NO171641C - Analogifremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider - Google Patents

Analogifremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider

Info

Publication number
NO171641C
NO171641C NO881537A NO881537A NO171641C NO 171641 C NO171641 C NO 171641C NO 881537 A NO881537 A NO 881537A NO 881537 A NO881537 A NO 881537A NO 171641 C NO171641 C NO 171641C
Authority
NO
Norway
Prior art keywords
dideoxynucleosides
substituted
preparing
analogue procedure
analogue
Prior art date
Application number
NO881537A
Other languages
English (en)
Norwegian (no)
Other versions
NO171641B (no
NO881537L (no
NO881537D0 (no
Inventor
George Walter Koszalka
Thomas Anthony Krenitsky
Janet Litster Rideout
Charlene Louise Burns
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878708512A external-priority patent/GB8708512D0/en
Priority claimed from GB878712691A external-priority patent/GB8712691D0/en
Priority claimed from GB878723013A external-priority patent/GB8723013D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO881537D0 publication Critical patent/NO881537D0/no
Publication of NO881537L publication Critical patent/NO881537L/no
Publication of NO171641B publication Critical patent/NO171641B/no
Publication of NO171641C publication Critical patent/NO171641C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO881537A 1987-04-09 1988-04-08 Analogifremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider NO171641C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878708512A GB8708512D0 (en) 1987-04-09 1987-04-09 Therapeutic nucleosides
GB878712691A GB8712691D0 (en) 1987-05-29 1987-05-29 Therapeutic nucleosides
GB878723013A GB8723013D0 (en) 1987-09-30 1987-09-30 Therapeutic nucleosides

Publications (4)

Publication Number Publication Date
NO881537D0 NO881537D0 (no) 1988-04-08
NO881537L NO881537L (no) 1988-10-10
NO171641B NO171641B (no) 1993-01-04
NO171641C true NO171641C (no) 1993-04-14

Family

ID=27263377

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881537A NO171641C (no) 1987-04-09 1988-04-08 Analogifremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider

Country Status (20)

Country Link
US (1) US5068320A (cs)
EP (1) EP0286425B1 (cs)
JP (1) JP2763888B2 (cs)
KR (1) KR880012630A (cs)
AP (1) AP78A (cs)
AT (1) ATE116984T1 (cs)
AU (1) AU608590B2 (cs)
CA (1) CA1326237C (cs)
CS (1) CS274461B2 (cs)
DE (1) DE3852710T2 (cs)
DK (1) DK191688A (cs)
FI (1) FI87214C (cs)
HU (1) HU201954B (cs)
IL (1) IL86007A0 (cs)
MC (1) MC1915A1 (cs)
NO (1) NO171641C (cs)
NZ (1) NZ224189A (cs)
PL (1) PL154956B1 (cs)
PT (1) PT87191B (cs)
RU (1) RU1779256C (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
JPH02164881A (ja) * 1988-10-24 1990-06-25 Wellcome Found Ltd:The 治療用ヌクレオシド化合物
WO1990006312A1 (de) * 1988-11-29 1990-06-14 Institut Für Molekularbiologie Und Analytik (Ima) Gmbh 2', 3'-didesoxyribofuranoside und ein verfahren zu ihrer herstellung
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
US5013829A (en) * 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
DE4020529A1 (de) * 1989-09-12 1991-03-21 Roxana Vasiloiu Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
JPH0637391B2 (ja) * 1989-09-29 1994-05-18 日本製紙株式会社 抗エイズウイルス剤
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
CA2075490A1 (en) * 1990-02-09 1991-08-10 Hiroaki Mitsuya 6-halo-and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
ES2209532T3 (es) * 1998-12-23 2004-06-16 Shire Biochem Inc. Analogos de nucleosidos antivirales.
CN101220071B (zh) * 2008-01-17 2011-04-06 南京长澳医药科技有限公司 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
CN102234280B (zh) * 2010-04-26 2014-01-08 北京大学 D,l-鸟嘌呤核苷类似物及其制备方法和应用
CA2810928A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
CA2837207A1 (en) 2011-06-01 2012-12-06 Janus Biotherapeutics, Inc. Novel immune system modulators
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
US9469644B2 (en) * 2013-03-05 2016-10-18 Hoffmann-La Roche Inc. Inhibitors of Bruton's tyrosine kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
DK164392C (da) * 1985-03-16 1992-11-09 Wellcome Found Anvendelse af 3'-azido-3'-desoxythymidin til fremstilling af et laegemiddel til behandling af eller profylakse for en human retrovirusinfektion
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
AU570855B2 (en) * 1985-08-26 1988-03-24 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Inhibition of in vitro infectivity and cytopathic effect of htlv-111/lav by 2' 3' -dideoxycytidine
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
IT1203558B (it) * 1986-05-20 1989-02-15 Firestone Int Dev Spa Metodo per la realizzazione di un pneumatico radiale di prima fase per veicoli
AU613026B2 (en) * 1987-03-24 1991-07-25 Nycomed As 2',3' dideoxyribofuranoxide derivatives
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL87149A (en) * 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE116984T1 (de) 1995-01-15
NO171641B (no) 1993-01-04
PL271722A1 (en) 1989-01-23
DK191688A (da) 1988-10-10
NO881537L (no) 1988-10-10
RU1779256C (ru) 1992-11-30
FI87214C (fi) 1992-12-10
FI881651A0 (fi) 1988-04-08
PL154956B1 (en) 1991-10-31
CS274461B2 (en) 1991-04-11
NZ224189A (en) 1991-09-25
FI881651L (fi) 1988-10-10
DK191688D0 (da) 1988-04-08
US5068320A (en) 1991-11-26
EP0286425B1 (en) 1995-01-11
FI87214B (fi) 1992-08-31
CS242188A2 (en) 1990-09-12
MC1915A1 (fr) 1989-04-06
HU201954B (en) 1991-01-28
NO881537D0 (no) 1988-04-08
PT87191A (pt) 1988-05-01
EP0286425A2 (en) 1988-10-12
AP8800086A0 (en) 1988-02-01
EP0286425A3 (en) 1990-12-05
DE3852710D1 (de) 1995-02-23
JP2763888B2 (ja) 1998-06-11
AU608590B2 (en) 1991-04-11
KR880012630A (ko) 1988-11-28
DE3852710T2 (de) 1995-05-24
IL86007A0 (en) 1988-09-30
CA1326237C (en) 1994-01-18
AP78A (en) 1990-03-12
PT87191B (pt) 1993-02-26
HUT48269A (en) 1989-05-29
JPS63267796A (ja) 1988-11-04
AU1444488A (en) 1988-10-13

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