NL8201890A - Nieuwe verbindingen van 2-aminothizolyl 2-oxyimino-aceetamido-bicycloocteencarbonzuur, hun bereiding, hun toepassing als geneesmiddelen, samenstellingen, die deze verbindingen bevatten en nieuwe tussenprodukten. - Google Patents
Nieuwe verbindingen van 2-aminothizolyl 2-oxyimino-aceetamido-bicycloocteencarbonzuur, hun bereiding, hun toepassing als geneesmiddelen, samenstellingen, die deze verbindingen bevatten en nieuwe tussenprodukten. Download PDFInfo
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- NL8201890A NL8201890A NL8201890A NL8201890A NL8201890A NL 8201890 A NL8201890 A NL 8201890A NL 8201890 A NL8201890 A NL 8201890A NL 8201890 A NL8201890 A NL 8201890A NL 8201890 A NL8201890 A NL 8201890A
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- 239000002253 acid Substances 0.000 title claims description 37
- 238000002360 preparation method Methods 0.000 title claims description 14
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- 229940126601 medicinal product Drugs 0.000 title 1
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- 125000006239 protecting group Chemical group 0.000 claims description 23
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- 239000011777 magnesium Substances 0.000 claims description 12
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- 230000036961 partial effect Effects 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
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- 238000000926 separation method Methods 0.000 claims 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 6
- 125000002252 acyl group Chemical group 0.000 description 5
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- 239000002904 solvent Substances 0.000 description 5
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
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- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008221 sterile excipient Substances 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 125000006000 trichloroethyl group Chemical group 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8109515A FR2505840A1 (fr) | 1981-05-13 | 1981-05-13 | Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments |
| FR8109515 | 1981-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8201890A true NL8201890A (nl) | 1982-12-01 |
Family
ID=9258391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8201890A NL8201890A (nl) | 1981-05-13 | 1982-05-07 | Nieuwe verbindingen van 2-aminothizolyl 2-oxyimino-aceetamido-bicycloocteencarbonzuur, hun bereiding, hun toepassing als geneesmiddelen, samenstellingen, die deze verbindingen bevatten en nieuwe tussenprodukten. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4476124A (fr) |
| JP (1) | JPS57192387A (fr) |
| AT (1) | AT384223B (fr) |
| BE (1) | BE893155A (fr) |
| CA (1) | CA1194873A (fr) |
| CH (1) | CH656386A5 (fr) |
| DE (1) | DE3218055A1 (fr) |
| ES (1) | ES8304142A1 (fr) |
| FR (1) | FR2505840A1 (fr) |
| GB (1) | GB2098217B (fr) |
| IT (1) | IT1189278B (fr) |
| LU (1) | LU84146A1 (fr) |
| NL (1) | NL8201890A (fr) |
| SE (1) | SE454177B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
| FR2559486B1 (fr) * | 1984-02-13 | 1988-02-12 | Roussel Uclaf | Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation et leur application comme medicaments |
| US5385897A (en) * | 1985-08-09 | 1995-01-31 | Roussel-Uclaf | 4-thia-1-aza-bicyclo[4,2,0]oct-2-ene derivatives |
| FR2586020B2 (fr) * | 1985-08-09 | 1988-10-14 | Roussel Uclaf | Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| DE3687870T2 (de) * | 1985-09-09 | 1993-08-19 | Otsuka Pharma Co Ltd | 2-oxa-isocephemverbindungen, sie enthaltende zusammensetzungen und verfahren zu deren herstellung. |
| FR2610630B2 (fr) * | 1987-02-06 | 1989-05-26 | Roussel Uclaf | Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| JPS63211283A (ja) * | 1987-02-27 | 1988-09-02 | Otsuka Pharmaceut Co Ltd | 抗菌剤 |
| DK123488A (da) * | 1987-03-09 | 1988-09-10 | Otsuka Pharma Co Ltd | 2-oxa-isocephemforbindelser, praeparater indeholdende dem, og fremgangsmaader til fremstilling af dem |
| DK582788A (da) * | 1987-10-22 | 1989-04-23 | Otsuka Pharma Co Ltd | 2-oxa-isocephemforbindelser, midler der indeholder dem og fremgangsmaader til fremstilling af dem |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4012383A (en) * | 1975-01-02 | 1977-03-15 | Bristol-Myers Company | Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents |
| US4011216A (en) * | 1975-04-11 | 1977-03-08 | Bristol-Myers Company | Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents |
| DK194776A (da) * | 1975-05-05 | 1976-11-06 | Smithkline Corp | Antibakterielle midler og mellemprodukter dertil |
| US4166816A (en) * | 1975-05-05 | 1979-09-04 | Smithkline Corporation | Methods and intermediates for preparing cis-4-oxoazetidine intermediates |
| US4103086A (en) * | 1975-10-29 | 1978-07-25 | Smithkline Corporation | 8-Oxo-4-thia-1-azabicyclo (4.2.0)-oct-2-ene derivatives |
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| JPS57116091A (en) | 1981-01-09 | 1982-07-19 | Sumitomo Chem Co Ltd | Novel beta-lactam compound and its preparation |
-
1981
- 1981-05-13 FR FR8109515A patent/FR2505840A1/fr active Granted
-
1982
- 1982-05-06 SE SE8202845A patent/SE454177B/sv not_active IP Right Cessation
- 1982-05-07 NL NL8201890A patent/NL8201890A/nl not_active Application Discontinuation
- 1982-05-12 BE BE0/208067A patent/BE893155A/fr not_active IP Right Cessation
- 1982-05-12 AT AT0186582A patent/AT384223B/de not_active IP Right Cessation
- 1982-05-12 CH CH2958/82A patent/CH656386A5/fr not_active IP Right Cessation
- 1982-05-12 IT IT48399/82A patent/IT1189278B/it active
- 1982-05-12 US US06/377,597 patent/US4476124A/en not_active Expired - Fee Related
- 1982-05-12 CA CA000402833A patent/CA1194873A/fr not_active Expired
- 1982-05-12 LU LU84146A patent/LU84146A1/fr unknown
- 1982-05-12 ES ES512112A patent/ES8304142A1/es not_active Expired
- 1982-05-13 JP JP57079253A patent/JPS57192387A/ja active Granted
- 1982-05-13 GB GB8213974A patent/GB2098217B/en not_active Expired
- 1982-05-13 DE DE19823218055 patent/DE3218055A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IT1189278B (it) | 1988-02-04 |
| SE8202845L (sv) | 1982-11-14 |
| JPH0355476B2 (fr) | 1991-08-23 |
| IT8248399A0 (it) | 1982-05-12 |
| JPS57192387A (en) | 1982-11-26 |
| ES512112A0 (es) | 1983-02-16 |
| GB2098217A (en) | 1982-11-17 |
| GB2098217B (en) | 1985-02-13 |
| AT384223B (de) | 1987-10-12 |
| FR2505840A1 (fr) | 1982-11-19 |
| ES8304142A1 (es) | 1983-02-16 |
| US4476124A (en) | 1984-10-09 |
| DE3218055A1 (de) | 1982-12-09 |
| CH656386A5 (fr) | 1986-06-30 |
| BE893155A (fr) | 1982-11-12 |
| SE454177B (sv) | 1988-04-11 |
| DE3218055C2 (fr) | 1991-07-11 |
| LU84146A1 (fr) | 1983-04-13 |
| FR2505840B1 (fr) | 1984-02-17 |
| CA1194873A (fr) | 1985-10-08 |
| ATA186582A (de) | 1987-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed |