NO173014C - Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater

Info

Publication number
NO173014C
NO173014C NO892799A NO892799A NO173014C NO 173014 C NO173014 C NO 173014C NO 892799 A NO892799 A NO 892799A NO 892799 A NO892799 A NO 892799A NO 173014 C NO173014 C NO 173014C
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
carboxy
halogen
amino
Prior art date
Application number
NO892799A
Other languages
English (en)
Norwegian (no)
Other versions
NO892799D0 (no
NO892799L (no
NO173014B (no
Inventor
Yoshinari Sato
Teruaki Matuo
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888816207A external-priority patent/GB8816207D0/en
Priority claimed from GB888820560A external-priority patent/GB8820560D0/en
Priority claimed from GB888823660A external-priority patent/GB8823660D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO892799D0 publication Critical patent/NO892799D0/no
Publication of NO892799L publication Critical patent/NO892799L/no
Publication of NO173014B publication Critical patent/NO173014B/no
Publication of NO173014C publication Critical patent/NO173014C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO892799A 1988-07-07 1989-07-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater NO173014C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888816207A GB8816207D0 (en) 1988-07-07 1988-07-07 Benzodiazepine derivatives
GB888820560A GB8820560D0 (en) 1988-08-31 1988-08-31 Benzodiazepine derivatives
GB888823660A GB8823660D0 (en) 1988-10-07 1988-10-07 Benzodiazepine derivatives

Publications (4)

Publication Number Publication Date
NO892799D0 NO892799D0 (no) 1989-07-06
NO892799L NO892799L (no) 1990-01-08
NO173014B NO173014B (no) 1993-07-05
NO173014C true NO173014C (no) 1993-10-13

Family

ID=27263983

Family Applications (1)

Application Number Title Priority Date Filing Date
NO892799A NO173014C (no) 1988-07-07 1989-07-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater

Country Status (17)

Country Link
US (1) US4970207A (ja)
EP (1) EP0349949B1 (ja)
JP (2) JP2536160B2 (ja)
KR (1) KR900001688A (ja)
CN (1) CN1041941A (ja)
AT (1) ATE147403T1 (ja)
AU (1) AU3785989A (ja)
CA (1) CA1334589C (ja)
DE (1) DE68927620T2 (ja)
DK (1) DK336589A (ja)
ES (1) ES2095833T3 (ja)
FI (1) FI95699C (ja)
GR (1) GR3022239T3 (ja)
HU (1) HUT50331A (ja)
IL (1) IL90830A (ja)
NO (1) NO173014C (ja)
PT (1) PT91092B (ja)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01211939A (ja) * 1988-02-18 1989-08-25 Nec Kyushu Ltd イオン注入装置
US5264433A (en) * 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
GB9015879D0 (en) * 1990-07-19 1990-09-05 Fujisawa Pharmaceutical Co Benzodiazepine derivatives
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
EP0523845A3 (en) * 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5583130A (en) * 1992-09-25 1996-12-10 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
WO1994018229A1 (en) * 1993-02-03 1994-08-18 Fisons Corporation 1,2,4-triazinone derivatives and their use in therapy
US5284841A (en) * 1993-02-04 1994-02-08 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
CA2196062A1 (en) * 1994-07-29 1996-02-15 Yoshinari Sato Benzodiazepine derivatives
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6562629B1 (en) * 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
AU722110B2 (en) * 1996-06-28 2000-07-20 Merck & Co., Inc. Pharmaceutical preparation
US5929071A (en) * 1996-07-02 1999-07-27 Merck & Co., Inc. Method for the treatment of preterm labor
WO1998000406A1 (en) * 1996-07-02 1998-01-08 Merck & Co., Inc. Method for the treatment of preterm labor
AUPO284396A0 (en) 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
PT944645E (pt) * 1996-12-06 2005-06-30 Vertex Pharma Inibidores da enzima conversora de interleucina 1beta
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
DE60007960T2 (de) * 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutische Anwendungen von pro-apoptotischen Benzodiazepinen
US6207638B1 (en) 2000-02-23 2001-03-27 Pacifichealth Laboratories, Inc. Nutritional intervention composition for enhancing and extending satiety
US6429190B1 (en) 2000-12-15 2002-08-06 Pacifichealth Laboratories, Inc. Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK)
AU2002232575A1 (en) 2000-12-15 2002-06-24 Pacifichealth Laboratories, Inc. Nutritional composition for improving the efficacy of a lipase inhibitor
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
CN1812982B (zh) * 2003-06-26 2010-10-27 默沙东公司 苯并二氮杂*cgrp受体拮抗剂
JP2008528448A (ja) 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
AU2006309291B2 (en) 2005-06-01 2010-05-27 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
US8088759B2 (en) 2005-11-01 2012-01-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (en) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Benzodiazepine derivatives for use in the treatment of immune, inflammatory and proliferative disorders
BRPI0808653A2 (pt) 2007-03-09 2014-08-19 Univ Michigan Composições e métodos referindo-se a novos compostos e alvos dos mesmos.
CA2698248C (en) 2007-09-14 2017-08-29 The Regents Of The University Of Michigan Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof
JP5539212B2 (ja) 2007-11-06 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 皮膚症状の治療に有用なベンゾジアゼピノン化合物
EP2352724B1 (en) 2008-09-11 2015-04-22 The Regents of the University of Michigan Aryl guanidine f1f0-atpase inhibitors and their medical use
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
AU2010322287B2 (en) 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
CA2915237C (en) 2009-11-17 2017-10-10 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
EP2953484B1 (en) 2013-02-05 2019-01-16 Ludwig Stocker Hofpfisterei GmbH Use of microorganisms for the prevention and treatment of intestinal diseases

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CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines

Also Published As

Publication number Publication date
JP2536160B2 (ja) 1996-09-18
AU3785989A (en) 1990-01-11
ES2095833T3 (es) 1997-03-01
NO892799D0 (no) 1989-07-06
JPH0256481A (ja) 1990-02-26
IL90830A0 (en) 1990-01-18
DE68927620D1 (de) 1997-02-20
PT91092A (pt) 1990-02-08
DK336589D0 (da) 1989-07-06
DK336589A (da) 1990-01-08
EP0349949A3 (en) 1991-09-04
US4970207A (en) 1990-11-13
NO892799L (no) 1990-01-08
EP0349949A2 (en) 1990-01-10
CN1041941A (zh) 1990-05-09
DE68927620T2 (de) 1997-04-24
ATE147403T1 (de) 1997-01-15
PT91092B (pt) 1995-05-04
FI893226A (fi) 1990-01-08
CA1334589C (en) 1995-02-28
IL90830A (en) 1995-06-29
FI893226A0 (fi) 1989-07-03
FI95699C (fi) 1996-03-11
NO173014B (no) 1993-07-05
FI95699B (fi) 1995-11-30
HUT50331A (en) 1990-01-29
EP0349949B1 (en) 1997-01-08
JPH07224060A (ja) 1995-08-22
KR900001688A (ko) 1990-02-27
GR3022239T3 (en) 1997-04-30

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