IT8348664A0 - Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva, loro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti - Google Patents
Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva, loro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenutiInfo
- Publication number
- IT8348664A0 IT8348664A0 IT8348664A IT4866483A IT8348664A0 IT 8348664 A0 IT8348664 A0 IT 8348664A0 IT 8348664 A IT8348664 A IT 8348664A IT 4866483 A IT4866483 A IT 4866483A IT 8348664 A0 IT8348664 A0 IT 8348664A0
- Authority
- IT
- Italy
- Prior art keywords
- pyridyl
- alkyl
- separation
- procedure
- preparation
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48664/83A IT1200928B (it) | 1983-07-11 | 1983-07-11 | Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti |
US06/627,583 US4578467A (en) | 1983-07-11 | 1984-07-03 | Process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines which are useful as antihypertensive compounds, their separation into the respective optical antipodes, and the stereoisomeric compounds so obtained |
CA000458335A CA1256108A (en) | 1983-07-11 | 1984-07-09 | PREPARATION OF L-PYRIDYL-ALCOYL-4-ARYL-PIPERAZINES USEFUL AS ANTIHYPERTENSIVE AGENTS; THEIR SEPARATION INTO OPTICAL ANTIPODS, AND STEREOISOMEERS THUS OBTAINED |
ES534170A ES534170A0 (es) | 1983-07-11 | 1984-07-10 | Un procedimiento para preparar 1-piridil-alquil-4-aril-piperazinas |
GB08417587A GB2143235B (en) | 1983-07-11 | 1984-07-10 | 1-pyridyl-alkyl-4-aryl piperazine derivatives |
BE0/213316A BE900136A (fr) | 1983-07-11 | 1984-07-11 | Procede de preparation de 1-pyridyl-alcoyl-4-aryl-piperazines antihypertensives, leur separation en antipodes optiques et les stereoisomeres ainsi obtenus. |
FR8411020A FR2549059B1 (fr) | 1983-07-11 | 1984-07-11 | Procede de preparation de 1-pyridyl-alkyl-4-aryl-piperazines, leur separation en les antipodes optiques (enantiomorphes) respectifs et les stereo-isomeres ainsi obtenus |
DE3448320A DE3448320C2 (it) | 1983-07-11 | 1984-07-11 | |
JP59144098A JPS6089470A (ja) | 1983-07-11 | 1984-07-11 | 1−ピリジル−アルキル−4−アリ−ルピペラジン化合物の製造方法 |
NL8402198A NL8402198A (nl) | 1983-07-11 | 1984-07-11 | Werkwijze voor de bereiding van 1-pyridyl-alkyl-4-arylpiperazinen, die bruikbaar zijn als antihypertensieve verbindingen, hun scheiding in de respektievelijke optische antipoden, en aldus verkregen stereoisomere verbindingen. |
DE19843425477 DE3425477A1 (de) | 1983-07-11 | 1984-07-11 | Verfahren zur herstellung von als blutdrucksenkende verbindungen verwendbaren 1-pyridylalkyl-4-arylpiperazinen und deren trennung in die entsprechenden optischen antipoden, und die so erhaltenen stereoisomeren verbindungen |
ES545191A ES8606228A1 (es) | 1983-07-11 | 1985-07-15 | Un procedimiento para separar los antipodas opticos de 1-pi-ridil-alquil-4-aril-piperazinas |
US06/807,714 US4692525A (en) | 1983-07-11 | 1985-12-11 | Process for the separation of optical isomers of racemic 1-pyridyl-alkyl-4-aryl piperazines, and optical isomers obtained thereby |
GB08621586A GB2178039B (en) | 1983-07-11 | 1986-09-08 | A process for the separation into the respective optical antipodes of 1-pyridylalkyl-4-aryl-piperazines which are useful as antihypertensive compounds, and the stereoisomeric compounds so obtained |
CA000575394A CA1263959A (en) | 1983-07-11 | 1988-08-22 | Process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines which are useful as antihypertensive compounds, their separation into the respective optical antipodes, and the stereoisomeric compounds so obtained |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48664/83A IT1200928B (it) | 1983-07-11 | 1983-07-11 | Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8348664A0 true IT8348664A0 (it) | 1983-07-11 |
IT1200928B IT1200928B (it) | 1989-01-27 |
Family
ID=11267912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT48664/83A IT1200928B (it) | 1983-07-11 | 1983-07-11 | Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti |
Country Status (10)
Country | Link |
---|---|
US (2) | US4578467A (it) |
JP (1) | JPS6089470A (it) |
BE (1) | BE900136A (it) |
CA (2) | CA1256108A (it) |
DE (2) | DE3448320C2 (it) |
ES (2) | ES534170A0 (it) |
FR (1) | FR2549059B1 (it) |
GB (2) | GB2143235B (it) |
IT (1) | IT1200928B (it) |
NL (1) | NL8402198A (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2543139B1 (fr) * | 1983-03-22 | 1985-08-16 | Cerm Cent Europ Rech Mauvernay | Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique |
IT1200928B (it) * | 1983-07-11 | 1989-01-27 | Malesci Sas | Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti |
US5364872A (en) * | 1984-04-16 | 1994-11-15 | Yamanouchi Pharmaceutical Co., Ltd. | Dihydropyridine-3,5-dicarboxylic acid ester derivatives |
DE3431152A1 (de) * | 1984-08-24 | 1986-03-06 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel |
US4975440A (en) * | 1984-09-28 | 1990-12-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Optically-active 1,4-dihydropyridine |
GB8530602D0 (en) * | 1985-12-12 | 1986-01-22 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
FR2635105B1 (fr) * | 1988-08-03 | 1991-01-25 | Synthelabo | Derives de piperazine et leur procede de preparation |
US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
US5364849A (en) * | 1989-04-22 | 1994-11-15 | John Wyeth & Brother, Limited | 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives |
US5453510A (en) * | 1990-07-13 | 1995-09-26 | Burroughs Wellcome Co. | Neuromuscular blocking agents |
JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な1,4−ジヒドロピリジン化合物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3332949A (en) * | 1962-11-13 | 1967-07-25 | Sterling Drug Inc | 1-phenyl-4-[2-(2-pyridyl)-ethyl] piperazines |
NL143925C (it) * | 1965-03-09 | |||
CH624402A5 (en) * | 1974-03-01 | 1981-07-31 | Malesci Sas | Process for the preparation of novel heterocyclic derivatives of 1-alkyl-substituted 4-phenylpiperazine and use of the novel derivatives |
IT1056055B (it) * | 1974-03-01 | 1982-01-30 | Malesci Sas Inst Farmaco Bilog | Derivati eterocicli della 4 fenil riperazina i alchil sostituita ad azione farmacologica e relativo procedimento di preparazione |
US3886167A (en) * | 1974-03-06 | 1975-05-27 | Us Army | 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials |
US4031108A (en) * | 1974-10-09 | 1977-06-21 | Pfizer Inc. | 2-Hydroxymethyl-3-benzyloxypyridine-6-epoxyethane |
GB1551993A (en) * | 1976-09-21 | 1979-09-05 | Malesci Sas | Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof |
DE2824764A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
IT1200928B (it) * | 1983-07-11 | 1989-01-27 | Malesci Sas | Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti |
-
1983
- 1983-07-11 IT IT48664/83A patent/IT1200928B/it active
-
1984
- 1984-07-03 US US06/627,583 patent/US4578467A/en not_active Expired - Fee Related
- 1984-07-09 CA CA000458335A patent/CA1256108A/en not_active Expired
- 1984-07-10 GB GB08417587A patent/GB2143235B/en not_active Expired
- 1984-07-10 ES ES534170A patent/ES534170A0/es active Granted
- 1984-07-11 DE DE3448320A patent/DE3448320C2/de not_active Expired - Fee Related
- 1984-07-11 NL NL8402198A patent/NL8402198A/nl not_active Application Discontinuation
- 1984-07-11 DE DE19843425477 patent/DE3425477A1/de active Granted
- 1984-07-11 FR FR8411020A patent/FR2549059B1/fr not_active Expired
- 1984-07-11 JP JP59144098A patent/JPS6089470A/ja active Pending
- 1984-07-11 BE BE0/213316A patent/BE900136A/fr not_active IP Right Cessation
-
1985
- 1985-07-15 ES ES545191A patent/ES8606228A1/es not_active Expired
- 1985-12-11 US US06/807,714 patent/US4692525A/en not_active Expired - Fee Related
-
1986
- 1986-09-08 GB GB08621586A patent/GB2178039B/en not_active Expired
-
1988
- 1988-08-22 CA CA000575394A patent/CA1263959A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB8417587D0 (en) | 1984-08-15 |
FR2549059A1 (fr) | 1985-01-18 |
GB2143235A (en) | 1985-02-06 |
NL8402198A (nl) | 1985-02-01 |
GB8621586D0 (en) | 1986-10-15 |
CA1263959C (it) | 1989-12-19 |
DE3448320C2 (it) | 1991-04-11 |
US4692525A (en) | 1987-09-08 |
BE900136A (fr) | 1984-11-05 |
ES8606228A1 (es) | 1986-04-01 |
CA1263959A (en) | 1989-12-19 |
DE3425477A1 (de) | 1985-01-31 |
ES8603461A1 (es) | 1985-12-16 |
GB2143235B (en) | 1987-08-19 |
US4578467A (en) | 1986-03-25 |
IT1200928B (it) | 1989-01-27 |
CA1256108A (en) | 1989-06-20 |
ES534170A0 (es) | 1985-12-16 |
GB2178039B (en) | 1987-08-19 |
ES545191A0 (es) | 1986-04-01 |
JPS6089470A (ja) | 1985-05-20 |
DE3425477C2 (it) | 1990-03-15 |
FR2549059B1 (fr) | 1987-04-17 |
GB2178039A (en) | 1987-02-04 |
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