NO159795C - Fremgangsmaate for fremstilling av 2-penemforbindelser. - Google Patents

Fremgangsmaate for fremstilling av 2-penemforbindelser.

Info

Publication number
NO159795C
NO159795C NO820264A NO820264A NO159795C NO 159795 C NO159795 C NO 159795C NO 820264 A NO820264 A NO 820264A NO 820264 A NO820264 A NO 820264A NO 159795 C NO159795 C NO 159795C
Authority
NO
Norway
Prior art keywords
preparation
procedure
compounds
penem compounds
alkyl
Prior art date
Application number
NO820264A
Other languages
English (en)
Norwegian (no)
Other versions
NO159795B (no
NO820264L (no
Inventor
Adriano Afonso
Frank Hon
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO820264L publication Critical patent/NO820264L/no
Publication of NO159795B publication Critical patent/NO159795B/no
Publication of NO159795C publication Critical patent/NO159795C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/22—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO820264A 1981-02-02 1982-01-28 Fremgangsmaate for fremstilling av 2-penemforbindelser. NO159795C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/230,774 US4347183A (en) 1981-02-02 1981-02-02 Process for the synthesis of penems and carbapenems

Publications (3)

Publication Number Publication Date
NO820264L NO820264L (no) 1982-08-03
NO159795B NO159795B (no) 1988-10-31
NO159795C true NO159795C (no) 1989-02-08

Family

ID=22866531

Family Applications (1)

Application Number Title Priority Date Filing Date
NO820264A NO159795C (no) 1981-02-02 1982-01-28 Fremgangsmaate for fremstilling av 2-penemforbindelser.

Country Status (17)

Country Link
US (1) US4347183A (ko)
EP (2) EP0162193A1 (ko)
JP (1) JPS57146777A (ko)
KR (1) KR880001774B1 (ko)
AT (1) ATE21699T1 (ko)
AU (1) AU557691B2 (ko)
DE (1) DE3272792D1 (ko)
DK (1) DK160877C (ko)
FI (1) FI74966C (ko)
HU (1) HU189559B (ko)
IE (1) IE54214B1 (ko)
IL (1) IL64905A (ko)
NO (1) NO159795C (ko)
NZ (1) NZ199599A (ko)
PH (1) PH21195A (ko)
PT (1) PT74356B (ko)
ZA (1) ZA82567B (ko)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH651037A5 (de) * 1980-06-06 1985-08-30 Sankyo Co Penem-3-carbonsaeurederivate und verfahren zu deren herstellung.
EP0046363B1 (en) * 1980-08-16 1984-11-14 Beecham Group Plc Process for the preparation of 2-thio penem derivatives and intermediates therefor
ES513672A0 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
EP0185651A1 (en) * 1981-07-08 1986-06-25 Hoechst Uk Limited Intermediates for the production of antibacterial penem derivates
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
DE3377132D1 (en) * 1982-07-08 1988-07-28 Hoechst Uk Ltd Antibacterial penem derivatives
KR900006449B1 (ko) * 1982-08-24 1990-08-31 상꾜 가부시끼가이샤 아제티디논 화합물의 제조방법
DE3366926D1 (en) * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
US4794109A (en) * 1982-11-16 1988-12-27 Ciba-Geigy Corporation 6-hydroxy-lower alkylpenem compounds, pharmaceutical preparations that contain these compounds, and the use of the latter
EP0110280B1 (en) * 1982-11-29 1994-10-12 Schering Corporation Process for the production of penem compounds
EP0115308A3 (en) * 1983-01-25 1984-10-10 Merck & Co. Inc. 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids and process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4619783A (en) * 1983-06-10 1986-10-28 Pfizer Inc. Process and intermediates for the preparation of penem derivatives
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
EP0134301A1 (en) * 1983-09-15 1985-03-20 Merck & Co. Inc. 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
JPS60224672A (ja) * 1984-04-23 1985-11-09 Sumitomo Chem Co Ltd β−ラクタム誘導体の製造法
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
AU577105B2 (en) * 1985-04-02 1988-09-15 T.P.O. :Pharmachim: Acylaminic penicillin derivatives
US4833167A (en) * 1985-06-10 1989-05-23 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US5140030A (en) * 1985-06-10 1992-08-18 Merck 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
EP0208889A1 (en) * 1985-06-10 1987-01-21 Merck & Co. Inc. 2-Aza-substituted 1-carbadethiapen-2-EM-3-carboxylic acids
US4783453A (en) * 1985-06-10 1988-11-08 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4782051A (en) * 1985-06-10 1988-11-01 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
ATE93861T1 (de) * 1985-09-11 1993-09-15 Ciba Geigy Ag Synthese von beta-lactamverbindungen.
US5215997A (en) * 1985-09-11 1993-06-01 Ciba-Geigy Corporation Synthesis of beta-lactam compounds
ATE66923T1 (de) * 1985-10-17 1991-09-15 Pfizer Verfahren fuer 2-(1-oxo-3-thiolanyl)-2penemantibiotika.
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
GB9103034D0 (en) * 1991-02-13 1991-03-27 Fujisawa Pharmaceutical Co Processes for preparing carbapenem derivatives
US9120808B2 (en) 2009-09-15 2015-09-01 Nabriva Therapeutics Ag Substituted clavulanic acid
JP2016069346A (ja) * 2014-09-30 2016-05-09 株式会社日本触媒 チオール化合物
EP3523309B1 (en) * 2016-10-10 2024-04-17 The Johns Hopkins University Antibacterial agents against d,d- and l,d-transpeptidases

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2548273A1 (de) * 1974-10-29 1976-05-13 Nippon Paint Co Ltd Verfahren zur herstellung von reliefmustern auf der oberflaeche von gegenstaenden oder untergruenden
US4172899A (en) * 1975-12-09 1979-10-30 Microlife Technics, Inc. Preparation of creamed cottage cheese with a Streptococcus diacetilactis mutant
US4234596A (en) * 1976-11-19 1980-11-18 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4172895A (en) * 1977-12-28 1979-10-30 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
EP0004132A1 (en) * 1978-03-04 1979-09-19 Beecham Group Plc Esters of beta-lactam antibiotics, a process for their preparation pharmaceutical compositions containing them and the compounds for use as antibacterial agents
US4203902A (en) * 1978-04-21 1980-05-20 Merck & Co., Inc. Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4217453A (en) * 1978-07-24 1980-08-12 Merck & Co., Inc. 6-Amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
US4206219A (en) * 1978-10-24 1980-06-03 Merck & Co., Inc. 6- and 1-Substituted-1-carbadethiapen-2-em-3-carboxylic acid
US4314942A (en) * 1979-01-10 1982-02-09 Schering Corporation Deprotection of allylic esters, carbonates and carbamates catalyzed by palladium compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
GB2042508B (en) * 1979-02-14 1983-02-23 Beecham Group Ltd 3-alkoxy-penem derivatives
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
DK389080A (da) * 1979-09-13 1981-03-14 Kyowa Hakko Kogyo Kk Fremgangsmaade til fremstilling af racemiske eller optisk aktive cephalosporin-analoge carbacephemforbindelser eller farmaceutisk accepable salte deraf
DE3169939D1 (en) * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
JPS579784A (en) * 1980-06-23 1982-01-19 Sankyo Co Ltd Production of penem-3-carboxylic derivative

Also Published As

Publication number Publication date
DK160877B (da) 1991-04-29
NZ199599A (en) 1985-11-08
PH21195A (en) 1987-08-19
FI820281L (fi) 1982-08-03
IE820211L (en) 1982-08-02
AU7991782A (en) 1982-08-12
DK38982A (da) 1982-08-03
EP0058317B1 (en) 1986-08-27
AU557691B2 (en) 1987-01-08
ATE21699T1 (de) 1986-09-15
IL64905A (en) 1986-04-29
FI74966B (fi) 1987-12-31
HU189559B (en) 1986-07-28
US4347183A (en) 1982-08-31
DK160877C (da) 1991-10-14
ZA82567B (en) 1983-01-26
NO159795B (no) 1988-10-31
IE54214B1 (en) 1989-07-19
NO820264L (no) 1982-08-03
DE3272792D1 (en) 1986-10-02
FI74966C (fi) 1988-04-11
JPS57146777A (en) 1982-09-10
EP0058317A1 (en) 1982-08-25
PT74356A (en) 1982-02-01
KR880001774B1 (ko) 1988-09-15
KR830009107A (ko) 1983-12-17
PT74356B (en) 1984-05-30
EP0162193A1 (en) 1985-11-27
IL64905A0 (en) 1982-04-30

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