NL9000917A - Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. - Google Patents

Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. Download PDF

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Publication number
NL9000917A
NL9000917A NL9000917A NL9000917A NL9000917A NL 9000917 A NL9000917 A NL 9000917A NL 9000917 A NL9000917 A NL 9000917A NL 9000917 A NL9000917 A NL 9000917A NL 9000917 A NL9000917 A NL 9000917A
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NL
Netherlands
Prior art keywords
furin
enzyme
protein
fragment
derivative
Prior art date
Application number
NL9000917A
Other languages
English (en)
Dutch (nl)
Original Assignee
Holland Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26646599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL9000917(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from NL8902651A external-priority patent/NL8902651A/nl
Application filed by Holland Biotechnology filed Critical Holland Biotechnology
Priority to NL9000917A priority Critical patent/NL9000917A/nl
Priority to EP95202272A priority patent/EP0693286A1/en
Priority to EP90915837A priority patent/EP0497828B2/en
Priority to AT90915837T priority patent/ATE147437T1/de
Priority to DE69029663T priority patent/DE69029663T3/de
Priority to ES90915837T priority patent/ES2099714T5/es
Priority to EP98200913A priority patent/EP0885956A1/en
Priority to PCT/NL1990/000151 priority patent/WO1991006314A2/en
Priority to DK90915837T priority patent/DK0497828T4/da
Priority to JP51489590A priority patent/JP3191111B2/ja
Priority to US07/849,420 priority patent/US5989856A/en
Priority to AU66132/90A priority patent/AU6613290A/en
Priority to CA002069929A priority patent/CA2069929C/en
Publication of NL9000917A publication Critical patent/NL9000917A/nl
Priority to NO19921611A priority patent/NO311895B1/no
Priority to FI921847A priority patent/FI105348B/fi
Priority to GR970400685T priority patent/GR3023013T3/el
Priority to US08/865,203 priority patent/US5935815A/en
Priority to US08/955,424 priority patent/US6274365B1/en
Priority to US09/253,854 priority patent/US6132717A/en
Priority to JP2000381776A priority patent/JP3270760B2/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NL9000917A 1989-10-25 1990-04-18 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. NL9000917A (nl)

Priority Applications (20)

Application Number Priority Date Filing Date Title
NL9000917A NL9000917A (nl) 1989-10-25 1990-04-18 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.
AU66132/90A AU6613290A (en) 1989-10-25 1990-10-12 Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
CA002069929A CA2069929C (en) 1989-10-25 1990-10-12 Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
JP51489590A JP3191111B2 (ja) 1989-10-25 1990-10-12 （前駆体）タンパクのエンドタンパク分解的プロセシングのための方法
US07/849,420 US5989856A (en) 1989-10-25 1990-10-12 Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
AT90915837T ATE147437T1 (de) 1989-10-25 1990-10-12 Verfahren zur endoproteolytischen bearbeitung von (vorläufer)proteinen und zur (mikro)biologischen herstellung
DE69029663T DE69029663T3 (de) 1989-10-25 1990-10-12 Verfahren zur endoproteolytischen bearbeitung von (vorläufer)proteinen und zur (mikro)biologischen herstellung
ES90915837T ES2099714T5 (es) 1989-10-25 1990-10-12 Procedimiento de tratamiento endoproteolitico de las proteinas (precursores) y de produccion microbiologica de proteinas.
EP98200913A EP0885956A1 (en) 1989-10-25 1990-10-12 Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro) biological production of proteins
PCT/NL1990/000151 WO1991006314A2 (en) 1989-10-25 1990-10-12 Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
DK90915837T DK0497828T4 (da) 1989-10-25 1990-10-12 Fremgangsmåde til endoproteolytisk behandling af (forstadie)proteiner og til (mikro)biologisk produktion af proteiner.
EP95202272A EP0693286A1 (en) 1989-10-25 1990-10-12 Pharmaceutical composition comprising furin
EP90915837A EP0497828B2 (en) 1989-10-25 1990-10-12 A process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
FI921847A FI105348B (fi) 1989-10-25 1992-04-24 Menetelmä proteiinien käsittelemiseksi endoproteolyyttisesti sekä menetelmä proteiinien valmistamiseksi (mikro)biologisesti
NO19921611A NO311895B1 (no) 1989-10-25 1992-04-24 Anvendelse av furin eller furinlignende enzym for spalting av et protein, fremgangsmåte for mikrobiologisk fremstilling av etprotein og pattedyrcelle som omfatter DNA som koder for enzymet
GR970400685T GR3023013T3 (en) 1989-10-25 1997-04-02 A process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
US08/865,203 US5935815A (en) 1989-10-25 1997-05-29 Process for micro biological production of proteins
US08/955,424 US6274365B1 (en) 1989-10-25 1997-10-22 Pharmaceutical composition having an endoproteolytic activity
US09/253,854 US6132717A (en) 1989-10-25 1999-02-19 Method for treating mammals having a deficiency in endoprotease
JP2000381776A JP3270760B2 (ja) 1989-10-25 2000-12-15 フリンによるタンパクの微生物的生産方法及びその生産のための細胞

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NL8902651A NL8902651A (nl) 1989-10-25 1989-10-25 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van eiwitten.
NL8902651 1989-10-25
NL9000917A NL9000917A (nl) 1989-10-25 1990-04-18 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.
NL9000917 1990-04-18

Publications (1)

Publication Number Publication Date
NL9000917A true NL9000917A (nl) 1991-05-16

Family

ID=26646599

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9000917A NL9000917A (nl) 1989-10-25 1990-04-18 Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten.

Country Status (13)

Country Link
US (1) US5989856A (ja)
EP (3) EP0497828B2 (ja)
JP (2) JP3191111B2 (ja)
AT (1) ATE147437T1 (ja)
AU (1) AU6613290A (ja)
CA (1) CA2069929C (ja)
DE (1) DE69029663T3 (ja)
DK (1) DK0497828T4 (ja)
ES (1) ES2099714T5 (ja)
FI (1) FI105348B (ja)
GR (1) GR3023013T3 (ja)
NL (1) NL9000917A (ja)
WO (1) WO1991006314A2 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935815A (en) * 1989-10-25 1999-08-10 Katholieke Universiteit Leuven Process for micro biological production of proteins
DK0574402T3 (da) * 1990-11-26 1998-05-18 Chiron Corp Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf
US6348327B1 (en) 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
DK52293D0 (ja) * 1993-05-05 1993-05-05 Novo Nordisk As
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
AT404838B (de) * 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
US6596526B1 (en) 2000-06-09 2003-07-22 Baxter Aktiengesellschaft Furin polypeptides with improved characteristics
EP1756275A1 (en) * 2004-04-23 2007-02-28 Novozymes A/S Method for obtaining mature protease by enzymatic digestion
JP5485873B2 (ja) * 2007-05-22 2014-05-07 バクスター・インターナショナル・インコーポレイテッド ヒトフューリンのための予備的な精製方法
PT2574677T (pt) 2007-12-27 2017-10-19 Baxalta Inc Processos para cultura de células
CN110066782B (zh) 2007-12-31 2024-04-16 武田药品工业株式会社 基本上无动物蛋白的重组体弗林蛋白酶及其生产方法
US20130149295A1 (en) 2010-05-12 2013-06-13 Martine Cohen-Solal Furin and biologically active derivatives thereof for use in the prevention or treatment of an inflammatory disease
CN103889454B (zh) 2011-06-02 2017-04-05 百深有限责任公司 重组成对碱性氨基酸蛋白酶的制剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246709A1 (en) * 1986-05-20 1987-11-25 Stichting Katholieke Universiteit Recombinant DNA and cDNA, mRNA, protein, antibodies, and a method of detecting tumor cells
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells

Also Published As

Publication number Publication date
JP3191111B2 (ja) 2001-07-23
DE69029663T3 (de) 2008-05-21
CA2069929A1 (en) 1991-04-26
EP0885956A1 (en) 1998-12-23
AU6613290A (en) 1991-05-31
FI921847A0 (fi) 1992-04-24
ES2099714T3 (es) 1997-06-01
JP3270760B2 (ja) 2002-04-02
DK0497828T3 (da) 1997-07-07
FI921847A (fi) 1992-04-24
EP0497828B2 (en) 2007-10-03
DK0497828T4 (da) 2008-02-04
EP0497828A1 (en) 1992-08-12
WO1991006314A2 (en) 1991-05-16
DE69029663T2 (de) 1997-09-04
GR3023013T3 (en) 1997-07-30
CA2069929C (en) 2002-08-27
US5989856A (en) 1999-11-23
EP0497828B1 (en) 1997-01-08
EP0693286A1 (en) 1996-01-24
JP2001238683A (ja) 2001-09-04
ES2099714T5 (es) 2008-04-01
WO1991006314A3 (en) 1991-09-05
FI105348B (fi) 2000-07-31
JPH05504051A (ja) 1993-07-01
ATE147437T1 (de) 1997-01-15
DE69029663D1 (de) 1997-02-20

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