MXPA04005838A - Nuevos compuestos de benzotiazina y benzotiadiazina un proceso para su prepacion y las composiciones farmaceuticas que los contienen. - Google Patents
Nuevos compuestos de benzotiazina y benzotiadiazina un proceso para su prepacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- MXPA04005838A MXPA04005838A MXPA04005838A MXPA04005838A MXPA04005838A MX PA04005838 A MXPA04005838 A MX PA04005838A MX PA04005838 A MXPA04005838 A MX PA04005838A MX PA04005838 A MXPA04005838 A MX PA04005838A MX PA04005838 A MXPA04005838 A MX PA04005838A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- sequels
- alkyl group
- disease
- benzothia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describen los compuestos de la formula (I):(ver formula I),En donde:R1 representa un grupo hidroxilo o un grupo RCO-O-,R2 representa un atomo de hidrogeno, un atomo de halogeno o un grupo hidroxilo, o un grupo R??CO-O,R, R?? los cuales pueden ser identicos o diferentes, representan un grupo alquilo lineal o ramificado de 1 a 6 atomos de carbono opcionalmente sustituidos con un grupo arilo, un grupo alquelino lineal o ramificado de 2 a 6 atomos de carbono, opcionalmente sustituido con un grupo arilo, un grupo perhaloalquilo lineal o ramificado de 1 a 6 atomos de carbono, un grupo cicloalquilo de 3 a 7 atomos de carbono, un grupo adamantilo, un grupo arilo o un grupo heteroarilo,R3 representa un atomo de hidrogeno, un grupo alquilo lineal o ramificado de 1 a 6 atomos de carbono, o un grupo cicloaquilo de 3 a 7 atomos de carbono,A representa un grupo CR4R5 o un grupo NR4,R4 representa un atomo de hidrogeno o un grupo alquilo lineal o ramificado de 1 a 6 atomos de carbono,Sus isomeros y sus sales de adicion con un acido o base farmaceuticamente aceptableLos medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116622A FR2833950B1 (fr) | 2001-12-21 | 2001-12-21 | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2002/004484 WO2003053947A1 (fr) | 2001-12-21 | 2002-12-20 | Derives de benzothia(dia)zine et leur utilisation comme modulateurs ampa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04005838A true MXPA04005838A (es) | 2004-09-10 |
Family
ID=8870810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04005838A MXPA04005838A (es) | 2001-12-21 | 2002-12-20 | Nuevos compuestos de benzotiazina y benzotiadiazina un proceso para su prepacion y las composiciones farmaceuticas que los contienen. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7250411B2 (es) |
| EP (1) | EP1456189B1 (es) |
| JP (1) | JP2005517668A (es) |
| KR (1) | KR100606606B1 (es) |
| CN (1) | CN1606550A (es) |
| AR (1) | AR038029A1 (es) |
| AT (1) | ATE366245T1 (es) |
| AU (1) | AU2002365017B2 (es) |
| BR (1) | BR0215145A (es) |
| CA (1) | CA2471057A1 (es) |
| DE (1) | DE60221041T2 (es) |
| DK (1) | DK1456189T3 (es) |
| EA (1) | EA007271B1 (es) |
| ES (1) | ES2289182T3 (es) |
| FR (1) | FR2833950B1 (es) |
| GE (1) | GEP20063758B (es) |
| HU (1) | HUP0402584A2 (es) |
| MA (1) | MA27089A1 (es) |
| MX (1) | MXPA04005838A (es) |
| NO (1) | NO20042684L (es) |
| NZ (1) | NZ533330A (es) |
| PL (1) | PL369767A1 (es) |
| PT (1) | PT1456189E (es) |
| UA (1) | UA78743C2 (es) |
| WO (1) | WO2003053947A1 (es) |
| ZA (1) | ZA200404296B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2856065B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2856064B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2865474B1 (fr) * | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2877342B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2877338B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB0724625D0 (en) * | 2007-12-18 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0636124A1 (fr) * | 1992-04-15 | 1995-02-01 | Aventis Pharma S.A. | Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant |
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| IL137720A0 (en) * | 1998-02-18 | 2001-10-31 | Neurosearch As | Compounds and their use as positive ampa receptor modulators |
| FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-12-21 FR FR0116622A patent/FR2833950B1/fr not_active Expired - Fee Related
-
2002
- 2002-12-18 AR ARP020104933A patent/AR038029A1/es unknown
- 2002-12-20 CA CA002471057A patent/CA2471057A1/fr not_active Abandoned
- 2002-12-20 EP EP02805407A patent/EP1456189B1/fr not_active Expired - Lifetime
- 2002-12-20 ES ES02805407T patent/ES2289182T3/es not_active Expired - Lifetime
- 2002-12-20 MX MXPA04005838A patent/MXPA04005838A/es active IP Right Grant
- 2002-12-20 PL PL02369767A patent/PL369767A1/xx not_active Application Discontinuation
- 2002-12-20 UA UA20040706010A patent/UA78743C2/uk unknown
- 2002-12-20 DE DE60221041T patent/DE60221041T2/de not_active Expired - Fee Related
- 2002-12-20 HU HU0402584A patent/HUP0402584A2/hu unknown
- 2002-12-20 EA EA200400756A patent/EA007271B1/ru not_active IP Right Cessation
- 2002-12-20 WO PCT/FR2002/004484 patent/WO2003053947A1/fr active IP Right Grant
- 2002-12-20 PT PT02805407T patent/PT1456189E/pt unknown
- 2002-12-20 NZ NZ533330A patent/NZ533330A/en unknown
- 2002-12-20 CN CNA028258142A patent/CN1606550A/zh active Pending
- 2002-12-20 AT AT02805407T patent/ATE366245T1/de not_active IP Right Cessation
- 2002-12-20 GE GE5644A patent/GEP20063758B/en unknown
- 2002-12-20 US US10/499,082 patent/US7250411B2/en not_active Expired - Fee Related
- 2002-12-20 AU AU2002365017A patent/AU2002365017B2/en not_active Ceased
- 2002-12-20 DK DK02805407T patent/DK1456189T3/da active
- 2002-12-20 BR BR0215145-6A patent/BR0215145A/pt not_active IP Right Cessation
- 2002-12-20 KR KR1020047009303A patent/KR100606606B1/ko not_active IP Right Cessation
- 2002-12-20 JP JP2003554663A patent/JP2005517668A/ja active Pending
-
2004
- 2004-06-01 ZA ZA200404296A patent/ZA200404296B/en unknown
- 2004-06-04 MA MA27718A patent/MA27089A1/fr unknown
- 2004-06-25 NO NO20042684A patent/NO20042684L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1606550A (zh) | 2005-04-13 |
| ZA200404296B (en) | 2005-06-01 |
| JP2005517668A (ja) | 2005-06-16 |
| NO20042684L (no) | 2004-06-25 |
| EA007271B1 (ru) | 2006-08-25 |
| US20050014744A1 (en) | 2005-01-20 |
| EP1456189B1 (fr) | 2007-07-04 |
| NZ533330A (en) | 2006-05-26 |
| AU2002365017A1 (en) | 2003-07-09 |
| DE60221041D1 (de) | 2007-08-16 |
| PT1456189E (pt) | 2007-09-20 |
| PL369767A1 (en) | 2005-05-02 |
| WO2003053947A1 (fr) | 2003-07-03 |
| UA78743C2 (en) | 2007-04-25 |
| DE60221041T2 (de) | 2008-04-10 |
| FR2833950A1 (fr) | 2003-06-27 |
| ATE366245T1 (de) | 2007-07-15 |
| AU2002365017B2 (en) | 2007-12-13 |
| EP1456189A1 (fr) | 2004-09-15 |
| GEP20063758B (en) | 2006-02-27 |
| EA200400756A1 (ru) | 2004-10-28 |
| US7250411B2 (en) | 2007-07-31 |
| BR0215145A (pt) | 2004-10-19 |
| CA2471057A1 (fr) | 2003-07-03 |
| HUP0402584A2 (hu) | 2005-04-28 |
| ES2289182T3 (es) | 2008-02-01 |
| AR038029A1 (es) | 2004-12-22 |
| KR100606606B1 (ko) | 2006-08-01 |
| MA27089A1 (fr) | 2004-12-20 |
| KR20040065276A (ko) | 2004-07-21 |
| DK1456189T3 (da) | 2007-11-05 |
| FR2833950B1 (fr) | 2005-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |