NL1003284C2 - Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. - Google Patents
Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. Download PDFInfo
- Publication number
- NL1003284C2 NL1003284C2 NL1003284A NL1003284A NL1003284C2 NL 1003284 C2 NL1003284 C2 NL 1003284C2 NL 1003284 A NL1003284 A NL 1003284A NL 1003284 A NL1003284 A NL 1003284A NL 1003284 C2 NL1003284 C2 NL 1003284C2
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- Netherlands
- Prior art keywords
- polypeptide
- amino acid
- electrotransport
- helix
- analog
- Prior art date
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- HOWHQWFXSLOJEF-MGZLOUMQSA-N systemin Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)CCC1 HOWHQWFXSLOJEF-MGZLOUMQSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46827595 | 1995-06-06 | ||
| US08/468,275 US5747453A (en) | 1995-06-06 | 1995-06-06 | Method for increasing the electrotransport flux of polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL1003284A1 NL1003284A1 (nl) | 1996-12-09 |
| NL1003284C2 true NL1003284C2 (nl) | 1997-03-20 |
Family
ID=23859150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1003284A NL1003284C2 (nl) | 1995-06-06 | 1996-06-06 | Werkwijze voor het vergroten van de elektrotransport-flux van polypeptiden. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5747453A (fr) |
| JP (1) | JPH11507634A (fr) |
| AU (1) | AU6264296A (fr) |
| BE (1) | BE1009752A5 (fr) |
| BR (1) | BR9609148A (fr) |
| CA (1) | CA2220060A1 (fr) |
| DE (1) | DE19681438B4 (fr) |
| FR (1) | FR2735133B1 (fr) |
| GB (1) | GB2316083B (fr) |
| IE (1) | IE960414A1 (fr) |
| IT (1) | IT1285404B1 (fr) |
| NL (1) | NL1003284C2 (fr) |
| WO (1) | WO1996039423A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333189B1 (en) | 1996-06-06 | 2001-12-25 | Alza Corporation | Method of making an electrotransport device |
| EP0922467A3 (fr) * | 1997-12-12 | 2000-05-24 | Takeda Chemical Industries, Ltd. | Administration de médicaments par ionophorèse |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8465425B2 (en) * | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) * | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) * | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| EP1572720A4 (fr) * | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Procede de production enzymatique de peptides glp-2 (1-34) et glp-2 (1-33) |
| AU2003239895C1 (en) * | 2002-05-24 | 2010-01-07 | Medtronic, Inc. | Methods and DNA constructs for high yield production of polypeptides |
| CA2485837A1 (fr) * | 2002-05-24 | 2003-12-04 | Yuannan Xia | Procedes et produits de recombinaison d'adn pour production a haut rendement de polypeptides |
| PL1704234T3 (pl) * | 2003-11-21 | 2012-06-29 | Nps Pharma Inc | Wytwarzanie glukagonopodobnego peptydu 2 i analogów |
| PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
| JP2009522288A (ja) * | 2005-12-28 | 2009-06-11 | アルザ コーポレイション | 安定な治療剤形 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3703321A1 (de) * | 1986-09-01 | 1988-03-10 | Transcutan Gmbh | Therapievorrichtung zur anwendung von elektrischem strom |
| WO1993025197A1 (fr) * | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions et procedes destines a ameliorer la liberation et l'acheminement de medicaments |
| EP0643981A1 (fr) * | 1993-09-22 | 1995-03-22 | Takeda Chemical Industries, Ltd. | Electrode concrétée pour iontophorèse |
| WO1995011988A1 (fr) * | 1993-10-25 | 1995-05-04 | Affymax Technologies N.V. | Composes a activite de parathormone et vecteurs d'adn recombine les codant |
| EP0667355A1 (fr) * | 1994-02-10 | 1995-08-16 | Hoechst Aktiengesellschaft | Dérivé de l'hirudine et leur méthode de fabrication |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250878A (en) * | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
| US4382529A (en) * | 1980-12-15 | 1983-05-10 | Drdlik Frank J | Sanitary dispensing closure |
| CA1231306A (fr) * | 1983-03-03 | 1988-01-12 | Erich Hochuli | Epuration de l'interferon |
| US4631211A (en) * | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
| AU609769B2 (en) * | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| AU639245B2 (en) * | 1989-07-10 | 1993-07-22 | Pharmacia & Upjohn Company | Somatotropin analogs |
| US5516512A (en) * | 1989-08-14 | 1996-05-14 | Gist-Brocades, N.V. | N- and C-terminal truncation and deletion mutants of human interleukin-3 |
| US5240913A (en) * | 1989-08-18 | 1993-08-31 | Biogen, Inc. | Inhibitors of thrombin |
| EP0429842B1 (fr) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide |
| NZ237202A (en) * | 1990-02-23 | 1994-01-26 | Bristol Myers Squibb Co | Composition containing beta-lactam antibiotic and cationic oligopeptide |
| USH1160H (en) * | 1990-11-26 | 1993-04-06 | Iontophoretic delivery of peptides | |
| DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| CA2087087C (fr) * | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules pour administration par ionophorese |
| US5312326A (en) * | 1992-06-02 | 1994-05-17 | Alza Corporation | Iontophoretic drug delivery apparatus |
| KR0154880B1 (ko) * | 1992-06-15 | 1998-10-15 | 피터 알.셰어러 | 글루카곤-유사 펩티드 및 인슐리노트로핀 유도체 |
| US5387189A (en) * | 1993-12-02 | 1995-02-07 | Alza Corporation | Electrotransport delivery device and method of making same |
-
1995
- 1995-06-06 US US08/468,275 patent/US5747453A/en not_active Expired - Lifetime
-
1996
- 1996-06-05 IE IE960414A patent/IE960414A1/en not_active IP Right Cessation
- 1996-06-05 IT IT96TO000495A patent/IT1285404B1/it active IP Right Grant
- 1996-06-06 BE BE9600518A patent/BE1009752A5/fr not_active IP Right Cessation
- 1996-06-06 DE DE19681438T patent/DE19681438B4/de not_active Expired - Fee Related
- 1996-06-06 WO PCT/US1996/009647 patent/WO1996039423A2/fr active Application Filing
- 1996-06-06 FR FR9607003A patent/FR2735133B1/fr not_active Expired - Fee Related
- 1996-06-06 JP JP9501922A patent/JPH11507634A/ja active Pending
- 1996-06-06 GB GB9725980A patent/GB2316083B/en not_active Expired - Fee Related
- 1996-06-06 BR BR9609148A patent/BR9609148A/pt not_active Application Discontinuation
- 1996-06-06 NL NL1003284A patent/NL1003284C2/nl not_active IP Right Cessation
- 1996-06-06 CA CA002220060A patent/CA2220060A1/fr not_active Abandoned
- 1996-06-06 AU AU62642/96A patent/AU6264296A/en not_active Abandoned
-
1998
- 1998-01-15 US US09/007,466 patent/US6313092B1/en not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3703321A1 (de) * | 1986-09-01 | 1988-03-10 | Transcutan Gmbh | Therapievorrichtung zur anwendung von elektrischem strom |
| WO1993025197A1 (fr) * | 1992-06-12 | 1993-12-23 | Affymax Technologies N.V. | Compositions et procedes destines a ameliorer la liberation et l'acheminement de medicaments |
| EP0643981A1 (fr) * | 1993-09-22 | 1995-03-22 | Takeda Chemical Industries, Ltd. | Electrode concrétée pour iontophorèse |
| WO1995011988A1 (fr) * | 1993-10-25 | 1995-05-04 | Affymax Technologies N.V. | Composes a activite de parathormone et vecteurs d'adn recombine les codant |
| EP0667355A1 (fr) * | 1994-02-10 | 1995-08-16 | Hoechst Aktiengesellschaft | Dérivé de l'hirudine et leur méthode de fabrication |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6264296A (en) | 1996-12-24 |
| US6313092B1 (en) | 2001-11-06 |
| BR9609148A (pt) | 1999-02-23 |
| BE1009752A5 (fr) | 1997-07-01 |
| GB9725980D0 (en) | 1998-02-04 |
| GB2316083B (en) | 2000-01-19 |
| WO1996039423A3 (fr) | 1997-01-30 |
| IT1285404B1 (it) | 1998-06-03 |
| WO1996039423A2 (fr) | 1996-12-12 |
| CA2220060A1 (fr) | 1996-12-12 |
| IE960414A1 (en) | 1996-12-11 |
| FR2735133B1 (fr) | 1998-02-13 |
| FR2735133A1 (fr) | 1996-12-13 |
| DE19681438T1 (de) | 1998-07-23 |
| US5747453A (en) | 1998-05-05 |
| GB2316083A (en) | 1998-02-18 |
| JPH11507634A (ja) | 1999-07-06 |
| DE19681438B4 (de) | 2010-02-04 |
| NL1003284A1 (nl) | 1996-12-09 |
| ITTO960495A0 (it) | 1996-06-05 |
| ITTO960495A1 (it) | 1997-12-05 |
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| RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 19970115 |
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| PD2B | A search report has been drawn up | ||
| V1 | Lapsed because of non-payment of the annual fee |
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