MXPA02010194A - Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age). - Google Patents

Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age).

Info

Publication number
MXPA02010194A
MXPA02010194A MXPA02010194A MXPA02010194A MXPA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A MX PA02010194 A MXPA02010194 A MX PA02010194A
Authority
MX
Mexico
Prior art keywords
protein
formation
end product
age
advanced glycation
Prior art date
Application number
MXPA02010194A
Other languages
English (en)
Inventor
Georg Thomas Wondrak
Original Assignee
Niadyne Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22730907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02010194(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Niadyne Corp filed Critical Niadyne Corp
Publication of MXPA02010194A publication Critical patent/MXPA02010194A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion se refiere a metodos para identificar compuestos que afectan la tension celular; en particular, el metodo se refiere a identificar compuestos que inhiben la formacion de proteina-producto final de glicacion avanzada, en que los compuestos son barredores de carbonilo que inhiben la formacion; el ensayo implica combinar la sustancia de interes con histona H1 y ADP-ribosa, y medir luego la fluorescencia y el entrelazamiento de proteina; se han identificado varios inhibidores de la glicacion de proteina-AGE, usando este ensayo.
MXPA02010194A 2000-04-14 2001-04-16 Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age). MXPA02010194A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19782900P 2000-04-14 2000-04-14
PCT/US2001/012368 WO2001079842A2 (en) 2000-04-14 2001-04-16 Method for identifying regulators of protein-age formation

Publications (1)

Publication Number Publication Date
MXPA02010194A true MXPA02010194A (es) 2004-08-19

Family

ID=22730907

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02010194A MXPA02010194A (es) 2000-04-14 2001-04-16 Metodo para identificar reguladores de formacion de proteina-producto final de glicacion avanzada (proteina-age).

Country Status (14)

Country Link
US (1) US6716635B2 (es)
EP (1) EP1272843B1 (es)
JP (1) JP3920641B2 (es)
CN (1) CN1205480C (es)
AT (1) ATE365319T1 (es)
AU (2) AU5355501A (es)
CY (1) CY1106852T1 (es)
DE (1) DE60129008T2 (es)
DK (1) DK1272843T3 (es)
ES (1) ES2286117T3 (es)
HK (1) HK1059117A1 (es)
MX (1) MXPA02010194A (es)
PT (1) PT1272843E (es)
WO (1) WO2001079842A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
JP2003530434A (ja) * 2000-04-14 2003-10-14 ナイアダイン コーポレーション Ｄｎａ損傷に起因する状態の処置にペニシラミン類を使用する方法
US6751792B1 (en) * 2000-10-04 2004-06-15 Sun Microsystems, Inc. Using value-expression graphs for data-flow optimizations
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
EP1575513A4 (en) * 2002-08-16 2007-04-04 Wyeth Corp COMPOSITIONS AND METHODS FOR TREATING RAGE-ASSOCIATED DISEASES
WO2005040798A1 (ja) * 2003-10-29 2005-05-06 Eisai Co., Ltd. アルツハイマー病の診断方法
FR2863620B1 (fr) * 2003-12-16 2007-05-25 Roquette Freres Utilisation d'au moins un cetose de 3 a 5 atomes de carbone comme substitut d'agents reticulants de proteines
SI1720538T1 (sl) * 2004-03-02 2009-04-30 Ersity Of Arizona The Arizona Postopek za induciranje celične smrti z odstranjevalci karbonila
SG161242A1 (en) * 2004-08-03 2010-05-27 Transtech Pharma Inc Rage fusion proteins and methods of use
CA2570324C (en) * 2004-08-03 2014-07-22 Transtech Pharma, Inc. Rage fusion proteins and methods of use
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
ES2431632T3 (es) * 2005-12-23 2013-11-27 Gcoder Systems Ab Patrón de posicionamiento
KR20080105066A (ko) * 2006-02-09 2008-12-03 트랜스테크 파르마, 인크. Ｒａｇｅ 융합 단백질 및 이의 사용 방법
NZ571692A (en) 2006-05-05 2012-01-12 Transtech Pharma Inc Rage fusion proteins, formulations, and methods of use thereof
WO2008100470A2 (en) * 2007-02-15 2008-08-21 Transtech Pharma, Inc. Rage - immunoglobulin fusion proteins
WO2008157378A2 (en) 2007-06-14 2008-12-24 Galactica Pharmaceuticals Page fusion proteins
KR20110139292A (ko) 2009-04-20 2011-12-28 화이자 인코포레이티드 단백질 글리코실화의 제어 및 그와 관련된 조성물 및 방법
US9309304B2 (en) * 2012-05-16 2016-04-12 Cornell University Glycation cross-link breakers to increase resistance to enzymatic degradation
CN108776131B (zh) * 2018-03-19 2020-06-09 深圳市南山区疾病预防控制中心 一种食品中AGEs含量的检测方法
CN109970730B (zh) * 2019-04-30 2022-06-17 华东理工大学 一种双功能荧光探针及其制备方法和应用
JP7411205B2 (ja) 2019-09-30 2024-01-11 丸善製薬株式会社 ＡＧＥｓ形成抑制剤及びその製造方法
CN111007135B (zh) * 2019-12-25 2022-08-02 广东食品药品职业学院 一种植物提取物抗糖化效果的评估方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2711990B1 (fr) 1993-11-05 1995-12-08 Exsymol Sa Produit pseudodipeptide possédant un groupement imidazole, et applications thérapeutiques, cosmétologiques et agroalimentaires.
FR2776188B1 (fr) 1998-03-20 2000-06-16 Fabre Pierre Dermo Cosmetique Oleamide de glycylglycine en dermo-cosmetologie

Also Published As

Publication number Publication date
HK1059117A1 (en) 2004-06-18
ATE365319T1 (de) 2007-07-15
WO2001079842A3 (en) 2002-10-24
DE60129008T2 (de) 2007-10-11
EP1272843A2 (en) 2003-01-08
EP1272843B1 (en) 2007-06-20
ES2286117T3 (es) 2007-12-01
DK1272843T3 (da) 2007-10-08
PT1272843E (pt) 2007-10-01
DE60129008D1 (de) 2007-08-02
CY1106852T1 (el) 2012-05-23
AU2001253555B2 (en) 2005-01-06
JP3920641B2 (ja) 2007-05-30
CN1451096A (zh) 2003-10-22
CN1205480C (zh) 2005-06-08
US20020037496A1 (en) 2002-03-28
US6716635B2 (en) 2004-04-06
WO2001079842A2 (en) 2001-10-25
JP2003531376A (ja) 2003-10-21
AU5355501A (en) 2001-10-30

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