MY178905A - Prevention, treatment and diagnosis of p.gingivalis infection - Google Patents

Prevention, treatment and diagnosis of p.gingivalis infection

Info

Publication number
MY178905A
MY178905A MYPI2011000894A MYPI2011000894A MY178905A MY 178905 A MY178905 A MY 178905A MY PI2011000894 A MYPI2011000894 A MY PI2011000894A MY PI2011000894 A MYPI2011000894 A MY PI2011000894A MY 178905 A MY178905 A MY 178905A
Authority
MY
Malaysia
Prior art keywords
prevention
treatment
diagnosis
gingivalis infection
gingivalis
Prior art date
Application number
MYPI2011000894A
Other languages
English (en)
Inventor
Eric Charles Reynolds
Simpson Neil Martin O'brien
Nada Slakeski
Keith J Cross
Original Assignee
Oral Health Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2008904476A external-priority patent/AU2008904476A0/en
Application filed by Oral Health Australia Pty Ltd filed Critical Oral Health Australia Pty Ltd
Publication of MY178905A publication Critical patent/MY178905A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0216Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Gram-negative bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Gram-negative bacteria
    • C07K16/1257Gram-negative bacteria from Bacteridaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56955Bacteria involved in periodontal diseases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21004Trypsin (3.4.21.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y306/00Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/05Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
    • C12Y306/05002Small monomeric GTPase (3.6.5.2)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
MYPI2011000894A 2008-08-29 2009-08-28 Prevention, treatment and diagnosis of p.gingivalis infection MY178905A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2008904476A AU2008904476A0 (en) 2008-08-29 Prevention, treatment and diagnosis of P.gingivalis infection
AU2008905483A AU2008905483A0 (en) 2008-10-23 Prevention, treatment and diagnosis of P.gingivalis infection
US15113209P 2009-02-09 2009-02-09
AU2009903052A AU2009903052A0 (en) 2009-06-30 Prevention, treatment and diagnosis of P.gingivalis infection

Publications (1)

Publication Number Publication Date
MY178905A true MY178905A (en) 2020-10-22

Family

ID=41720713

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2011000894A MY178905A (en) 2008-08-29 2009-08-28 Prevention, treatment and diagnosis of p.gingivalis infection

Country Status (19)

Country Link
US (6) US8871213B2 (enExample)
EP (2) EP3255057B1 (enExample)
JP (2) JP2012500633A (enExample)
KR (1) KR101721904B1 (enExample)
CN (2) CN107266582B (enExample)
AU (1) AU2009287340B2 (enExample)
BR (1) BRPI0917321A2 (enExample)
CA (1) CA2735171C (enExample)
DK (1) DK2328914T3 (enExample)
ES (1) ES2633738T3 (enExample)
IL (1) IL211394B (enExample)
MX (1) MX2011001949A (enExample)
MY (1) MY178905A (enExample)
NZ (2) NZ598834A (enExample)
PL (1) PL2328914T3 (enExample)
RU (1) RU2535898C2 (enExample)
TW (1) TWI473626B (enExample)
WO (1) WO2010022463A1 (enExample)
ZA (1) ZA201101814B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO652897A0 (en) 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
EP2038297A4 (en) 2006-06-27 2010-03-03 Oral Health Australia Pty Ltd PORPHYROMONAS GINGIVALIS POLYPEPTIDES SUITABLE FOR PREVENTION OF PERIODONTITIS
WO2009006699A1 (en) 2007-07-12 2009-01-15 Oral Health Australia Pty Ltd Biofilm treatment
ES2633738T3 (es) * 2008-08-29 2017-09-25 Oral Health Australia Pty Ltd Prevención, tratamiento y diagnóstico de la infección por p. gingivales
US8140041B2 (en) * 2009-08-27 2012-03-20 Mediatek Inc. Tunable capacitive device with linearization technique employed therein
JP6310631B2 (ja) * 2011-10-18 2018-04-11 サンスター株式会社 歯周病原菌血漿または血清抗体価検査キット
US20170247674A1 (en) * 2014-10-14 2017-08-31 The Forsyth Institute Conjugates for delivery to mitochondria
CN110272472B (zh) * 2019-07-18 2020-09-15 河南科技大学 一种抗牙龈卟啉单胞菌及具核酸杆菌多肽及应用
CN111172177B (zh) * 2019-07-30 2023-08-08 镇江市江澜绿洲生物技术有限公司 cra4S1基因及其编码的蛋白和应用
RU2714506C1 (ru) * 2019-10-03 2020-02-18 федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Способ оценки эффективности лечения хронического катарального гингивита у детей
AU2022205389A1 (en) * 2021-01-11 2023-07-13 Keystone Bio, Inc. Antigenic composition(s) and method(s) against porphyromonas gingivalis for the prevention and/or treatment of infection and/or diseases
US20250334585A1 (en) * 2021-07-13 2025-10-30 Keystone Bio, Inc. Diagnostics for porphyromonas gingivalis
CN116474096A (zh) * 2022-01-14 2023-07-25 中山大学附属口腔医院 靶向牙龈卟啉单胞菌RgpB在结直肠癌的治疗及预防中的应用
CA3248847A1 (en) * 2022-01-20 2023-07-27 Denteric Pty Ltd CHIMERA POLYPEPTIDES
AU2023209364A1 (en) * 2022-01-20 2024-08-01 Denteric Pty Ltd Chimeric polypeptides
CN118946367A (zh) * 2022-01-20 2024-11-12 丹特瑞克有限公司 嵌合多肽
CN121889496A (zh) * 2023-07-19 2026-04-17 赛诺菲 牙龈卟啉单胞菌抗原构建体
AU2024301594A1 (en) * 2023-07-26 2026-01-08 Cadmus Animal Health Limited Rna vaccines for use in animal health
CN121909042A (zh) * 2023-07-26 2026-04-21 卡德摩斯动物健康有限公司 嵌合蛋白疫苗
WO2025019901A1 (en) * 2023-07-26 2025-01-30 Denteric Pty Ltd Rna vaccines
WO2025019902A1 (en) * 2023-07-26 2025-01-30 Denteric Pty Ltd Methods of treatment
CN120157758B (zh) * 2025-03-26 2025-12-05 河南大学 牙龈卟啉单胞菌FimA单克隆抗体及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735801A (en) 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
US5210035A (en) 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4837151A (en) 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US5830710A (en) * 1988-09-08 1998-11-03 University Of Florida Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease
US5711937A (en) 1993-06-28 1998-01-27 Lion Corporation Oral composition
US6017532A (en) 1993-09-10 2000-01-25 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase
WO1995007286A1 (en) 1993-09-10 1995-03-16 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase coding sequences
US5475097A (en) 1993-10-21 1995-12-12 University Of Georgia Research Foundation, Inc. Lysine-specific Porphyromonas gingivalis proteinase
US5523390A (en) 1993-09-10 1996-06-04 University Of Georgia Research Foundation, Inc. Porphyromonas gingivalis arginine-specific proteinase
JPH0797395A (ja) 1993-09-28 1995-04-11 Kyowa Medex Co Ltd ポルフイロモナス・ジンジバリス線毛蛋白質の配列を含有するペプチド類及びその用途
EP0753577B1 (en) 1994-03-29 2002-07-24 Kyowa Hakko Kogyo Co., Ltd. Cell-surface polypeptide gene
AUPN627595A0 (en) * 1995-10-30 1995-11-23 University Of Melbourne, The Diagnostics and treatments of periodontal disease
EP0888124A4 (en) 1996-03-22 2001-04-11 Univ Georgia Res Found Immunogenic assemblies of Porphyromonas Gingivalis peptides and their methods
AUPN901296A0 (en) 1996-03-29 1996-04-26 University Of Melbourne, The Porphyromonas gingivalis antigens for the diagnosis and treatment of periodontitis
US7341727B1 (en) 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
AUPO652897A0 (en) * 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
AUPP083997A0 (en) 1997-12-10 1998-01-08 Csl Limited Porphyromonas gingivalis nucleotides
US8129500B2 (en) 1997-12-10 2012-03-06 Csl Limited Porphyromonas gingivalis polypeptides and nucleotides
US6444799B1 (en) 1997-12-31 2002-09-03 Csl Limited P. gingivalis polynucleotides and uses thereof
US6627193B1 (en) 1999-01-13 2003-09-30 University Of Georgia Research Foundation, Inc. Methods and compositions for control of blood coagulation
AUPP893999A0 (en) 1999-03-01 1999-03-25 Csl Limited Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis
EP1210182A1 (en) 1999-05-12 2002-06-05 The General Hospital Corporation Permeabilizing biofilms
GB9913437D0 (en) 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
AUPQ485999A0 (en) 1999-12-24 2000-02-03 Csl Limited P. gingivalis antigenic composition
AU782624B2 (en) * 1999-12-30 2005-08-18 Board Of Trustees Of Miami University Methods and compositions for inhibiting adhesion by microorganisms
AUPQ718200A0 (en) 2000-04-28 2000-05-25 Csl Limited Porphyromonas gingivalis recombinant proteins and truncations
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US20030083287A1 (en) 2000-11-30 2003-05-01 Burgess Nicola A. ginS
AUPR575401A0 (en) 2001-06-18 2001-07-12 Unisearch Limited Method of causing sloughing
JP2003192616A (ja) 2001-12-27 2003-07-09 Univ Nihon 歯周病用dnaワクチン
JP2003286191A (ja) 2002-03-27 2003-10-07 Univ Nihon 歯周病用粘膜免疫ワクチン
US20070036734A1 (en) 2003-03-17 2007-02-15 Kirin Beer Kabushiki Kaisha Therapeutic agent for periodontal disease
CA2535799A1 (en) 2003-08-15 2005-03-03 University Of Florida Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
WO2005058344A1 (en) * 2003-12-19 2005-06-30 The University Of Melbourne Antimicrobial composition
KR101178776B1 (ko) 2004-02-06 2012-09-07 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 치료학적 잠재성을 가진 어드헤신 및 어드헤신계 단백질을 동정하기 위한 컴퓨터 장치
US20070098649A1 (en) 2004-03-22 2007-05-03 The Board Of Trustees Of The University Of Illinois Method and composition for controlling oral pathogens
GB0411150D0 (en) * 2004-05-19 2004-06-23 Queen Mary & Westfield College Vaccine
NZ554331A (en) 2004-09-23 2009-04-30 Univ Melbourne Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection
US20060121031A1 (en) * 2004-12-07 2006-06-08 Mckenzie Brent S Relay vaccine
US8673363B2 (en) * 2005-06-07 2014-03-18 The University Of Melbourne Dental mineralization
WO2008016385A2 (en) 2006-01-20 2008-02-07 The University Of Washington Deacylase polypeptides, deacylase polynucleotides, and methods of use thereof
EP2038297A4 (en) * 2006-06-27 2010-03-03 Oral Health Australia Pty Ltd PORPHYROMONAS GINGIVALIS POLYPEPTIDES SUITABLE FOR PREVENTION OF PERIODONTITIS
NZ596269A (en) * 2006-07-05 2012-12-21 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
WO2008124646A2 (en) 2007-04-06 2008-10-16 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Use of amyloid proteins as vaccine scaffolds
WO2009006699A1 (en) * 2007-07-12 2009-01-15 Oral Health Australia Pty Ltd Biofilm treatment
NZ595378A (en) 2007-07-12 2013-04-26 Immunology treatment for biofilms
ES2633738T3 (es) * 2008-08-29 2017-09-25 Oral Health Australia Pty Ltd Prevención, tratamiento y diagnóstico de la infección por p. gingivales
RU2012107993A (ru) 2009-08-02 2013-09-10 Санофи Пастер Лимитид Полипептиды porhyromonas gingivalis
DK2473605T3 (en) * 2009-09-03 2018-05-28 Pfizer Vaccines Llc PCSK9-VACCINE
CA2791045A1 (en) * 2010-02-25 2011-09-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patieentenzorg A process for the preparation of substituted prolyl peptides and similar peptidomimetics
MY162557A (en) 2010-02-26 2017-06-15 Oral Health Australia Pty Ltd Treatment or prevention of infection
TWI542695B (zh) * 2010-12-15 2016-07-21 日星股份有限公司 牙周病原菌血漿或血清抗體價檢查套組
DE102011003604A1 (de) 2011-02-03 2012-08-09 Battenfeld-Cincinnati Germany Gmbh Kühlvorrichtung und Kühlverfahren
JP6310631B2 (ja) 2011-10-18 2018-04-11 サンスター株式会社 歯周病原菌血漿または血清抗体価検査キット
US20160347829A1 (en) * 2015-05-27 2016-12-01 Merial Inc. Compositions containing antimicrobial IgY antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (OHC) microorganisms
EP3387439B1 (en) * 2015-12-09 2020-02-26 H. Hoffnabb-La Roche Ag Direct affinity measurement of human igg1 binding multimeric antigens
EP3387440B1 (en) 2015-12-09 2021-05-12 F. Hoffmann-La Roche AG Method for determining the in vivo interaction mode
CN108038398B (zh) * 2017-12-22 2021-03-23 珠海市君天电子科技有限公司 一种二维码解析能力测试方法、装置及电子设备

Also Published As

Publication number Publication date
ES2633738T3 (es) 2017-09-25
EP2328914A1 (en) 2011-06-08
NZ591612A (en) 2012-08-31
US20150079095A1 (en) 2015-03-19
US20170247420A1 (en) 2017-08-31
JP2015212284A (ja) 2015-11-26
CA2735171C (en) 2023-10-03
EP3255057A1 (en) 2017-12-13
US11572391B2 (en) 2023-02-07
WO2010022463A1 (en) 2010-03-04
TW201021845A (en) 2010-06-16
CN102203121A (zh) 2011-09-28
TWI473626B (zh) 2015-02-21
US9518109B2 (en) 2016-12-13
ZA201101814B (en) 2016-10-26
KR20110061586A (ko) 2011-06-09
KR101721904B1 (ko) 2017-04-11
BRPI0917321A2 (pt) 2015-11-17
RU2535898C2 (ru) 2014-12-20
AU2009287340B2 (en) 2015-03-19
AU2009287340A1 (en) 2010-03-04
US20110280880A1 (en) 2011-11-17
MX2011001949A (es) 2011-07-20
US8871213B2 (en) 2014-10-28
JP6235533B2 (ja) 2017-11-22
JP2012500633A (ja) 2012-01-12
IL211394B (en) 2018-07-31
DK2328914T3 (en) 2017-07-10
EP3255057B1 (en) 2020-03-18
US20230374081A1 (en) 2023-11-23
NZ598834A (en) 2013-06-28
CN107266582B (zh) 2021-09-10
CA2735171A1 (en) 2010-03-04
US20210079047A1 (en) 2021-03-18
US20190194263A1 (en) 2019-06-27
PL2328914T3 (pl) 2017-09-29
EP2328914A4 (en) 2012-12-19
RU2011108943A (ru) 2012-10-10
EP2328914B1 (en) 2017-05-10
CN107266582A (zh) 2017-10-20
US10851138B2 (en) 2020-12-01

Similar Documents

Publication Publication Date Title
MX2018009945A (es) Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
IN2012DN00624A (enExample)
MX2011007930A (es) Conjugados de insulina cristalina.
IN2012DN03883A (enExample)
EA201390967A1 (ru) Специфические для грамположительных бактерий связывающие соединения
EA201200977A1 (ru) Лечение синдрома ли и ли-подобного синдрома токотриенолхинонами
EA201101530A1 (ru) ИММУНОНАНОТЕРАПИЯ, ОБЕСПЕЧИВАЮЩАЯ Th1-СМЕЩЕННЫЙ ОТВЕТ
MY165579A (en) Synthetic methods for spiro-oxindole compounds
ZA201101814B (en) Prevention, treatment and diagnosis of p.gingivalis infection
EA201171367A1 (ru) Винилиндазолильные соединения
EA201170521A1 (ru) Новые соединения
EA201200473A1 (ru) Замещенные (гетероарилметил)тиогидантоины
EA201190217A1 (ru) Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение
EA201100505A1 (ru) Органические соединения для применения для лечения бактериальных инфекций
MY164731A (en) Compound
MX2010007490A (es) Preparacion de derivados de sulfamida.
IN2012DN02471A (enExample)
TN2011000482A1 (en) Organic compounds and their uses
EA201101686A1 (ru) Новые композиции для лечения шмт и связанных с ней расстройств
EA201170356A1 (ru) Полиморфные и аморфные формы лакозамида и аморфные композиции
UA107204C2 (uk) Протигрибкова композиція, що містить грибковий організм pythium oligandrum
UA107666C2 (uk) Застосування l-серину як лікарського засобу для попередження та/або лікування свербіжу шкіри
MX357166B (es) Anticuerpos que se unen a notum pectinacetilesterasa.
WO2010101793A3 (en) Methods and compositions for the diagnosis, prognosis and treatment of cancer
WO2010135521A3 (en) Compositions and methods for the therapy and diagnosis of influenza