MXPA05011166A - Antagonistas del receptor del peptido relacionado con el gen de la calcitonina. - Google Patents

Antagonistas del receptor del peptido relacionado con el gen de la calcitonina.

Info

Publication number
MXPA05011166A
MXPA05011166A MXPA05011166A MXPA05011166A MXPA05011166A MX PA05011166 A MXPA05011166 A MX PA05011166A MX PA05011166 A MXPA05011166 A MX PA05011166A MX PA05011166 A MXPA05011166 A MX PA05011166A MX PA05011166 A MXPA05011166 A MX PA05011166A
Authority
MX
Mexico
Prior art keywords
receptor antagonists
cgrp
cgrp receptor
diseases
involved
Prior art date
Application number
MXPA05011166A
Other languages
English (en)
Inventor
Theresa M Williams
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MXPA05011166A publication Critical patent/MXPA05011166A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La Presente invencion de refiere a compuestos de Formula I (ver Formula I): (donde las variables R1, R2 y R3 son como se define aqui) utiles como antagonistas de los receptores CGRP y utiles en el tratamiento o prevencion de enfermedades en las cuales el CGRP esta relacionado, tales como dolor de cabeza, migrana y cefaleas en racimos; esta invencion esta tambien dirigida a composiciones farmaceuticas que compenden estos compuestos y el uso de estos compuestos y composiciones en la prevencion de tales enfermedades en las cuales el CGRP esta relacionado.
MXPA05011166A 2003-04-15 2004-04-09 Antagonistas del receptor del peptido relacionado con el gen de la calcitonina. MXPA05011166A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46308903P 2003-04-15 2003-04-15
US51035203P 2003-10-10 2003-10-10
PCT/US2004/011280 WO2004092168A1 (en) 2003-04-15 2004-04-09 Cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
MXPA05011166A true MXPA05011166A (es) 2005-12-14

Family

ID=33303112

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011166A MXPA05011166A (es) 2003-04-15 2004-04-09 Antagonistas del receptor del peptido relacionado con el gen de la calcitonina.

Country Status (33)

Country Link
US (6) US6953790B2 (es)
EP (2) EP2039694B1 (es)
JP (1) JP3967766B2 (es)
KR (1) KR100769030B1 (es)
CN (1) CN100384843C (es)
AR (1) AR045887A1 (es)
AT (1) ATE413400T1 (es)
AU (1) AU2004230926B2 (es)
BR (1) BRPI0409601A (es)
CA (1) CA2522220C (es)
CL (1) CL2004000788A1 (es)
CO (1) CO5640130A2 (es)
CY (1) CY1108714T1 (es)
DE (1) DE602004017608D1 (es)
DK (1) DK1638969T3 (es)
EC (1) ECSP056097A (es)
ES (1) ES2314417T3 (es)
HK (1) HK1090922A1 (es)
HR (1) HRP20080666T3 (es)
IS (1) IS2759B (es)
JO (1) JO2355B1 (es)
MA (1) MA27728A1 (es)
MX (1) MXPA05011166A (es)
NO (1) NO327655B1 (es)
NZ (1) NZ543357A (es)
PE (1) PE20050020A1 (es)
PL (1) PL1638969T3 (es)
PT (1) PT1638969E (es)
RU (1) RU2308458C2 (es)
SI (1) SI1638969T1 (es)
TW (1) TWI314931B (es)
UA (1) UA82877C2 (es)
WO (2) WO2004092166A2 (es)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL374017A1 (en) * 2002-06-05 2005-09-19 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
EP1615914B1 (en) * 2003-04-15 2010-05-05 Merck Sharp & Dohme Corp. Cgrp receptor antagonists
GB0310881D0 (en) * 2003-05-12 2003-06-18 Merck Sharp & Dohme Pharmaceutical formulation
WO2005013894A2 (en) * 2003-06-26 2005-02-17 Merck & Co., Inc. Benzodiazepine cgrp receptor antagonists
WO2005000807A2 (en) * 2003-06-26 2005-01-06 Merck & Co., Inc. Benzodiazepine cgrp receptor antagonists
AR046787A1 (es) 2003-12-05 2005-12-21 Bristol Myers Squibb Co Agentes antimigrana heterociclicos
CN101124217A (zh) * 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂
EP1732885A1 (en) * 2004-02-23 2006-12-20 Trustees Of Tufts College Lactams as conformationally constrained peptidomimetic inhibitors
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
AU2005294448B2 (en) * 2004-10-07 2011-07-14 Merck Sharp & Dohme Corp. CGRP receptor antagonists
DE602005027870D1 (de) 2004-10-14 2011-06-16 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
DE602005027230D1 (de) * 2004-10-22 2011-05-12 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
GB2467060B (en) * 2005-02-11 2010-09-01 Cambridge Entpr Ltd Ligands for G-protein coupled receptors
GB2423085C (en) * 2005-02-11 2011-11-09 Cambridge Entpr Ltd Ligands for G-protein coupled receptors
US7994325B2 (en) 2005-03-14 2011-08-09 Merck Sharp & Dohme Corp. CGRP receptor antagonists
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
PT2380592T (pt) 2005-11-14 2018-06-06 Teva Pharmaceuticals Int Gmbh Anticorpos antagonistas dirigidos contra o péptido relacionado com o gene da calcitonina e métodos utilizando os mesmos
CN100371327C (zh) * 2005-11-17 2008-02-27 江苏工业学院 2-氨基-6-烷氧基-3-硝基吡啶的一步合成法
JP2009515972A (ja) * 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド スピロラクタムアリールｃｇｒｐ受容体アンタゴニスト
EP2007764B1 (en) 2006-04-10 2009-08-26 Merck & Co., Inc. Process for the preparation of cgrp antagonist
AU2007238896A1 (en) * 2006-04-10 2007-10-25 Merck Sharp & Dohme Corp. CGRP antagonist salt
EP2007731B1 (en) 2006-04-10 2009-07-22 Merck & Co., Inc. Process for the preparation of caprolactam cgrp antagonist intermediate
CN101421267B (zh) * 2006-04-10 2011-10-19 默沙东公司 制备吡啶杂环cgrp拮抗剂中间体的方法
ATE517903T1 (de) * 2006-05-02 2011-08-15 Bristol Myers Squibb Co Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.
US7470680B2 (en) * 2006-05-03 2008-12-30 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
BRPI0711352A2 (pt) * 2006-05-09 2011-09-27 Merck & Co Inc composto, composição farmacêutica, e, métodos para o antagonismo de atividade receptora de cgrp em um mamìfero, e para, tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca , ou cefaléia vascular
US8163737B2 (en) 2006-06-13 2012-04-24 Vertex Pharmaceuticals Incorporated CGRP receptor antagonists
CN101501009A (zh) * 2006-06-13 2009-08-05 沃泰克斯药物股份有限公司 Cgrp受体拮抗剂
US7834000B2 (en) 2006-06-13 2010-11-16 Vertex Pharmaceuticals Incorporated CGRP receptor antagonists
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008016669A2 (en) 2006-08-02 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
AU2007293032A1 (en) * 2006-09-08 2008-03-13 Merck Sharp & Dohme Corp. Liquid pharmaceutical formulations for oral administration of a CGRP antagonist
WO2008147518A1 (en) 2007-05-23 2008-12-04 Merck & Co., Inc. Pyridyl piperidine orexin receptor antagonists
GB0712392D0 (en) * 2007-06-26 2007-08-01 Glaxo Group Ltd Novel compounds
US20090075977A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched mk0974
WO2009100090A1 (en) 2008-02-05 2009-08-13 Merck & Co., Inc. Prodrugs of cgrp receptor antagonist
JP2011512410A (ja) * 2008-02-19 2011-04-21 メルク・シャープ・エンド・ドーム・コーポレイション イミダゾベンゾアゼピンｃｇｒｐ受容体アンタゴニスト
MX2010009722A (es) 2008-03-04 2010-09-30 Pfizer Ltd Procedimiento de tratamiento del dolor cronico.
US8044043B2 (en) * 2008-04-11 2011-10-25 Bristol-Myers Squibb Company CGRP receptor antagonists
US8143403B2 (en) 2008-04-11 2012-03-27 Bristol-Myers Squibb Company CGRP receptor antagonists
CN102076330A (zh) * 2008-06-30 2011-05-25 默沙东公司 替卡格泮钾的固体剂量制剂
WO2010048017A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. Disubstituted azepan orexin receptor antagonists
US8715715B2 (en) 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
BR112012004464B8 (pt) 2009-08-28 2021-05-25 Labrys Biologics Inc uso de um anticorpo antagonista anti-cgrp para preparar uma composição farmacêutica para tratar e/ou prevenir dor visceral e/ou um ou mais sintomas de dor visceral, em que a dor visceral está associada á cistite intersticial (ic), e dita composição farmacêutica
US8314117B2 (en) 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists
US8669368B2 (en) 2010-10-12 2014-03-11 Bristol-Myers Squibb Company Process for the preparation of cycloheptapyridine CGRP receptor antagonists
TWI487706B (zh) 2010-11-12 2015-06-11 Merck Sharp & Dohme 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑
EP2686324B1 (en) * 2011-03-18 2016-01-06 Merck Sharp & Dohme Corp. Piperidine carboxamide spirohydantoin cgrp receptor antagonists
US8748429B2 (en) 2011-04-12 2014-06-10 Bristol-Myers Squibb Company CGRP receptor antagonists
ES2873837T3 (es) 2011-05-20 2021-11-04 H Lundbeck As Composiciones anti CGRP y uso de las mismas
CN108359008B (zh) 2011-05-20 2022-03-29 H.伦德贝克公司 抗cgrp或抗cgrp-r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途
CN107827982B (zh) 2011-05-20 2021-07-06 H.伦德贝克公司 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途
SG10201605707UA (en) 2011-07-13 2016-09-29 Cytokinetics Inc Combination als therapy
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
PL2820016T3 (pl) 2012-02-27 2018-01-31 Bristol Myers Squibb Co 4 - (2 - okso-2, 3 - dihydro - 1h- imidazo [4, 5 -b]pirydyn - 1 - ylo) piperydyno - 1 - karboksylan n- (5s, 6s, 9r) - 5 -amino- 6 - (2, 3 - difluorofenylo) -6, 7, 8, 9 - tetrahydro - 5h - cyklohepta [b]pirydyn-9 - ylu, sól hemisiarczanowa
CN104203925A (zh) 2012-03-29 2014-12-10 拜耳知识产权有限责任公司 5-氨基嘧啶衍生物及其用于防治不希望的植物生长的用途
RU2019123406A (ru) 2014-02-05 2019-10-03 Мерк Шарп И Доум Корп. Технология приготовления таблеток для cgrp-активных соединений
RS65360B1 (sr) 2014-03-21 2024-04-30 Teva Pharmaceuticals Int Gmbh Antagonistička antitela specifična za peptid genski srodan kalcitoninu i postupci njihove upotrebe
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
GB201417707D0 (en) 2014-10-07 2014-11-19 Viral Ltd Pharmaceutical compounds
WO2017001434A1 (en) * 2015-06-29 2017-01-05 Galderma Research & Development Cgrp receptor antagonist compounds for topical treatment of skin disorders
GB201519195D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519194D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP receptor antagonists
GB201519196D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
WO2018055574A1 (en) 2016-09-23 2018-03-29 Teva Pharmaceuticals International Gmbh Treating refractory migraine
EP3366286A1 (en) 2017-02-22 2018-08-29 Johannes Keller Compounds for treating sepsis
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
CA3087784A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
CN108892635A (zh) * 2018-09-07 2018-11-27 江苏工程职业技术学院 一种西沙必利关键中间体的制备方法
SG11202106766SA (en) 2019-01-08 2021-07-29 H Lundbeck As Acute treatment and rapid treatment of headache using anti-cgrp antibodies
US11717515B2 (en) 2020-12-22 2023-08-08 Allergan Pharmaceuticals International Limited Treatment of migraine
MX2023010115A (es) 2021-03-02 2023-11-09 Cgrp Diagnostics Gmbh Tratamiento y/o reducción de la aparición de la migraña.
WO2023026205A1 (en) 2021-08-24 2023-03-02 Cgrp Diagnostics Gmbh Preventative treatment of migraine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
EP1117662A1 (en) * 1998-09-30 2001-07-25 Merck Sharp & Dohme Limited Benzimidazolinyl piperidines as cgrp ligands
WO2000018765A1 (fr) 1998-09-30 2000-04-06 Taisho Pharmaceutical Co., Ltd. Composes d'isoxazolylthiophene substitue
PL374017A1 (en) * 2002-06-05 2005-09-19 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
EP1615914B1 (en) * 2003-04-15 2010-05-05 Merck Sharp & Dohme Corp. Cgrp receptor antagonists

Also Published As

Publication number Publication date
HRP20080666T3 (en) 2009-01-31
AR045887A1 (es) 2005-11-16
KR20050121734A (ko) 2005-12-27
US7452903B2 (en) 2008-11-18
EP2039694A1 (en) 2009-03-25
CL2004000788A1 (es) 2005-02-25
BRPI0409601A (pt) 2006-04-18
US20040229861A1 (en) 2004-11-18
NO20055375L (no) 2005-11-14
SI1638969T1 (sl) 2009-02-28
JP3967766B2 (ja) 2007-08-29
US7893052B2 (en) 2011-02-22
PT1638969E (pt) 2009-01-16
CO5640130A2 (es) 2006-05-31
IS8055A (is) 2005-09-29
US7235545B2 (en) 2007-06-26
KR100769030B1 (ko) 2007-10-22
DK1638969T3 (da) 2009-01-26
WO2004092168A1 (en) 2004-10-28
CA2522220A1 (en) 2004-10-28
ECSP056097A (es) 2006-03-01
ES2314417T3 (es) 2009-03-16
CY1108714T1 (el) 2014-04-09
NO327655B1 (no) 2009-09-07
PL1638969T3 (pl) 2009-04-30
TWI314931B (en) 2009-09-21
US6953790B2 (en) 2005-10-11
CA2522220C (en) 2009-06-23
DE602004017608D1 (de) 2008-12-18
PE20050020A1 (es) 2005-02-18
US20050256098A1 (en) 2005-11-17
US20100298303A1 (en) 2010-11-25
EP2039694B1 (en) 2014-03-26
US7772224B2 (en) 2010-08-10
NZ543357A (en) 2008-08-29
US20090192139A1 (en) 2009-07-30
MA27728A1 (fr) 2006-01-02
JP2006523697A (ja) 2006-10-19
WO2004092166A2 (en) 2004-10-28
US20070225272A1 (en) 2007-09-27
EP1638969A2 (en) 2006-03-29
EP1638969B1 (en) 2008-11-05
IS2759B (is) 2011-10-15
UA82877C2 (en) 2008-05-26
JO2355B1 (en) 2006-12-12
RU2005135440A (ru) 2006-03-20
US7534784B2 (en) 2009-05-19
RU2308458C2 (ru) 2007-10-20
AU2004230926A1 (en) 2004-10-28
WO2004092166A3 (en) 2005-01-20
CN100384843C (zh) 2008-04-30
TW200505903A (en) 2005-02-16
US20080280857A1 (en) 2008-11-13
HK1090922A1 (en) 2007-01-05
CN1802376A (zh) 2006-07-12
ATE413400T1 (de) 2008-11-15
AU2004230926B2 (en) 2008-07-17

Similar Documents

Publication Publication Date Title
MXPA05011166A (es) Antagonistas del receptor del peptido relacionado con el gen de la calcitonina.
EP1615914A4 (en) CGRP RECEPTOR ANTAGONISTS
IL182317A0 (en) Cgrp receptor antagonists
WO2005013894A3 (en) Benzodiazepine cgrp receptor antagonists
EP1804919A4 (en) CGRP RECEPTOR ANTAGONISTS
EP1796678A4 (en) CARBOXAMIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
EP1861399A4 (en) CGRP RECEPTOR ANTAGONISTS
DE602004013563D1 (de) Rantagonisten
WO2005000807A3 (en) Benzodiazepine cgrp receptor antagonists
EP1605936A4 (en) ARYL SPIROHYDANTINE CGRP RECEPTOR ANTAGONISTS
EP1606286A4 (en) BENZODIAZEPINE SPIROHYDANTOINES AS CGRP RECEPTOR ANTAGONISTS
EP1794133A4 (en) ARYL SPIROLACTAM COMPOUNDS AS ANTAGONISTS OF THE CGRP RECEPTOR
EP1613368A4 (en) Carboxamide-spiro hydantoin-CGRP Receptor Antagonists
EP1797073A4 (en) BICYCLIC ANILID SPIROLACTAME AS ANTAGONISTS OF THE CGRP RECEPTOR
WO2006041830A3 (en) Cgrp receptor antagonists
EP1802372A4 (en) CGRP RECEPTOR ANTAGONISTS)
WO2007016087A3 (en) Heterocyclic benzodiazepine cgrp receptor antagonists
EP1856100A4 (en) CGRP RECEPTOR ANTAGONISTS

Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status
GB Transfer or rights
HC Change of company name or juridical status