BRPI0208870B8 - método de produção de polipeptídeos, vetor, composição farmacêutica, bem como método para diagnóstico de distrofia retinal - Google Patents

método de produção de polipeptídeos, vetor, composição farmacêutica, bem como método para diagnóstico de distrofia retinal

Info

Publication number
BRPI0208870B8
BRPI0208870B8 BRPI0208870A BR0208870A BRPI0208870B8 BR PI0208870 B8 BRPI0208870 B8 BR PI0208870B8 BR PI0208870 A BRPI0208870 A BR PI0208870A BR 0208870 A BR0208870 A BR 0208870A BR PI0208870 B8 BRPI0208870 B8 BR PI0208870B8
Authority
BR
Brazil
Prior art keywords
retinal dystrophy
syndrome
disease
polypeptides
vector
Prior art date
Application number
BRPI0208870A
Other languages
English (en)
Other versions
BR0208870A (pt
BRPI0208870B1 (pt
Inventor
Hicks David
Mohand-Said Saddek
Leveillard Thierry
Original Assignee
Novartis Ag
Univ Pasteur
Univ Strasbourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Pasteur, Univ Strasbourg filed Critical Novartis Ag
Publication of BR0208870A publication Critical patent/BR0208870A/pt
Publication of BRPI0208870B1 publication Critical patent/BRPI0208870B1/pt
Publication of BRPI0208870B8 publication Critical patent/BRPI0208870B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Abstract

"proteína associada à doença". a presente invenção refere-se a métodos e composições para o diagnóstico precoce, monitoração e tratamento de distrofia retinal, degeneração macular relacionada com a idade, síndrome de bardet-biedel, síndrome de bassen-kornzweig, doença de best, coroidema, atrofia do giro, amourose congênita, síndrome de refsun, doença de stargardt e síndrome usher. em particular, a invenção refere-se a uma proteína, chamada "rdcvf1", que é diferencialmente descrita e expressa em indivíduos que sofrem de distrofia retinal e semelhantes, tais como, distrofia retinal e degeneração macular relacionada com a idade em comparação com não-sofredores, anticorpos que reconhecem esta proteína, e métodos para o diagnóstico de tais condições.
BRPI0208870A 2001-04-06 2002-04-05 método de produção de polipeptídeos, vetor, composição farmacêutica, bem como método para diagnóstico de distrofia retinal BRPI0208870B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104712A FR2823221B1 (fr) 2001-04-06 2001-04-06 Sequences associees a la degenerescence retinienne et applications
PCT/EP2002/003810 WO2002081513A2 (en) 2001-04-06 2002-04-05 Disease-associated protein

Publications (3)

Publication Number Publication Date
BR0208870A BR0208870A (pt) 2004-04-27
BRPI0208870B1 BRPI0208870B1 (pt) 2016-01-12
BRPI0208870B8 true BRPI0208870B8 (pt) 2021-05-25

Family

ID=8862037

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0208870A BRPI0208870B8 (pt) 2001-04-06 2002-04-05 método de produção de polipeptídeos, vetor, composição farmacêutica, bem como método para diagnóstico de distrofia retinal

Country Status (22)

Country Link
US (6) US7795387B2 (pt)
EP (1) EP1379657B1 (pt)
JP (2) JP4370428B2 (pt)
KR (1) KR100913258B1 (pt)
CN (1) CN1529753B (pt)
AU (1) AU2002312794B8 (pt)
BR (1) BRPI0208870B8 (pt)
CA (1) CA2443345C (pt)
CZ (1) CZ305800B6 (pt)
EC (1) ECSP024345A (pt)
ES (1) ES2597835T3 (pt)
FR (1) FR2823221B1 (pt)
HU (1) HU226307B1 (pt)
IL (3) IL158013A0 (pt)
MX (1) MXPA03009114A (pt)
NO (1) NO331277B1 (pt)
NZ (1) NZ528376A (pt)
PL (1) PL213658B1 (pt)
RU (1) RU2384586C2 (pt)
SK (1) SK288465B6 (pt)
WO (1) WO2002081513A2 (pt)
ZA (1) ZA200307403B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823221B1 (fr) * 2001-04-06 2004-04-02 Univ Pasteur Sequences associees a la degenerescence retinienne et applications
DE602004030327D1 (de) 2003-05-21 2011-01-13 Genzyme Corp Verfahren zur herstellung von präparationen rekombinanter aav-virionen, die weitgehend frei von leeren capsiden sind
FR2870241B1 (fr) 2004-05-13 2015-02-27 Novartis Ag Facteur de viabilite des cones derive des batonnets ou rdcvf et applications
EP2027889A1 (en) * 2007-06-05 2009-02-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) New neuronal viability factor and use thereof
US9567382B2 (en) * 2008-04-15 2017-02-14 Genzyme Corporation Methods to produce rod-derived cone viability factor (RdCVF)
JP5748223B2 (ja) * 2008-09-10 2015-07-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ニューロン生存因子およびその使用
EP2383286A1 (en) 2010-04-30 2011-11-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of retinal degenerative diseases
MX354516B (es) 2011-10-27 2018-03-08 Wellstat Ophthalmics Corp Vectores que codifican el factor de viabilidad de conos derivado de bastones.
US20150038557A1 (en) 2012-02-24 2015-02-05 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treatment of retinal degenerative diseases
US10004780B2 (en) 2012-10-17 2018-06-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of age-related macular degeneration (AMD)
CN112029791A (zh) 2013-07-31 2020-12-04 诺华股份有限公司 选择真核宿主细胞的选择载体和方法
JP6684343B2 (ja) * 2015-05-21 2020-04-22 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ニューロン生存因子の相乗組み合わせ及びその使用
WO2017120294A1 (en) 2016-01-05 2017-07-13 The Trustees Of The University Of Pennsylvania Methods and compositions for treatment of ocular disorders and blinding diseases
AU2017344059B2 (en) * 2016-10-11 2021-12-23 Pharma Cinq, Llc Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide
US20230146121A1 (en) * 2019-12-09 2023-05-11 Chigenovo Co., Ltd. Use of cyp4v2 and rdcvf in the manufacture of medicament
CN111733174B (zh) * 2020-08-07 2021-02-09 北京大学第三医院（北京大学第三临床医学院） 一种分离的核酸分子及其用途
WO2023280926A1 (en) * 2021-07-07 2023-01-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Synergistic combination of rdcfv2 and rdcvf2l for the treatment of tauopathies
CN113774019B (zh) * 2021-08-11 2024-02-13 东南大学 一种脐带血间充质干细胞无血清培养基、培养方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4771036A (en) 1986-02-10 1988-09-13 Trustees Of Columbia University In The City Of New York Method and ophthalmic composition for the prevention and reversal of cataracts
GB9701710D0 (en) * 1997-01-28 1997-03-19 Karobio Ab Mammalian protein
US6106825A (en) * 1997-05-07 2000-08-22 University Of Florida Entomopoxvirus-vertebrate gene delivery vector and method
FR2784030B1 (fr) * 1998-10-02 2002-12-20 Inst Nat Sante Rech Med Utilisation de bloqueurs des canaux calciques et/ou cgmp-dependants pour le traitement de pathologies de la retine
FR2784898A1 (fr) * 1998-10-26 2000-04-28 Univ Pasteur Utilisation du gdnf pour le traitement de la degenerescence retinienne
EP1033405A3 (en) * 1999-02-25 2001-08-01 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
EP1242443A4 (en) * 1999-12-23 2005-06-22 Nuvelo Inc NEW NUCLEIC ACIDS AND POLYPEPTIDES
FR2823221B1 (fr) * 2001-04-06 2004-04-02 Univ Pasteur Sequences associees a la degenerescence retinienne et applications
US20060275794A1 (en) 2005-03-07 2006-12-07 Invitrogen Corporation Collections of matched biological reagents and methods for identifying matched reagents
JP5748223B2 (ja) 2008-09-10 2015-07-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ニューロン生存因子およびその使用

Also Published As

Publication number Publication date
NO20034452L (no) 2003-12-04
CA2443345A1 (en) 2002-10-17
US20120108523A1 (en) 2012-05-03
FR2823221B1 (fr) 2004-04-02
KR20030094317A (ko) 2003-12-11
IL158013A (en) 2010-12-30
US20120108657A1 (en) 2012-05-03
US8957043B2 (en) 2015-02-17
MXPA03009114A (es) 2004-11-22
FR2823221A1 (fr) 2002-10-11
CN1529753B (zh) 2013-06-12
PL364681A1 (en) 2004-12-13
RU2003130638A (ru) 2005-04-20
CZ20032706A3 (cs) 2003-12-17
NZ528376A (en) 2005-09-30
CN1529753A (zh) 2004-09-15
WO2002081513A2 (en) 2002-10-17
ES2597835T3 (es) 2017-01-23
JP4571695B2 (ja) 2010-10-27
NO331277B1 (no) 2011-11-14
US8518695B2 (en) 2013-08-27
KR100913258B1 (ko) 2009-08-21
EP1379657A2 (en) 2004-01-14
JP4370428B2 (ja) 2009-11-25
US20040204350A1 (en) 2004-10-14
US8394756B2 (en) 2013-03-12
HU226307B1 (en) 2008-08-28
NO20034452D0 (no) 2003-10-03
EP1379657B1 (en) 2016-08-17
ECSP024345A (es) 2004-06-28
AU2002312794B2 (en) 2005-12-01
US7795387B2 (en) 2010-09-14
RU2384586C2 (ru) 2010-03-20
US8071745B2 (en) 2011-12-06
JP2005502319A (ja) 2005-01-27
BR0208870A (pt) 2004-04-27
BRPI0208870B1 (pt) 2016-01-12
AU2002312794B8 (en) 2006-01-12
PL213658B1 (pl) 2013-04-30
US20090062188A1 (en) 2009-03-05
IL199316A (en) 2011-01-31
WO2002081513A3 (en) 2003-05-01
US20130287738A1 (en) 2013-10-31
ZA200307403B (en) 2004-04-21
US20080004231A1 (en) 2008-01-03
CZ305800B6 (cs) 2016-03-23
US8114849B2 (en) 2012-02-14
CA2443345C (en) 2012-12-04
JP2009232843A (ja) 2009-10-15
SK288465B6 (sk) 2017-06-02
IL158013A0 (en) 2004-03-28
SK12232003A3 (sk) 2004-03-02
HUP0303730A2 (en) 2006-02-28

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