NO171594C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-substituerte 4-amino-6,7-dimetoksykinoliner - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-substituerte 4-amino-6,7-dimetoksykinoliner

Info

Publication number
NO171594C
NO171594C NO832688A NO832688A NO171594C NO 171594 C NO171594 C NO 171594C NO 832688 A NO832688 A NO 832688A NO 832688 A NO832688 A NO 832688A NO 171594 C NO171594 C NO 171594C
Authority
NO
Norway
Prior art keywords
dimetoxykinolines
amino
substituted
preparation
therapeutic active
Prior art date
Application number
NO832688A
Other languages
English (en)
Norwegian (no)
Other versions
NO171594B (no
NO832688L (no
Inventor
Simon Fraser Campbell
John David Hardstone
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO832688L publication Critical patent/NO832688L/no
Priority to NO903181A priority Critical patent/NO173605C/no
Publication of NO171594B publication Critical patent/NO171594B/no
Publication of NO171594C publication Critical patent/NO171594C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO832688A 1982-07-24 1983-07-22 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-substituerte 4-amino-6,7-dimetoksykinoliner NO171594C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO903181A NO173605C (no) 1982-07-24 1990-07-17 Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 4-amino-6,7-dimetoksy-2(6,7-dimetoksy-1,2,3,4-tetrahydroisokinol-2-yl)-kinolin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8221457 1982-07-24

Publications (3)

Publication Number Publication Date
NO832688L NO832688L (no) 1984-01-25
NO171594B NO171594B (no) 1992-12-28
NO171594C true NO171594C (no) 1993-04-07

Family

ID=10531886

Family Applications (1)

Application Number Title Priority Date Filing Date
NO832688A NO171594C (no) 1982-07-24 1983-07-22 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-substituerte 4-amino-6,7-dimetoksykinoliner

Country Status (26)

Country Link
US (3) US4656174A (sl)
EP (1) EP0100200B1 (sl)
JP (1) JPS5933264A (sl)
KR (1) KR880001315B1 (sl)
AU (1) AU548036B2 (sl)
CA (1) CA1255670A (sl)
CS (1) CS247073B2 (sl)
DD (1) DD211555A5 (sl)
DE (1) DE3371336D1 (sl)
DK (1) DK166821B1 (sl)
ES (1) ES8504131A1 (sl)
FI (1) FI78296C (sl)
GR (1) GR79603B (sl)
HK (1) HK32289A (sl)
HU (1) HU190907B (sl)
IE (1) IE55798B1 (sl)
IL (1) IL69311A (sl)
NO (1) NO171594C (sl)
NZ (1) NZ204996A (sl)
PH (1) PH19424A (sl)
PL (1) PL139498B1 (sl)
PT (1) PT77082B (sl)
SG (1) SG6489G (sl)
SU (2) SU1251801A3 (sl)
YU (1) YU42628B (sl)
ZA (1) ZA835355B (sl)

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AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
GB8716972D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Treatment of cardiac arrhythmias
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US4882337A (en) * 1988-08-12 1989-11-21 Pfizer Inc. Tetrahydroisoquinoline antiarrhythmic agents
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
TW304945B (sl) * 1992-06-27 1997-05-11 Hoechst Ag
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9526546D0 (en) * 1995-12-23 1996-02-28 Pfizer Ltd Compounds useful in therapy
BR9709230A (pt) * 1996-05-10 1999-08-10 Icos Corp Composto
GB9700504D0 (en) 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
KR20030024799A (ko) * 2000-07-20 2003-03-26 뉴로젠 코포레이션 캡사이신 수용체 리간드
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
EP1178036A1 (en) 2000-08-04 2002-02-06 Aventis Cropscience S.A. Fungicidal phenylimidate derivatives
US6900220B2 (en) 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
KR100420663B1 (ko) * 2001-01-09 2004-03-02 주식회사 켐온 퀴놀린 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
US6734303B2 (en) 2001-05-18 2004-05-11 Pfizer Inc. Process for the production of quinazolines
CA2468015A1 (en) * 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
EP1937252B1 (en) * 2005-09-19 2017-10-25 Neuronascent, Inc. Compositions for stimulating neurogenesis and inhibiting neuronal degeneration
AU2013211455B2 (en) * 2005-09-19 2017-12-07 Neuronascent, Inc. Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
EP2864322B1 (en) 2012-06-20 2016-04-27 Novartis AG Complement pathway modulators and uses thereof
TWI649308B (zh) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物

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GB890533A (en) * 1959-11-09 1962-03-07 Allen & Hanburys Ltd Improvements in or relating to heterocyclic quaternary ammonium salts
CH414637A (de) * 1962-08-31 1966-06-15 Geigy Ag J R Verfahren zur Herstellung von Carbostyrilderivaten
US3272824A (en) * 1962-12-06 1966-09-13 Norwich Pharma Co 4-amino-6, 7-di(lower) alkoxyquinolines
US3542785A (en) * 1967-05-15 1970-11-24 Ciba Geigy Corp 2-hydroxy-4-aryl-quinolines
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3629418A (en) * 1969-02-14 1971-12-21 Miles Lab Process for producing an anti-depressant effect with piperazine quinolines
GB1383409A (en) * 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
JPS54125688A (en) * 1978-02-27 1979-09-29 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative*its manufacture and antihypertensive drug
JPS5480372A (en) * 1977-12-12 1979-06-27 Toray Ind Inc Production of fishing rod made of carbon fiber-reinforced resin
JPS54122283A (en) * 1978-03-13 1979-09-21 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS54128582A (en) * 1978-03-30 1979-10-05 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
US4287341A (en) * 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
DE3034001A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Also Published As

Publication number Publication date
FI832658A0 (fi) 1983-07-21
YU157283A (en) 1986-02-28
PL139498B1 (en) 1987-01-31
FI832658A (fi) 1984-01-25
DK337383D0 (da) 1983-07-22
EP0100200A1 (en) 1984-02-08
CS247073B2 (en) 1986-11-13
AU548036B2 (en) 1985-11-21
ZA835355B (en) 1984-05-30
NZ204996A (en) 1986-05-09
DD211555A5 (de) 1984-07-18
AU1722283A (en) 1984-01-26
GR79603B (sl) 1984-10-31
KR840005428A (ko) 1984-11-12
SU1340589A3 (ru) 1987-09-23
ES524320A0 (es) 1985-04-16
JPS5933264A (ja) 1984-02-23
ES8504131A1 (es) 1985-04-16
US4758568A (en) 1988-07-19
HK32289A (en) 1989-04-28
NO171594B (no) 1992-12-28
PL243131A1 (en) 1984-12-17
DK166821B1 (da) 1993-07-19
NO832688L (no) 1984-01-25
DK337383A (da) 1984-01-25
FI78296B (fi) 1989-03-31
IE55798B1 (en) 1991-01-16
HU190907B (en) 1986-12-28
SU1251801A3 (ru) 1986-08-15
IL69311A (en) 1987-01-30
SG6489G (en) 1989-06-09
FI78296C (fi) 1989-07-10
CA1255670A (en) 1989-06-13
DE3371336D1 (en) 1987-06-11
KR880001315B1 (ko) 1988-07-23
PT77082B (en) 1986-04-11
IE831730L (en) 1984-01-24
IL69311A0 (en) 1983-11-30
YU42628B (en) 1988-10-31
PH19424A (en) 1986-04-15
US4686228A (en) 1987-08-11
JPH0219112B2 (sl) 1990-04-27
PT77082A (en) 1983-08-01
EP0100200B1 (en) 1987-05-06
US4656174A (en) 1987-04-07

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