NL7513141A - Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie. - Google Patents

Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.

Info

Publication number
NL7513141A
NL7513141A NL7513141A NL7513141A NL7513141A NL 7513141 A NL7513141 A NL 7513141A NL 7513141 A NL7513141 A NL 7513141A NL 7513141 A NL7513141 A NL 7513141A NL 7513141 A NL7513141 A NL 7513141A
Authority
NL
Netherlands
Prior art keywords
influencing
preparations
preparation
acid secretion
benzimidazole derivatives
Prior art date
Application number
NL7513141A
Other languages
English (en)
Dutch (nl)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SE7406513A priority Critical patent/SE416649B/xx
Priority to FI752327A priority patent/FI63756C/fi
Priority to NO75752851A priority patent/NO143222C/no
Priority to DK372175AA priority patent/DK140840B/da
Priority to ZA00756600A priority patent/ZA756600B/xx
Priority to GB43039/75A priority patent/GB1525958A/en
Priority to CY1125A priority patent/CY1125A/xx
Priority to IE2313/75A priority patent/IE42451B1/en
Priority to DE19752548340 priority patent/DE2548340A1/de
Priority to AT838075A priority patent/AT337697B/de
Priority to CS757458A priority patent/CS196289B2/cs
Application filed by Haessle Ab filed Critical Haessle Ab
Priority to NL7513141A priority patent/NL7513141A/xx
Priority to US05/630,916 priority patent/US4045563A/en
Priority to HU75HE00000696A priority patent/HU172653B/hu
Priority to SU752189960A priority patent/SU602118A3/ru
Priority to CA239,643A priority patent/CA1055033A/en
Priority to DD189463A priority patent/DD122534A5/xx
Priority to FR7534910A priority patent/FR2331340A1/fr
Priority to CH1481475A priority patent/CH623814A5/de
Priority to JP50137712A priority patent/JPS5262275A/ja
Priority to FR7616732A priority patent/FR2392021A1/fr
Priority to AT752276A priority patent/AT351524B/de
Publication of NL7513141A publication Critical patent/NL7513141A/xx
Priority to DK783659A priority patent/DK365978A/da
Priority to CS786886A priority patent/CS196290B2/cs
Priority to CH976079A priority patent/CH623582A5/de
Priority to FI811747A priority patent/FI65617C/fi
Priority to HK87/82A priority patent/HK8782A/xx
Priority to MY159/82A priority patent/MY8200159A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL7513141A 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie. NL7513141A (nl)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE7406513A SE416649B (sv) 1974-05-16 1974-05-16 Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
FI752327A FI63756C (fi) 1974-05-16 1975-08-15 Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan
NO75752851A NO143222C (no) 1974-05-16 1975-08-15 Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet
DK372175AA DK140840B (da) 1974-05-16 1975-08-18 Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf.
GB43039/75A GB1525958A (en) 1974-05-16 1975-10-20 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
ZA00756600A ZA756600B (en) 1974-05-16 1975-10-20 Gastric acid secretion agents
CY1125A CY1125A (en) 1974-05-16 1975-10-20 2-(heterocaclic asbstituted alkylsulphinyl)-benzinmidazoles and their pharmaceutical compositions
IE2313/75A IE42451B1 (en) 1974-05-16 1975-10-23 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
DE19752548340 DE2548340A1 (de) 1974-05-16 1975-10-29 Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel
AT838075A AT337697B (de) 1974-05-16 1975-11-04 Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen
CS757458A CS196289B2 (en) 1974-05-16 1975-11-05 Process for preparing new compounds
NL7513141A NL7513141A (nl) 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.
US05/630,916 US4045563A (en) 1974-05-16 1975-11-11 Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects
HU75HE00000696A HU172653B (hu) 1974-05-16 1975-11-12 Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov
SU752189960A SU602118A3 (ru) 1974-05-16 1975-11-13 Способ получени производных бензимидазола или их солей
CA239,643A CA1055033A (en) 1974-05-16 1975-11-14 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds
DD189463A DD122534A5 (US20050192411A1-20050901-C00001.png) 1974-05-16 1975-11-14
FR7534910A FR2331340A1 (fr) 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant
CH1481475A CH623814A5 (en) 1974-05-16 1975-11-14 Process for the preparation of novel benzimidazoles
JP50137712A JPS5262275A (en) 1974-05-16 1975-11-15 Production of organic compound
FR7616732A FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention
AT752276A AT351524B (de) 1974-05-16 1976-10-11 Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren
DK783659A DK365978A (da) 1974-05-16 1978-08-18 Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater
CS786886A CS196290B2 (en) 1974-05-16 1978-10-23 Process for preparing new compounds
CH976079A CH623582A5 (en) 1974-05-16 1979-10-31 Process for the preparation of benzimidazoles
FI811747A FI65617C (fi) 1974-05-16 1981-06-04 Mellanprodukt foer framstaellning av magsyrasekretionsinhiberande 2-(2-pyridylmetylsulfinyl)-benzimidazolderivat
HK87/82A HK8782A (en) 1974-05-16 1982-02-25 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
MY159/82A MY8200159A (en) 1974-05-16 1982-12-30 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
SE7406513A SE416649B (sv) 1974-05-16 1974-05-16 Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
FI752327A FI63756C (fi) 1974-05-16 1975-08-15 Foerfarande foer framstaellning av 2-(2-pyridylmetylsulfinyl)-bensimidazolderivat med magsyrasekretionsinhiberande verkan
NO75752851A NO143222C (no) 1974-05-16 1975-08-15 Analogifremgangsmaate for fremstilling av nye substituerte pyridylsulfinyl-benzimidazoler med terapeutisk aktivitet
DK372175AA DK140840B (da) 1974-05-16 1975-08-18 Analogifremgangsmåde til fremstilling af benzimidazolderivater eller syreadditionssalte deraf.
GB43039/75A GB1525958A (en) 1974-05-16 1975-10-20 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
ZA00756600A ZA756600B (en) 1974-05-16 1975-10-20 Gastric acid secretion agents
IE2313/75A IE42451B1 (en) 1974-05-16 1975-10-23 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
DE19752548340 DE2548340A1 (de) 1974-05-16 1975-10-29 Benzimidazole, verfahren zu deren herstellung und sie enthaltende mittel
AT838075A AT337697B (de) 1974-05-16 1975-11-04 Verfahren zur herstellung von neuen benzimidazolderivaten und ihren salzen
CS757458A CS196289B2 (en) 1974-05-16 1975-11-05 Process for preparing new compounds
NL7513141A NL7513141A (nl) 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.
US05/630,916 US4045563A (en) 1974-05-16 1975-11-11 Substituted 2-[pyridylalkylenesulfinyl]-benzimidazoles with gastric acid secretion inhibiting effects
HU75HE00000696A HU172653B (hu) 1974-05-16 1975-11-12 Sposob poluchenija zamehhennykh 2-skobka-2-piridil-metil-sul'finil-skobka zakryta-benzimidazolov
SU752189960A SU602118A3 (ru) 1974-05-16 1975-11-13 Способ получени производных бензимидазола или их солей
CA239,643A CA1055033A (en) 1974-05-16 1975-11-14 2-(2-heterocyclic-methylsulphinyl)-benzimidazole compounds
DD189463A DD122534A5 (US20050192411A1-20050901-C00001.png) 1974-05-16 1975-11-14
FR7534910A FR2331340A1 (fr) 1974-05-16 1975-11-14 Nouveaux derives du benzimidazole, procede pour leur obtention et compositions pharmaceutiques les contenant
CH1481475A CH623814A5 (en) 1974-05-16 1975-11-14 Process for the preparation of novel benzimidazoles
JP50137712A JPS5262275A (en) 1974-05-16 1975-11-15 Production of organic compound
FR7616732A FR2392021A1 (fr) 1974-05-16 1976-06-03 Nouveaux derives du benzimidazole et procede pour leur obtention
AT752276A AT351524B (de) 1974-05-16 1976-10-11 Verfahren zur herstellung von neuen benzimida- zolderivaten, ihren salzen und optischen isomeren
DK783659A DK365978A (da) 1974-05-16 1978-08-18 Mellemprodukt til anvendelse ved fremstilling af benzimidazolderivater
CS786886A CS196290B2 (en) 1974-05-16 1978-10-23 Process for preparing new compounds
HU8782 1982-02-25
MY159/82A MY8200159A (en) 1974-05-16 1982-12-30 2-[heterocylic substituted alkylsulphinyl]-benzimidazoles and their pharmaceutical compositions

Publications (1)

Publication Number Publication Date
NL7513141A true NL7513141A (nl) 1977-05-12

Family

ID=40486266

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7513141A NL7513141A (nl) 1974-05-16 1975-11-10 Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.

Country Status (22)

Country Link
US (1) US4045563A (US20050192411A1-20050901-C00001.png)
JP (1) JPS5262275A (US20050192411A1-20050901-C00001.png)
AT (2) AT337697B (US20050192411A1-20050901-C00001.png)
CA (1) CA1055033A (US20050192411A1-20050901-C00001.png)
CH (2) CH623814A5 (US20050192411A1-20050901-C00001.png)
CS (2) CS196289B2 (US20050192411A1-20050901-C00001.png)
CY (1) CY1125A (US20050192411A1-20050901-C00001.png)
DD (1) DD122534A5 (US20050192411A1-20050901-C00001.png)
DE (1) DE2548340A1 (US20050192411A1-20050901-C00001.png)
DK (2) DK140840B (US20050192411A1-20050901-C00001.png)
FI (2) FI63756C (US20050192411A1-20050901-C00001.png)
FR (2) FR2331340A1 (US20050192411A1-20050901-C00001.png)
GB (1) GB1525958A (US20050192411A1-20050901-C00001.png)
HK (1) HK8782A (US20050192411A1-20050901-C00001.png)
HU (1) HU172653B (US20050192411A1-20050901-C00001.png)
IE (1) IE42451B1 (US20050192411A1-20050901-C00001.png)
MY (1) MY8200159A (US20050192411A1-20050901-C00001.png)
NL (1) NL7513141A (US20050192411A1-20050901-C00001.png)
NO (1) NO143222C (US20050192411A1-20050901-C00001.png)
SE (1) SE416649B (US20050192411A1-20050901-C00001.png)
SU (1) SU602118A3 (US20050192411A1-20050901-C00001.png)
ZA (1) ZA756600B (US20050192411A1-20050901-C00001.png)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148930B (US20050192411A1-20050901-C00001.png) * 1977-09-19 1981-07-25 Hoffmann La Roche
AT406119B (de) * 1978-04-14 2000-02-25 Haessle Ab Verfahren zur herstellung von granulaten bzw. tabletten oder kapseln zur oralen verabreichung
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
AT375365B (de) * 1978-04-14 1984-07-25 Haessle Ab Verfahren zur herstellung von neuen 2-pyridylalkyl-sulfinyl-benzimidazolen, von deren hydraten, stereoisomeren und salzen
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS58135881A (ja) * 1981-11-05 1983-08-12 ビク−グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング 置換ベンズイミダゾ−ル類、その製造方法と利用、およびこれを含む医薬
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
HU193408B (en) * 1983-05-03 1987-10-28 Byk Gulden Lomberg Chem Fqb Process for production of new tree-cycle compounds
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles
US5077407A (en) * 1983-07-01 1991-12-31 The Upjohn Company Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles
DE3333314A1 (de) * 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
KR890000387B1 (ko) * 1984-09-24 1989-03-16 디 엎존 캄파니 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
DE3579436D1 (de) * 1984-12-18 1990-10-04 Otsuka Pharma Co Ltd Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen.
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
DK8600939A (US20050192411A1-20050901-C00001.png) * 1985-03-05 1986-09-06
FI861772A (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
AU5768886A (en) 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US6749864B2 (en) 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
US5433959A (en) 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
EP0234485B1 (de) * 1986-02-20 1992-04-01 Hoechst Aktiengesellschaft Substituierte Thienoimidazol-Derivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Magensäuresekretionshemmer
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents
ES2038612T3 (es) * 1986-03-28 1993-08-01 Otsuka Pharmaceutical Co., Ltd. Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas.
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
SE8604998D0 (sv) 1986-11-21 1986-11-21 Haessle Ab Novel pharmacological compounds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
US5330982A (en) * 1986-12-17 1994-07-19 Glaxo Group Limited Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith
GB8630080D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
AU2621888A (en) * 1987-10-30 1989-05-23 Aktiebolaget Hassle Omeprazole for treatment of diseases related to bone loss
WO1990003373A1 (en) * 1988-09-20 1990-04-05 Hisamitsu Pharmaceutical Co., Inc. NOVEL DIBENZ[b,e]OXEPIN DERIVATIVES
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US5149702A (en) * 1989-11-29 1992-09-22 Toa Eiyo Ltd. Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5049674A (en) 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
JP2524420B2 (ja) * 1990-05-16 1996-08-14 明治製菓株式会社 ピペリジン誘導体及びそれらを有効成分とする抗潰瘍剤
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
PL307026A1 (en) * 1992-07-08 1995-05-02 Monsanto Co Method of producing ppaliative effect in respect to swine gastric ulcers
WO1994002141A1 (en) * 1992-07-28 1994-02-03 Astra Aktiebolag Injection and injection kit containing omeprazole and its analogs
TW280770B (US20050192411A1-20050901-C00001.png) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
AU2395095A (en) 1994-04-29 1995-11-29 G.D. Searle & Co. Method of using (h+/k+) atpase inhibitors as antiviral agents
AU6369696A (en) * 1995-07-17 1997-02-18 Fuji Photo Film Co., Ltd. Benzimidazole compounds
US5824339A (en) * 1995-09-08 1998-10-20 Takeda Chemical Industries, Ltd Effervescent composition and its production
SK284291B6 (sk) * 1995-09-21 2005-01-03 Pharma Pass L.L.C. Farmaceutická kompozícia vo forme tabliet alebo mikrotabliet obsahujúca acidolabilný omeprazol a spôsob jej prípravy
KR100559169B1 (ko) * 1997-07-11 2006-03-10 에자이 가부시키가이샤 피리딘 유도체의 제조방법
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
GB9805558D0 (en) * 1998-03-17 1998-05-13 Knoll Ag Chemical process`
AU3731699A (en) 1998-05-18 1999-12-06 Takeda Chemical Industries Ltd. Orally disintegrable tablets
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
HUP0103464A3 (en) 1998-08-10 2002-11-28 U S Government Represented By Prodrugs of proton pump inhibitors and pharmaceutical compositions containing them
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
DE60015607T2 (de) 2000-02-24 2005-11-10 Kopran Research Laboratories Ltd. Oral verabreichbare säurebeständige geschwürbehandelnde benzimidazolderivate
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
WO2002026210A2 (en) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Proton pump inhibitor formulation
EP1437352A4 (en) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd BENZYMIDAZOLE COMPOUND, PROCESS FOR PRODUCING AND USING THE SAME
DK2258351T3 (da) 2001-10-17 2013-08-26 Takeda Pharmaceutical Granula indeholdende lansoprazol i stor mængde
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
ATE437642T1 (de) * 2002-06-14 2009-08-15 Takeda Pharmaceutical Prodrugs von imidazol-derivaten, zur verwendung als protonenpumpen-hemmer zur behandlung von z.b. peptischen magengeschwüren
DK1556371T3 (da) * 2002-07-19 2006-08-21 Winston Pharmaceuticals Llc Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
EP1552833B1 (en) 2002-10-16 2016-12-28 Takeda Pharmaceutical Company Limited Process for producing an amorphous optically active isomer of lansoprazole
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US20050232992A1 (en) * 2003-09-03 2005-10-20 Agi Therapeutics Limited Proton pump inhibitor formulations, and methods of preparing and using such formulations
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
WO2005077936A1 (en) 2004-02-11 2005-08-25 Ulkar Kimya Sanayii Ve Ticaret A.S. Pyridine benzimidazole sulfoxides with high purity
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
BRPI0507784A (pt) * 2004-02-18 2007-07-17 Allergan Inc métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons
MXPA06011820A (es) * 2004-04-16 2006-12-15 Santarus Inc Combinacion de inhibidor de bomba de proton, agente regulador del ph y agente procinetico.
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8592598B2 (en) 2004-09-13 2013-11-26 Takeda Pharmaceutical Company Limited Method of producing a crystal of an imidazole compound
ES2675581T3 (es) 2005-02-25 2018-07-11 Takeda Pharmaceutical Company Limited Método para producir gránulos de un compuesto de bencimidazol recubiertos
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
WO2007074856A1 (ja) 2005-12-28 2007-07-05 Takeda Pharmaceutical Company Limited 口腔内崩壊性固形製剤の製造法
US20070199890A1 (en) * 2006-02-27 2007-08-30 Agion Technologies, Inc. Antimicrobial activated carbon and use thereof
CA2648280C (en) 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US7786309B2 (en) * 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
WO2008036201A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
EP2068841B1 (en) 2006-10-05 2018-09-26 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
ZA200904573B (en) 2006-12-22 2010-09-29 Ironwood Pharmaceuticals Inc Compositions comprising bile acid sequestrants for treating esophageal disorders
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
JP6011982B2 (ja) 2011-08-26 2016-10-25 国立大学法人名古屋大学 骨形成促進剤及びその用途
AU2012351342A1 (en) 2011-12-16 2014-07-24 Atopix Therapeutics Limited Combination of CRTH2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
JP6716255B2 (ja) 2013-01-15 2020-07-01 アイロンウッド ファーマシューティカルズ,インコーポレーテッドIronwood Pharmaceuticals, Inc. 胆汁酸捕捉剤の胃内滞留型徐放性経口剤形
US20180015118A1 (en) 2015-02-03 2018-01-18 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10736855B2 (en) 2016-02-25 2020-08-11 Dexcel Pharma Technologies Ltd. Compositions comprising proton pump inhibitors
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
KR102409502B1 (ko) * 2016-09-14 2022-06-16 위펑 제인 쳉 D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (US20050192411A1-20050901-C00001.png) * 1968-10-21 1971-06-03
DE1903755B2 (de) * 1969-01-25 1971-04-22 Th Goldschmidt AG, 4300 Essen Verfahren zur herstellung von zinnhaltigen keramischen farbkoerpern
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan

Also Published As

Publication number Publication date
DK372175A (US20050192411A1-20050901-C00001.png) 1977-02-19
FR2392021B1 (US20050192411A1-20050901-C00001.png) 1979-08-17
MY8200159A (en) 1982-12-31
GB1525958A (en) 1978-09-27
HK8782A (en) 1982-03-05
FI65617C (fi) 1984-06-11
FR2331340A1 (fr) 1977-06-10
DK365978A (da) 1978-08-18
AT337697B (de) 1977-07-11
FI752327A (US20050192411A1-20050901-C00001.png) 1977-02-16
FI63756B (fi) 1983-04-29
ATA838075A (de) 1976-11-15
FR2331340B1 (US20050192411A1-20050901-C00001.png) 1979-01-19
CH623582A5 (en) 1981-06-15
CS196289B2 (en) 1980-03-31
NO143222C (no) 1981-01-02
DK140840C (US20050192411A1-20050901-C00001.png) 1980-05-05
JPS6128673B2 (US20050192411A1-20050901-C00001.png) 1986-07-01
HU172653B (hu) 1978-11-28
DE2548340A1 (de) 1977-05-05
DK140840B (da) 1979-11-26
FI63756C (fi) 1983-08-10
SE416649B (sv) 1981-01-26
CS196290B2 (en) 1980-03-31
JPS5262275A (en) 1977-05-23
CH623814A5 (en) 1981-06-30
NO143222B (no) 1980-09-22
CA1055033A (en) 1979-05-22
IE42451B1 (en) 1980-08-13
DE2548340C2 (US20050192411A1-20050901-C00001.png) 1987-12-03
DD122534A5 (US20050192411A1-20050901-C00001.png) 1976-10-12
AT351524B (de) 1979-07-25
FR2392021A1 (fr) 1978-12-22
ZA756600B (en) 1976-09-29
CY1125A (en) 1982-02-19
SE7406513L (sv) 1975-11-17
NO752851L (US20050192411A1-20050901-C00001.png) 1977-02-16
FI811747L (fi) 1981-06-04
FI65617B (fi) 1984-02-29
SU602118A3 (ru) 1978-04-05
ATA752276A (de) 1979-01-15
US4045563A (en) 1977-08-30

Similar Documents

Publication Publication Date Title
NL7513141A (nl) Benzimidazoolderivaten en werkwijze voor het be- reiden daarvan alsmede preparaten voor het bein- vloeden van de maagzuursecretie.
NL7601958A (nl) Werkwijze voor het overbrengen van steriele stof- fen en aansluitorgaan daarvoor.
NL7515129A (nl) Werkwijze voor het bereiden van benzoezuren en derivaten daarvan.
NL7501917A (nl) Farmaceutisch preparaat en heterocyclische verbinding alsmede werkwijze voor het bereiden daarvan.
NL7606288A (nl) Digestief enzympreparaat alsmede werkwijze voor het bereiden daarvan.
BE826260A (nl) Werkwijze voor het bereiden van werkzame cyclohexanolderivaten en van preparaten, die deze bevatten
NL7607159A (nl) Werkwijzen voor de bereiding en toepassing van fenylazijnzuurderivaten.
NL7707152A (nl) Werkwijze voor het bereiden van derivaten van pe- nicillaanzuur.
NL7614047A (nl) Werkwijze en inrichting voor het bereiden van polycondensaten.
NL7700425A (nl) Werkwijze voor de bereiding van preparaten en stoffen tegen maagzuur en maagzweren.
NL7510944A (nl) Werkwijze voor het bereiden van derivaten van indenyl-3-azijnzuur.
NL7606668A (nl) Omega-aminoalkoxybenzeenderivaten en farmaceu- tisch preparaat alsmede werkwijze voor het be- reiden daarvan.
NL7417031A (nl) Werkwijze voor het continu bereiden van loseglycolaat.
NL184111C (nl) Werkwijze voor het bereiden van androstenonen en van farmaceutische preparaten welke deze bevatten.
NL187354C (nl) Werkwijze voor de bereiding van farmaceutische preparaten met prostaglandinewerking en werkwijze voor de bereiding van daarin bruikbare prostaglandinederivaten.
NL7504302A (nl) Prostaglandinederivaat en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan.
NL7608491A (nl) Werkwijze voor het bereiden van geneesmiddelen en farmacologisch actieve verbindingen.
NL7609962A (nl) Werkwijze voor het bereiden van 5-oxohexaanzuur en zijn derivaten.
NL7506625A (nl) Barbituurzuurderivaat en herbicide preparaat alsmede werkwijze voor het bereiden daarvan.
NL7502879A (nl) Aralkylesters van aminozuren en farmaceutisch preparaat alsmede werkwijze voor het bereiden daarvan.
NL7506865A (nl) Werkwijze voor de bereiding van tegen allergieen werkzame preparaten en verbindingen.
NL7607764A (nl) Werkwijze en preparaat voor het verzorgen van wasgoed.
NL7604795A (nl) Werkwijze voor het bereiden van zeer zuiver isobuteen.
NL7611753A (nl) Polypeptide alsmede preparaat voor het beeindigen van zwangerschap.
NL7610915A (nl) Oxanilzuurderivaten alsmede werkwijze voor het bereiden daarvan.

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
BV The patent application has lapsed