MXPA01003836A - Metodo para `produccion de hemoglobina libre de estroma.. - Google Patents
Metodo para `produccion de hemoglobina libre de estroma..Info
- Publication number
- MXPA01003836A MXPA01003836A MXPA01003836A MXPA01003836A MXPA01003836A MX PA01003836 A MXPA01003836 A MX PA01003836A MX PA01003836 A MXPA01003836 A MX PA01003836A MX PA01003836 A MXPA01003836 A MX PA01003836A MX PA01003836 A MXPA01003836 A MX PA01003836A
- Authority
- MX
- Mexico
- Prior art keywords
- solution
- red blood
- blood cells
- hemoglobin
- blood
- Prior art date
Links
- 108010001708 stroma free hemoglobin Proteins 0.000 title claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 title description 15
- 210000004369 blood Anatomy 0.000 claims abstract description 84
- 239000008280 blood Substances 0.000 claims abstract description 84
- 238000000034 method Methods 0.000 claims abstract description 84
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 81
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 78
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 78
- 238000012545 processing Methods 0.000 claims abstract description 50
- 239000000306 component Substances 0.000 claims abstract description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 17
- 230000001413 cellular effect Effects 0.000 claims abstract description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 13
- 239000001301 oxygen Substances 0.000 claims abstract description 13
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- 230000036512 infertility Effects 0.000 claims abstract description 5
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- 238000011065 in-situ storage Methods 0.000 claims abstract description 4
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- 239000000243 solution Substances 0.000 claims description 65
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- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 239000000815 hypotonic solution Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
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- 230000000415 inactivating effect Effects 0.000 claims 1
- 239000003633 blood substitute Substances 0.000 abstract description 19
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- 239000000047 product Substances 0.000 description 17
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- 239000012153 distilled water Substances 0.000 description 11
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- 238000012360 testing method Methods 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 238000011109 contamination Methods 0.000 description 7
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- 150000003278 haem Chemical class 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
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- 229910019142 PO4 Inorganic materials 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
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- 108010036302 hemoglobin AS Proteins 0.000 description 5
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 238000003908 quality control method Methods 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 108010061951 Methemoglobin Proteins 0.000 description 4
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- 238000006243 chemical reaction Methods 0.000 description 4
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000012480 LAL reagent Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
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- 238000001802 infusion Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
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- 230000002441 reversible effect Effects 0.000 description 2
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- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 108010003320 Carboxyhemoglobin Proteins 0.000 description 1
- 241001529572 Chaceon affinis Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 238000011050 LAL assay Methods 0.000 description 1
- 241000239217 Limulidae Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010031004 PEG-hemoglobin Proteins 0.000 description 1
- 208000034809 Product contamination Diseases 0.000 description 1
- 208000031306 Rare hereditary hemochromatosis Diseases 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
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- 239000002473 artificial blood Substances 0.000 description 1
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- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
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- 239000000539 dimer Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 230000008014 freezing Effects 0.000 description 1
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- 102000018146 globin Human genes 0.000 description 1
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- 150000002334 glycols Chemical class 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- 238000005342 ion exchange Methods 0.000 description 1
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- 210000004698 lymphocyte Anatomy 0.000 description 1
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- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
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- 229920002492 poly(sulfone) Polymers 0.000 description 1
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- 239000002244 precipitate Substances 0.000 description 1
- 238000009417 prefabrication Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000011046 pyrogen test Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
- A61M2202/0433—Free haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Centrifugal Separators (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10431998P | 1998-10-15 | 1998-10-15 | |
| US12218099P | 1999-03-01 | 1999-03-01 | |
| PCT/US1999/024149 WO2000021591A1 (en) | 1998-10-15 | 1999-10-15 | Method for production of stroma-free hemoglobin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01003836A true MXPA01003836A (es) | 2002-09-18 |
Family
ID=26801402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01003836A MXPA01003836A (es) | 1998-10-15 | 1999-10-15 | Metodo para `produccion de hemoglobina libre de estroma.. |
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| EP (1) | EP1121165A1 (https=) |
| JP (1) | JP2002527149A (https=) |
| KR (1) | KR20010099700A (https=) |
| CN (1) | CN1332646A (https=) |
| AU (1) | AU771465B2 (https=) |
| BR (1) | BR9915734A (https=) |
| CA (1) | CA2346825C (https=) |
| MX (1) | MXPA01003836A (https=) |
| WO (1) | WO2000021591A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1740285A4 (en) * | 2004-04-13 | 2007-07-04 | Sangart Inc | METHOD AND COMPOSITIONS FOR SIMULTANEOUS ISOLATION OF HEMOGLOBIN FROM RED BLOOD BODIES AND INACTIVATION OF VIRUSES |
| JP2006021121A (ja) | 2004-07-08 | 2006-01-26 | Hitachi Koki Co Ltd | 遠心分離機 |
| ITLU20070013A1 (it) * | 2007-06-22 | 2008-12-23 | Kedrion Spa | Processo per la purificazione di emoglobina umana apirogena e virus inattivata. |
| ES2660180T3 (es) * | 2007-12-07 | 2018-03-21 | Miltenyi Biotec Gmbh | Sistemas y métodos para procesamiento de células |
| CN102859364A (zh) * | 2010-02-25 | 2013-01-02 | 桑格特公司 | 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 |
| US20150273132A1 (en) * | 2012-11-05 | 2015-10-01 | Haemonetics Corporation | System and Method for Continuous Separation of Whole Blood |
| CN103091149B (zh) * | 2013-01-10 | 2015-08-05 | 济南金域医学检验中心有限公司 | 血红蛋白电泳液的制备方法 |
| JP6067889B2 (ja) | 2013-02-26 | 2017-01-25 | イー・エム・デイー・ミリポア・コーポレイシヨン | 溶液条件を調整することによる活性化炭素を使用したタンパク質混合物からの１種のタンパク質の選択的除去 |
| CN106456813B (zh) * | 2014-04-15 | 2020-06-30 | 勃林格殷格翰国际公司 | 在制造生物制品期间连续灭活病毒的方法、装置和系统 |
| CN111801412A (zh) * | 2018-03-02 | 2020-10-20 | 赛默电子Led有限公司 | 用于分离生物悬浮液的一次性离心容器和使用方法 |
| CN109298171B (zh) * | 2018-11-15 | 2022-06-28 | 武汉中生毓晋生物医药有限责任公司 | 醛化红细胞中内毒素的去除方法与应用 |
| CO2023018740A1 (es) * | 2023-12-29 | 2025-07-07 | Lifefactors S A S | Sistema de separación de componentes plasmáticos por descongelamiento controlado mediante unos mecanismos integrados de transferencia térmica controlada y sedimentación acelerada en unos medios continuos |
| CN119746044A (zh) * | 2025-03-06 | 2025-04-04 | 润方（北京）生物医药研究院有限公司 | 血红蛋白氧载体在制备抗病毒药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303193A (en) | 1979-01-22 | 1981-12-01 | Haemonetics Corporation | Apparatus for separating blood into components thereof |
| US4401652A (en) * | 1980-12-31 | 1983-08-30 | Allied Corporation | Process for the preparation of stroma-free hemoglobin solutions |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| JPH02121931A (ja) * | 1988-10-29 | 1990-05-09 | Res Inst For Prod Dev | 濃縮ヘモグロビンの製造方法 |
| US5646252A (en) * | 1992-02-10 | 1997-07-08 | Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid | Hemoglobin composition and preparation thereof |
| US5676644A (en) | 1995-06-07 | 1997-10-14 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
| US5814601A (en) | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
-
1999
- 1999-10-15 CA CA002346825A patent/CA2346825C/en not_active Expired - Fee Related
- 1999-10-15 JP JP2000575563A patent/JP2002527149A/ja not_active Withdrawn
- 1999-10-15 AU AU11170/00A patent/AU771465B2/en not_active Ceased
- 1999-10-15 WO PCT/US1999/024149 patent/WO2000021591A1/en not_active Ceased
- 1999-10-15 CN CN99813429A patent/CN1332646A/zh active Pending
- 1999-10-15 MX MXPA01003836A patent/MXPA01003836A/es unknown
- 1999-10-15 EP EP99954950A patent/EP1121165A1/en not_active Withdrawn
- 1999-10-15 BR BR9915734-9A patent/BR9915734A/pt not_active IP Right Cessation
- 1999-10-15 KR KR1020017004781A patent/KR20010099700A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010099700A (ko) | 2001-11-09 |
| CA2346825A1 (en) | 2000-04-20 |
| EP1121165A1 (en) | 2001-08-08 |
| AU771465B2 (en) | 2004-03-25 |
| WO2000021591A1 (en) | 2000-04-20 |
| JP2002527149A (ja) | 2002-08-27 |
| AU1117000A (en) | 2000-05-01 |
| BR9915734A (pt) | 2001-10-02 |
| CA2346825C (en) | 2008-07-29 |
| CN1332646A (zh) | 2002-01-23 |
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