NL8002679A - Werkwijze voor de bereiding van met een stikstofbrug gecondenseerde pyrimidineverbindingen, zouten, hydraten en isomeren daarvan, de bereiding van deze verbindingen en farmaceutische preparaten die deze verbindingen bevatten. - Google Patents
Werkwijze voor de bereiding van met een stikstofbrug gecondenseerde pyrimidineverbindingen, zouten, hydraten en isomeren daarvan, de bereiding van deze verbindingen en farmaceutische preparaten die deze verbindingen bevatten. Download PDFInfo
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- NL8002679A NL8002679A NL8002679A NL8002679A NL8002679A NL 8002679 A NL8002679 A NL 8002679A NL 8002679 A NL8002679 A NL 8002679A NL 8002679 A NL8002679 A NL 8002679A NL 8002679 A NL8002679 A NL 8002679A
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- Prior art keywords
- group
- optionally substituted
- hydrogen
- short chain
- formula
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- 150000001875 compounds Chemical class 0.000 title claims description 52
- 238000000034 method Methods 0.000 title claims description 23
- 150000003839 salts Chemical class 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 title claims description 10
- 150000004677 hydrates Chemical class 0.000 title claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 6
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
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- 239000001257 hydrogen Substances 0.000 claims description 36
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- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000002004 n-butylamino group Chemical group [H]N(*)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- CMJCEVKJYRZMIA-UHFFFAOYSA-M thallium(i) iodide Chemical compound [Tl]I CMJCEVKJYRZMIA-UHFFFAOYSA-M 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001933 | 1979-05-11 | ||
| HU79CI1933A HU178452B (en) | 1979-05-11 | 1979-05-11 | Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8002679A true NL8002679A (nl) | 1980-11-13 |
Family
ID=10994748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8002679A NL8002679A (nl) | 1979-05-11 | 1980-05-09 | Werkwijze voor de bereiding van met een stikstofbrug gecondenseerde pyrimidineverbindingen, zouten, hydraten en isomeren daarvan, de bereiding van deze verbindingen en farmaceutische preparaten die deze verbindingen bevatten. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4452982A (cs) |
| JP (1) | JPS5618981A (cs) |
| AT (1) | AT375938B (cs) |
| AU (1) | AU546194B2 (cs) |
| BE (1) | BE883218A (cs) |
| CA (1) | CA1140124A (cs) |
| CH (1) | CH653335A5 (cs) |
| CS (1) | CS236752B2 (cs) |
| DD (1) | DD150604A5 (cs) |
| DE (1) | DE3017560A1 (cs) |
| DK (1) | DK204980A (cs) |
| ES (1) | ES8105004A1 (cs) |
| FI (1) | FI67549C (cs) |
| FR (1) | FR2456100B1 (cs) |
| GB (1) | GB2051784B (cs) |
| HU (1) | HU178452B (cs) |
| IL (1) | IL59968A (cs) |
| IT (1) | IT8067718A0 (cs) |
| LU (1) | LU82434A1 (cs) |
| NL (1) | NL8002679A (cs) |
| PL (1) | PL127344B1 (cs) |
| PT (1) | PT71214A (cs) |
| SE (1) | SE441748B (cs) |
| SU (1) | SU1024007A3 (cs) |
| YU (1) | YU122180A (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178453B (en) * | 1979-05-11 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
| US5252572A (en) * | 1988-02-03 | 1993-10-12 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. | Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same |
| JP4747414B2 (ja) * | 1999-11-09 | 2011-08-17 | 株式会社セガ | キーボード取付構造を有するビデオゲーム機 |
| AU2003270783C1 (en) * | 2002-09-20 | 2010-05-20 | Merck Sharp & Dohme Corp. | Octahydro-2-H-naphtho[1,2-F] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3141043A (en) * | 1961-03-24 | 1964-07-14 | Purdue Research Foundation | Cyclopentadienylimines, process for their production and condensation products thereof |
| AT296996B (de) * | 1966-11-02 | 1972-03-10 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Homopyrimidazolderivaten und deren Säureadditionssalzen und quaternären Ammoniumsalzen |
| HU178496B (en) * | 1977-12-29 | 1982-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity |
| HU180439B (en) * | 1977-12-29 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
-
1979
- 1979-05-11 HU HU79CI1933A patent/HU178452B/hu unknown
-
1980
- 1980-05-01 IL IL59968A patent/IL59968A/xx unknown
- 1980-05-08 SE SE8003480A patent/SE441748B/sv not_active IP Right Cessation
- 1980-05-08 YU YU01221/80A patent/YU122180A/xx unknown
- 1980-05-08 CS CS803259A patent/CS236752B2/cs unknown
- 1980-05-08 SU SU802923101A patent/SU1024007A3/ru active
- 1980-05-08 DE DE19803017560 patent/DE3017560A1/de not_active Withdrawn
- 1980-05-09 LU LU82434A patent/LU82434A1/fr unknown
- 1980-05-09 IT IT8067718A patent/IT8067718A0/it unknown
- 1980-05-09 BE BE0/200551A patent/BE883218A/fr not_active IP Right Cessation
- 1980-05-09 DK DK204980A patent/DK204980A/da not_active Application Discontinuation
- 1980-05-09 AU AU58279/80A patent/AU546194B2/en not_active Ceased
- 1980-05-09 PT PT71214A patent/PT71214A/pt unknown
- 1980-05-09 CH CH3664/80A patent/CH653335A5/de not_active IP Right Cessation
- 1980-05-09 GB GB8015470A patent/GB2051784B/en not_active Expired
- 1980-05-09 FI FI801511A patent/FI67549C/fi not_active IP Right Cessation
- 1980-05-09 NL NL8002679A patent/NL8002679A/nl unknown
- 1980-05-09 FR FR8010480A patent/FR2456100B1/fr not_active Expired
- 1980-05-09 US US06/148,238 patent/US4452982A/en not_active Expired - Lifetime
- 1980-05-09 DD DD80220984A patent/DD150604A5/de unknown
- 1980-05-09 CA CA000351664A patent/CA1140124A/en not_active Expired
- 1980-05-09 JP JP6161480A patent/JPS5618981A/ja active Pending
- 1980-05-09 AT AT0247780A patent/AT375938B/de not_active IP Right Cessation
- 1980-05-10 PL PL1980224164A patent/PL127344B1/pl unknown
- 1980-05-10 ES ES491770A patent/ES8105004A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES491770A0 (es) | 1981-06-01 |
| FI67549C (fi) | 1985-04-10 |
| PT71214A (en) | 1980-06-01 |
| DD150604A5 (de) | 1981-09-09 |
| YU122180A (en) | 1983-02-28 |
| FI801511A7 (fi) | 1980-11-12 |
| CH653335A5 (de) | 1985-12-31 |
| US4452982A (en) | 1984-06-05 |
| IT8067718A0 (it) | 1980-05-09 |
| ATA247780A (de) | 1984-02-15 |
| SE8003480L (sv) | 1980-11-12 |
| FR2456100A1 (fr) | 1980-12-05 |
| ES8105004A1 (es) | 1981-06-01 |
| CS236752B2 (en) | 1985-05-15 |
| DE3017560A1 (de) | 1980-11-13 |
| PL224164A1 (cs) | 1981-02-13 |
| FI67549B (fi) | 1984-12-31 |
| LU82434A1 (fr) | 1980-07-31 |
| AU5827980A (en) | 1980-11-13 |
| SU1024007A3 (ru) | 1983-06-15 |
| JPS5618981A (en) | 1981-02-23 |
| GB2051784B (en) | 1983-03-02 |
| IL59968A0 (en) | 1980-07-31 |
| DK204980A (da) | 1980-11-12 |
| IL59968A (en) | 1984-05-31 |
| SE441748B (sv) | 1985-11-04 |
| GB2051784A (en) | 1981-01-21 |
| PL127344B1 (en) | 1983-10-31 |
| HU178452B (en) | 1982-05-28 |
| AU546194B2 (en) | 1985-08-22 |
| CA1140124A (en) | 1983-01-25 |
| AT375938B (de) | 1984-09-25 |
| BE883218A (fr) | 1980-09-01 |
| FR2456100B1 (fr) | 1985-08-09 |
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