MXPA03009114A - Proteina asociada con enfermedad. - Google Patents
Proteina asociada con enfermedad.Info
- Publication number
- MXPA03009114A MXPA03009114A MXPA03009114A MXPA03009114A MXPA03009114A MX PA03009114 A MXPA03009114 A MX PA03009114A MX PA03009114 A MXPA03009114 A MX PA03009114A MX PA03009114 A MXPA03009114 A MX PA03009114A MX PA03009114 A MXPA03009114 A MX PA03009114A
- Authority
- MX
- Mexico
- Prior art keywords
- sec
- seq
- polypeptide
- cells
- rdcvf2
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0104712A FR2823221B1 (fr) | 2001-04-06 | 2001-04-06 | Sequences associees a la degenerescence retinienne et applications |
| PCT/EP2002/003810 WO2002081513A2 (en) | 2001-04-06 | 2002-04-05 | Disease-associated protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03009114A true MXPA03009114A (es) | 2004-11-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03009114A MXPA03009114A (es) | 2001-04-06 | 2002-04-05 | Proteina asociada con enfermedad. |
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|---|---|
| US (6) | US7795387B2 (https=) |
| EP (1) | EP1379657B1 (https=) |
| JP (2) | JP4370428B2 (https=) |
| KR (1) | KR100913258B1 (https=) |
| CN (1) | CN1529753B (https=) |
| AU (1) | AU2002312794B8 (https=) |
| BR (1) | BRPI0208870B8 (https=) |
| CA (1) | CA2443345C (https=) |
| CZ (1) | CZ305800B6 (https=) |
| EC (1) | ECSP024345A (https=) |
| ES (1) | ES2597835T3 (https=) |
| FR (1) | FR2823221B1 (https=) |
| HU (1) | HU226307B1 (https=) |
| IL (3) | IL158013A0 (https=) |
| MX (1) | MXPA03009114A (https=) |
| NO (1) | NO331277B1 (https=) |
| NZ (1) | NZ528376A (https=) |
| PL (1) | PL213658B1 (https=) |
| RU (1) | RU2384586C2 (https=) |
| SK (1) | SK288465B6 (https=) |
| WO (1) | WO2002081513A2 (https=) |
| ZA (1) | ZA200307403B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823221B1 (fr) | 2001-04-06 | 2004-04-02 | Univ Pasteur | Sequences associees a la degenerescence retinienne et applications |
| DE602004030327D1 (de) | 2003-05-21 | 2011-01-13 | Genzyme Corp | Verfahren zur herstellung von präparationen rekombinanter aav-virionen, die weitgehend frei von leeren capsiden sind |
| FR2870241B1 (fr) * | 2004-05-13 | 2015-02-27 | Novartis Ag | Facteur de viabilite des cones derive des batonnets ou rdcvf et applications |
| EP2027889A1 (en) * | 2007-06-05 | 2009-02-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New neuronal viability factor and use thereof |
| WO2009146183A1 (en) * | 2008-04-15 | 2009-12-03 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (rdcvf) |
| WO2010029130A1 (en) * | 2008-09-10 | 2010-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neuronal viability factor and use thereof |
| EP2383286A1 (en) | 2010-04-30 | 2011-11-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of retinal degenerative diseases |
| KR102000141B1 (ko) | 2011-10-27 | 2019-07-15 | 웰스테이트 옵탈믹스 코퍼레이션 | 간상세포 유래 원추세포 생존능 인자를 인코딩하는 벡터 |
| WO2013124477A1 (en) | 2012-02-24 | 2013-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of retinal degenerative diseases |
| WO2014060517A1 (en) * | 2012-10-17 | 2014-04-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of age-related macular degeneration (amd) |
| PT3027646T (pt) | 2013-07-31 | 2018-10-16 | Novartis Ag | Novos vetores e métodos de seleção de células hospedeiras eucarióticas |
| JP6684343B2 (ja) | 2015-05-21 | 2020-04-22 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ニューロン生存因子の相乗組み合わせ及びその使用 |
| US10857240B2 (en) | 2016-01-05 | 2020-12-08 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treatment of ocular disorders and blinding diseases |
| GB201603987D0 (en) | 2016-03-08 | 2016-04-20 | Immatics Biotechnologies Gmbh | Uterine cancer treatments |
| EP3526238A4 (en) | 2016-10-11 | 2020-04-29 | Wellstat Ophthalmics Corporation | FUSION PROTEIN BETWEEN A SHORT-ROD-DERIVED CONE VIABILITY FACTOR AND A HYDROPHILIC PEPTIDE |
| JP7495756B2 (ja) * | 2019-12-09 | 2024-06-05 | 北京中因科技有限公司 | 医薬の製造におけるＣＹＰ４Ｖ２およびＲｄＣＶＦの使用 |
| CN111733174B (zh) * | 2020-08-07 | 2021-02-09 | 北京大学第三医院（北京大学第三临床医学院） | 一种分离的核酸分子及其用途 |
| EP4366757A1 (en) * | 2021-07-07 | 2024-05-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Synergistic combination of rdcfv2 and rdcvf2l for the treatment of tauopathies |
| CN113774019B (zh) * | 2021-08-11 | 2024-02-13 | 东南大学 | 一种脐带血间充质干细胞无血清培养基、培养方法及其应用 |
| CN121285568A (zh) | 2023-03-30 | 2026-01-06 | 制药五有限责任公司 | 编码视杆细胞源性视锥细胞活力因子和人IgK信号序列的载体 |
| WO2026072752A1 (en) | 2024-09-27 | 2026-04-02 | Pharma Cinq, Llc | Rod-derived cone viability factor fusion protein |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771036A (en) * | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| GB9701710D0 (en) | 1997-01-28 | 1997-03-19 | Karobio Ab | Mammalian protein |
| US6106825A (en) * | 1997-05-07 | 2000-08-22 | University Of Florida | Entomopoxvirus-vertebrate gene delivery vector and method |
| FR2784030B1 (fr) | 1998-10-02 | 2002-12-20 | Inst Nat Sante Rech Med | Utilisation de bloqueurs des canaux calciques et/ou cgmp-dependants pour le traitement de pathologies de la retine |
| FR2784898A1 (fr) | 1998-10-26 | 2000-04-28 | Univ Pasteur | Utilisation du gdnf pour le traitement de la degenerescence retinienne |
| EP1033405A3 (en) * | 1999-02-25 | 2001-08-01 | Ceres Incorporated | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby |
| WO2001053312A1 (en) * | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| FR2823221B1 (fr) * | 2001-04-06 | 2004-04-02 | Univ Pasteur | Sequences associees a la degenerescence retinienne et applications |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| WO2010029130A1 (en) | 2008-09-10 | 2010-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neuronal viability factor and use thereof |
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