NL193541C - 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten. - Google Patents

8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten. Download PDF

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Publication number
NL193541C
NL193541C NL8500008A NL8500008A NL193541C NL 193541 C NL193541 C NL 193541C NL 8500008 A NL8500008 A NL 8500008A NL 8500008 A NL8500008 A NL 8500008A NL 193541 C NL193541 C NL 193541C
Authority
NL
Netherlands
Prior art keywords
formula
methyl
compounds
base
acid
Prior art date
Application number
NL8500008A
Other languages
English (en)
Dutch (nl)
Other versions
NL8500008A (nl
NL193541B (nl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NL8500008A publication Critical patent/NL8500008A/nl
Publication of NL193541B publication Critical patent/NL193541B/xx
Application granted granted Critical
Publication of NL193541C publication Critical patent/NL193541C/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
NL8500008A 1984-01-12 1985-01-03 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten. NL193541C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3400853 1984-01-12
DE3400853 1984-01-12

Publications (3)

Publication Number Publication Date
NL8500008A NL8500008A (nl) 1985-08-01
NL193541B NL193541B (nl) 1999-09-01
NL193541C true NL193541C (nl) 2000-01-04

Family

ID=6224786

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8500008A NL193541C (nl) 1984-01-12 1985-01-03 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.

Country Status (28)

Country Link
US (2) US4950672A (it)
JP (1) JPH0655739B2 (it)
AT (1) AT391317B (it)
AU (3) AU583489B2 (it)
BE (1) BE901456A (it)
CA (1) CA1245640A (it)
CH (1) CH664568A5 (it)
CY (1) CY1542A (it)
DE (1) DE3500251C2 (it)
DK (1) DK169891B1 (it)
ES (1) ES8605514A1 (it)
FI (1) FI82466C (it)
FR (1) FR2560196B1 (it)
GB (1) GB2152507B (it)
GR (1) GR850065B (it)
HK (1) HK48590A (it)
HU (1) HU197569B (it)
IE (1) IE58228B1 (it)
IL (1) IL74043A (it)
IT (1) IT1214648B (it)
LU (1) LU85725A1 (it)
NL (1) NL193541C (it)
NZ (1) NZ210818A (it)
PH (1) PH23286A (it)
PT (1) PT79818B (it)
SE (1) SE460420B (it)
SG (1) SG32390G (it)
ZA (1) ZA85276B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH664568A5 (de) * 1984-01-12 1988-03-15 Sandoz Ag 8-alpha-acylaminoergoline.
EP0160842B1 (de) * 1984-04-09 1994-06-22 Schering Aktiengesellschaft 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NL8700046A (nl) * 1986-01-24 1987-08-17 Sandoz Ag 8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) * 1987-06-15 1991-01-01 Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
DE3820159A1 (de) * 1987-06-23 1989-01-05 Sandoz Ag 8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
JP2018502889A (ja) 2015-01-20 2018-02-01 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ イソエルゴリン化合物およびその使用
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
BR112019025420A2 (pt) 2017-06-01 2020-06-16 Xoc Pharmaceuticals, Inc. Compostos policíclicos e usos destes

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
CH664568A5 (de) * 1984-01-12 1988-03-15 Sandoz Ag 8-alpha-acylaminoergoline.
NL8503426A (nl) * 1984-12-24 1986-07-16 Sandoz Ag 8alfa-acylamino-ergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
IT1219652B (it) * 1987-06-23 1990-05-24 Sandoz Ag 8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

Also Published As

Publication number Publication date
LU85725A1 (fr) 1985-10-22
ES8605514A1 (es) 1986-03-16
IL74043A (en) 1988-10-31
FI850130A0 (fi) 1985-01-11
DK12685D0 (da) 1985-01-10
ZA85276B (en) 1986-08-27
NL8500008A (nl) 1985-08-01
DK12685A (da) 1985-07-13
DE3500251A1 (de) 1985-07-18
GB8500454D0 (en) 1985-02-13
BE901456A (fr) 1985-07-08
NL193541B (nl) 1999-09-01
IL74043A0 (en) 1985-04-30
FI82466C (fi) 1991-03-11
IT1214648B (it) 1990-01-18
SE460420B (sv) 1989-10-09
CY1542A (en) 1991-03-22
US4950672A (en) 1990-08-21
DK169891B1 (da) 1995-03-27
CA1245640A (en) 1988-11-29
AU2506788A (en) 1989-03-02
FI82466B (fi) 1990-11-30
AU3760985A (en) 1985-07-18
PT79818A (en) 1985-02-01
AU609539B2 (en) 1991-05-02
HU197569B (en) 1989-04-28
AT391317B (de) 1990-09-25
SG32390G (en) 1990-08-03
DE3500251C2 (de) 1995-01-26
HUT37148A (en) 1985-11-28
PT79818B (en) 1987-01-07
AU583489B2 (en) 1989-05-04
JPH0655739B2 (ja) 1994-07-27
IE58228B1 (en) 1993-08-11
ES539511A0 (es) 1986-03-16
NZ210818A (en) 1989-02-24
IT8547538A0 (it) 1985-01-11
SE8500107D0 (sv) 1985-01-10
ATA5985A (de) 1990-03-15
GR850065B (it) 1985-05-03
GB2152507A (en) 1985-08-07
AU618290B2 (en) 1991-12-19
US5077298A (en) 1991-12-31
PH23286A (en) 1989-06-30
GB2152507B (en) 1987-07-15
JPS60174783A (ja) 1985-09-09
SE8500107L (sv) 1985-07-13
FR2560196A1 (fr) 1985-08-30
AU2506688A (en) 1989-02-23
CH664568A5 (de) 1988-03-15
HK48590A (en) 1990-06-29
FI850130L (fi) 1985-07-13
FR2560196B1 (fr) 1986-07-18
IE850064L (en) 1985-07-12

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BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

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V1 Lapsed because of non-payment of the annual fee

Effective date: 20000801