596A NO173279C NO 173279 C NO173279 C NO 173279C NO 884596 A NO884596 A NO 884596A NO 884596 A NO884596 A NO 884596A NO 173279 C NO173279 C NO 173279C
Authority
NO
Norway
Prior art keywords
protamine
alpha
preparing
stable zinc
interferon complex
Prior art date
Application number
NO884596A
Other languages
English (en)
Norwegian (no)
Other versions
NO884596D0 (no
NO884596L (no
NO173279B (no
Inventor
Zachary Yim
Michael A Zupon
Imtiaz A Chaudry
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO884596D0 publication Critical patent/NO884596D0/no
Publication of NO884596L publication Critical patent/NO884596L/no
Publication of NO173279B publication Critical patent/NO173279B/no
Publication of NO173279C publication Critical patent/NO173279C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
NO884596A 1987-02-24 1988-10-14 Fremgangsm}te for fremstilling av et stabilt zink-protamin-alfa-interferonkompleks NO173279C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex
PCT/US1988/000410 WO1988006456A1 (en) 1987-02-24 1988-02-23 Stable interferon complexes

Publications (4)

Publication Number Publication Date
NO884596D0 NO884596D0 (no) 1988-10-14
NO884596L NO884596L (no) 1988-10-14
NO173279B NO173279B (no) 1993-08-16
NO173279C true NO173279C (no) 1993-11-24

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
NO884596A NO173279C (no) 1987-02-24 1988-10-14 Fremgangsm}te for fremstilling av et stabilt zink-protamin-alfa-interferonkompleks

Country Status (23)

Country Link
US (1) US4853218A (cs)
EP (2) EP0281299B1 (cs)
JP (1) JPH0611712B2 (cs)
KR (1) KR940001372B1 (cs)
AT (1) ATE76580T1 (cs)
AU (1) AU608584B2 (cs)
CA (1) CA1316105C (cs)
DE (1) DE3871407D1 (cs)
DK (1) DK167048B1 (cs)
ES (1) ES2032009T3 (cs)
FI (1) FI93309C (cs)
GR (1) GR3005358T3 (cs)
HU (1) HU201881B (cs)
IE (1) IE61340B1 (cs)
IL (1) IL85523A (cs)
MX (1) MX9203328A (cs)
MY (1) MY103212A (cs)
NO (1) NO173279C (cs)
NZ (1) NZ223598A (cs)
OA (1) OA09737A (cs)
PT (1) PT86810B (cs)
WO (1) WO1988006456A1 (cs)
ZA (1) ZA881258B (cs)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ZA873743B (en) * 1986-05-27 1987-11-25 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ES2054815T3 (es) * 1987-09-08 1994-08-16 Takeda Chemical Industries Ltd Citoquinas insolubilizadas en agua.
MX9203319A (es) * 1990-06-04 1992-07-31 Schering Corp Metodo para la preparacion de cristales de alfa-2 interferona.
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
AU670168B2 (en) * 1992-12-02 1996-07-04 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
AU710347B2 (en) * 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
IL130532A0 (en) * 1996-12-20 2000-06-01 Alza Corp Gel composition and methods
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
NZ533434A (en) * 2001-11-14 2006-11-30 Alza Corp Thixotropic gel composition for injectable deposition
CA2466632C (en) * 2001-11-14 2014-02-11 Alza Corporation Injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
BR0206987A (pt) * 2001-11-14 2004-02-10 Alza Corp Composições de depósito injetáveis por cateter e usos destes
TWI353854B (en) 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AU2002359397B2 (en) * 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
CA2494400A1 (en) 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
SG176314A1 (en) * 2002-12-31 2011-12-29 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them
ZA200505306B (en) * 2002-12-31 2006-09-27 Altus Pharmaceuticals Inc Complexes of protein crystals and ionic polymers
EP1643968A1 (en) * 2003-05-30 2006-04-12 ALZA Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
CA2634053A1 (en) * 2005-12-23 2007-07-05 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
CA2750262C (en) * 2009-01-28 2016-08-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
EP2643009A4 (en) * 2010-11-24 2015-04-01 Durect Corp COMPOSITION FOR THE RELEASE OF BIODEGRADABLE ACTIVE SUBSTANCES
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (cs) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI86558C (fi) * 1980-01-08 1992-09-10 Biogen Inc Dna- sekvenser, rekombinant-dna- molekyler och foerfaranden foer framstaellning av humant interferon av -typ och val av dna-sekvensen.
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
KR940001372B1 (ko) 1994-02-21
AU608584B2 (en) 1991-04-11
PT86810B (pt) 1992-05-29
EP0281299A1 (en) 1988-09-07
IE61340B1 (en) 1994-11-02
NO884596D0 (no) 1988-10-14
DK167048B1 (da) 1993-08-23
ATE76580T1 (de) 1992-06-15
IL85523A (en) 1992-11-15
HU201881B (en) 1991-01-28
PT86810A (pt) 1988-03-01
IE880480L (en) 1988-08-24
GR3005358T3 (cs) 1993-05-24
DK582188D0 (da) 1988-10-19
JPH0611712B2 (ja) 1994-02-16
FI893929A0 (fi) 1989-08-22
KR890700359A (ko) 1989-04-24
ZA881258B (en) 1988-08-23
WO1988006456A1 (en) 1988-09-07
ES2032009T3 (es) 1993-01-01
OA09737A (en) 1993-11-30
FI893929L (fi) 1989-08-22
EP0281299B1 (en) 1992-05-27
CA1316105C (en) 1993-04-13
NO884596L (no) 1988-10-14
MX9203328A (es) 1992-07-01
DE3871407D1 (de) 1992-07-02
NZ223598A (en) 1989-12-21
NO173279B (no) 1993-08-16
FI93309B (fi) 1994-12-15
US4853218A (en) 1989-08-01
AU1394688A (en) 1988-09-26
JPH03500286A (ja) 1991-01-24
FI93309C (fi) 1995-03-27
DK582188A (da) 1988-10-19
EP0375678A1 (en) 1990-07-04
HUT51902A (en) 1990-06-28
IL85523A0 (en) 1988-08-31
MY103212A (en) 1993-05-29

Similar Documents

Publication Publication Date Title
NO173279C (no) Fremgangsm}te for fremstilling av et stabilt zink-protamin-alfa-interferonkompleks
EG18574A (en) Process for production of an controlled release bases for pharmaceuticals
NO883062L (no) Fremgangsmaate for alfa-c-alkylering av 8-acylgrupper paa mevinolin og analoger derav.
FI885884A0 (fi) Menetelmä hitaasti vapautuvan farmaseuttisen koostumuksen valmistamiseksi
FI885101L (fi) Menetelmä lääkettä säännöstellysti vapauttavan annostusmuodon valmistamiseksi
FI900249A0 (fi) Menetelmä superaktiivisten insuliinianalogien valmistamiseksi
FI920957A0 (fi) En doseringsform foer tillfoersel av loesliga eller oloesliga laekemedel.
ATE74346T1 (de) Alkensaeurederivate.
ATE114973T1 (de) Hepatocyt-stimulierender faktor.
FI871378A0 (fi) Menetelmä valmistaa farmaseuttiseen käyttöön tarkoitettu muotokappale pelleteistä
ATE55250T1 (de) Ifosfamid-lyophilisat und verfahren zu dessen herstellung.
PT87672A (pt) Process for preparing a pharmaceutical composition
MC1981A1 (fr) Derives d'acides catechol carboxyliques
PT87564A (pt) Process for preparing substituted vinylcephalosporins useful as medicaments
PT87388A (pt) Process for preparing a stable lyophilized live herpes virus vaccine
NO870950D0 (no) Fremgangsmaate for fremstilling av et stabilt injiserbart farmasoeytisk preparat.
EP0415564A3 (en) Improvement of excretion of nonprotein nitrogen into the intestine by prostanoic acid derivaties
BG60697B2 (en) Medicamentous form having continous release based on ethodolacquer
BE866610A (fr) Composition pharmaceutique a base d'acides eicosapolynoiques
PT87064A (pt) Process for the preparation of 5-hydroxydiprafenone and its acid addition salts
IL47784A0 (en) A method for cultivating foot and mouth(fmd)disease virus