NL950031I1 - - Google Patents

Info

Publication number
NL950031I1
NL950031I1 NL950031C NL950031C NL950031I1 NL 950031 I1 NL950031 I1 NL 950031I1 NL 950031 C NL950031 C NL 950031C NL 950031 C NL950031 C NL 950031C NL 950031 I1 NL950031 I1 NL 950031I1
Authority
NL
Netherlands
Application number
NL950031C
Other versions
NL950031I2 (nl
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL950031(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NL950031I1 publication Critical patent/NL950031I1/xx
Publication of NL950031I2 publication Critical patent/NL950031I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL950031C 1988-03-23 1995-12-11 Middelen voor het verlagen van de bloeddruk. NL950031I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17274788A 1988-03-23 1988-03-23

Publications (2)

Publication Number Publication Date
NL950031I1 true NL950031I1 (enExample) 1996-02-01
NL950031I2 NL950031I2 (nl) 1997-01-06

Family

ID=22629045

Family Applications (1)

Application Number Title Priority Date Filing Date
NL950031C NL950031I2 (nl) 1988-03-23 1995-12-11 Middelen voor het verlagen van de bloeddruk.

Country Status (19)

Country Link
EP (1) EP0334429B1 (enExample)
JP (1) JPH0637487B2 (enExample)
KR (1) KR970011287B1 (enExample)
AU (1) AU621591B2 (enExample)
CA (1) CA1337432C (enExample)
CY (1) CY1802A (enExample)
DE (2) DE68903516C5 (enExample)
DK (1) DK174422B1 (enExample)
ES (1) ES2052881T3 (enExample)
GR (1) GR3006972T3 (enExample)
HK (1) HK123594A (enExample)
HU (1) HU211539A9 (enExample)
IE (1) IE62159B1 (enExample)
IL (1) IL89691A (enExample)
LU (1) LU88842I2 (enExample)
NL (1) NL950031I2 (enExample)
NZ (1) NZ228321A (enExample)
PT (1) PT90095B (enExample)
ZA (1) ZA892179B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
KR100264348B1 (ko) * 1994-12-28 2000-08-16 디르크 반테 항-죽종형성제로서 네비볼롤을 함유하는 조성물
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US7417038B1 (en) 1998-10-15 2008-08-26 Imperial Innovations Limited Methods of treating cachexia
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
CN101006081B (zh) * 2004-07-30 2011-02-09 托伦特药物有限公司 奈必洛尔及其药学可接受盐、制备方法以及奈必洛尔的药物组合物
EP1776354B1 (en) * 2004-08-11 2010-04-21 Hetero Drugs Limited A novel process for preparation of nebivolol intermediates
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
AP2764A (en) 2005-01-31 2013-09-30 Mylan Lab Inc Hydroxylated nebivolol metabolites
NZ560385A (en) * 2005-01-31 2010-10-29 Mylan Lab Inc Glucuronidated nebivolol metabolites
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
US7858812B2 (en) 2006-01-18 2010-12-28 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
BRPI0719281B8 (pt) 2006-11-27 2021-05-25 Fis Fabbrica Italiana Sintetici Spa processo para preparação de nebivolol
CN101541791B (zh) * 2006-11-27 2014-01-29 Zach系统股份公司 制备奈必洛尔的方法
GB0624282D0 (en) 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
AU2008209264B2 (en) 2007-01-22 2014-11-27 Mylan Pharmaceuticals Ulc Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
CN101531651B (zh) * 2008-03-13 2011-05-04 四川大学 光学活性3,4-二氢-2h-1-苯并吡喃-2-羧酸和3,4-二氢-4-氧-2h-1-苯并吡喃-2-羧酸类化合物的制备方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) * 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
US8785664B2 (en) 2010-02-11 2014-07-22 Menarini International Operations Luxembourg S.A. Process for the preparation of nebivolol
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
WO2014111903A2 (en) 2013-01-21 2014-07-24 Cadila Pharmaceuticals Limited A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde
ES2700973T3 (es) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
KR102529680B1 (ko) 2015-05-19 2023-05-09 저장 아우선 파마슈티칼 씨오., 엘티디. 네비볼롤 합성방법 및 그의 중간 화합물
CN105085499B (zh) * 2015-08-07 2018-09-25 上海现代制药海门有限公司 盐酸奈必洛尔中间体混合物的结晶分离方法
ITUB20160227A1 (it) 2016-01-21 2017-07-21 Menarini Int Operations Luxembourg Sa Processo per la sintesi di intermedi di Nebivololo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol

Also Published As

Publication number Publication date
EP0334429B1 (en) 1992-11-19
CA1337432C (en) 1995-10-24
CY1802A (en) 1995-02-17
HU211539A9 (en) 1995-12-28
DE19675037I1 (de) 2003-09-04
ZA892179B (en) 1990-11-28
GR3006972T3 (enExample) 1993-06-30
DK146289D0 (da) 1989-03-22
ES2052881T3 (es) 1994-07-16
IL89691A0 (en) 1989-09-28
DE68903516T2 (de) 1993-04-01
NZ228321A (en) 1991-02-26
PT90095A (pt) 1989-11-10
NL950031I2 (nl) 1997-01-06
AU621591B2 (en) 1992-03-19
PT90095B (pt) 1994-11-30
JPH01283220A (ja) 1989-11-14
DE68903516D1 (de) 1992-12-24
IL89691A (en) 1994-04-12
IE890906L (en) 1989-09-23
IE62159B1 (en) 1994-12-28
JPH0637487B2 (ja) 1994-05-18
DK146289A (da) 1989-09-24
EP0334429A1 (en) 1989-09-27
LU88842I2 (fr) 1997-01-27
DK174422B1 (da) 2003-02-24
KR970011287B1 (ko) 1997-07-09
AU3074289A (en) 1989-09-28
HK123594A (en) 1994-11-18
DE68903516C5 (de) 2017-07-13
KR890014510A (ko) 1989-10-24

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