MXPA03007729A - Combinacion que comprende un inhibidor de transduccion de senal y un derivado de epotilona. - Google Patents

Combinacion que comprende un inhibidor de transduccion de senal y un derivado de epotilona.

Info

Publication number
MXPA03007729A
MXPA03007729A MXPA03007729A MXPA03007729A MXPA03007729A MX PA03007729 A MXPA03007729 A MX PA03007729A MX PA03007729 A MXPA03007729 A MX PA03007729A MX PA03007729 A MXPA03007729 A MX PA03007729A MX PA03007729 A MXPA03007729 A MX PA03007729A
Authority
MX
Mexico
Prior art keywords
combination
signal transduction
transduction inhibitor
epothilone derivative
derivative
Prior art date
Application number
MXPA03007729A
Other languages
English (en)
Inventor
Peter Traxler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0104840.4A external-priority patent/GB0104840D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA03007729A publication Critical patent/MXPA03007729A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MXPA03007729A 2001-02-27 2002-02-26 Combinacion que comprende un inhibidor de transduccion de senal y un derivado de epotilona. MXPA03007729A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0104840.4A GB0104840D0 (en) 2001-02-27 2001-02-27 Use of organic compounds
US33904001P 2001-10-30 2001-10-30
PCT/EP2002/002049 WO2002067941A2 (en) 2001-02-27 2002-02-26 Combination comprising a signal transduction inhibitor and an epothilone derivative

Publications (1)

Publication Number Publication Date
MXPA03007729A true MXPA03007729A (es) 2003-12-04

Family

ID=26245767

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007729A MXPA03007729A (es) 2001-02-27 2002-02-26 Combinacion que comprende un inhibidor de transduccion de senal y un derivado de epotilona.

Country Status (23)

Country Link
US (1) US7723339B2 (es)
EP (1) EP1385522B1 (es)
JP (1) JP4499359B2 (es)
KR (1) KR100848197B1 (es)
CN (1) CN1511036B (es)
AT (1) ATE434438T1 (es)
AU (1) AU2002308218B2 (es)
BR (1) BR0207649A (es)
CA (1) CA2439268C (es)
CY (1) CY1109347T1 (es)
DE (1) DE60232719D1 (es)
DK (1) DK1385522T3 (es)
ES (1) ES2326264T3 (es)
HK (1) HK1062266A1 (es)
IL (2) IL157466A0 (es)
MX (1) MXPA03007729A (es)
NO (1) NO325416B1 (es)
NZ (1) NZ527764A (es)
PL (1) PL207197B1 (es)
PT (1) PT1385522E (es)
RU (1) RU2313345C2 (es)
SK (1) SK287489B6 (es)
WO (1) WO2002067941A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
CZ305799B6 (cs) 2001-03-14 2016-03-23 Bristol-Myers Squibb Company Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí
CZ299756B6 (cs) * 2001-05-16 2008-11-12 Novartis Ag Kombinace s obsahem N-{5-[4-(4-methyl-piperazino-methyl)benzoylamido]-2-methylfenyl}-4-(3-pyridyl)-2-pyrimidin-aminu k lécení proliferativních onemocnení
EP1704863A3 (en) * 2001-05-16 2010-11-24 Novartis AG Combination comprising N-5-4-(4-Methyl-Piperazino-Methyl-)Benzoyla Mido]-2-Methylphenyl -4-(3-Pyridyl)-2Phyrimidine-amine and a chemotherapeutic agent
AU2002349013A1 (en) * 2001-10-29 2003-05-12 Novartis Ag Use of 7h-pyrrolo(2,3-d)pyrimidine derivatives in the treatment of solid tumor diseases
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1506203B1 (en) 2002-08-23 2007-01-03 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
JO2596B1 (en) * 2004-11-30 2011-02-27 نوفارتيس ايه جي Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses
AU2006336468B2 (en) 2005-02-11 2012-04-12 University Of Southern California Method of expressing proteins with disulfide bridges
EP2029156A4 (en) * 2006-05-01 2010-07-21 Univ Southern California POLY THERAPY FOR TREATING CANCER
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
EP2571525A4 (en) 2010-05-18 2016-04-27 Cerulean Pharma Inc Compositions and methods for treating autoimmune and other diseases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
PT836605E (pt) * 1995-07-06 2002-07-31 Novartis Ag Pirrolopirimidinas e processos para a sua preparacao
PT941227E (pt) 1996-11-18 2004-08-31 Biotechnolog Forschung Mbh Gbf Epothilona d sua preparacao e sua utilizacao como agente citostatico ou como agente de proteccao fitossanitaria
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6302838B1 (en) * 1998-02-25 2001-10-16 Novartis Ag Cancer treatment with epothilones
AU5036999A (en) * 1998-06-30 2000-01-17 Schering Aktiengesellschaft Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
KR20010094763A (ko) * 1999-02-11 2001-11-01 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 에포틸론 유도체, 그 제조방법 및 제약적 용도
DE19908760A1 (de) * 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung

Also Published As

Publication number Publication date
DE60232719D1 (de) 2009-08-06
CY1109347T1 (el) 2014-07-02
WO2002067941A2 (en) 2002-09-06
CA2439268A1 (en) 2002-09-06
BR0207649A (pt) 2004-03-09
US7723339B2 (en) 2010-05-25
PL207197B1 (pl) 2010-11-30
SK10712003A3 (sk) 2004-02-03
IL157466A (en) 2012-04-30
JP4499359B2 (ja) 2010-07-07
KR100848197B1 (ko) 2008-07-24
RU2003127392A (ru) 2005-03-27
US20040132754A1 (en) 2004-07-08
EP1385522A2 (en) 2004-02-04
JP2004527493A (ja) 2004-09-09
DK1385522T3 (da) 2009-10-12
PT1385522E (pt) 2009-09-04
NO325416B1 (no) 2008-04-21
NZ527764A (en) 2006-01-27
RU2313345C2 (ru) 2007-12-27
NO20033769L (no) 2003-08-25
CN1511036A (zh) 2004-07-07
AU2002308218B2 (en) 2005-11-10
ES2326264T3 (es) 2009-10-06
NO20033769D0 (no) 2003-08-25
ATE434438T1 (de) 2009-07-15
CN1511036B (zh) 2010-05-05
KR20040025900A (ko) 2004-03-26
WO2002067941A8 (en) 2003-12-18
HK1062266A1 (en) 2004-10-29
EP1385522B1 (en) 2009-06-24
IL157466A0 (en) 2004-03-28
CA2439268C (en) 2010-01-19
SK287489B6 (sk) 2010-11-08
WO2002067941A3 (en) 2003-11-20
PL363288A1 (en) 2004-11-15

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