NO165105C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer.

Info

Publication number
NO165105C
NO165105C NO852063A NO852063A NO165105C NO 165105 C NO165105 C NO 165105C NO 852063 A NO852063 A NO 852063A NO 852063 A NO852063 A NO 852063A NO 165105 C NO165105 C NO 165105C
Authority
NO
Norway
Prior art keywords
carbon atoms
piperazinyl
cyclopropyl
dihydro
oxo
Prior art date
Application number
NO852063A
Other languages
English (en)
Norwegian (no)
Other versions
NO165105B (no
NO852063L (no
Inventor
Uwe Petersen
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO852063L publication Critical patent/NO852063L/no
Publication of NO165105B publication Critical patent/NO165105B/no
Publication of NO165105C publication Critical patent/NO165105C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO852063A 1984-06-04 1985-05-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer. NO165105C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420798 DE3420798A1 (de) 1984-06-04 1984-06-04 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren

Publications (3)

Publication Number Publication Date
NO852063L NO852063L (no) 1985-12-05
NO165105B NO165105B (no) 1990-09-17
NO165105C true NO165105C (no) 1990-12-27

Family

ID=6237597

Family Applications (1)

Application Number Title Priority Date Filing Date
NO852063A NO165105C (no) 1984-06-04 1985-05-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer.

Country Status (21)

Country Link
US (1) US4599334A (ja)
EP (1) EP0169993B1 (ja)
JP (2) JPS611683A (ja)
KR (1) KR920000759B1 (ja)
AT (1) ATE39488T1 (ja)
AU (1) AU571333B2 (ja)
CA (1) CA1248954A (ja)
DD (1) DD240016A5 (ja)
DE (2) DE3420798A1 (ja)
DK (1) DK162527C (ja)
ES (3) ES8607294A1 (ja)
FI (1) FI82041C (ja)
GR (1) GR851314B (ja)
HU (1) HU194866B (ja)
IE (1) IE57814B1 (ja)
IL (1) IL75370A (ja)
NO (1) NO165105C (ja)
NZ (1) NZ212271A (ja)
PH (1) PH22492A (ja)
PT (1) PT80580B (ja)
ZA (1) ZA854168B (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH0637489B2 (ja) * 1985-09-21 1994-05-18 杏林製薬株式会社 キノロンカルボン酸誘導体およびその製造方法
NZ217650A (en) * 1985-09-24 1989-09-27 Hoffmann La Roche Quinoline derivatives and pharmaceutical compositions
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
EP0230053A3 (en) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
EP0230946A3 (en) * 1986-01-20 1988-09-07 Kyorin Pharmaceutical Co., Ltd. Process for the preparation of quinolonecarboxylic acid derivatives
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
US4689423A (en) * 1986-04-01 1987-08-25 Warner-Lambert Company Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
HU196987B (en) * 1986-10-15 1989-02-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
DE3639465A1 (de) * 1986-11-18 1988-05-19 Hoechst Ag Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika
NZ229605A (en) * 1988-07-15 1990-07-26 Abbott Lab Preparation of 1,4-dihydro-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-quinoline (or naphthyridine) carboxylic acid derivatives
FR2664595B1 (fr) * 1990-07-10 1992-09-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8, leur preparation et les compositions qui les contiennent.
FR2653663A1 (en) * 1989-10-30 1991-05-03 Bellon Labor Sa Roger Novel benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
JPH05506033A (ja) 1990-04-18 1993-09-02 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 抗微生物性キノロニルラクタム類
DE10108750A1 (de) * 2001-02-23 2002-09-05 Bayer Ag Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
WO2007110835A2 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
DK2001862T3 (da) * 2006-03-28 2011-08-08 Warner Chilcott Co Llc Malatsalte og polymorfe af (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyklopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylsyre
CN111989314B (zh) 2018-04-25 2024-04-30 拜耳动物保健有限责任公司 喹诺酮甲酸酯水解的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
JPS5910580A (ja) * 1982-07-09 1984-01-20 Hokuriku Seiyaku Co Ltd ７−フエニル置換ピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
JPS5929685A (ja) * 1982-08-11 1984-02-16 Hokuriku Seiyaku Co Ltd ７−置換フエニルピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306772A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
ES543839A0 (es) 1986-06-01
CA1248954A (en) 1989-01-17
CA1259315C (ja) 1989-09-12
EP0169993A3 (en) 1986-03-26
IL75370A0 (en) 1985-09-29
GR851314B (ja) 1985-11-25
EP0169993B1 (de) 1988-12-28
US4599334A (en) 1986-07-08
ZA854168B (en) 1986-01-29
ES8800196A1 (es) 1987-11-01
ES552573A0 (es) 1987-11-01
ES8800195A1 (es) 1987-11-01
FI852205L (fi) 1985-12-05
HUT39175A (en) 1986-08-28
DD240016A5 (de) 1986-10-15
KR920000759B1 (ko) 1992-01-21
DK162527C (da) 1992-03-30
FI82041B (fi) 1990-09-28
FI852205A0 (fi) 1985-05-31
HU194866B (en) 1988-03-28
IL75370A (en) 1989-03-31
DE3420798A1 (de) 1985-12-05
NO165105B (no) 1990-09-17
DK162527B (da) 1991-11-11
PT80580A (en) 1985-07-01
ES8607294A1 (es) 1986-06-01
DK249685A (da) 1985-12-05
PT80580B (pt) 1987-11-11
JPH06279411A (ja) 1994-10-04
IE57814B1 (en) 1993-04-21
DK249685D0 (da) 1985-06-03
IE851364L (en) 1985-12-04
AU571333B2 (en) 1988-04-14
ATE39488T1 (de) 1989-01-15
EP0169993A2 (de) 1986-02-05
PH22492A (en) 1988-09-12
AU4320685A (en) 1985-12-12
JPS611683A (ja) 1986-01-07
ES552574A0 (es) 1987-11-01
DE3567021D1 (en) 1989-02-02
FI82041C (fi) 1991-01-10
KR860000280A (ko) 1986-01-27
NZ212271A (en) 1988-10-28
NO852063L (no) 1985-12-05

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