NL8402198A - Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen. - Google Patents

Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen. Download PDF

Info

Publication number
NL8402198A
NL8402198A NL8402198A NL8402198A NL8402198A NL 8402198 A NL8402198 A NL 8402198A NL 8402198 A NL8402198 A NL 8402198A NL 8402198 A NL8402198 A NL 8402198A NL 8402198 A NL8402198 A NL 8402198A
Authority
NL
Netherlands
Prior art keywords
formula
compound
process according
formula sheet
alcohol
Prior art date
Application number
NL8402198A
Other languages
English (en)
Dutch (nl)
Original Assignee
Malesci Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Malesci Sas filed Critical Malesci Sas
Publication of NL8402198A publication Critical patent/NL8402198A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
NL8402198A 1983-07-11 1984-07-11 Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen. NL8402198A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT4866483 1983-07-11
IT48664/83A IT1200928B (it) 1983-07-11 1983-07-11 Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti

Publications (1)

Publication Number Publication Date
NL8402198A true NL8402198A (nl) 1985-02-01

Family

ID=11267912

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8402198A NL8402198A (nl) 1983-07-11 1984-07-11 Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen.

Country Status (10)

Country Link
US (2) US4578467A (es)
JP (1) JPS6089470A (es)
BE (1) BE900136A (es)
CA (2) CA1256108A (es)
DE (2) DE3448320C2 (es)
ES (2) ES534170A0 (es)
FR (1) FR2549059B1 (es)
GB (2) GB2143235B (es)
IT (1) IT1200928B (es)
NL (1) NL8402198A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543139B1 (fr) * 1983-03-22 1985-08-16 Cerm Cent Europ Rech Mauvernay Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique
IT1200928B (it) * 1983-07-11 1989-01-27 Malesci Sas Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
US4975440A (en) * 1984-09-28 1990-12-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically-active 1,4-dihydropyridine
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
FR2635105B1 (fr) * 1988-08-03 1991-01-25 Synthelabo Derives de piperazine et leur procede de preparation
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
US5364849A (en) * 1989-04-22 1994-11-15 John Wyeth & Brother, Limited 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
JPH11106375A (ja) * 1997-08-18 1999-04-20 Pfizer Pharmaceut Inc ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332949A (en) * 1962-11-13 1967-07-25 Sterling Drug Inc 1-phenyl-4-[2-(2-pyridyl)-ethyl] piperazines
NL143925C (es) * 1965-03-09
CH624402A5 (en) * 1974-03-01 1981-07-31 Malesci Sas Process for the preparation of novel heterocyclic derivatives of 1-alkyl-substituted 4-phenylpiperazine and use of the novel derivatives
IT1056055B (it) * 1974-03-01 1982-01-30 Malesci Sas Inst Farmaco Bilog Derivati eterocicli della 4 fenil riperazina i alchil sostituita ad azione farmacologica e relativo procedimento di preparazione
US3886167A (en) * 1974-03-06 1975-05-27 Us Army 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials
US4031108A (en) * 1974-10-09 1977-06-21 Pfizer Inc. 2-Hydroxymethyl-3-benzyloxypyridine-6-epoxyethane
GB1551993A (en) * 1976-09-21 1979-09-05 Malesci Sas Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
IT1200928B (it) * 1983-07-11 1989-01-27 Malesci Sas Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti

Also Published As

Publication number Publication date
GB8417587D0 (en) 1984-08-15
FR2549059A1 (fr) 1985-01-18
GB2143235A (en) 1985-02-06
GB8621586D0 (en) 1986-10-15
CA1263959C (es) 1989-12-19
DE3448320C2 (es) 1991-04-11
US4692525A (en) 1987-09-08
BE900136A (fr) 1984-11-05
ES8606228A1 (es) 1986-04-01
IT8348664A0 (it) 1983-07-11
CA1263959A (en) 1989-12-19
DE3425477A1 (de) 1985-01-31
ES8603461A1 (es) 1985-12-16
GB2143235B (en) 1987-08-19
US4578467A (en) 1986-03-25
IT1200928B (it) 1989-01-27
CA1256108A (en) 1989-06-20
ES534170A0 (es) 1985-12-16
GB2178039B (en) 1987-08-19
ES545191A0 (es) 1986-04-01
JPS6089470A (ja) 1985-05-20
DE3425477C2 (es) 1990-03-15
FR2549059B1 (fr) 1987-04-17
GB2178039A (en) 1987-02-04

Similar Documents

Publication Publication Date Title
RU2178414C2 (ru) Производные пиперазина и пиперидина и способ их получения
CA1155853A (en) Imidazole derivatives and preparation thereof
EP0702010B1 (fr) Nouveaux dérivés du benzopyrane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
FR2727682A1 (fr) Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament
NL8402198A (nl) Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen.
NO155490B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktivt 4-)1"-hydroksy-2"-(n-imidazolyl)etyl)bibenzyl.
FR2545825A1 (fr) 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols, leur preparation et leurs utilisations therapeutiques
EP0148167B1 (fr) Nouveaux dérivés de la quinoléine, leur procédé de préparation et les compositions pharmaceutiques les renfermant
FR2680172A1 (fr) Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
US4882316A (en) Pyrimidine derivatives
FR2533563A1 (fr) Nouveaux derives de la sulfonyluree, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
EP0638568B1 (fr) Pipérazines substituées, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP1207160A1 (en) Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
FR2884251A1 (fr) Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HU196196B (en) Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
IL103229A (en) History of imidazolylmethyl-pyridine, their preparation and pharmaceutical preparations containing them
WO2003106449A1 (fr) Nouveaux derives d'aryl-{4-halogeno-4-[heteroaryl-methylamino)-methyl]-piperidin-1-yl}-methanone, leur procede de preparation et leur utilisation a titre de medicaments
FR2750991A1 (fr) Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament
NO179513B (no) 2-substituerte kinolylmetoksy-fenyleddiksyrederivater, legemidler inneholdende dem samt deres anvendelse for fremstilling av legemidler
FR2665160A1 (fr) Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
EP0338895A1 (fr) Nouveaux dérivés hétéroarotinoides, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
JPS58188868A (ja) オレフイン系ベンズイミダゾ−ル類
JPH0288566A (ja) ジフエルエニタン誘導体、その製法及びこの化合物を含むアロマターゼ抑制医薬及び獣医薬組成物
CA2306428C (fr) Derives de la 3-oxo-2(h)-1,2,4 - triazine en tant que ligands des recepteurs 5ht1a
Katritzky et al. Preparation, characterization and reactions of novel vicinal dibenzotriazol‐1‐yl derivatives of benzotriazole and glyoxal

Legal Events

Date Code Title Description
BV The patent application has lapsed