ATE517903T1 - Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten. - Google Patents

Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.

Info

Publication number
ATE517903T1
ATE517903T1 AT07761624T AT07761624T ATE517903T1 AT E517903 T1 ATE517903 T1 AT E517903T1 AT 07761624 T AT07761624 T AT 07761624T AT 07761624 T AT07761624 T AT 07761624T AT E517903 T1 ATE517903 T1 AT E517903T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
compounds
cgrp
cgrp receptor
treatment
Prior art date
Application number
AT07761624T
Other languages
English (en)
Inventor
Stephen E Mercer
Prasad V Chaturvedula
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE517903T1 publication Critical patent/ATE517903T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07761624T 2006-05-02 2007-05-01 Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten. ATE517903T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79670206P 2006-05-02 2006-05-02
PCT/US2007/067857 WO2007130927A2 (en) 2006-05-02 2007-05-01 Condensed tricyclic compounds as cgrp-receptor antagonists

Publications (1)

Publication Number Publication Date
ATE517903T1 true ATE517903T1 (de) 2011-08-15

Family

ID=38561983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07761624T ATE517903T1 (de) 2006-05-02 2007-05-01 Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.

Country Status (5)

Country Link
US (1) US7470679B2 (de)
EP (1) EP2013213B1 (de)
AT (1) ATE517903T1 (de)
ES (1) ES2368456T3 (de)
WO (1) WO2007130927A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007332898A1 (en) * 2006-12-08 2008-06-19 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
AU2009215731A1 (en) * 2008-02-19 2009-08-27 Merck Sharp & Dohme Corp. Imidazobenzazepine CGRP receptor antagonists
WO2010006168A2 (en) * 2008-07-09 2010-01-14 University Of Rochester Methods of treating cancer using and agent that modulates activity of the calcitonin-gene related peptide ("cgrp") receptor
WO2015016195A1 (ja) 2013-07-29 2015-02-05 協和発酵キリン株式会社 Ｗｎｔシグナル阻害剤
EP3366286A1 (de) 2017-02-22 2018-08-29 Johannes Keller Verbindungen zur behandlung von sepsis
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
CN112110824B (zh) * 2020-09-17 2023-04-07 上海凌凯医药科技有限公司 一种制备2-溴-5-氟苯胺的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1613368B1 (de) 2003-03-14 2011-11-30 Merck Sharp & Dohme Corp. Carboxamid-spirohydantoin-cgrp-rezeptor-antagonisten
JP4584914B2 (ja) 2003-03-14 2010-11-24 メルク・シャープ・エンド・ドーム・コーポレイション ベノジアゼピンスピロヒダントインｃｇｒｐ受容体拮抗物質
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
AU2004229518B2 (en) * 2003-04-15 2010-02-18 Merck Sharp & Dohme Corp. CGRP receptor antagonists
JP4705912B2 (ja) * 2003-06-26 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション ベンゾジアゼピンｃｇｒｐ受容体拮抗物質
US7196079B2 (en) * 2003-06-26 2007-03-27 Merck & Co, Inc. Benzodiazepine CGRP receptor antagonists
CN101124217A (zh) 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
EP1799672B1 (de) 2004-10-07 2013-01-02 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
CA2583536A1 (en) 2004-10-13 2006-04-27 Merck & Co., Inc. Cgrp receptor antagonists
EP1802372B1 (de) 2004-10-14 2011-05-04 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
EP1804919B1 (de) 2004-10-22 2011-03-30 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
US7384931B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
WO2006078554A2 (en) 2005-01-18 2006-07-27 Merck & Co., Inc. Cgrp receptor antagonists
EP1861399B1 (de) 2005-03-14 2011-12-14 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
US7947678B2 (en) 2005-07-29 2011-05-24 Merck Sharp & Dohme Corp. Heterocyclic benzodiazepine CGRP receptor antagonists
WO2008085317A1 (en) 2006-12-20 2008-07-17 Merck & Co., Inc. Benzazepine compounds as cgrp receptor antagonists

Also Published As

Publication number Publication date
WO2007130927A2 (en) 2007-11-15
US20070259850A1 (en) 2007-11-08
ES2368456T3 (es) 2011-11-17
EP2013213B1 (de) 2011-07-27
EP2013213A2 (de) 2009-01-14
WO2007130927A3 (en) 2009-09-11
US7470679B2 (en) 2008-12-30

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