NL7510505A - Tetracyclische verbindingen. - Google Patents

Tetracyclische verbindingen.

Info

Publication number
NL7510505A
NL7510505A NL7510505A NL7510505A NL7510505A NL 7510505 A NL7510505 A NL 7510505A NL 7510505 A NL7510505 A NL 7510505A NL 7510505 A NL7510505 A NL 7510505A NL 7510505 A NL7510505 A NL 7510505A
Authority
NL
Netherlands
Prior art keywords
tetracyclical
connections
tetracyclical connections
Prior art date
Application number
NL7510505A
Other languages
English (en)
Dutch (nl)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NL7510505A publication Critical patent/NL7510505A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/18Ring systems of four or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
NL7510505A 1974-09-06 1975-09-05 Tetracyclische verbindingen. NL7510505A (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2442829A DE2442829A1 (de) 1974-09-06 1974-09-06 Tetracyclische verbindungen und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
NL7510505A true NL7510505A (nl) 1976-03-09

Family

ID=5925100

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7510505A NL7510505A (nl) 1974-09-06 1975-09-05 Tetracyclische verbindingen.

Country Status (21)

Country Link
US (1) US4024272A (forum.php)
JP (1) JPS5154564A (forum.php)
AT (1) AT344890B (forum.php)
BE (1) BE833048A (forum.php)
CA (1) CA1068285A (forum.php)
CS (1) CS191275B2 (forum.php)
DD (1) DD121637A5 (forum.php)
DE (1) DE2442829A1 (forum.php)
DK (1) DK397875A (forum.php)
ES (1) ES440765A1 (forum.php)
FR (1) FR2283690A1 (forum.php)
GB (1) GB1467206A (forum.php)
HU (2) HU173491B (forum.php)
IE (1) IE41675B1 (forum.php)
IL (1) IL48044A (forum.php)
IT (1) IT7948216A0 (forum.php)
LU (1) LU73332A1 (forum.php)
NL (1) NL7510505A (forum.php)
PL (1) PL96677B1 (forum.php)
SE (1) SE7509880L (forum.php)
ZA (1) ZA755699B (forum.php)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2746044C2 (de) * 1977-10-13 1979-09-06 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur Herstellung von e-Thiatetracyclinracematen mit natürlicher Konfiguration und ihren optischen Antipoden
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4672138A (en) * 1980-10-20 1987-06-09 Hoechst Roussel Pharmaceuticals Inc. Phenyl substituted carbamothioic acid esters
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0416564A3 (en) * 1989-09-05 1992-03-11 Kao Corporation Novel aroyl ketone derivative, uv ray absorber comprising the same, and cosmetic composition containing the same
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
FR2795722A1 (fr) * 1999-07-02 2001-01-05 Rhodia Chimie Sa Procede de preparation d'une arylhydrazine hydroxylee, produits intermediaires et leur procede d'obtention
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
IL148482A0 (en) 1999-09-14 2002-09-12 Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6833365B2 (en) 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
ES2288945T3 (es) * 2000-03-31 2008-02-01 Trustees Of Tufts College Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos.
WO2001087824A2 (en) * 2000-05-15 2001-11-22 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
EP2204361B1 (en) 2000-07-07 2011-09-28 Trustees Of Tufts College 13-substituted methacycline compounds
CZ303702B6 (cs) 2000-07-07 2013-03-20 Trustees Of Tufts College Minocyklinové slouceniny
DE60144375D1 (de) 2000-07-07 2011-05-19 Trustees Of Tufts College Medford 7-, 8- und 9-substitutierte tetracyclinverbindungen
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR100997596B1 (ko) 2000-07-07 2010-11-30 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP2301913A1 (en) 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
WO2002072022A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
DE60235083D1 (de) 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP1474380A4 (en) 2002-01-08 2007-04-18 Paratek Pharm Innc 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS
US6730697B2 (en) * 2002-02-07 2004-05-04 Aventis Pharma Deutschland Gmbh Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid
EP2316450A1 (en) 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
AU2003218243B2 (en) 2002-03-21 2010-04-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CN1700922A (zh) * 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
EP2277504A1 (en) 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20050137174A1 (en) 2003-07-09 2005-06-23 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EA200600221A1 (ru) 2003-07-09 2006-06-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
EP1716101A1 (en) 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2284156A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2005299294B2 (en) * 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
EP1910273A2 (en) * 2005-07-21 2008-04-16 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
WO2007087416A2 (en) * 2006-01-24 2007-08-02 Paratek Pharaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
WO2007127292A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Tigeycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
CA2652346A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2251320A1 (en) * 2006-11-29 2010-11-17 Teva Pharmaceutical Industries Ltd. Crystalline form of tigecycline and processes for preparation thereof
WO2008066908A1 (en) * 2006-11-30 2008-06-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
ES2463457T3 (es) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
PL2120963T3 (pl) 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
EP2144614A1 (en) * 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
EP2144870A2 (en) 2007-04-27 2010-01-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
ATE555079T1 (de) 2007-07-06 2012-05-15 Paratek Pharm Innc Verfahren zur synthese von 9-substituiertem minocyclin
BRPI0908951A2 (pt) 2008-03-05 2017-01-17 Paratek Pharm Innc compostos de minociclina e método de uso dos mesmos
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TW202021946A (zh) 2008-05-19 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
EA201170425A1 (ru) * 2008-09-19 2011-10-31 Паратек Фармасьютикалс, Инк. Тетрациклиновые соединения для лечения ревматоидного артрита и связанные с ними способы лечения
DE202010018378U1 (de) 2009-04-10 2016-04-07 Tufts Medical Center, Inc. PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1)
CN107021887A (zh) 2009-05-08 2017-08-08 四相制药公司 四环素类化合物
EP3574908B8 (en) 2011-05-12 2024-09-11 Almirall LLC Pharmaceutical composition for oral administration comprising crystalline salts of (4s, 4as, 5ar, 12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2carboxylic acid amide
EA031523B1 (ru) 2012-08-31 2019-01-31 Тетрафейз Фармасьютикалс, Инк. Тетрациклиновые соединения
JP6269300B2 (ja) * 2014-05-01 2018-01-31 国立大学法人大阪大学 スルホキシドの脱酸素用触媒、及び該脱酸素用触媒を用いたスルフィドの製造方法
SI3529236T1 (sl) 2016-10-19 2024-08-30 Tetraphase Pharmaceuticals, Inc. Kristalinične oblike eravaciklina
EP3534908B1 (en) 2016-11-01 2025-07-09 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
US20200222432A1 (en) 2017-07-21 2020-07-16 Almirall, Llc. Treatment of non-inflammatory lesions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PL96677B1 (pl) 1978-01-31
IE41675L (en) 1976-03-06
FR2283690A1 (fr) 1976-04-02
AT344890B (de) 1978-08-10
GB1467206A (en) 1977-03-16
HU176136B (en) 1980-12-28
DD121637A5 (forum.php) 1976-08-12
ZA755699B (en) 1976-08-25
US4024272A (en) 1977-05-17
JPS5154564A (forum.php) 1976-05-13
DE2442829A1 (de) 1976-03-18
IT7948216A0 (it) 1979-03-05
CS191275B2 (en) 1979-06-29
BE833048A (nl) 1976-03-03
LU73332A1 (forum.php) 1976-04-13
AU8459975A (en) 1977-03-10
ES440765A1 (es) 1977-06-16
HU173491B (hu) 1979-05-28
DK397875A (da) 1976-03-07
ATA689275A (de) 1977-12-15
IL48044A0 (en) 1975-11-25
IL48044A (en) 1978-12-17
IE41675B1 (en) 1980-02-27
FR2283690B1 (forum.php) 1980-03-28
SE7509880L (sv) 1976-03-08
CA1068285A (en) 1979-12-18

Similar Documents

Publication Publication Date Title
NL7510505A (nl) Tetracyclische verbindingen.
NO144731C (no) Roerdeformeringsklemme.
SE7507441L (sv) Metapparat.
NL7512409A (nl) Vraag-hartgangmaker.
NL7416177A (nl) Hartpacer.
SE7504531L (sv) Glasogonbage.
NL7510886A (nl) Thiofeensaccharinen.
SE7503927L (sv) Halupptagande festorgan.
DK135492B (da) Lastpalle.
NL7502168A (nl) Dieselheiblok.
NO139206C (no) Havgaaende katamaran.
NL7413741A (nl) Gammakamera.
SE7507132L (sv) Hogtalargaller.
NL7500282A (nl) Wanmolen.
SE412093B (sv) Brensleinsugningssystem.
BE809593A (fr) Groupe-moteur-autopropulseur.
SE7506699L (sv) Taxameterhus.
NL7505400A (nl) Bicyclische verbindingen.
DK137669B (da) Piberiver.
BE814204A (nl) Werkkledij.
DK136503B (da) Termokopieringsmaskine.
SE7505438L (sv) Vegvelt.
SE7505226L (sv) Takarmatur.
NL7503137A (nl) Tricyclische verbindingen.
ES208642Y (es) Conjunto cartera-folleto.

Legal Events

Date Code Title Description
BV The patent application has lapsed