MXPA06014187A - Procedimiento para carbonilar derivados de fenilalquilo por medio de monoxido de carbono. - Google Patents

Procedimiento para carbonilar derivados de fenilalquilo por medio de monoxido de carbono.

Info

Publication number
MXPA06014187A
MXPA06014187A MXPA06014187A MXPA06014187A MXPA06014187A MX PA06014187 A MXPA06014187 A MX PA06014187A MX PA06014187 A MXPA06014187 A MX PA06014187A MX PA06014187 A MXPA06014187 A MX PA06014187A MX PA06014187 A MXPA06014187 A MX PA06014187A
Authority
MX
Mexico
Prior art keywords
carbon monoxide
carbonylating
formula
alkyl
phenylalkyl
Prior art date
Application number
MXPA06014187A
Other languages
English (en)
Inventor
Gerhard Korb
Heiner Jendralla
Matthias Braun
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of MXPA06014187A publication Critical patent/MXPA06014187A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invencion se refiere a un metodo para preparar derivados de acido fenilalquilcarboxilico de la formula general (1) (1) R3 en la que Rl y R2, iguales o diferentes, representan cada uno independientemente alquilo(C1-C4), Z es un atomo de hidrogeno o -(CH2)- CH3 en el que n desde O a 9 y R3 es -C(O)-alquil(C1-C4) en el que el alquilo esta sin sustituir o monosustituido por CI o Br, o -C(O)-cicloalquil(C3-C6), en el que el compuesto de la formula (II) Rl R4 (II) en la que X es CI, Br o -OH y R4 es como se define para el radical R2 o, junto con X, en un doble enlace C=C se hace reaccionar con monoxido de carbono en presencia de acido sulfurico concentrado, fluoruro de hidrogeno o de superacidos, y posteriormente se anade agua o un alcohol de la formula CH3- (CH2)-OH en la que n = desde O a 9.
MXPA06014187A 2004-06-30 2005-06-15 Procedimiento para carbonilar derivados de fenilalquilo por medio de monoxido de carbono. MXPA06014187A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004031849A DE102004031849A1 (de) 2004-06-30 2004-06-30 Verfahren zur Carbonylierung von Phenylalkylderivaten mit Kohlenmonoxid
PCT/EP2005/006414 WO2006002762A2 (de) 2004-06-30 2005-06-15 Verfahren zur carbonylierung von phenylalkylderivaten mit kohlenmonoxid

Publications (1)

Publication Number Publication Date
MXPA06014187A true MXPA06014187A (es) 2007-05-23

Family

ID=35219528

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06014187A MXPA06014187A (es) 2004-06-30 2005-06-15 Procedimiento para carbonilar derivados de fenilalquilo por medio de monoxido de carbono.

Country Status (23)

Country Link
US (2) US20070161814A1 (es)
EP (1) EP1776330B1 (es)
JP (1) JP4934028B2 (es)
KR (1) KR101228860B1 (es)
CN (2) CN1976888B (es)
AR (1) AR049948A1 (es)
AT (1) ATE479648T1 (es)
AU (1) AU2005259632B2 (es)
BR (1) BRPI0512650A (es)
CA (1) CA2572124C (es)
CY (1) CY1110955T1 (es)
DE (2) DE102004031849A1 (es)
DK (1) DK1776330T3 (es)
ES (1) ES2348666T3 (es)
HK (1) HK1101071A1 (es)
IL (1) IL180330A (es)
MX (1) MXPA06014187A (es)
PL (1) PL1776330T3 (es)
PT (1) PT1776330E (es)
SI (1) SI1776330T1 (es)
TW (1) TW200621699A (es)
UY (1) UY28992A1 (es)
WO (1) WO2006002762A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2968658B1 (fr) 2010-12-13 2013-04-26 Aet Group Procede continu de carbonylation d'alcools, et notamment de phenylalcools
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
BR112016028609B1 (pt) 2014-06-10 2021-01-26 Igm Resins Italia S.R.L. Processo para a preparação de 5-[4-(2-hidroxi-2-metil)-1-oxo-prop-1-il] -3-[4-(2-hidroxi-2-metil) -1-oxo-prop-1-il-fenil]-2,3-diidro-1,1,3-trimetil-1h-indeno (dímero de isômero 5)
CN109704941A (zh) * 2019-01-24 2019-05-03 淄博润源化工有限公司 3,4-二甲基苯甲醛的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2634294A (en) * 1950-04-08 1953-04-07 Monsanto Chemicals Preparation of aromatic keto alcohols
NZ267830A (en) * 1993-06-25 1998-05-27 Merrell Pharma Inc Preparation of 4-diphenylmethyl or 4-diphenylmethoxy piperidine derivatives and intermediates therefor
US6531597B2 (en) * 2001-02-13 2003-03-11 Hoffmann-La Roche Inc. Process for preparation of 2-phenyl acetic acid derivatives
SK712003A3 (en) 2001-06-25 2003-12-02 Aurobindo Pharma Ltd Process for the preparation of 4-(cyclopropylcarbonyl)-alpha, alpha-dimethylphenylacetic acid

Also Published As

Publication number Publication date
EP1776330B1 (de) 2010-09-01
JP4934028B2 (ja) 2012-05-16
CA2572124A1 (en) 2006-01-12
PT1776330E (pt) 2010-11-09
AU2005259632B2 (en) 2010-11-18
EP1776330A2 (de) 2007-04-25
US20100069661A1 (en) 2010-03-18
TW200621699A (en) 2006-07-01
UY28992A1 (es) 2006-01-31
IL180330A0 (en) 2007-07-04
CA2572124C (en) 2013-03-12
US20070161814A1 (en) 2007-07-12
SI1776330T1 (sl) 2011-01-31
DE102004031849A1 (de) 2006-01-26
KR101228860B1 (ko) 2013-02-04
CN1976888B (zh) 2010-11-10
CY1110955T1 (el) 2015-06-11
ES2348666T3 (es) 2010-12-10
HK1101071A1 (en) 2007-10-05
DE502005010183D1 (de) 2010-10-14
WO2006002762A2 (de) 2006-01-12
PL1776330T3 (pl) 2011-01-31
BRPI0512650A (pt) 2008-03-25
ATE479648T1 (de) 2010-09-15
DK1776330T3 (da) 2011-01-03
AU2005259632A1 (en) 2006-01-12
CN1976888A (zh) 2007-06-06
CN101570476A (zh) 2009-11-04
AR049948A1 (es) 2006-09-20
WO2006002762A3 (de) 2006-05-18
IL180330A (en) 2011-07-31
KR20070026680A (ko) 2007-03-08
US8269033B2 (en) 2012-09-18
JP2008504314A (ja) 2008-02-14
CN101570476B (zh) 2012-12-19

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