NL175814C - Werkwijze voor de bereiding van een radiologisch preparaat en voor de bereiding van een daarin te gebruiken trijoodisoftaalamide. - Google Patents

Werkwijze voor de bereiding van een radiologisch preparaat en voor de bereiding van een daarin te gebruiken trijoodisoftaalamide.

Info

Publication number
NL175814C
NL175814C NLAANVRAGE7706385,A NL7706385A NL175814C NL 175814 C NL175814 C NL 175814C NL 7706385 A NL7706385 A NL 7706385A NL 175814 C NL175814 C NL 175814C
Authority
NL
Netherlands
Prior art keywords
preparation
trijoodisophalamide
radiological
radiological preparation
Prior art date
Application number
NLAANVRAGE7706385,A
Other languages
English (en)
Dutch (nl)
Other versions
NL7706385A (nl
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of NL7706385A publication Critical patent/NL7706385A/xx
Application granted granted Critical
Publication of NL175814C publication Critical patent/NL175814C/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NLAANVRAGE7706385,A 1976-06-11 1977-06-10 Werkwijze voor de bereiding van een radiologisch preparaat en voor de bereiding van een daarin te gebruiken trijoodisoftaalamide. NL175814C (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24338/76A GB1548594A (en) 1976-06-11 1976-06-11 Triiodoisophthalic acid amides

Publications (2)

Publication Number Publication Date
NL7706385A NL7706385A (nl) 1977-12-13
NL175814C true NL175814C (nl) 1985-01-02

Family

ID=10210154

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7706385,A NL175814C (nl) 1976-06-11 1977-06-10 Werkwijze voor de bereiding van een radiologisch preparaat en voor de bereiding van een daarin te gebruiken trijoodisoftaalamide.

Country Status (11)

Country Link
US (1) US4250113A (en18)
JP (1) JPS5321137A (en18)
BE (1) BE855580A (en18)
CH (1) CH630064A5 (en18)
DE (1) DE2726196C2 (en18)
DK (1) DK150504C (en18)
FR (1) FR2354316A1 (en18)
GB (1) GB1548594A (en18)
HK (1) HK56683A (en18)
NL (1) NL175814C (en18)
SE (1) SE441181B (en18)

Families Citing this family (102)

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DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
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CN102249948B (zh) * 2011-05-23 2014-01-29 苏州昊帆生物科技有限公司 5-乙酰氨基-n,n’-双-(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺的合成方法
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WO2015082720A1 (en) 2013-12-06 2015-06-11 Ge Healthcare As Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
EP3077366B1 (en) * 2013-12-06 2017-08-09 GE Healthcare AS Alternative acetylation process in the synthesis of non-ionic xray contrast agents
WO2015082718A1 (en) * 2013-12-06 2015-06-11 Ge Healthcare As Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
RU2711501C2 (ru) 2014-03-04 2020-01-17 Оцука Фармасьютикал Ко., Лтд. Порошок йогексола и способ его применения
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
RU2655619C1 (ru) * 2017-06-13 2018-05-29 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе йогексола
CN107857714B (zh) * 2017-11-29 2020-11-13 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途
CN108191690A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 碘海醇节能环保的连续化制备方法
CN108191689A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 一种新型碘海醇节能环保的连续化制备方法
EP4001261A1 (en) 2020-11-23 2022-05-25 Justesa Imagen S.A.U Procedure for obtaining high purity iohexol

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GB1321591A (en) 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
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BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
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Also Published As

Publication number Publication date
US4250113A (en) 1981-02-10
JPS5654310B2 (en18) 1981-12-24
DK150504C (da) 1988-01-11
FR2354316B1 (en18) 1982-11-12
SE7706792L (sv) 1977-12-12
GB1548594A (en) 1979-07-18
DE2726196A1 (de) 1977-12-22
SE441181B (sv) 1985-09-16
DE2726196C2 (de) 1983-12-29
BE855580A (fr) 1977-12-12
CH630064A5 (de) 1982-05-28
FR2354316A1 (fr) 1978-01-06
DK150504B (da) 1987-03-16
JPS5321137A (en) 1978-02-27
HK56683A (en) 1983-11-25
NL7706385A (nl) 1977-12-13
DK258477A (da) 1977-12-12

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