BRPI0512650A - processo para carbonilação de derivados de fenilalquila por meio de monóxido de carbono - Google Patents

processo para carbonilação de derivados de fenilalquila por meio de monóxido de carbono

Info

Publication number
BRPI0512650A
BRPI0512650A BRPI0512650-9A BRPI0512650A BRPI0512650A BR PI0512650 A BRPI0512650 A BR PI0512650A BR PI0512650 A BRPI0512650 A BR PI0512650A BR PI0512650 A BRPI0512650 A BR PI0512650A
Authority
BR
Brazil
Prior art keywords
carbon monoxide
carbonylation
formula
derivatives
alkyl
Prior art date
Application number
BRPI0512650-9A
Other languages
English (en)
Inventor
Heiner Jendralla
Matthias Braun
Gerhard Korb
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0512650A publication Critical patent/BRPI0512650A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA CARBONILAçãO DE DERIVADOS DE FENILALQUILA POR MEIO DE MONóXIDO DE CARBONO. A invenção refere-se a um método para produção de ácido fenilalquil carboxilico da fórmula geral (I), onde R1 e R2 idênticos ou diferentes representam independentemente um do outro -(C~ 1~-C~ 4~)-alquila, Z é um átomo de hidrogênio ou -(CH~ 2~)~ n~-CH~ 3~, onde n = 0 a 9 e R3 é -C(0)-(C~ 1~-C~ 4~)-alquila que é substituida ou não-substituida por CI ou Br, apenas, ou -C(0)-(C~ 3~-C~ 6~)-cicloalquila, consistindo em reação de um composto da fórmula (II), onde X é CI ou Br ou OH e R4 é definido como R2 o resto representa juntamente com X uma ligação dupla C-C com um monóxido de carbono na presença de um ácido sulfúrico concentrado, fluoreto de hidrogênio ou perácidos e subseqüentemente adição de água ou álcool da fórmula CH~ 3~-(CH~ 2~)~ n~-OH, onde n = 0 a 9.
BRPI0512650-9A 2004-06-30 2005-06-15 processo para carbonilação de derivados de fenilalquila por meio de monóxido de carbono BRPI0512650A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004031849A DE102004031849A1 (de) 2004-06-30 2004-06-30 Verfahren zur Carbonylierung von Phenylalkylderivaten mit Kohlenmonoxid
PCT/EP2005/006414 WO2006002762A2 (de) 2004-06-30 2005-06-15 Verfahren zur carbonylierung von phenylalkylderivaten mit kohlenmonoxid

Publications (1)

Publication Number Publication Date
BRPI0512650A true BRPI0512650A (pt) 2008-03-25

Family

ID=35219528

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512650-9A BRPI0512650A (pt) 2004-06-30 2005-06-15 processo para carbonilação de derivados de fenilalquila por meio de monóxido de carbono

Country Status (23)

Country Link
US (2) US20070161814A1 (pt)
EP (1) EP1776330B1 (pt)
JP (1) JP4934028B2 (pt)
KR (1) KR101228860B1 (pt)
CN (2) CN1976888B (pt)
AR (1) AR049948A1 (pt)
AT (1) ATE479648T1 (pt)
AU (1) AU2005259632B2 (pt)
BR (1) BRPI0512650A (pt)
CA (1) CA2572124C (pt)
CY (1) CY1110955T1 (pt)
DE (2) DE102004031849A1 (pt)
DK (1) DK1776330T3 (pt)
ES (1) ES2348666T3 (pt)
HK (1) HK1101071A1 (pt)
IL (1) IL180330A (pt)
MX (1) MXPA06014187A (pt)
PL (1) PL1776330T3 (pt)
PT (1) PT1776330E (pt)
SI (1) SI1776330T1 (pt)
TW (1) TW200621699A (pt)
UY (1) UY28992A1 (pt)
WO (1) WO2006002762A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2968658B1 (fr) 2010-12-13 2013-04-26 Aet Group Procede continu de carbonylation d'alcools, et notamment de phenylalcools
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
BR112016028609B1 (pt) 2014-06-10 2021-01-26 Igm Resins Italia S.R.L. Processo para a preparação de 5-[4-(2-hidroxi-2-metil)-1-oxo-prop-1-il] -3-[4-(2-hidroxi-2-metil) -1-oxo-prop-1-il-fenil]-2,3-diidro-1,1,3-trimetil-1h-indeno (dímero de isômero 5)
CN109704941A (zh) * 2019-01-24 2019-05-03 淄博润源化工有限公司 3,4-二甲基苯甲醛的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2634294A (en) * 1950-04-08 1953-04-07 Monsanto Chemicals Preparation of aromatic keto alcohols
NZ267830A (en) * 1993-06-25 1998-05-27 Merrell Pharma Inc Preparation of 4-diphenylmethyl or 4-diphenylmethoxy piperidine derivatives and intermediates therefor
US6531597B2 (en) * 2001-02-13 2003-03-11 Hoffmann-La Roche Inc. Process for preparation of 2-phenyl acetic acid derivatives
SK712003A3 (en) 2001-06-25 2003-12-02 Aurobindo Pharma Ltd Process for the preparation of 4-(cyclopropylcarbonyl)-alpha, alpha-dimethylphenylacetic acid

Also Published As

Publication number Publication date
EP1776330B1 (de) 2010-09-01
JP4934028B2 (ja) 2012-05-16
CA2572124A1 (en) 2006-01-12
PT1776330E (pt) 2010-11-09
AU2005259632B2 (en) 2010-11-18
EP1776330A2 (de) 2007-04-25
US20100069661A1 (en) 2010-03-18
TW200621699A (en) 2006-07-01
UY28992A1 (es) 2006-01-31
IL180330A0 (en) 2007-07-04
CA2572124C (en) 2013-03-12
US20070161814A1 (en) 2007-07-12
SI1776330T1 (sl) 2011-01-31
DE102004031849A1 (de) 2006-01-26
KR101228860B1 (ko) 2013-02-04
CN1976888B (zh) 2010-11-10
MXPA06014187A (es) 2007-05-23
CY1110955T1 (el) 2015-06-11
ES2348666T3 (es) 2010-12-10
HK1101071A1 (en) 2007-10-05
DE502005010183D1 (de) 2010-10-14
WO2006002762A2 (de) 2006-01-12
PL1776330T3 (pl) 2011-01-31
ATE479648T1 (de) 2010-09-15
DK1776330T3 (da) 2011-01-03
AU2005259632A1 (en) 2006-01-12
CN1976888A (zh) 2007-06-06
CN101570476A (zh) 2009-11-04
AR049948A1 (es) 2006-09-20
WO2006002762A3 (de) 2006-05-18
IL180330A (en) 2011-07-31
KR20070026680A (ko) 2007-03-08
US8269033B2 (en) 2012-09-18
JP2008504314A (ja) 2008-02-14
CN101570476B (zh) 2012-12-19

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07C 51/12 , C07C 45/64 , C07C 57/30 , C07C 57/58 , C07C 49/82 , C07C 59/64 , C07C 45/63 , C07C 49/697

Ipc: C07C 51/12 (2006.01), C07C 45/64 (2006.01), C07C 5

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]