NL1008302C2 - Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. - Google Patents

Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. Download PDF

Info

Publication number
NL1008302C2
NL1008302C2 NL1008302A NL1008302A NL1008302C2 NL 1008302 C2 NL1008302 C2 NL 1008302C2 NL 1008302 A NL1008302 A NL 1008302A NL 1008302 A NL1008302 A NL 1008302A NL 1008302 C2 NL1008302 C2 NL 1008302C2
Authority
NL
Netherlands
Prior art keywords
indoline
carboxylic acid
acid
derivative
acyl
Prior art date
Application number
NL1008302A
Other languages
English (en)
Dutch (nl)
Inventor
Thijs Kuilman
Andreas Joseph Johan Hendrickx
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL1008302A priority Critical patent/NL1008302C2/nl
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to AT99200383T priority patent/ATE278668T1/de
Priority to IL12846299A priority patent/IL128462A/xx
Priority to EP99200383A priority patent/EP0937714B1/de
Priority to PT99200383T priority patent/PT937714E/pt
Priority to DK99200383T priority patent/DK0937714T3/da
Priority to ES99200383T priority patent/ES2230794T3/es
Priority to DE69920784T priority patent/DE69920784T2/de
Priority to CA002261453A priority patent/CA2261453C/en
Priority to HU9900344A priority patent/HU222432B1/hu
Priority to IN179MA1999 priority patent/IN188422B/en
Priority to US09/249,025 priority patent/US6121460A/en
Priority to CNB991018923A priority patent/CN100383119C/zh
Priority to JP11036063A priority patent/JPH11292844A/ja
Application granted granted Critical
Publication of NL1008302C2 publication Critical patent/NL1008302C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL1008302A 1998-02-13 1998-02-13 Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. NL1008302C2 (nl)

Priority Applications (14)

Application Number Priority Date Filing Date Title
NL1008302A NL1008302C2 (nl) 1998-02-13 1998-02-13 Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
DE69920784T DE69920784T2 (de) 1998-02-13 1999-02-10 Verfahren zur Herstellung von optisch aktiver Indolin-2-carbon-säurens oder eines Derivats
EP99200383A EP0937714B1 (de) 1998-02-13 1999-02-10 Verfahren zur Herstellung von optisch aktives Indolin-2-carbonsäures oder eines Derivates
PT99200383T PT937714E (pt) 1998-02-13 1999-02-10 Processo para a preparacao de um acido indolina-2-carboxilico opticamente activo ou um seu derivado
DK99200383T DK0937714T3 (da) 1998-02-13 1999-02-10 Fremgangsmåde til fremstilling af en optisk aktiv indolin-2-carboxylsyre eller et derivat deraf
ES99200383T ES2230794T3 (es) 1998-02-13 1999-02-10 Proceso para la preparacion de un acido indolin-2-carboxilico opticamente activo o un derivado suyo.
AT99200383T ATE278668T1 (de) 1998-02-13 1999-02-10 Verfahren zur herstellung von optisch aktives indolin-2-carbonsäures oder eines derivates
IL12846299A IL128462A (en) 1998-02-13 1999-02-10 Process for the preparation of an optically active n-acyl-indoline-2-carboxylic acid or derivative thereof
CA002261453A CA2261453C (en) 1998-02-13 1999-02-11 Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof
HU9900344A HU222432B1 (hu) 1998-02-13 1999-02-12 Eljárás optikailag aktív indolin-2-karbonsavnak vagy származékának előállítására
IN179MA1999 IN188422B (de) 1998-02-13 1999-02-12
US09/249,025 US6121460A (en) 1998-02-13 1999-02-12 Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof
CNB991018923A CN100383119C (zh) 1998-02-13 1999-02-12 旋光二氢吲哚－2－羧酸或其衍生物的制备方法
JP11036063A JPH11292844A (ja) 1998-02-13 1999-02-15 光学的に活性なインドリン―２―カルボン酸またはその誘導体の製造法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1008302 1998-02-13
NL1008302A NL1008302C2 (nl) 1998-02-13 1998-02-13 Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.

Publications (1)

Publication Number Publication Date
NL1008302C2 true NL1008302C2 (nl) 1999-08-16

Family

ID=19766536

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1008302A NL1008302C2 (nl) 1998-02-13 1998-02-13 Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.

Country Status (14)

Country Link
US (1) US6121460A (de)
EP (1) EP0937714B1 (de)
JP (1) JPH11292844A (de)
CN (1) CN100383119C (de)
AT (1) ATE278668T1 (de)
CA (1) CA2261453C (de)
DE (1) DE69920784T2 (de)
DK (1) DK0937714T3 (de)
ES (1) ES2230794T3 (de)
HU (1) HU222432B1 (de)
IL (1) IL128462A (de)
IN (1) IN188422B (de)
NL (1) NL1008302C2 (de)
PT (1) PT937714E (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001266678A1 (en) * 2000-06-02 2001-12-17 Eli Lilly And Company Methods for resolving chiral (2s) and (2r) chromanes
DE60301980T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril
ES2249691T3 (es) * 2003-02-28 2006-04-01 Les Laboratoires Servier Procedimiento de sintesis de derivados del acido (2s,3as,7as)-1-(s)-alanil)-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindopril.
KR100710539B1 (ko) 2003-11-26 2007-04-24 에스케이 주식회사 가수분해 효소를 이용한 (ｓ)-인돌린-2-카르복실산 및이의 메틸 에스테르 화합물의 제조방법
WO2006069799A1 (en) * 2004-12-28 2006-07-06 Dsm Ip Assets B.V. Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid
EP1676838A1 (de) * 2004-12-28 2006-07-05 DSM IP Assets B.V. Verfahren zur Herstellung von Enantiomeren-angereicherter Indol-2-Carbonsäure
EP1792896A1 (de) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur Herstellung von Perindopril und deren Salze
JP5093248B2 (ja) * 2008-02-06 2012-12-12 三菱瓦斯化学株式会社 光学活性インドリン−２−カルボン酸類またはその誘導体の製造方法
CN102060745A (zh) * 2010-11-23 2011-05-18 安徽世华化工有限公司 一种(s)-吲哚啉-2-羧酸的制备方法
CN106631977A (zh) * 2016-11-11 2017-05-10 上海雅本化学有限公司 一种s‑吲哚啉‑2‑羧酸合成的优化方法
CN112375028A (zh) * 2020-12-14 2021-02-19 安徽美诺华药物化学有限公司 合成（2s）-二氢吲哚-甲酸的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520205A (en) * 1982-06-28 1985-05-28 American Home Products Corporation Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid
EP0171616A1 (de) * 1984-07-13 1986-02-19 Toray Industries, Inc. Verwendung von alpha-amino-epsilon-caprolactam für die optische Spaltung von N-acetylindolin-2-Karbonsäure und Verfahren zur Herstellung von optisch aktiver N-acetylindolin-2-Karbonsäure
US4665087A (en) * 1982-02-22 1987-05-12 Ciba-Geigy Corporation 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
JPH06130572A (ja) * 1992-10-22 1994-05-13 Konica Corp ハロゲン化銀写真感光材料処理用錠剤状定着剤及び該定着剤を用いた処理方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6130572A (ja) * 1984-07-20 1986-02-12 Dainippon Pharmaceut Co Ltd （ｒｓ）−１−アセチルインドリン−２−カルボン酸の光学分割法
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
US5149821A (en) * 1990-10-11 1992-09-22 Pfizer Inc Process and intermediates for optically active 3-formyltetrahydropyrans

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665087A (en) * 1982-02-22 1987-05-12 Ciba-Geigy Corporation 1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
US4520205A (en) * 1982-06-28 1985-05-28 American Home Products Corporation Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid
EP0171616A1 (de) * 1984-07-13 1986-02-19 Toray Industries, Inc. Verwendung von alpha-amino-epsilon-caprolactam für die optische Spaltung von N-acetylindolin-2-Karbonsäure und Verfahren zur Herstellung von optisch aktiver N-acetylindolin-2-Karbonsäure
JPH06130572A (ja) * 1992-10-22 1994-05-13 Konica Corp ハロゲン化銀写真感光材料処理用錠剤状定着剤及び該定着剤を用いた処理方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 105, no. 7, 18 August 1986, Columbus, Ohio, US; abstract no. 60525w, TSUKAMOTO,MASATOSHI ET AL.: "Optical resolution of (RS)-1-acetyl-2-carboxylic acid" XP002079597 *

Also Published As

Publication number Publication date
IL128462A0 (en) 2000-01-31
HU9900344D0 (en) 1999-04-28
HU222432B1 (hu) 2003-07-28
ES2230794T3 (es) 2005-05-01
EP0937714A1 (de) 1999-08-25
US6121460A (en) 2000-09-19
CA2261453A1 (en) 1999-08-13
CN1228423A (zh) 1999-09-15
DE69920784T2 (de) 2005-11-03
HUP9900344A3 (en) 2000-03-28
IL128462A (en) 2003-07-31
HUP9900344A2 (hu) 1999-10-28
DE69920784D1 (de) 2004-11-11
ATE278668T1 (de) 2004-10-15
CA2261453C (en) 2009-05-12
DK0937714T3 (da) 2005-02-07
IN188422B (de) 2002-09-21
EP0937714B1 (de) 2004-10-06
JPH11292844A (ja) 1999-10-26
CN100383119C (zh) 2008-04-23
PT937714E (pt) 2005-02-28

Similar Documents

Publication Publication Date Title
NL1008302C2 (nl) Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
NL193694C (nl) 5 Gesubstitueerde 3-(aminoalkyl)-1H-indoolderivaten met werking tegen migraine en farmaceutisch preparaat daarvan.
US7781598B2 (en) Process for the preparation of substituted indoles
KR100421073B1 (ko) 치환된퍼히드로이소인돌의제조방법
Inokuma et al. Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides
US4005088A (en) Process for the chemical separation of racemic modifications of α-aminocarboxylic acid derivatives, and cinchonidine salt intermediates
EP0164389B1 (de) Herstellung von phenylalaninen durch hydrierung von phenylserinen
CA2767132C (en) Intermediates and processes for the preparation of 4-(acetylamino))-3-[(4-chloro-phenyl)thio]-2-methyl-1h-indole-1-acetic acid
FI75805B (fi) Foerfarande och mellanprodukt foer framstaellning av 7-acyl-indolin-2-oner.
US10323040B2 (en) Process for the preparation of 5-fluorotryptophol
US6258956B1 (en) Synthesis of 3-amino-3-aryl propanoates
JPH0557265B2 (de)
US3804821A (en) Method for the direct acylation of aminobenzoic acids
KR20090007610A (ko) Ａｃｅ-억제제의 합성에서의 약학적 중간체 및 이의 용도
US5811572A (en) Process for the preparation of N-carboxymethyleneanthranilic acid
NL9101582A (nl) Werkwijze voor bereiding van 1-(2s)-3-mercapto-methyl-1-oxo-propyl-l-proline.
KR100192123B1 (ko) 비사이클릭아민의 신규한 제조방법
FR2489824A1 (fr) Procede pour la preparation d'esters d'acide apovincaminique et produits ainsi obtenus
JP2007204460A (ja) インドールカルボン酸エステル類の製造方法
JP2002053552A (ja) ４，６−ジメチルインドール及びその誘導体の製造方法

Legal Events

Date Code Title Description
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20020901