NO166709B - Fremgangsmaate for fremstilling av akrylamider. - Google Patents
Fremgangsmaate for fremstilling av akrylamider. Download PDFInfo
- Publication number
- NO166709B NO166709B NO854925A NO854925A NO166709B NO 166709 B NO166709 B NO 166709B NO 854925 A NO854925 A NO 854925A NO 854925 A NO854925 A NO 854925A NO 166709 B NO166709 B NO 166709B
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- chloride
- acrylamids
- procedure
- lower alkanoyl
- Prior art date
Links
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
- 239000007858 starting material Substances 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 229940054066 benzamide antipsychotics Drugs 0.000 claims description 3
- 150000003936 benzamides Chemical class 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 230000000144 pharmacologic effect Effects 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims 1
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 6
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- 238000005618 Fries rearrangement reaction Methods 0.000 description 2
- 230000003474 anti-emetic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- HHUMLXVBJQCSCW-UHFFFAOYSA-N (3-acetamido-4-chlorophenyl) acetate Chemical compound C(C)(=O)OC1=CC(=C(C=C1)Cl)NC(C)=O HHUMLXVBJQCSCW-UHFFFAOYSA-N 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- FAPDDOBMIUGHIN-UHFFFAOYSA-K antimony trichloride Chemical compound Cl[Sb](Cl)Cl FAPDDOBMIUGHIN-UHFFFAOYSA-K 0.000 description 1
- JHXKRIRFYBPWGE-UHFFFAOYSA-K bismuth chloride Chemical compound Cl[Bi](Cl)Cl JHXKRIRFYBPWGE-UHFFFAOYSA-K 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
- UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Description
Foreliggende oppfinnelse angår nye 2-lavere alkanoyl-4-halogen-5-acetylaminofenoler for anvendelse som utgangsmaterialer ved fremstilling av de tilsvarende benzamider med verdifulle farmakologiske egenskaper,og som har den generelle formel:
hvor R^ er en lavere alkanoylgruppe, R,, er en acetylgruppe og X er et halogenatom.
Disse nye forbindelser kan fremstilles ved at et 3-acet-ylamino-4-halogenfenolderivat av den generelle formel:
hvor R^, R2 og X har de ovenfor angitte betydninger, oppvarmes i nærvær av en katalysator, hvorved der oppnåes en Fries-omleiring.
Den lavere alkanoylgruppe kan være f.eks. acetyl, pro-pionyl,'butyryl eller valeryl- Halogenatomet kan være f.eks. et klor- eller bromatom.
Som katalysator kan man i den ovenfor angitte reaksjon anvende en av de i Fries-omleiringer vanlig anvendte katalysato-rer, som f".eks. sinkklorid, alurainiumklorid, jernklorid, tinnklo-rid, aluminiumbromid, vismutklorid, ti tan klorid, antimonklorid, hydrogenklorid, hydrogenfluorid, bortrifluorid eller fosforpenta-klorid. Reaksjonen kan utfores i fravær av opplosningsmid del, men der kan også anvendes et inert opplosn ingsmiddel såsom carbondisulfid, carbontetraklorid, nitrobenzen, klorbenzen eller tet-raklorethan.
De erholdte 2-lavere alkanoyl-4-halogen-5-acetylamino-fenoler (I) er nyttige som utgangsma terialer ved syntese av de tilsvarende benzamider som har verdifulle farmakologiske egenskaper såsom analgetiske, spasmolyti ske, sedative, narkotiske og an-tiemetiske egenskaper, f.eks. ved syntese av N-(2-dialkylaraino-alkyl)-2-alkoxy-4-amino-5-halogenbenzamider.
Således'kan N-(diethylaminoethyl)-2-methoxy-4-amino-5-klorbenzamid, som er et kjent antiemeticum, fremstilles ut fra 2-hydroxy-4-acetamido-5-klor-acetofenon ved methylering av denne forbindelses 2-hydroxygruppe med dimethylsulfat, forestring av dens acetylgruppe, amidering av den herved erholdte forbindelses estergruppe med diethylaminoethylamin og påfolgende hydrolyse av den herved dannede 4-acetamidogruppe.
I nedenstående eksempel vises ytterligere hvordan de nye utgangsmaterialer (I) kan fremstilles.
Eksempel
En suspensjon av 22 g vannfritt aluminiumklorid i 20 ml carbondisulfid tilsettes 25 g 3-acetamido-4-klorfenylacetat, og den erholdte blanding oppvarmes på et oljebad. Efter fjernelse av carbondisulfidet ved avdesti1lering oppvarmes den erholdte blanding ved 160°C i 4 timer. Efter at reaksjonen er fullsten-dig, blandes reaksjonsblandingen med IO %'s vandig saltsyre, og blandingen ekstraheres med ethylacetat. Ekstraktet vaskes med vann, befries derpå for vann og inndampes, hvorved man får 0,8 g (tilsvarende 32 % utbytte) 2-hydroxy-4-acetamido-5-kloraceto-fenon i form av hvite krystaller med smeltepunkt 207 - 208°C.
Analyse: Beregnet for C10<H>10<N>03C1:
C 52,75;' 'h 4,42; N 6,15; Cl 15,57 Funnet: C 52,74;' H 4,67; N 6,14; Cl 15,66.
Claims (1)
- 2-lavere alkanoyl-4-halogen-5-acetylatninofenoler for anvendelse som utgangsmaterialer ved fremstilling av de tilsvarende benzamider med verdifulle farmakologiske egenskaper, karakterisert ved at de har den generelle formel:hvor R^ er en lavere alkanoylgruppe, R2 er en acetylgruppe og X er et ha logen a tom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68384084A | 1984-12-19 | 1984-12-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO854925L NO854925L (no) | 1986-06-20 |
| NO166709B true NO166709B (no) | 1991-05-21 |
| NO166709C NO166709C (no) | 1991-08-28 |
Family
ID=24745663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO854925A NO166709C (no) | 1984-12-19 | 1985-12-06 | Fremgangsmaate for fremstilling av akrylamider. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0185350A3 (no) |
| JP (1) | JPH0615513B2 (no) |
| CA (1) | CA1336718C (no) |
| MX (1) | MX166688B (no) |
| NO (1) | NO166709C (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230438B1 (hu) * | 2010-12-16 | 2016-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. 20% | Új palládium katalizátor, eljárás előállítására és alkalmazása |
| CN115806499A (zh) * | 2021-09-15 | 2023-03-17 | 深圳有为技术控股集团有限公司 | 一种由卤代烯烃制备甲酰胺和丙烯酰胺型化合物的联产方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168553A (en) * | 1961-08-25 | 1965-02-02 | Shell Oil Co | Reactions of olefins with carbon monoxide |
| US3988358A (en) * | 1974-05-10 | 1976-10-26 | The University Of Delaware | Process for the preparation of carboxylic acid esters from organic halides |
-
1985
- 1985-12-06 NO NO854925A patent/NO166709C/no unknown
- 1985-12-17 EP EP85116070A patent/EP0185350A3/en not_active Withdrawn
- 1985-12-17 CA CA000497863A patent/CA1336718C/en not_active Expired - Fee Related
- 1985-12-18 JP JP60283233A patent/JPH0615513B2/ja not_active Expired - Lifetime
- 1985-12-19 MX MX001035A patent/MX166688B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO854925L (no) | 1986-06-20 |
| MX166688B (es) | 1993-01-28 |
| CA1336718C (en) | 1995-08-15 |
| EP0185350A3 (en) | 1987-10-28 |
| NO166709C (no) | 1991-08-28 |
| JPS61145151A (ja) | 1986-07-02 |
| EP0185350A2 (en) | 1986-06-25 |
| JPH0615513B2 (ja) | 1994-03-02 |
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