EP1274418A4 - Methods of use of penicillamines for the treatment of conditions resulting from dna damage - Google Patents

Methods of use of penicillamines for the treatment of conditions resulting from dna damage

Info

Publication number
EP1274418A4
EP1274418A4 EP01927051A EP01927051A EP1274418A4 EP 1274418 A4 EP1274418 A4 EP 1274418A4 EP 01927051 A EP01927051 A EP 01927051A EP 01927051 A EP01927051 A EP 01927051A EP 1274418 A4 EP1274418 A4 EP 1274418A4
Authority
EP
European Patent Office
Prior art keywords
penicillamines
treatment
methods
dna damage
conditions resulting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01927051A
Other languages
German (de)
French (fr)
Other versions
EP1274418A1 (en
Inventor
Myron K Jacobson
Elaine L Jacobson
Georg T Wondrak
Daniel Cervantes-Laurean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Publication of EP1274418A1 publication Critical patent/EP1274418A1/en
Publication of EP1274418A4 publication Critical patent/EP1274418A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP01927051A 2000-04-14 2001-04-16 Methods of use of penicillamines for the treatment of conditions resulting from dna damage Withdrawn EP1274418A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19721600P 2000-04-14 2000-04-14
US197216P 2000-04-14
PCT/US2001/012325 WO2001078718A1 (en) 2000-04-14 2001-04-16 Methods of use of penicillamines for the treatment of conditions resulting from dna damage

Publications (2)

Publication Number Publication Date
EP1274418A1 EP1274418A1 (en) 2003-01-15
EP1274418A4 true EP1274418A4 (en) 2005-02-09

Family

ID=22728499

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01927051A Withdrawn EP1274418A4 (en) 2000-04-14 2001-04-16 Methods of use of penicillamines for the treatment of conditions resulting from dna damage

Country Status (6)

Country Link
EP (1) EP1274418A4 (en)
JP (1) JP2003530434A (en)
CN (1) CN1431898A (en)
AU (2) AU5353901A (en)
MX (1) MXPA02010182A (en)
WO (1) WO2001078718A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622117B2 (en) * 2002-04-17 2009-11-24 Dynamis Therapeutics, Inc. 3-deoxyglucosone and skin
JP4985214B2 (en) * 2007-08-20 2012-07-25 ソニー株式会社 Biological substance detection method using laser

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070483A (en) * 1975-06-30 1978-01-24 Sidney Lerman Method of administering a human ocular treating agent and product therefor
WO1993014750A2 (en) * 1992-01-27 1993-08-05 The Rockefeller University Amino acids useful as inhibitors of the advanced glycosylation of proteins
WO1994004129A2 (en) * 1992-08-26 1994-03-03 Beiersdorf Ag Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates
JPH1053516A (en) * 1996-05-20 1998-02-24 Shiseido Co Ltd Aging resistant and collagen crosslinking preventing skin lotion
WO2001079842A2 (en) * 2000-04-14 2001-10-25 Niadyne Corporation Method for identifying regulators of protein-age formation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070483A (en) * 1975-06-30 1978-01-24 Sidney Lerman Method of administering a human ocular treating agent and product therefor
WO1993014750A2 (en) * 1992-01-27 1993-08-05 The Rockefeller University Amino acids useful as inhibitors of the advanced glycosylation of proteins
WO1994004129A2 (en) * 1992-08-26 1994-03-03 Beiersdorf Ag Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates
JPH1053516A (en) * 1996-05-20 1998-02-24 Shiseido Co Ltd Aging resistant and collagen crosslinking preventing skin lotion
WO2001079842A2 (en) * 2000-04-14 2001-10-25 Niadyne Corporation Method for identifying regulators of protein-age formation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; *
DILLON J ET AL: "IN-VITRO AND IN-VIVO PROTECTION AGAINST PHOTOTOXIC SIDE EFFECTS OF PHOTODYNAMIC THERAPY BY RADIOPROTECTIVE AGENTS WR-2721 AND WR-77913", PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 48, no. 2, 1988, pages 235 - 238, XP009041622, ISSN: 0031-8655 *
JAKUS V ET AL: "Inhibition of nonenzymatic protein glycation and lipid peroxidation by drugs with antioxidant activity", LIFE SCIENCES, vol. 65, no. 18-19, 1 October 1999 (1999-10-01), pages 1991 - 1993, XP001204512, ISSN: 0024-3205 *
ROBERTS MICHAEL JOHN ET AL: "Identification and evaluation of D-penicillamine as an inhibitor of reactive carbonyl species to prevent DNA damage in human skin cells", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 444, XP001204260, ISSN: 0197-016X *
See also references of WO0178718A1 *
VOGEL H G: "STRAIN OF RAT SKIN AT CONSTANT LOAD CREEP EXPERIMENTS INFLUENCE OF AGE AND DESMOTROPIC AGENTS", GERONTOLOGY, vol. 23, no. 2, 1976, pages 77 - 86, XP009041621, ISSN: 0304-324X *

Also Published As

Publication number Publication date
AU2001253539B2 (en) 2005-08-04
AU5353901A (en) 2001-10-30
CN1431898A (en) 2003-07-23
WO2001078718A1 (en) 2001-10-25
EP1274418A1 (en) 2003-01-15
JP2003530434A (en) 2003-10-14
MXPA02010182A (en) 2004-08-19

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20021014

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Effective date: 20041230

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 39/06 B

Ipc: 7A 61K 31/198 A

17Q First examination report despatched

Effective date: 20050630

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18D Application deemed to be withdrawn

Effective date: 20070327