MXPA05009156A - Procedimiento para preparar la sal de 5-(r)-2 -(5, 6-dietil -indan- 2-ilamino) -1-hidroxi- etil-8-hidroxi -(1h)-quinolin- 2-ona, util como un agonista de adrenoceptor. - Google Patents

Procedimiento para preparar la sal de 5-(r)-2 -(5, 6-dietil -indan- 2-ilamino) -1-hidroxi- etil-8-hidroxi -(1h)-quinolin- 2-ona, util como un agonista de adrenoceptor.

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Publication number
MXPA05009156A
MXPA05009156A MXPA05009156A MXPA05009156A MXPA05009156A MX PA05009156 A MXPA05009156 A MX PA05009156A MX PA05009156 A MXPA05009156 A MX PA05009156A MX PA05009156 A MXPA05009156 A MX PA05009156A MX PA05009156 A MXPA05009156 A MX PA05009156A
Authority
MX
Mexico
Prior art keywords
hydroxy
quinolin
ylamino
diethyl
ethyl
Prior art date
Application number
MXPA05009156A
Other languages
English (en)
Inventor
Vogel Caspar
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32927689&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05009156(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA05009156A publication Critical patent/MXPA05009156A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se describe un procedimiento para preparar la sal de 5-[(R)-2-(5, 6-dietil-indan- 2-ilamino)- 1-hidroxi -etil]-8- hidroxi-(1H) -quinolin-2 -ona. El procedimiento implica formar una sal de acido de oxi-(1H)quinolin -2-ona 5-[(R)-2- (5, 6-dietil- indan-2 -ilamino)- 1-hidroxi-etil] -8- substituida (V); y convertir la sal de acido a una sal de 5-[(R) -2-(5, 6-dietil-indan -2-ilamino)-1 -hidroxi-etil] -8-hidroxi- (1H)-quinolin-2 -ona (VI) sin aislar la base libre de 5-[(R) -2-(5, 6-dietil-indan -2-ilamino)- 1-hidroxi -etil]-8 -hidroxi-(1H) -quinolin-2 -ona. Formula (A); (V): R= un grupo protector, (VI): R = H.
MXPA05009156A 2003-02-28 2004-02-27 Procedimiento para preparar la sal de 5-(r)-2 -(5, 6-dietil -indan- 2-ilamino) -1-hidroxi- etil-8-hidroxi -(1h)-quinolin- 2-ona, util como un agonista de adrenoceptor. MXPA05009156A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45094503P 2003-02-28 2003-02-28
PCT/EP2004/001981 WO2004076422A1 (en) 2003-02-28 2004-02-27 Process for preparing 5-‘(r)-2-(5,6-diethyl-indian-2-ylamino)-1-hydroxy-ethyl!-8-hydroxy-(1h)-quinolin-2-one salt, useful as an adrenoceptor agonist

Publications (1)

Publication Number Publication Date
MXPA05009156A true MXPA05009156A (es) 2005-10-20

Family

ID=32927689

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009156A MXPA05009156A (es) 2003-02-28 2004-02-27 Procedimiento para preparar la sal de 5-(r)-2 -(5, 6-dietil -indan- 2-ilamino) -1-hidroxi- etil-8-hidroxi -(1h)-quinolin- 2-ona, util como un agonista de adrenoceptor.

Country Status (30)

Country Link
US (1) US7534890B2 (es)
EP (1) EP1599450B1 (es)
JP (1) JP4802089B2 (es)
KR (1) KR101076929B1 (es)
CN (1) CN100363349C (es)
AR (1) AR043406A1 (es)
AT (1) ATE434609T1 (es)
AU (1) AU2004215647B2 (es)
BR (1) BRPI0407904B1 (es)
CA (1) CA2517033C (es)
CL (1) CL2004000381A1 (es)
CY (1) CY1109442T1 (es)
DE (1) DE602004021675D1 (es)
DK (1) DK1599450T3 (es)
EC (1) ECSP055977A (es)
ES (1) ES2326974T3 (es)
HK (1) HK1086255A1 (es)
IL (1) IL170138A (es)
MX (1) MXPA05009156A (es)
MY (1) MY142491A (es)
NO (1) NO331985B1 (es)
NZ (1) NZ541727A (es)
PE (1) PE20040956A1 (es)
PL (1) PL213932B1 (es)
PT (1) PT1599450E (es)
RU (1) RU2332405C2 (es)
SI (1) SI1599450T1 (es)
TW (1) TWI324150B (es)
WO (1) WO2004076422A1 (es)
ZA (1) ZA200506060B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20100399A1 (es) * 2003-04-02 2010-06-01 Novartis Ag Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
PT1613315E (pt) * 2003-04-04 2009-04-22 Novartis Ag Derivados da quinolina-2-ona para o tratamento de doenças das vias aéreas respiratórias
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GB0413960D0 (en) * 2004-06-22 2004-07-28 Novartis Ag Organic compounds
BRPI0713951B8 (pt) 2006-06-30 2021-05-25 Novartis Ag derivados de quinazolina, e composição farmacêutica
EP2132179B1 (en) 2007-02-28 2012-08-08 Cipla Limited Process for preparing isomers of carmoterol
WO2011056929A1 (en) * 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
US8680303B2 (en) 2010-03-01 2014-03-25 Massachusetts Institute Of Technology Epoxidation catalysts
WO2013132514A2 (en) * 2012-03-09 2013-09-12 Rao Davuluri Ramamohan A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one
WO2014008640A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 茚达特罗中间体及茚达特罗的合成方法
WO2014008639A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 制备茚达特罗的方法
WO2014044288A1 (en) * 2012-09-21 2014-03-27 Crystal Pharma Sa Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
EP2897937B1 (en) 2012-09-21 2017-12-06 Crystal Pharma S.A.U Process for the preparation of indacaterol and intermediates thereof
CZ306252B6 (cs) 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
EP2978745B1 (en) * 2013-03-27 2017-03-15 Laboratorios Lesvi, S.L. Process for the manufacture of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1h)-quinolin-2-one
EP3092217B1 (en) 2014-01-09 2020-06-03 Davuluri, Ramamohan Rao A novel process for preparation of indacaterol or its pharmaceutically acceptable salts
WO2016027283A2 (en) 2014-08-22 2016-02-25 Reddy G Pratap A process for preparing indacaterol and salts thereof
CN105693603B (zh) * 2014-11-24 2019-11-29 上海医药工业研究院 改良的马来酸茚达特罗制备工艺
CN107531636B (zh) * 2015-04-09 2022-11-25 正大天晴药业集团股份有限公司 茚达特罗或其盐的制备方法
WO2017012489A1 (zh) * 2015-07-21 2017-01-26 四川海思科制药有限公司 具有β2受体激动及M3受体拮抗活性的苯并环衍生物及其在医药上的用途
WO2017055506A1 (en) 2015-09-29 2017-04-06 Laboratorios Lesvi, S.L. Mixed solvate of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl] -8-hydroxy-1h-quinolin-2-one l-tartrate
CN107021921A (zh) * 2016-02-02 2017-08-08 常州爱诺新睿医药技术有限公司 一种茚达特罗中间体的盐及其制备方法
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN108101841B (zh) * 2016-11-24 2021-04-06 江苏恒瑞医药股份有限公司 一种制备茚达特罗或其盐的方法
CN108264483A (zh) * 2016-12-31 2018-07-10 天津金耀集团有限公司 一种马来酸茚达特罗的制备方法
CN109516974B (zh) * 2017-09-19 2022-05-27 南京圣和药业股份有限公司 取代嘧啶类pi3k抑制剂的制备方法
EP3735406B1 (en) 2018-01-02 2022-05-11 Deva Holding Anonim Sirketi A process for preparation of 5-(2-(substituted-amino)-1-hydroxyethyl)-8-(substituted-oxy) quinolin-2(1h)-one
CN109721534B (zh) * 2018-09-25 2022-05-20 四川海思科制药有限公司 一种马来酸茚达特罗中间体及其制备方法和用途
CN109988111A (zh) * 2019-05-06 2019-07-09 淮北师范大学 一种马来酸茚达特罗的杂质及其合成方法
CN110128339B (zh) * 2019-05-31 2022-03-08 苏州芝宇生物科技有限公司 一种茚达特罗及其盐衍生物的合成方法和合成用中间体
CN113731406B (zh) * 2021-10-12 2023-07-28 南京工业大学 一种提高钯碳活性加氢脱除保护基的方法

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GB9405019D0 (en) 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
US6362371B1 (en) * 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
PT1599450E (pt) 2009-08-31
CL2004000381A1 (es) 2005-01-14
CY1109442T1 (el) 2014-08-13
EP1599450A1 (en) 2005-11-30
PL213932B1 (pl) 2013-05-31
HK1086255A1 (en) 2006-09-15
ECSP055977A (es) 2006-01-16
ES2326974T3 (es) 2009-10-22
TWI324150B (en) 2010-05-01
PE20040956A1 (es) 2005-01-20
NO331985B1 (no) 2012-05-21
NO20054452L (no) 2005-11-28
CN100363349C (zh) 2008-01-23
AU2004215647B2 (en) 2006-12-21
CN1753874A (zh) 2006-03-29
BRPI0407904B1 (pt) 2016-09-20
PL378358A1 (pl) 2006-03-20
RU2005129547A (ru) 2007-04-10
US20060252794A1 (en) 2006-11-09
CA2517033C (en) 2011-11-15
NO20054452D0 (no) 2005-09-26
CA2517033A1 (en) 2004-09-10
SI1599450T1 (sl) 2009-12-31
AU2004215647A1 (en) 2004-09-10
ZA200506060B (en) 2006-07-26
BRPI0407904A (pt) 2006-02-14
KR101076929B1 (ko) 2011-10-26
EP1599450B1 (en) 2009-06-24
DK1599450T3 (da) 2009-10-05
JP2006519206A (ja) 2006-08-24
IL170138A (en) 2011-09-27
JP4802089B2 (ja) 2011-10-26
MY142491A (en) 2010-11-30
NZ541727A (en) 2008-07-31
KR20050105258A (ko) 2005-11-03
RU2332405C2 (ru) 2008-08-27
AR043406A1 (es) 2005-07-27
WO2004076422A1 (en) 2004-09-10
TW200505864A (en) 2005-02-16
US7534890B2 (en) 2009-05-19
DE602004021675D1 (de) 2009-08-06
ATE434609T1 (de) 2009-07-15

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