MX9805168A - Derivados de tiol con actividad inhibitoria de la metalopeptidasa (ace-nep). - Google Patents

Derivados de tiol con actividad inhibitoria de la metalopeptidasa (ace-nep).

Info

Publication number
MX9805168A
MX9805168A MX9805168A MX9805168A MX9805168A MX 9805168 A MX9805168 A MX 9805168A MX 9805168 A MX9805168 A MX 9805168A MX 9805168 A MX9805168 A MX 9805168A MX 9805168 A MX9805168 A MX 9805168A
Authority
MX
Mexico
Prior art keywords
nep
inhibitory activity
ace
metallopeptidase
thiol derivatives
Prior art date
Application number
MX9805168A
Other languages
English (en)
Inventor
Franco Pellacini
Stefano Romagnano
Gabriele Norcini
Francesco Santangelo
Claudio Semeraro
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of MX9805168A publication Critical patent/MX9805168A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Detergent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de la formula (I) en donde R, R1, R2, R3 tienen los significados reportados en la descripcion, procedimientos para su preparacion y composiciones farmacéuticos que los contienen como ingredientes activos. Los compuestos de la formula (I) están dotados con una actividad inhibitoria de la ACE e inhibitoria de la NEP, mezclada y son utiles en el tratamiento de enfermedades cardiovasculares.
MX9805168A 1995-12-28 1998-06-25 Derivados de tiol con actividad inhibitoria de la metalopeptidasa (ace-nep). MX9805168A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI002772A IT1277736B1 (it) 1995-12-28 1995-12-28 Derivati tiolici ad attivita' inibitrice delle metallopeptidasi

Publications (1)

Publication Number Publication Date
MX9805168A true MX9805168A (es) 1998-10-31

Family

ID=11372826

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805168A MX9805168A (es) 1995-12-28 1998-06-25 Derivados de tiol con actividad inhibitoria de la metalopeptidasa (ace-nep).

Country Status (15)

Country Link
US (1) US6166051A (es)
EP (1) EP0883612B1 (es)
KR (1) KR19990076808A (es)
CN (1) CN1108295C (es)
AT (1) ATE289597T1 (es)
AU (1) AU706978B2 (es)
CA (1) CA2241452A1 (es)
CZ (1) CZ295804B6 (es)
DE (1) DE69634387D1 (es)
EA (1) EA002339B1 (es)
HU (1) HUP9903840A3 (es)
IT (1) IT1277736B1 (es)
MX (1) MX9805168A (es)
WO (1) WO1997024341A1 (es)
ZA (1) ZA9610819B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2805259B1 (fr) * 2000-02-17 2002-03-29 Inst Nat Sante Rech Med Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8307671B2 (en) * 2008-09-22 2012-11-13 Jungerhans Robert R J Purification of gases in synthesis gas production process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199512A (en) * 1976-05-10 1980-04-22 E. R. Squibb & Sons, Inc. Compounds for alleviating hypertension
EP0566157A1 (en) * 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5223516A (en) * 1990-03-22 1993-06-29 E. R. Squibb & Sons, Inc. 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
CA2038379C (en) * 1990-03-22 2002-11-05 Norma G. Delaney Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5225401A (en) * 1991-08-12 1993-07-06 E. R. Squibb & Sons, Inc. Treatment of congestive heart failure
FR2682952B1 (fr) * 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
AU3494093A (en) * 1993-01-22 1994-08-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
JPH0841015A (ja) * 1994-07-27 1996-02-13 Fujisawa Pharmaceut Co Ltd 新規メルカプト−アミド誘導体
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi

Also Published As

Publication number Publication date
ZA9610819B (en) 1997-06-24
KR19990076808A (ko) 1999-10-15
AU1369197A (en) 1997-07-28
CZ204798A3 (cs) 1998-11-11
CA2241452A1 (en) 1997-07-10
EP0883612B1 (en) 2005-02-23
CN1268945A (zh) 2000-10-04
ATE289597T1 (de) 2005-03-15
US6166051A (en) 2000-12-26
EA199800546A1 (ru) 1999-02-25
IT1277736B1 (it) 1997-11-12
WO1997024341A1 (en) 1997-07-10
HUP9903840A2 (hu) 2000-03-28
DE69634387D1 (de) 2005-03-31
CN1108295C (zh) 2003-05-14
AU706978B2 (en) 1999-07-01
EP0883612A1 (en) 1998-12-16
ITMI952772A1 (it) 1997-06-28
ITMI952772A0 (es) 1995-12-28
EA002339B1 (ru) 2002-04-25
HUP9903840A3 (en) 2001-12-28
CZ295804B6 (cs) 2005-11-16

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees