NL8001593A - Meerfasisch combinatiepreparaat voor orale anticonceptie. - Google Patents
Meerfasisch combinatiepreparaat voor orale anticonceptie. Download PDFInfo
- Publication number
- NL8001593A NL8001593A NL8001593A NL8001593A NL8001593A NL 8001593 A NL8001593 A NL 8001593A NL 8001593 A NL8001593 A NL 8001593A NL 8001593 A NL8001593 A NL 8001593A NL 8001593 A NL8001593 A NL 8001593A
- Authority
- NL
- Netherlands
- Prior art keywords
- phase
- tablets
- desogestrel
- gestagen
- estrogen
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- 239000000262 estrogen Substances 0.000 claims abstract description 55
- 239000000583 progesterone congener Substances 0.000 claims abstract description 45
- 229940011871 estrogen Drugs 0.000 claims description 51
- 229960004976 desogestrel Drugs 0.000 claims description 39
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 29
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 16
- 229960002568 ethinylestradiol Drugs 0.000 claims description 15
- 229940127234 oral contraceptive Drugs 0.000 claims description 6
- 239000003539 oral contraceptive agent Substances 0.000 claims description 6
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
- 239000008101 lactose Substances 0.000 description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 8
- 239000008298 dragée Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920001592 potato starch Polymers 0.000 description 6
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 5
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 5
- 235000021355 Stearic acid Nutrition 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- 229960004400 levonorgestrel Drugs 0.000 description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 239000008117 stearic acid Substances 0.000 description 5
- 229960000984 tocofersolan Drugs 0.000 description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
- 230000002051 biphasic effect Effects 0.000 description 4
- 230000002254 contraceptive effect Effects 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 230000001076 estrogenic effect Effects 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 229960002941 etonogestrel Drugs 0.000 description 3
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 2
- RPGGYYVWJTWVMS-ZPSVQYCPSA-N (8r,9s,10r,13s,14s,17r)-17-ethynyl-10,13-dimethyl-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPGGYYVWJTWVMS-ZPSVQYCPSA-N 0.000 description 2
- JFRPGRWPRUCLQL-TWYXDQSVSA-N (8r,9s,13s,14s,17r)-3-ethyl-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-ol;(8r,9s,10r,13s,14s,17r)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(CC)=CC=C3[C@H]21 JFRPGRWPRUCLQL-TWYXDQSVSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- YNVGQYHLRCDXFQ-XGXHKTLJSA-N Lynestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YNVGQYHLRCDXFQ-XGXHKTLJSA-N 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003433 contraceptive agent Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- -1 d-norgestrel Chemical compound 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229960001910 lynestrenol Drugs 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 description 1
- HSYWFJBHXIUUCZ-XGXHKTLJSA-N (8r,9s,10r,13s,14s,17r)-17-ethynyl-13-methyl-2,3,4,7,8,9,10,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol Chemical compound C1CCC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CC=C21 HSYWFJBHXIUUCZ-XGXHKTLJSA-N 0.000 description 1
- JMEVHYCNAPFOAB-UHFFFAOYSA-N 2-(3-hydroxy-5-sulfo-1H-indol-2-yl)-3-oxoindole-5-sulfonic acid Chemical compound Oc1c([nH]c2ccc(cc12)S(O)(=O)=O)C1=Nc2ccc(cc2C1=O)S(O)(=O)=O JMEVHYCNAPFOAB-UHFFFAOYSA-N 0.000 description 1
- HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical compound O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 1
- ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 description 1
- 206010067572 Oestrogenic effect Diseases 0.000 description 1
- OIQPTROHQCGFEF-QIKYXUGXSA-L Sunset Yellow FCF Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-QIKYXUGXSA-L 0.000 description 1
- 206010047998 Withdrawal bleed Diseases 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229950000136 cingestol Drugs 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 150000002159 estradiols Chemical class 0.000 description 1
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 description 1
- 229940012028 ethynodiol diacetate Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003152 gestagenic effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 1
- 229960001390 mestranol Drugs 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229940053934 norethindrone Drugs 0.000 description 1
- 229960001652 norethindrone acetate Drugs 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 229960001858 norethynodrel Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000012751 sunset yellow FCF Nutrition 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/60—Components specifically designed for the therapeutic baths of groups A61H33/00
- A61H33/601—Inlet to the bath
- A61H33/6021—Nozzles
- A61H33/6052—Having flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/60—Components specifically designed for the therapeutic baths of groups A61H33/00
- A61H33/601—Inlet to the bath
- A61H33/6021—Nozzles
- A61H33/6063—Specifically adapted for fitting in bathtub walls
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B3/00—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements
- B05B3/02—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements
- B05B3/04—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet
- B05B3/0409—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements
- B05B3/0418—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements comprising a liquid driven rotor, e.g. a turbine
- B05B3/0422—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements comprising a liquid driven rotor, e.g. a turbine with rotating outlet elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B3/00—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements
- B05B3/02—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements
- B05B3/04—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet
- B05B3/0409—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements
- B05B3/0418—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements comprising a liquid driven rotor, e.g. a turbine
- B05B3/0422—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements comprising a liquid driven rotor, e.g. a turbine with rotating outlet elements
- B05B3/0459—Spraying or sprinkling apparatus with moving outlet elements or moving deflecting elements with rotating elements driven by the liquid or other fluent material discharged, e.g. the liquid actuating a motor before passing to the outlet with moving, e.g. rotating, outlet elements comprising a liquid driven rotor, e.g. a turbine with rotating outlet elements the rotor axis not being parallel to the rotation axis of the outlet, e.g. being perpendicular thereto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/12—Driving means
- A61H2201/1238—Driving means with hydraulic or pneumatic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H33/00—Bathing devices for special therapeutic or hygienic purposes
- A61H33/02—Bathing devices for use with gas-containing liquid, or liquid in which gas is led or generated, e.g. carbon dioxide baths
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Rehabilitation Therapy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Details Of Television Scanning (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8001593A NL8001593A (nl) | 1980-03-18 | 1980-03-18 | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
| DE8181200240T DE3168420D1 (en) | 1980-03-18 | 1981-03-02 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| EP81200240A EP0036229B1 (en) | 1980-03-18 | 1981-03-02 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| AT81200240T ATE11371T1 (de) | 1980-03-18 | 1981-03-02 | Multistufen-kombinationssequentialpraeparate fuer die orale kontrazeption und verfahren zur kontrazeption. |
| DE2000175014 DE10075014I1 (de) | 1980-03-18 | 1981-03-02 | Multistufen-Kombinationssequentialpraeparate fuer die orale Kontrazeption und Verfahren zu Kontrazeption |
| IE468/81A IE50988B1 (en) | 1980-03-18 | 1981-03-04 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| ZA00811490A ZA811490B (en) | 1980-03-18 | 1981-03-05 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| AU68210/81A AU546010B2 (en) | 1980-03-18 | 1981-03-10 | Method of oral contraception |
| GR64405A GR74473B (xx) | 1980-03-18 | 1981-03-16 | |
| FI810805A FI72649C (fi) | 1980-03-18 | 1981-03-16 | Gestagen- och estrogenhaltigt preventivmedel av kombinationserie-typ foer oral anvaendning. |
| US06/244,071 US4378356A (en) | 1980-03-18 | 1981-03-16 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| DK118881A DK162474C (da) | 1980-03-18 | 1981-03-17 | Fler-fasesekvenspraeparat af kombinationstypen til oral svangerskabsforebyggelse |
| JP3857681A JPS56140914A (en) | 1980-03-18 | 1981-03-17 | Oral contraception multiphase combination type sequential preparation and oral contraception method |
| CA000373188A CA1158981A (en) | 1980-03-18 | 1981-03-17 | Multi-phase combination-type sequential preparation for oral contraception and method of oral contraception |
| MX9203812A MX9203812A (es) | 1980-03-18 | 1992-06-29 | Preparacion oral secuencial del tipo que combina fases multiples para la contraconcepcion y el metodo de contraconcepcion oral. |
| NL930030C NL930030I2 (nl) | 1980-03-18 | 1993-04-28 | Meerfasisch 'opeenvolgend' preparaat van het combinatie-type voor orale anticonceptie en methode voor orale anticonceptie. |
| NL950017C NL950017I2 (nl) | 1980-03-18 | 1995-08-29 | Meerfasisch "opeenvolgend" preparaat van het combinatie-type voor orale anticonceptie en methode vo or orale anticonceptie. |
| LU90587C LU90587I2 (fr) | 1980-03-18 | 2000-05-24 | Trimiron |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8001593 | 1980-03-18 | ||
| NL8001593A NL8001593A (nl) | 1980-03-18 | 1980-03-18 | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8001593A true NL8001593A (nl) | 1981-10-16 |
Family
ID=19835016
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8001593A NL8001593A (nl) | 1980-03-18 | 1980-03-18 | Meerfasisch combinatiepreparaat voor orale anticonceptie. |
| NL930030C NL930030I2 (nl) | 1980-03-18 | 1993-04-28 | Meerfasisch 'opeenvolgend' preparaat van het combinatie-type voor orale anticonceptie en methode voor orale anticonceptie. |
| NL950017C NL950017I2 (nl) | 1980-03-18 | 1995-08-29 | Meerfasisch "opeenvolgend" preparaat van het combinatie-type voor orale anticonceptie en methode vo or orale anticonceptie. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL930030C NL930030I2 (nl) | 1980-03-18 | 1993-04-28 | Meerfasisch 'opeenvolgend' preparaat van het combinatie-type voor orale anticonceptie en methode voor orale anticonceptie. |
| NL950017C NL950017I2 (nl) | 1980-03-18 | 1995-08-29 | Meerfasisch "opeenvolgend" preparaat van het combinatie-type voor orale anticonceptie en methode vo or orale anticonceptie. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4378356A (xx) |
| EP (1) | EP0036229B1 (xx) |
| JP (1) | JPS56140914A (xx) |
| AT (1) | ATE11371T1 (xx) |
| AU (1) | AU546010B2 (xx) |
| CA (1) | CA1158981A (xx) |
| DE (2) | DE3168420D1 (xx) |
| DK (1) | DK162474C (xx) |
| FI (1) | FI72649C (xx) |
| GR (1) | GR74473B (xx) |
| IE (1) | IE50988B1 (xx) |
| LU (1) | LU90587I2 (xx) |
| MX (1) | MX9203812A (xx) |
| NL (3) | NL8001593A (xx) |
| ZA (1) | ZA811490B (xx) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4530839A (en) * | 1983-09-26 | 1985-07-23 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| US4544554A (en) * | 1983-09-26 | 1985-10-01 | Ortho Pharmaceutical Corporation | Triphasic oral contraceptive |
| DE3347125A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrstufenkombinationspraeparat und seine verwendung zur oralen kontrazeption |
| AU581486B2 (en) * | 1985-12-30 | 1989-02-23 | Warner-Lambert Company | Graduated estrogen contraceptive |
| US5010070A (en) * | 1987-06-15 | 1991-04-23 | Warner-Lambert Company | Graduated estrogen contraceptive |
| US4962098A (en) * | 1987-06-15 | 1990-10-09 | Warner-Lambert Company | Graduated estrogen contraceptive |
| DK174724B1 (da) * | 1986-07-15 | 2003-10-06 | Wyeth Corp | Anvendelse af et præparat omfattende et østrogen og et progestogen til fremstilling af en dosisform til tilvejebringelse af hormonerstatningsterapi og kontraception til kvinder i præmenopausen samt pakning til tilvejebringelse af præparatet |
| JPH0621072B2 (ja) * | 1986-11-12 | 1994-03-23 | 呉羽化学工業株式会社 | エストラジオ−ル誘導体よりなる免疫調節剤 |
| ATE66149T1 (de) * | 1987-07-06 | 1991-08-15 | Akzo Nv | Pharmazeutische dosierungseinheit zur vorbeugung bzw. behandlung von klimakterischen beschwerden. |
| US5108995A (en) * | 1987-09-24 | 1992-04-28 | Jencap Research Ltd. | Hormone preparation and method |
| US5276022A (en) * | 1987-09-24 | 1994-01-04 | Jencap Research Ltd. | Hormone preparation and method |
| IE71203B1 (en) * | 1990-12-13 | 1997-02-12 | Akzo Nv | Low estrogen oral contraceptives |
| IE62665B1 (en) * | 1990-12-17 | 1995-02-22 | Akzo Nv | Contraceptive regimen |
| DE4104385C1 (xx) * | 1991-02-09 | 1992-08-13 | Marika Dr.Med. 6509 Framersheim De Ehrlich | |
| IE67345B1 (en) * | 1991-03-12 | 1996-03-20 | Akzo Nv | Low dose dry pharmaceutical preparations |
| AU2926897A (en) * | 1996-05-08 | 1997-11-26 | American Home Products Corporation | Oral contraceptive |
| US6214815B1 (en) | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| US6855703B1 (en) | 2000-03-10 | 2005-02-15 | Endeavor Pharmaceuticals | Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds |
| US7459445B2 (en) * | 2000-03-10 | 2008-12-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and topical pharmaceutical formulations of the same |
| US6660726B2 (en) * | 2000-03-10 | 2003-12-09 | Endeavor Pharmaceuticals | Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same |
| US7989436B2 (en) | 2003-07-23 | 2011-08-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and pharmaceutical formulations comprising the same |
| JP2004140323A (ja) * | 2002-08-20 | 2004-05-13 | Sharp Corp | 半導体レーザ装置およびその製造方法 |
| US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
| CA2521471A1 (en) * | 2003-04-11 | 2004-10-28 | Barr Laboratories, Inc. | Methods of administering estrogens and progestins |
| DE102004019743B4 (de) * | 2004-04-20 | 2008-11-27 | Bayer Schering Pharma Aktiengesellschaft | Mehrphasenpräparat zur Kontrazeption auf der Basis eines natürlichen Estrogens |
| EP1853272A1 (en) * | 2005-02-03 | 2007-11-14 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
| US8153616B2 (en) * | 2005-10-17 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same |
| EP1930010A1 (de) | 2006-10-20 | 2008-06-11 | Bayer Schering Pharma Aktiengesellschaft | Verwendung von Estradiolvalerat oder 17ß-Estradiol in Kombination mit Dienogest zur oralen Therapie für den Erhalt und/oder die Steigerung der weiblichen Libido |
| HUP0900698A2 (en) | 2009-11-06 | 2011-06-28 | Richter Gedeon Nyrt | Pharmaceutical compositions of enhanced stability containing drospirenone and ethynyl estradiol and process for their preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US39264A (en) * | 1863-07-14 | Improvement in hay-loaders | ||
| US3409721A (en) * | 1967-09-15 | 1968-11-05 | Neomed Lab Inc | Oral dosage system effective to control the reproduction cycle |
| DE2265435C2 (de) * | 1972-04-14 | 1980-01-24 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verwendung von Hormonen zur Kontrazeption |
| DE2310963A1 (de) * | 1972-04-14 | 1974-09-05 | Schering Ag | Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten |
| DE2365103C3 (de) * | 1973-12-21 | 1980-08-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | V erwendung von Hormonen zur Kontrazeption |
| US4018919A (en) * | 1975-07-16 | 1977-04-19 | Eli Lilly And Company | Sequential contraceptive method using two types of progestational agents |
-
1980
- 1980-03-18 NL NL8001593A patent/NL8001593A/nl not_active Application Discontinuation
-
1981
- 1981-03-02 DE DE8181200240T patent/DE3168420D1/de not_active Expired
- 1981-03-02 DE DE2000175014 patent/DE10075014I1/de active Pending
- 1981-03-02 EP EP81200240A patent/EP0036229B1/en not_active Expired
- 1981-03-02 AT AT81200240T patent/ATE11371T1/de active
- 1981-03-04 IE IE468/81A patent/IE50988B1/en active Protection Beyond IP Right Term
- 1981-03-05 ZA ZA00811490A patent/ZA811490B/xx unknown
- 1981-03-10 AU AU68210/81A patent/AU546010B2/en not_active Expired
- 1981-03-16 US US06/244,071 patent/US4378356A/en not_active Expired - Lifetime
- 1981-03-16 GR GR64405A patent/GR74473B/el unknown
- 1981-03-16 FI FI810805A patent/FI72649C/fi not_active IP Right Cessation
- 1981-03-17 DK DK118881A patent/DK162474C/da active Protection Beyond IP Right Term
- 1981-03-17 CA CA000373188A patent/CA1158981A/en not_active Expired
- 1981-03-17 JP JP3857681A patent/JPS56140914A/ja active Granted
-
1992
- 1992-06-29 MX MX9203812A patent/MX9203812A/es unknown
-
1993
- 1993-04-28 NL NL930030C patent/NL930030I2/nl unknown
-
1995
- 1995-08-29 NL NL950017C patent/NL950017I2/nl unknown
-
2000
- 2000-05-24 LU LU90587C patent/LU90587I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL930030I1 (nl) | 1993-07-01 |
| DE10075014I1 (de) | 2000-09-07 |
| DK118881A (da) | 1981-09-19 |
| EP0036229A1 (en) | 1981-09-23 |
| AU546010B2 (en) | 1985-08-08 |
| GR74473B (xx) | 1984-06-28 |
| NL950017I2 (nl) | 1996-12-02 |
| ZA811490B (en) | 1982-03-31 |
| ATE11371T1 (de) | 1985-02-15 |
| CA1158981A (en) | 1983-12-20 |
| IE50988B1 (en) | 1986-09-03 |
| FI810805L (fi) | 1981-09-19 |
| EP0036229B1 (en) | 1985-01-23 |
| JPH0153252B2 (xx) | 1989-11-13 |
| DK162474B (da) | 1991-11-04 |
| FI72649C (fi) | 1987-07-10 |
| DE3168420D1 (en) | 1985-03-07 |
| NL950017I1 (nl) | 1995-11-01 |
| US4378356A (en) | 1983-03-29 |
| IE810468L (en) | 1981-09-18 |
| AU6821081A (en) | 1981-09-24 |
| LU90587I2 (fr) | 2000-07-24 |
| NL930030I2 (nl) | 1994-02-16 |
| MX9203812A (es) | 1992-07-01 |
| FI72649B (fi) | 1987-03-31 |
| DK162474C (da) | 1992-04-06 |
| JPS56140914A (en) | 1981-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1B | A search report has been drawn up | ||
| A85 | Still pending on 85-01-01 | ||
| BV | The patent application has lapsed |