NO154345C - Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner. - Google Patents

Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner.

Info

Publication number
NO154345C
NO154345C NO803550A NO803550A NO154345C NO 154345 C NO154345 C NO 154345C NO 803550 A NO803550 A NO 803550A NO 803550 A NO803550 A NO 803550A NO 154345 C NO154345 C NO 154345C
Authority
NO
Norway
Prior art keywords
pyridinones
pyridinyl
analogy procedure
cardiotonic activity
preparing
Prior art date
Application number
NO803550A
Other languages
English (en)
Norwegian (no)
Other versions
NO154345B (no
NO803550L (no
Inventor
George Yohe Lesher
Richard Everett Philion
Donald Frederick Page
Chester Joseph Opalka
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/135,100 external-priority patent/US4297360A/en
Priority claimed from US06/198,461 external-priority patent/US4313951A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of NO803550L publication Critical patent/NO803550L/no
Publication of NO154345B publication Critical patent/NO154345B/no
Publication of NO154345C publication Critical patent/NO154345C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO803550A 1979-11-26 1980-11-25 Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner. NO154345C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9750479A 1979-11-26 1979-11-26
US06/135,100 US4297360A (en) 1980-03-28 1980-03-28 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
US06/198,461 US4313951A (en) 1979-11-26 1980-10-20 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
US06/204,726 US4312875A (en) 1980-03-28 1980-11-06 5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof

Publications (3)

Publication Number Publication Date
NO803550L NO803550L (no) 1981-05-27
NO154345B NO154345B (no) 1986-05-26
NO154345C true NO154345C (no) 1986-09-03

Family

ID=27492921

Family Applications (2)

Application Number Title Priority Date Filing Date
NO803550A NO154345C (no) 1979-11-26 1980-11-25 Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner.
NO85854001A NO156127C (no) 1979-11-26 1985-10-09 1-pyridinyl-2(dialkylamino)-etenylalkylketoner.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO85854001A NO156127C (no) 1979-11-26 1985-10-09 1-pyridinyl-2(dialkylamino)-etenylalkylketoner.

Country Status (20)

Country Link
AT (1) AT379387B (OSRAM)
CH (1) CH649535A5 (OSRAM)
DE (1) DE3044568A1 (OSRAM)
DK (1) DK151799C (OSRAM)
ES (1) ES507620A0 (OSRAM)
FI (1) FI76564C (OSRAM)
FR (2) FR2470124B1 (OSRAM)
GB (2) GB2065642B (OSRAM)
GR (1) GR71608B (OSRAM)
HK (2) HK31189A (OSRAM)
IE (1) IE50632B1 (OSRAM)
IL (2) IL61501A (OSRAM)
IT (1) IT1148740B (OSRAM)
LU (1) LU82957A1 (OSRAM)
MX (1) MX155904A (OSRAM)
NL (2) NL192202C (OSRAM)
NO (2) NO154345C (OSRAM)
NZ (1) NZ195564A (OSRAM)
PT (1) PT72106B (OSRAM)
SE (1) SE442398B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4305948A (en) * 1980-12-22 1981-12-15 Sterling Drug Inc. N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use
US4465686A (en) * 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation
FR2529891A1 (fr) * 1982-07-12 1984-01-13 Nativelle Sa Ets Derives du pyridyl-3 alcoxy-5 pyrazole, procede de preparation et application en therapeutique
IL69407A (en) * 1982-08-23 1987-10-20 Warner Lambert Co 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
IL70169A0 (en) * 1982-11-18 1984-02-29 Sterling Drug Inc 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
GB8414220D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Medicaments in unit dose form
DE69108733T2 (de) * 1990-08-21 1995-09-14 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
CZ403592A3 (en) * 1992-02-20 1993-12-15 Hoechst Ag Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8101770B2 (en) * 2004-12-16 2012-01-24 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2012223337C1 (en) 2011-03-01 2016-11-10 Bausch Health Ireland Limited Process of preparing guanylate cyclase C agonists
EP2744496A4 (en) 2011-08-16 2015-04-08 Baker Idi Heart And Diabetes Inst Holdings Ltd FORMULATIONS WITH TAXED RELEASE
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
MX375926B (es) 2013-08-09 2025-03-07 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
MX2017008248A (es) 2014-12-22 2018-02-19 Cardiora Pty Ltd Metodo de tratamiento.
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
FR2470124A1 (fr) 1981-05-29
NO154345B (no) 1986-05-26
NL192202B (nl) 1996-11-01
NO156127C (no) 1987-07-29
FI803652L (fi) 1981-05-27
FR2553767B1 (fr) 1987-01-16
IL61501A (en) 1984-06-29
GB2131421A (en) 1984-06-20
HK83090A (en) 1990-10-19
NL8006399A (nl) 1981-06-16
FR2553767A1 (fr) 1985-04-26
GB8315983D0 (en) 1983-07-13
LU82957A1 (fr) 1981-06-04
FI76564C (fi) 1988-11-10
CH649535A5 (fr) 1985-05-31
FR2470124B1 (fr) 1986-12-19
PT72106A (fr) 1980-12-01
DK151799B (da) 1988-01-04
NO854001L (no) 1981-05-27
DE3044568C2 (OSRAM) 1990-11-29
AT379387B (de) 1985-12-27
SE442398B (sv) 1985-12-23
HK31189A (en) 1989-04-21
GB2065642B (en) 1984-04-04
GB2065642A (en) 1981-07-01
SE8008252L (sv) 1981-05-27
ATA578080A (de) 1985-05-15
NZ195564A (en) 1983-09-30
GR71608B (OSRAM) 1983-06-17
DK151799C (da) 1988-06-20
IT1148740B (it) 1986-12-03
NO803550L (no) 1981-05-27
IE50632B1 (en) 1986-05-28
IL69847A0 (en) 1983-12-30
IL61501A0 (en) 1981-05-20
MX155904A (es) 1988-05-23
ES8301920A1 (es) 1982-11-16
IE802430L (en) 1981-05-26
ES507620A0 (es) 1982-11-16
NL192202C (nl) 1997-03-04
DK501180A (da) 1981-05-27
FI76564B (fi) 1988-07-29
DE3044568A1 (de) 1981-08-27
PT72106B (fr) 1981-09-29
NL970028I2 (nl) 1998-03-02
GB2131421B (en) 1985-06-26
NO156127B (no) 1987-04-21
NL970028I1 (nl) 1997-10-01
IT8026218A0 (it) 1980-11-25

Similar Documents

Publication Publication Date Title
NO154345C (no) Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 5-(pyridinyl)-2(1h)-pyridinoner.
NO148187C (no) Analogifremgangsmaate for fremstilling av kardiotonisk virksomme 2(1h)-pyridinon-forbindelser
NL7712852A (nl) Werkwijze voor het bereiden van heterocyclische verbindingen.
NL181904C (nl) Capsule, alsmede werkwijze voor het vervaardigen daarvan.
NL7612439A (nl) Stabiel erytrocytenpreparaat, werkwijze voor het vervaardigen en toepassen daarvan.
NL7810595A (nl) Alkanoylprolinederivaten en homologen daarvan, alsmede werkwijzen voor het bereiden en toepassen van deze verbindingen.
NL7713903A (nl) Eendelige houder, en werkwijze voor het vervaardigen daarvan.
NL7709096A (nl) Werkwijze voor het bereiden van nieuwe insekticiden.
NO782043L (no) Fremgangsmaate ved fremstilling av 3-(a-pyrazolyl)-pyridazinderivater.
NO156086C (no) Analogifremgangsmaate for fremstilling av substituerte heterocykliske fenoksyaminer.
NL7709010A (nl) Werkwijze voor het bereiden van 1-(2-deoxy-(beta)-d- -pentofuranosyl)-5,6-dihydro-s-triazinen.
NL7703783A (nl) Benzodioxoolderivaten, werkwijze voor het be- reiden daarvan, alsmede werkwijze voor het be- reiden van deze derivaten bevattende herbiciden.
NL7802829A (nl) Piperazinylpyrazineverbindingen alsmede werk- wijze voor het bereiden daarvan.
NL189132C (nl) Werkwijze voor het bereiden van 2-(4-(2-furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxychinazoline.
NL7807752A (nl) Kleurstof, werkwijze voor het bereiden van de kleur- stof, toepassing van de kleurstof.
NO154795C (no) Analogifremgangsmaate ved fremstilling av terapeutisk virksomme 1,2,4-oxadiazolin-5-on-derivater.
BE886766A (fr) 3-acylamino-5(pyridinyl)-2(1h)-pyridinones, leur preparation et leur utilisation comme agents cardiotoniques
FI802298A7 (fi) Kardiotonisia aineina käyttökelpoiset 5- (4-pyridinyyli)-2(1H)- pyridionit ja niiden valmistus.
NL7607073A (nl) Werkwijze voor het bereiden van nieuwe verbin- dingen, alsmede deze verbindingen bevattende preparaten en de toepassing daarvan voor de bestrijding van schadelijk ongedierte.
NO158737C (no) Analogifremgangsmaate til fremstilling av nye 3-alkoksy-6-alkylidenhydrazinpyridaziner.
NO154840C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive substituerte 2-amino-3,4-dihydropyridinderivater.
DK159418C (da) Analogifremgangsmaade til fremstilling af 1-substituerede 3-cycloalkylsulfonylpyrrolidin-2,5-dionderivater
NO782042L (no) Fremgangsmaate ved fremstilling av nye pyridazinylhydraziner.
ZA807267B (en) 5-(pyridinyl)-2(1h)-pyridinones,useful as cardiotonic agents and their preparation
NO153849C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinderivater.