AR038029A1 - Derivados de benzotiazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents
Derivados de benzotiazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR038029A1 AR038029A1 ARP020104933A ARP020104933A AR038029A1 AR 038029 A1 AR038029 A1 AR 038029A1 AR P020104933 A ARP020104933 A AR P020104933A AR P020104933 A ARP020104933 A AR P020104933A AR 038029 A1 AR038029 A1 AR 038029A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- branched
- linear
- aryl
- benzotiazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos de fórmula (1) en la cual: R1 representa un grupo hidroxi, RCO-O-; R2 representa H, halógeno, un grupo hidroxi o un grupo R´CO-O; R, R´, idénticos o diferentes representan un grupo alquilo C1-6 lineal o ramificado, eventualmente substituido por un grupo arilo, un grupo alquenilo C2-6 lineal o ramificado eventualmente substituido por un grupo arilo, perhalógenoalquilo C1-6 lineal o ramificado, cicloalquilo C3-7, adamantilo, arilo o heteroarilo; R3 representa H o un grupo alquilo C1-6 lineal o ramificado, o un grupo cicloalquilo C3-7, A representa un grupo CR4R5, o un grupo NR4, R4 representa H o un grupo alquilo C1-6 lineal o ramificado, sus isómeros, así como sus sales de adición con un ácido o con una base farmacéuticamente aceptable: Son moduladores de receptores AMPA. Medicamentos para tratar desórdenes en la memoria y aprendizaje asociado con la edad, síndrome de ansiedad o depresión, enfermedades neurodegenerativas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116622A FR2833950B1 (fr) | 2001-12-21 | 2001-12-21 | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038029A1 true AR038029A1 (es) | 2004-12-22 |
Family
ID=8870810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104933A AR038029A1 (es) | 2001-12-21 | 2002-12-18 | Derivados de benzotiazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7250411B2 (es) |
| EP (1) | EP1456189B1 (es) |
| JP (1) | JP2005517668A (es) |
| KR (1) | KR100606606B1 (es) |
| CN (1) | CN1606550A (es) |
| AR (1) | AR038029A1 (es) |
| AT (1) | ATE366245T1 (es) |
| AU (1) | AU2002365017B2 (es) |
| BR (1) | BR0215145A (es) |
| CA (1) | CA2471057A1 (es) |
| DE (1) | DE60221041T2 (es) |
| DK (1) | DK1456189T3 (es) |
| EA (1) | EA007271B1 (es) |
| ES (1) | ES2289182T3 (es) |
| FR (1) | FR2833950B1 (es) |
| GE (1) | GEP20063758B (es) |
| HU (1) | HUP0402584A2 (es) |
| MA (1) | MA27089A1 (es) |
| MX (1) | MXPA04005838A (es) |
| NO (1) | NO20042684L (es) |
| NZ (1) | NZ533330A (es) |
| PL (1) | PL369767A1 (es) |
| PT (1) | PT1456189E (es) |
| UA (1) | UA78743C2 (es) |
| WO (1) | WO2003053947A1 (es) |
| ZA (1) | ZA200404296B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2856064B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2856065B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2865474B1 (fr) * | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2877342B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2877338B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB0724625D0 (en) * | 2007-12-18 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3957093A (en) * | 1992-04-15 | 1993-11-18 | Rhone-Poulenc Rorer S.A. | 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxyl ic acid derivatives, preparation thereof and drugs containing same |
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| CA2320354A1 (en) * | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
| FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-12-21 FR FR0116622A patent/FR2833950B1/fr not_active Expired - Fee Related
-
2002
- 2002-12-18 AR ARP020104933A patent/AR038029A1/es unknown
- 2002-12-20 DK DK02805407T patent/DK1456189T3/da active
- 2002-12-20 AU AU2002365017A patent/AU2002365017B2/en not_active Ceased
- 2002-12-20 HU HU0402584A patent/HUP0402584A2/hu unknown
- 2002-12-20 ES ES02805407T patent/ES2289182T3/es not_active Expired - Lifetime
- 2002-12-20 EA EA200400756A patent/EA007271B1/ru not_active IP Right Cessation
- 2002-12-20 KR KR1020047009303A patent/KR100606606B1/ko not_active IP Right Cessation
- 2002-12-20 PL PL02369767A patent/PL369767A1/xx not_active Application Discontinuation
- 2002-12-20 DE DE60221041T patent/DE60221041T2/de not_active Expired - Fee Related
- 2002-12-20 GE GE5644A patent/GEP20063758B/en unknown
- 2002-12-20 CN CNA028258142A patent/CN1606550A/zh active Pending
- 2002-12-20 WO PCT/FR2002/004484 patent/WO2003053947A1/fr active IP Right Grant
- 2002-12-20 PT PT02805407T patent/PT1456189E/pt unknown
- 2002-12-20 NZ NZ533330A patent/NZ533330A/en unknown
- 2002-12-20 UA UA20040706010A patent/UA78743C2/uk unknown
- 2002-12-20 CA CA002471057A patent/CA2471057A1/fr not_active Abandoned
- 2002-12-20 MX MXPA04005838A patent/MXPA04005838A/es active IP Right Grant
- 2002-12-20 AT AT02805407T patent/ATE366245T1/de not_active IP Right Cessation
- 2002-12-20 EP EP02805407A patent/EP1456189B1/fr not_active Expired - Lifetime
- 2002-12-20 US US10/499,082 patent/US7250411B2/en not_active Expired - Fee Related
- 2002-12-20 BR BR0215145-6A patent/BR0215145A/pt not_active IP Right Cessation
- 2002-12-20 JP JP2003554663A patent/JP2005517668A/ja active Pending
-
2004
- 2004-06-01 ZA ZA200404296A patent/ZA200404296B/en unknown
- 2004-06-04 MA MA27718A patent/MA27089A1/fr unknown
- 2004-06-25 NO NO20042684A patent/NO20042684L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60221041T2 (de) | 2008-04-10 |
| AU2002365017A1 (en) | 2003-07-09 |
| EP1456189B1 (fr) | 2007-07-04 |
| EP1456189A1 (fr) | 2004-09-15 |
| BR0215145A (pt) | 2004-10-19 |
| DE60221041D1 (de) | 2007-08-16 |
| EA200400756A1 (ru) | 2004-10-28 |
| KR100606606B1 (ko) | 2006-08-01 |
| GEP20063758B (en) | 2006-02-27 |
| FR2833950B1 (fr) | 2005-12-16 |
| PT1456189E (pt) | 2007-09-20 |
| PL369767A1 (en) | 2005-05-02 |
| AU2002365017B2 (en) | 2007-12-13 |
| MXPA04005838A (es) | 2004-09-10 |
| NO20042684L (no) | 2004-06-25 |
| CN1606550A (zh) | 2005-04-13 |
| FR2833950A1 (fr) | 2003-06-27 |
| NZ533330A (en) | 2006-05-26 |
| JP2005517668A (ja) | 2005-06-16 |
| KR20040065276A (ko) | 2004-07-21 |
| HUP0402584A2 (hu) | 2005-04-28 |
| ZA200404296B (en) | 2005-06-01 |
| DK1456189T3 (da) | 2007-11-05 |
| ES2289182T3 (es) | 2008-02-01 |
| UA78743C2 (en) | 2007-04-25 |
| WO2003053947A1 (fr) | 2003-07-03 |
| MA27089A1 (fr) | 2004-12-20 |
| CA2471057A1 (fr) | 2003-07-03 |
| US20050014744A1 (en) | 2005-01-20 |
| ATE366245T1 (de) | 2007-07-15 |
| US7250411B2 (en) | 2007-07-31 |
| EA007271B1 (ru) | 2006-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |