ATE289597T1 - Mercapto derivate mit metallopeptidase(ace/nep) inhibiernder wirkung - Google Patents
Mercapto derivate mit metallopeptidase(ace/nep) inhibiernder wirkungInfo
- Publication number
- ATE289597T1 ATE289597T1 AT96943903T AT96943903T ATE289597T1 AT E289597 T1 ATE289597 T1 AT E289597T1 AT 96943903 T AT96943903 T AT 96943903T AT 96943903 T AT96943903 T AT 96943903T AT E289597 T1 ATE289597 T1 AT E289597T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- nep
- ace
- metallopeptidase
- inhibiting effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002772A IT1277736B1 (it) | 1995-12-28 | 1995-12-28 | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
| PCT/EP1996/005496 WO1997024341A1 (en) | 1995-12-28 | 1996-12-09 | Thiol derivatives with metallopeptidase (ace/nep) inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE289597T1 true ATE289597T1 (de) | 2005-03-15 |
Family
ID=11372826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96943903T ATE289597T1 (de) | 1995-12-28 | 1996-12-09 | Mercapto derivate mit metallopeptidase(ace/nep) inhibiernder wirkung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6166051A (de) |
| EP (1) | EP0883612B1 (de) |
| KR (1) | KR19990076808A (de) |
| CN (1) | CN1108295C (de) |
| AT (1) | ATE289597T1 (de) |
| AU (1) | AU706978B2 (de) |
| CA (1) | CA2241452A1 (de) |
| CZ (1) | CZ295804B6 (de) |
| DE (1) | DE69634387D1 (de) |
| EA (1) | EA002339B1 (de) |
| HU (1) | HUP9903840A3 (de) |
| IT (1) | IT1277736B1 (de) |
| MX (1) | MX9805168A (de) |
| WO (1) | WO1997024341A1 (de) |
| ZA (1) | ZA9610819B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805259B1 (fr) * | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US8307671B2 (en) * | 2008-09-22 | 2012-11-13 | Jungerhans Robert R J | Purification of gases in synthesis gas production process |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199512A (en) * | 1976-05-10 | 1980-04-22 | E. R. Squibb & Sons, Inc. | Compounds for alleviating hypertension |
| EP0566157A1 (de) * | 1986-06-20 | 1993-10-20 | Schering Corporation | Hemmer der neutralen Metalloendopeptidase zur Behandlung von Hypertension |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
| US5599951A (en) * | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| CA2038379C (en) * | 1990-03-22 | 2002-11-05 | Norma G. Delaney | Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same |
| US5223516A (en) * | 1990-03-22 | 1993-06-29 | E. R. Squibb & Sons, Inc. | 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| US5225401A (en) * | 1991-08-12 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Treatment of congestive heart failure |
| FR2682952B1 (fr) * | 1991-10-25 | 1993-12-03 | Institut Nal Sante Recherc Medic | Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| AU3494093A (en) * | 1993-01-22 | 1994-08-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents |
| JPH0841015A (ja) * | 1994-07-27 | 1996-02-13 | Fujisawa Pharmaceut Co Ltd | 新規メルカプト−アミド誘導体 |
| IT1273455B (it) * | 1995-01-27 | 1997-07-08 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
-
1995
- 1995-12-28 IT IT95MI002772A patent/IT1277736B1/it active IP Right Grant
-
1996
- 1996-12-09 CA CA002241452A patent/CA2241452A1/en not_active Abandoned
- 1996-12-09 KR KR1019980704933A patent/KR19990076808A/ko active IP Right Grant
- 1996-12-09 HU HU9903840A patent/HUP9903840A3/hu unknown
- 1996-12-09 US US09/091,415 patent/US6166051A/en not_active Expired - Fee Related
- 1996-12-09 AT AT96943903T patent/ATE289597T1/de not_active IP Right Cessation
- 1996-12-09 CN CN96199355A patent/CN1108295C/zh not_active Expired - Fee Related
- 1996-12-09 WO PCT/EP1996/005496 patent/WO1997024341A1/en active IP Right Grant
- 1996-12-09 DE DE69634387T patent/DE69634387D1/de not_active Expired - Lifetime
- 1996-12-09 EA EA199800546A patent/EA002339B1/ru not_active IP Right Cessation
- 1996-12-09 EP EP96943903A patent/EP0883612B1/de not_active Expired - Lifetime
- 1996-12-09 AU AU13691/97A patent/AU706978B2/en not_active Ceased
- 1996-12-09 CZ CZ19982047A patent/CZ295804B6/cs not_active IP Right Cessation
- 1996-12-20 ZA ZA9610819A patent/ZA9610819B/xx unknown
-
1998
- 1998-06-25 MX MX9805168A patent/MX9805168A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ204798A3 (cs) | 1998-11-11 |
| CZ295804B6 (cs) | 2005-11-16 |
| KR19990076808A (ko) | 1999-10-15 |
| AU706978B2 (en) | 1999-07-01 |
| ITMI952772A1 (it) | 1997-06-28 |
| MX9805168A (es) | 1998-10-31 |
| DE69634387D1 (de) | 2005-03-31 |
| ITMI952772A0 (de) | 1995-12-28 |
| EA002339B1 (ru) | 2002-04-25 |
| CN1108295C (zh) | 2003-05-14 |
| EP0883612B1 (de) | 2005-02-23 |
| IT1277736B1 (it) | 1997-11-12 |
| CN1268945A (zh) | 2000-10-04 |
| ZA9610819B (en) | 1997-06-24 |
| EA199800546A1 (ru) | 1999-02-25 |
| CA2241452A1 (en) | 1997-07-10 |
| AU1369197A (en) | 1997-07-28 |
| EP0883612A1 (de) | 1998-12-16 |
| US6166051A (en) | 2000-12-26 |
| WO1997024341A1 (en) | 1997-07-10 |
| HUP9903840A3 (en) | 2001-12-28 |
| HUP9903840A2 (hu) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |