NO132482B - - Google Patents
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- Publication number
- NO132482B NO132482B NO2293/70A NO229370A NO132482B NO 132482 B NO132482 B NO 132482B NO 2293/70 A NO2293/70 A NO 2293/70A NO 229370 A NO229370 A NO 229370A NO 132482 B NO132482 B NO 132482B
- Authority
- NO
- Norway
- Prior art keywords
- coating
- solution
- mandrel
- cellulose ether
- aqueous
- Prior art date
Links
- 238000000576 coating method Methods 0.000 claims description 29
- 239000011248 coating agent Substances 0.000 claims description 28
- 229920003086 cellulose ether Polymers 0.000 claims description 27
- 239000000243 solution Substances 0.000 claims description 20
- 230000006698 induction Effects 0.000 claims description 17
- 239000002775 capsule Substances 0.000 claims description 16
- 238000003618 dip coating Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 9
- 229920013820 alkyl cellulose Polymers 0.000 claims description 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 5
- 150000002170 ethers Chemical class 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 description 22
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- -1 hydroxypropyl Chemical group 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 238000001248 thermal gelation Methods 0.000 description 2
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- RLMXGBGAZRVYIX-UHFFFAOYSA-N hexane-1,2,3,6-tetrol Chemical compound OCCCC(O)C(O)CO RLMXGBGAZRVYIX-UHFFFAOYSA-N 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- 229920013819 hydroxyethyl ethylcellulose Polymers 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S264/00—Plastic and nonmetallic article shaping or treating: processes
- Y10S264/37—Processes and molds for making capsules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S264/00—Plastic and nonmetallic article shaping or treating: processes
- Y10S264/46—Molding using an electrical heat
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83371569A | 1969-06-16 | 1969-06-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO132482B true NO132482B (xx) | 1975-08-11 |
| NO132482C NO132482C (xx) | 1975-11-19 |
Family
ID=25265092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2293/70A NO132482C (xx) | 1969-06-16 | 1970-06-12 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3617588A (xx) |
| CH (1) | CH542887A (xx) |
| DK (1) | DK128053B (xx) |
| GB (1) | GB1310697A (xx) |
| NO (1) | NO132482C (xx) |
| SE (1) | SE366322B (xx) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001211A (en) * | 1974-12-02 | 1977-01-04 | The Dow Chemical Company | Pharmaceutical capsules from improved thermogelling methyl cellulose ethers |
| US4026986A (en) * | 1975-05-22 | 1977-05-31 | The Dow Chemical Company | Capsule shell |
| DE3674234D1 (de) | 1985-02-28 | 1990-10-25 | Dow Chemical Co | Hydroxypropylmethylcellulose verwendbar als suspendierungsmittel fuer die perlpolymerisation von vinylchlorid. |
| US4747992A (en) * | 1986-03-24 | 1988-05-31 | Sypula Donald S | Process for fabricating a belt |
| US4705658A (en) * | 1986-04-07 | 1987-11-10 | Capsule Technology International, Ltd. | Method for drying gelatin in the manufacture of hard shell gelatin capsules |
| KR900000254B1 (ko) * | 1986-05-12 | 1990-01-24 | 신에쯔까 가가꾸 고우교우 가부시끼가이샤 | 의약용 경질 캅셀의 제조방법과 그 제조장치 |
| GB8710833D0 (en) * | 1987-05-07 | 1987-06-10 | Porous Plastics Ltd | Microwave heating |
| JPH02113912A (ja) * | 1988-10-24 | 1990-04-26 | Dobashi Kikai:Kk | 複合発泡成形体の製造方法 |
| JPH0634807B2 (ja) * | 1989-06-08 | 1994-05-11 | 信越化学工業株式会社 | 医薬用硬質カプセルの製造方法 |
| US5576306A (en) * | 1991-03-01 | 1996-11-19 | Dow Chemical Company | Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers |
| US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| EP0781542B1 (en) | 1991-05-31 | 2000-03-08 | American Home Products Corporation | Method and apparatus for manufacturing pharmaceutical cellulose capsules - fully gelatinizing |
| US5756123A (en) * | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
| US5993185A (en) * | 1996-03-21 | 1999-11-30 | Farmacapsulas S.A. | Deck plate assemblies for forming capsules |
| US5945136A (en) * | 1997-04-03 | 1999-08-31 | Technophar Equipment & Service Limited | Heating elevator for capsule making machine |
| US6000928A (en) * | 1997-04-03 | 1999-12-14 | Technophar Equipment & Service Limited | Capsule making machine having improved pin bars and air flow characteristics |
| US6217815B1 (en) * | 1998-06-10 | 2001-04-17 | Carter-Wallace, Inc. | Method and apparatus for manufacturing prophylactic devices |
| US6752953B2 (en) * | 2001-12-03 | 2004-06-22 | Yung Shin Pharmaceutical Co., Ltd. | Method for manufacturing hard non-gelatin pharmaceutical capsules |
| GB0314832D0 (en) * | 2003-06-25 | 2003-07-30 | Phoqus Pharmaceuticals Ltd | Production of capsule shells and capsules |
| US7485609B2 (en) * | 2005-09-29 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Encapsulated liquid cleanser |
| ES2895666T3 (es) | 2006-10-27 | 2022-02-22 | Capsugel Belgium Nv | Cápsulas duras de hidroxipropilmetilcelulosa y proceso de fabricación |
| US20090321087A1 (en) * | 2008-06-27 | 2009-12-31 | Electrical/Electronic Mechanical Industrial Equipment Ltd. | Expandable plug |
| EP3354335A1 (en) | 2010-10-26 | 2018-08-01 | Capsugel Belgium NV | Bulk enteric capsule shells |
| US10525010B2 (en) | 2012-05-02 | 2020-01-07 | Capsugel Belgium Nv | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
| BR112014030160A2 (pt) | 2012-07-23 | 2017-06-27 | Dow Global Technologies Llc | composição formadora de película, uso de uma composição formadora de película, película e cápsula dura |
| WO2014135965A1 (en) | 2013-03-07 | 2014-09-12 | Capsugel Belgium Nv | Bismuth liquid filled hard capsules |
| WO2015065848A1 (en) | 2013-11-04 | 2015-05-07 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| WO2015108768A1 (en) | 2014-01-16 | 2015-07-23 | Dow Global Technologies Llc | Support materials for 3d printing |
| US10471152B2 (en) | 2014-08-29 | 2019-11-12 | Capsugel Belgium Nv | Colloidal dispersion comprising HPMCAS |
| JP6412853B2 (ja) * | 2015-12-16 | 2018-10-24 | 信越化学工業株式会社 | フィルム成型用組成物 |
| KR102296142B1 (ko) | 2016-07-06 | 2021-08-31 | 쿠오리카프스 가부시키가이샤 | 경도가 개선된 경질 캡슐 및 그 제조 방법 |
| CN110191723B (zh) | 2016-12-07 | 2023-03-10 | 快力胶囊股份有限公司 | 表现出改善的凝胶助剂的沉积的硬胶囊及其制备方法 |
| CN114867363A (zh) | 2019-12-10 | 2022-08-05 | 比利时胶囊公司 | 含脂质基质核心和活性成分的颗粒 |
| WO2021154774A1 (en) | 2020-01-29 | 2021-08-05 | Lonza Consumer Health Inc. | Joint health composition and use thereof in healthy mammals |
| WO2023172430A1 (en) | 2022-03-07 | 2023-09-14 | Lonza Greenwood Llc | Method and composition for improving skin health |
| WO2024026067A1 (en) | 2022-07-29 | 2024-02-01 | Lonza Greenwood Llc | Method and composition for treating conditions associated with a leaky gut barrier |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1010389A (en) * | 1963-05-16 | 1965-11-17 | Veedip Ltd | Improvements in the manufacture of hollow articles by dip moulding |
| US3315016A (en) * | 1964-06-25 | 1967-04-18 | Davidson Rubber Company Inc | Induction heated-slush molding process |
| GB1144225A (en) * | 1965-09-07 | 1969-03-05 | Dow Chemical Co | Preparation of medicinal capsule shells from hydroxyalkyl-alkyl cellulose ethers |
-
1969
- 1969-06-16 US US833715A patent/US3617588A/en not_active Expired - Lifetime
-
1970
- 1970-06-11 SE SE08121/70A patent/SE366322B/xx unknown
- 1970-06-12 NO NO2293/70A patent/NO132482C/no unknown
- 1970-06-15 CH CH902170A patent/CH542887A/de not_active IP Right Cessation
- 1970-06-15 DK DK307570AA patent/DK128053B/da unknown
- 1970-06-16 GB GB2911970A patent/GB1310697A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO132482C (xx) | 1975-11-19 |
| DE2029402A1 (de) | 1970-12-17 |
| GB1310697A (en) | 1973-03-21 |
| SE366322B (xx) | 1974-04-22 |
| US3617588A (en) | 1971-11-02 |
| CH542887A (de) | 1973-10-15 |
| DK128053B (da) | 1974-02-25 |
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